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The map label for this gene is fabZ

Identifier: 88658660

GI number: 88658660

Start: 1102795

End: 1103226

Strand: Direct

Name: fabZ

Synonym: ECH_1073

Alternate gene names: 88658660

Gene position: 1102795-1103226 (Clockwise)

Preceding gene: 88657746

Following gene: 88657596

Centisome position: 93.76

GC content: 33.56

Gene sequence:

>432_bases
ATGCAGTTCAATATTCAAGAAATCATAAAAATGATACCACATTCGTATCCATTTTTGTTAATTGATAGAGTAACTGCATG
CACACCTAATGAATCTGTAACAGCAATAAAAAATGTTACTTTTAATGAACCTTTTTTTATTGGTCATTTCCCTGGTAATC
CAATTATGCCTGGCGTACTTATTGTAGAAGCTATGGCACAAGCATGTATAATATGTACAATGAGTAGCATGCAGAATTAC
TCCGTATATCTCATGTCAATAGAGCTAGCAAAATTTCGCAAGCCTGTTATTCCAGGAGACACATTAATTCTTACAGTAAA
CGTTGTACATAAAAGAAAAAATACATGCAAGTTTGAGTGTCATGCACATGTAGAGGGTACATTAGTTGCAGAAGCACAAA
TTCTAGCAATGACTAAACAAAATGAAGCATGA

Upstream 100 bases:

>100_bases
CTGCTGATAATATAGATTTTTCTAACGAAGTATTAGAAATGTTAAACAAAGAATTACCAAATATAGAAATAAAGAAGTGA
GATATTAATTAGAGATTTGT

Downstream 100 bases:

>100_bases
TTTTTTTAAATTTATACATCAATTTTTAGAAAAATATGAAAATAAAAAGAGCAATTATATCTGTATATAATAAAACAAAC
ATTATAGAACTTGCAAAATT

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: trans-Delta2-enoyl-acyl-ACP; H2O [C]

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MQFNIQEIIKMIPHSYPFLLIDRVTACTPNESVTAIKNVTFNEPFFIGHFPGNPIMPGVLIVEAMAQACIICTMSSMQNY
SVYLMSIELAKFRKPVIPGDTLILTVNVVHKRKNTCKFECHAHVEGTLVAEAQILAMTKQNEA

Sequences:

>Translated_143_residues
MQFNIQEIIKMIPHSYPFLLIDRVTACTPNESVTAIKNVTFNEPFFIGHFPGNPIMPGVLIVEAMAQACIICTMSSMQNY
SVYLMSIELAKFRKPVIPGDTLILTVNVVHKRKNTCKFECHAHVEGTLVAEAQILAMTKQNEA
>Mature_143_residues
MQFNIQEIIKMIPHSYPFLLIDRVTACTPNESVTAIKNVTFNEPFFIGHFPGNPIMPGVLIVEAMAQACIICTMSSMQNY
SVYLMSIELAKFRKPVIPGDTLILTVNVVHKRKNTCKFECHAHVEGTLVAEAQILAMTKQNEA

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=136, Percent_Identity=44.1176470588235, Blast_Score=128, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_EHRCR (Q2GFC5)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507858.1
- ProteinModelPortal:   Q2GFC5
- SMR:   Q2GFC5
- STRING:   Q2GFC5
- GeneID:   3927680
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_1073
- TIGR:   ECH_1073
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- PhylomeDB:   Q2GFC5
- ProtClustDB:   PRK00006
- BioCyc:   ECHA205920:ECH_1073-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.- [C]

Molecular weight: Translated: 15998; Mature: 15998

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: ACT_SITE 49-49

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
9.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
9.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFNIQEIIKMIPHSYPFLLIDRVTACTPNESVTAIKNVTFNEPFFIGHFPGNPIMPGVL
CCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHH
IVEAMAQACIICTMSSMQNYSVYLMSIELAKFRKPVIPGDTLILTVNVVHKRKNTCKFEC
HHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEE
HAHVEGTLVAEAQILAMTKQNEA
EECCCEEEEEEEEEEEEECCCCC
>Mature Secondary Structure
MQFNIQEIIKMIPHSYPFLLIDRVTACTPNESVTAIKNVTFNEPFFIGHFPGNPIMPGVL
CCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCCHHH
IVEAMAQACIICTMSSMQNYSVYLMSIELAKFRKPVIPGDTLILTVNVVHKRKNTCKFEC
HHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEE
HAHVEGTLVAEAQILAMTKQNEA
EECCCEEEEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-3-hydroxy-acyl-ACP [C]

Specific reaction: D-3-hydroxy-acyl-ACP = trans-Delta2-enoyl-acyl-ACP + H2O [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA