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The map label for this gene is mutS [H]

Identifier: 88658581

GI number: 88658581

Start: 838813

End: 841227

Strand: Reverse

Name: mutS [H]

Synonym: ECH_0824

Alternate gene names: 88658581

Gene position: 841227-838813 (Counterclockwise)

Preceding gene: 88657777

Following gene: 88658114

Centisome position: 71.52

GC content: 30.52

Gene sequence:

>2415_bases
GTGAATCATGATAGCAAGATAACCCCTATAATGCAGCAGTACATGATGCTGAAGAGTCAATATAAGGAGTATTTATTATT
TTATAGATTAGGTGATTTTTATGAGTTATTTTTTGATGATGCAATAGAGACGTCTAGAATATTAAATATTGTATTAACTA
AAAAGGGGAATGTACCTATGTGTGGTGTTCCCTTTCATAGTAGTGAATCTTATTTAAATAGATTGGTAAAATTAGGTTAT
AAGATAGCAATTTGTGAGCAGTTAGAAACGTCAGAAGAAGCTAAGAAAAGAGGATATAAGGCTTTAGTAAAACGTGATGT
TGTAAGAATAGTTACTCCAGGGACTATATTAGAGGATTCTTTACTTGAAGCAAAAGAGAATAATTATTTATCTTGTATAG
TTAATGTTGACCATAATTATGCTATTGCATGGTTGGAATTGTCTACTGGGTTATTTTATTATCATACAACAGAATTGCAT
AAGCTTGATAGTGATTTGTTCAGAATTAATCCCAAGGAAGTTTTGATTTCTGATAAGTTAGTGGAATTGGATTCTATATA
TTCTATTTTAAGGAAATACAAATTTTCGGTGACACAATATTCGGGTAGTTTTTTTGATGTGAGTAGATCCTATAATACTT
TGTGTAATGTTTATGGAATATCTACTTTAAAAGGATTAGGTGATTTAAAAAATGAAGAGATAGCAGTATGTGGTTCTTTG
TTGGAATATGTTAAAGCTACGCAAAAAGGGAATCTACCTCAGTTGGAATTTCCAAAAGCTTATTCAAAGGGTGATTTTAT
GTTTATAGATGCAGCAGCATTAAGGAACCTTGAGTTATTTTGTACACAATCTGGAGATTTAGAAGGATCCTTAATTTCTT
CTATAGATTATACTATTACAGCATGTGGTGGAAGATTATTAAAACGATGTTTGTCAGCTCCTTTAGCATGTTCTCATGCA
ATAAATCGTAGGTTAGATATTGTTGAGTTTTTTGTAAATGATAGAACATTGTGTAGGGGTGTTAGGGAAACATTACGTGG
TATTGCAGATATAGAGCGTATTTTAACAAGAATTAAAGTTGGTAAATGTTCACCTAAGGATTTATATGCTCTGAAGTTAA
CTTTGGACAAAATTTTTGTATTATTAGATTTATTGCATAAGTTTGATTCTAGTGTTGTAGGTGATTTTTGTTCAAGGTTG
GGTAAATATGATGATTTGTGTAAAACGCTTGATGATGTGTTAATACCGAATAATGTTAATAATGTTAAAGATGGGGGATT
TATTAATCCTGACTATGATGCACAATTGTCAGAATATATATATATTCAAAGTTATAGTAATGATTTAATTCAAGAATTAC
GGGATAAGTACCGTAATATTACTAATATTCAAAGTTTAAAAATATTGTATAACAATATTTTAGGTTATTATGTTGAAGTT
TCATCAAGCTATTTGATTAGTGATAAAGACTTTATTCATAGGCAAACTCTAGCAAATAGTATTAGATATACGACAAGTGA
ATTAAAAGCATTGGAAAGTAAAATAATTTCTGCTAGGGATGCAGCGATTAATTTGGAAGTAAAAATTTTTGGTCAATTAT
GTACATGTATTATTGAAGTTGCAGATAAAATCACTATGACTGCACATGCTATTGCTGAAATTGATATGCTAACTTCTTTT
GCTGAGTTGGCAATACAATATTCTTATACTAAACCTATAGTTGATGATAGTTATGAATTTAACATAAAAAAAGGTAGGCA
TCCTGTGGTTGAACGTAATGGGAAATTTGTAGCTAATGATATTGACCTTTCATTAATGCAAAGAGTACATTTAATCACTG
GACCTAATATGGCTGGTAAAAGTACTTTCTTAAGACAGAATGCATTGATAGGTATTTTAGCGCATATTGGATCATTTGTT
CCTGCTCAACATGCTCATATAGGAGTTATTGATAAAGTATTTAGTAGAGTAGGGGCTTCTGATAATATTGCATCTGGGCA
TTCTACGTTTATGGTAGAAATGACAGAAACTGCTGCAATAATCAATCAAGCCACAGATAAATCTTTTGTAATACTTGATG
AAATTGGTAGGGGTACAGGAACATATGATGGATTATCAATAGCATGGTCGGTTATTGAACAAATTCATAATGTTAACAAG
AGTAGAGCAATTTTTGCAACCCATTATCATGAATTGTCAAAGTTAGATAGGTATTTAGAAAATATAAAGTGTTTTTGTAT
GAAAGTAGAAGAATGGAATGGAAAAGTAGTGTTCTTGCATGAAATTATACCTGGATCAACTAATAAATCTTATGGAATAC
ATGTTGCAAAATTAGCAGGATTCCCACAATCAGTCCTAGATAGGGCAGAAGATTTAATGAGTAAATTAAAAGCAAATGAG
GATTTATTAACTTAG

Upstream 100 bases:

>100_bases
AAGATTTTTATTAAAATATTTATTATTCACTTTGTGCATTATCTTTTTATCGTTACTGCGTATAATATACTGTAAGATAA
AGGTTAACAATAGGTAAAAA

Downstream 100 bases:

>100_bases
CATATTTAATTGTTTTTTACTCAACTACTCTAAGTGATGTGTGAATATTAGAGGTTAGCTATCACTGTAGTAGTAATGAA
TAGTGGAATTGGCTTAGAAA

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 804; Mature: 804

Protein sequence:

>804_residues
MNHDSKITPIMQQYMMLKSQYKEYLLFYRLGDFYELFFDDAIETSRILNIVLTKKGNVPMCGVPFHSSESYLNRLVKLGY
KIAICEQLETSEEAKKRGYKALVKRDVVRIVTPGTILEDSLLEAKENNYLSCIVNVDHNYAIAWLELSTGLFYYHTTELH
KLDSDLFRINPKEVLISDKLVELDSIYSILRKYKFSVTQYSGSFFDVSRSYNTLCNVYGISTLKGLGDLKNEEIAVCGSL
LEYVKATQKGNLPQLEFPKAYSKGDFMFIDAAALRNLELFCTQSGDLEGSLISSIDYTITACGGRLLKRCLSAPLACSHA
INRRLDIVEFFVNDRTLCRGVRETLRGIADIERILTRIKVGKCSPKDLYALKLTLDKIFVLLDLLHKFDSSVVGDFCSRL
GKYDDLCKTLDDVLIPNNVNNVKDGGFINPDYDAQLSEYIYIQSYSNDLIQELRDKYRNITNIQSLKILYNNILGYYVEV
SSSYLISDKDFIHRQTLANSIRYTTSELKALESKIISARDAAINLEVKIFGQLCTCIIEVADKITMTAHAIAEIDMLTSF
AELAIQYSYTKPIVDDSYEFNIKKGRHPVVERNGKFVANDIDLSLMQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFV
PAQHAHIGVIDKVFSRVGASDNIASGHSTFMVEMTETAAIINQATDKSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNK
SRAIFATHYHELSKLDRYLENIKCFCMKVEEWNGKVVFLHEIIPGSTNKSYGIHVAKLAGFPQSVLDRAEDLMSKLKANE
DLLT

Sequences:

>Translated_804_residues
MNHDSKITPIMQQYMMLKSQYKEYLLFYRLGDFYELFFDDAIETSRILNIVLTKKGNVPMCGVPFHSSESYLNRLVKLGY
KIAICEQLETSEEAKKRGYKALVKRDVVRIVTPGTILEDSLLEAKENNYLSCIVNVDHNYAIAWLELSTGLFYYHTTELH
KLDSDLFRINPKEVLISDKLVELDSIYSILRKYKFSVTQYSGSFFDVSRSYNTLCNVYGISTLKGLGDLKNEEIAVCGSL
LEYVKATQKGNLPQLEFPKAYSKGDFMFIDAAALRNLELFCTQSGDLEGSLISSIDYTITACGGRLLKRCLSAPLACSHA
INRRLDIVEFFVNDRTLCRGVRETLRGIADIERILTRIKVGKCSPKDLYALKLTLDKIFVLLDLLHKFDSSVVGDFCSRL
GKYDDLCKTLDDVLIPNNVNNVKDGGFINPDYDAQLSEYIYIQSYSNDLIQELRDKYRNITNIQSLKILYNNILGYYVEV
SSSYLISDKDFIHRQTLANSIRYTTSELKALESKIISARDAAINLEVKIFGQLCTCIIEVADKITMTAHAIAEIDMLTSF
AELAIQYSYTKPIVDDSYEFNIKKGRHPVVERNGKFVANDIDLSLMQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFV
PAQHAHIGVIDKVFSRVGASDNIASGHSTFMVEMTETAAIINQATDKSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNK
SRAIFATHYHELSKLDRYLENIKCFCMKVEEWNGKVVFLHEIIPGSTNKSYGIHVAKLAGFPQSVLDRAEDLMSKLKANE
DLLT
>Mature_804_residues
MNHDSKITPIMQQYMMLKSQYKEYLLFYRLGDFYELFFDDAIETSRILNIVLTKKGNVPMCGVPFHSSESYLNRLVKLGY
KIAICEQLETSEEAKKRGYKALVKRDVVRIVTPGTILEDSLLEAKENNYLSCIVNVDHNYAIAWLELSTGLFYYHTTELH
KLDSDLFRINPKEVLISDKLVELDSIYSILRKYKFSVTQYSGSFFDVSRSYNTLCNVYGISTLKGLGDLKNEEIAVCGSL
LEYVKATQKGNLPQLEFPKAYSKGDFMFIDAAALRNLELFCTQSGDLEGSLISSIDYTITACGGRLLKRCLSAPLACSHA
INRRLDIVEFFVNDRTLCRGVRETLRGIADIERILTRIKVGKCSPKDLYALKLTLDKIFVLLDLLHKFDSSVVGDFCSRL
GKYDDLCKTLDDVLIPNNVNNVKDGGFINPDYDAQLSEYIYIQSYSNDLIQELRDKYRNITNIQSLKILYNNILGYYVEV
SSSYLISDKDFIHRQTLANSIRYTTSELKALESKIISARDAAINLEVKIFGQLCTCIIEVADKITMTAHAIAEIDMLTSF
AELAIQYSYTKPIVDDSYEFNIKKGRHPVVERNGKFVANDIDLSLMQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFV
PAQHAHIGVIDKVFSRVGASDNIASGHSTFMVEMTETAAIINQATDKSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNK
SRAIFATHYHELSKLDRYLENIKCFCMKVEEWNGKVVFLHEIIPGSTNKSYGIHVAKLAGFPQSVLDRAEDLMSKLKANE
DLLT

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=872, Percent_Identity=29.5871559633028, Blast_Score=295, Evalue=2e-79,
Organism=Homo sapiens, GI4504191, Length=940, Percent_Identity=28.2978723404255, Blast_Score=262, Evalue=8e-70,
Organism=Homo sapiens, GI4557761, Length=677, Percent_Identity=26.8833087149188, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI36949366, Length=608, Percent_Identity=26.1513157894737, Blast_Score=192, Evalue=2e-48,
Organism=Homo sapiens, GI26638666, Length=554, Percent_Identity=25.0902527075812, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI4505253, Length=554, Percent_Identity=25.0902527075812, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI26638664, Length=555, Percent_Identity=25.045045045045, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI262231786, Length=515, Percent_Identity=25.4368932038835, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1789089, Length=803, Percent_Identity=37.733499377335, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17508445, Length=558, Percent_Identity=31.1827956989247, Blast_Score=237, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17508447, Length=604, Percent_Identity=28.6423841059603, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534743, Length=555, Percent_Identity=26.3063063063063, Blast_Score=157, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17539736, Length=377, Percent_Identity=28.9124668435013, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321912, Length=896, Percent_Identity=29.7991071428571, Blast_Score=330, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6320302, Length=870, Percent_Identity=27.2413793103448, Blast_Score=263, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319935, Length=889, Percent_Identity=27.4465691788526, Blast_Score=244, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6324482, Length=637, Percent_Identity=27.7864992150706, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320047, Length=320, Percent_Identity=29.6875, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6321109, Length=548, Percent_Identity=25.5474452554745, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24584320, Length=736, Percent_Identity=27.5815217391304, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24664545, Length=584, Percent_Identity=30.1369863013699, Blast_Score=205, Evalue=1e-52,
Organism=Drosophila melanogaster, GI62471629, Length=620, Percent_Identity=25.1612903225806, Blast_Score=144, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 90794; Mature: 90794

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHDSKITPIMQQYMMLKSQYKEYLLFYRLGDFYELFFDDAIETSRILNIVLTKKGNVPM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCE
CGVPFHSSESYLNRLVKLGYKIAICEQLETSEEAKKRGYKALVKRDVVRIVTPGTILEDS
ECCCCCCCHHHHHHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHH
LLEAKENNYLSCIVNVDHNYAIAWLELSTGLFYYHTTELHKLDSDLFRINPKEVLISDKL
HHHHCCCCEEEEEEEECCCEEEEEEEECCCEEEEEEHHHHHHCCHHHCCCHHHHHHHHHH
VELDSIYSILRKYKFSVTQYSGSFFDVSRSYNTLCNVYGISTLKGLGDLKNEEIAVCGSL
HHHHHHHHHHHHHHHHHEEECCCEEECHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHH
LEYVKATQKGNLPQLEFPKAYSKGDFMFIDAAALRNLELFCTQSGDLEGSLISSIDYTIT
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHCCEEEEEECCCCCCCHHHHHCCHHHH
ACGGRLLKRCLSAPLACSHAINRRLDIVEFFVNDRTLCRGVRETLRGIADIERILTRIKV
HHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GKCSPKDLYALKLTLDKIFVLLDLLHKFDSSVVGDFCSRLGKYDDLCKTLDDVLIPNNVN
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
NVKDGGFINPDYDAQLSEYIYIQSYSNDLIQELRDKYRNITNIQSLKILYNNILGYYVEV
CCCCCCCCCCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEE
SSSYLISDKDFIHRQTLANSIRYTTSELKALESKIISARDAAINLEVKIFGQLCTCIIEV
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHH
ADKITMTAHAIAEIDMLTSFAELAIQYSYTKPIVDDSYEFNIKKGRHPVVERNGKFVAND
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEC
IDLSLMQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFVPAQHAHIGVIDKVFSRVGAS
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
DNIASGHSTFMVEMTETAAIINQATDKSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNK
CCCCCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
SRAIFATHYHELSKLDRYLENIKCFCMKVEEWNGKVVFLHEIIPGSTNKSYGIHVAKLAG
CCEEEHHHHHHHHHHHHHHHHHEEEEEEEEECCCCEEEEEEECCCCCCCCCCEEEHHHCC
FPQSVLDRAEDLMSKLKANEDLLT
CCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNHDSKITPIMQQYMMLKSQYKEYLLFYRLGDFYELFFDDAIETSRILNIVLTKKGNVPM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCE
CGVPFHSSESYLNRLVKLGYKIAICEQLETSEEAKKRGYKALVKRDVVRIVTPGTILEDS
ECCCCCCCHHHHHHHHHCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHH
LLEAKENNYLSCIVNVDHNYAIAWLELSTGLFYYHTTELHKLDSDLFRINPKEVLISDKL
HHHHCCCCEEEEEEEECCCEEEEEEEECCCEEEEEEHHHHHHCCHHHCCCHHHHHHHHHH
VELDSIYSILRKYKFSVTQYSGSFFDVSRSYNTLCNVYGISTLKGLGDLKNEEIAVCGSL
HHHHHHHHHHHHHHHHHEEECCCEEECHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHH
LEYVKATQKGNLPQLEFPKAYSKGDFMFIDAAALRNLELFCTQSGDLEGSLISSIDYTIT
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHCCEEEEEECCCCCCCHHHHHCCHHHH
ACGGRLLKRCLSAPLACSHAINRRLDIVEFFVNDRTLCRGVRETLRGIADIERILTRIKV
HHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GKCSPKDLYALKLTLDKIFVLLDLLHKFDSSVVGDFCSRLGKYDDLCKTLDDVLIPNNVN
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCC
NVKDGGFINPDYDAQLSEYIYIQSYSNDLIQELRDKYRNITNIQSLKILYNNILGYYVEV
CCCCCCCCCCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEE
SSSYLISDKDFIHRQTLANSIRYTTSELKALESKIISARDAAINLEVKIFGQLCTCIIEV
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHH
ADKITMTAHAIAEIDMLTSFAELAIQYSYTKPIVDDSYEFNIKKGRHPVVERNGKFVAND
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEC
IDLSLMQRVHLITGPNMAGKSTFLRQNALIGILAHIGSFVPAQHAHIGVIDKVFSRVGAS
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
DNIASGHSTFMVEMTETAAIINQATDKSFVILDEIGRGTGTYDGLSIAWSVIEQIHNVNK
CCCCCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
SRAIFATHYHELSKLDRYLENIKCFCMKVEEWNGKVVFLHEIIPGSTNKSYGIHVAKLAG
CCEEEHHHHHHHHHHHHHHHHHEEEEEEEEECCCCEEEEEEECCCCCCCCCCEEEHHHCC
FPQSVLDRAEDLMSKLKANEDLLT
CCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA