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The map label for this gene is tlyC [H]

Identifier: 88658322

GI number: 88658322

Start: 27362

End: 28249

Strand: Direct

Name: tlyC [H]

Synonym: ECH_0031

Alternate gene names: 88658322

Gene position: 27362-28249 (Clockwise)

Preceding gene: 88658210

Following gene: 88657644

Centisome position: 2.33

GC content: 31.31

Gene sequence:

>888_bases
ATGAGTGATAAACTTTCTGATAATAGTGATAGTGAAGATAGGTTATCTTTAAAAGAGTCGTTAAGCGCTAAGTTAGTTTC
ATTTATGATAGAGAGAATGCCTAAATTAAAAAGGGTTGTCGAAAACAATTTGATTGATGATAACGAGTGTTTCACCAACT
CCCGCATGTTTTATAATCTTAGAAAGTTCAATGATTGCTTGGTGAGAGATGTAATGATTCCTAGAACAGAAATTTATGCC
ATAGACATTACAGATGTACCTGATAGCAAAAACTTGATAGATAAGGTAGTGAGCGGGCAGTACACCAGAATTCCAGCATA
TGAGAACAATTTGGATAACATAATAGGGTTTATTCACATTAAAGACATAATTTCAAATTTTCATAATGATTTTAATGTGA
GAAATATAATTCGTGAGGTTATGTATATCCCTCCATCTATGAAAGCAGTCAACTTATTTATAAAAATGCAATCTTCTCAC
ATACATGTTGCTGTAGTAGTAGATGAGTATGGTGGAACAGAAGGATTAGTGACTATGGCGGATCTTATTGAAGAAATAGT
AGGTGATATAGACGATGAGCACGATGTTCCCACTGTTCCAAGTATTGTTAATATCTCTGATAATAAAATTGAAGTAAATG
CCAGGGTATTAGTTAAAAACTTGGAAGAAATTTTCAATATTGATTTTAGAGATTGTAAAGAAGATGATTATGTAACAATA
GGTGGACTCATTTTATCTATGATCGGTAGAGTACCTATGACAAATGAAGTTTTTAAACATAAAAGTGGAGCTGTATTTTC
CATTAAAGAGGCTGATGATAGGTGTATTTATAAAATAGTTATTGATTTAAGTGATGTAAAAAAAGTTGACTTAAAAATCG
ATTATTGA

Upstream 100 bases:

>100_bases
TCGTATCGGGTTATTAACAAACTTATTAACACAAACTTTATATAGAAAATAAAGTTTTGAATAGTATACTTGAGTGATAA
TAAAGAATTACAAATTGTAT

Downstream 100 bases:

>100_bases
GCTTAATCTATCTAGTGTGAGTTTAGCTTTTATAAAAGATGTTGCTAAATCTTCATGTGTATCTTTAACATTGGTGACCT
TTGAATATATATTAGCAGGA

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSDKLSDNSDSEDRLSLKESLSAKLVSFMIERMPKLKRVVENNLIDDNECFTNSRMFYNLRKFNDCLVRDVMIPRTEIYA
IDITDVPDSKNLIDKVVSGQYTRIPAYENNLDNIIGFIHIKDIISNFHNDFNVRNIIREVMYIPPSMKAVNLFIKMQSSH
IHVAVVVDEYGGTEGLVTMADLIEEIVGDIDDEHDVPTVPSIVNISDNKIEVNARVLVKNLEEIFNIDFRDCKEDDYVTI
GGLILSMIGRVPMTNEVFKHKSGAVFSIKEADDRCIYKIVIDLSDVKKVDLKIDY

Sequences:

>Translated_295_residues
MSDKLSDNSDSEDRLSLKESLSAKLVSFMIERMPKLKRVVENNLIDDNECFTNSRMFYNLRKFNDCLVRDVMIPRTEIYA
IDITDVPDSKNLIDKVVSGQYTRIPAYENNLDNIIGFIHIKDIISNFHNDFNVRNIIREVMYIPPSMKAVNLFIKMQSSH
IHVAVVVDEYGGTEGLVTMADLIEEIVGDIDDEHDVPTVPSIVNISDNKIEVNARVLVKNLEEIFNIDFRDCKEDDYVTI
GGLILSMIGRVPMTNEVFKHKSGAVFSIKEADDRCIYKIVIDLSDVKKVDLKIDY
>Mature_294_residues
SDKLSDNSDSEDRLSLKESLSAKLVSFMIERMPKLKRVVENNLIDDNECFTNSRMFYNLRKFNDCLVRDVMIPRTEIYAI
DITDVPDSKNLIDKVVSGQYTRIPAYENNLDNIIGFIHIKDIISNFHNDFNVRNIIREVMYIPPSMKAVNLFIKMQSSHI
HVAVVVDEYGGTEGLVTMADLIEEIVGDIDDEHDVPTVPSIVNISDNKIEVNARVLVKNLEEIFNIDFRDCKEDDYVTIG
GLILSMIGRVPMTNEVFKHKSGAVFSIKEADDRCIYKIVIDLSDVKKVDLKIDY

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=189, Percent_Identity=34.9206349206349, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1786879, Length=296, Percent_Identity=28.7162162162162, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI145693175, Length=208, Percent_Identity=26.9230769230769, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082033, Length=208, Percent_Identity=24.5192307692308, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788119, Length=192, Percent_Identity=24.4791666666667, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 33733; Mature: 33602

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKLSDNSDSEDRLSLKESLSAKLVSFMIERMPKLKRVVENNLIDDNECFTNSRMFYNL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHEEEH
RKFNDCLVRDVMIPRTEIYAIDITDVPDSKNLIDKVVSGQYTRIPAYENNLDNIIGFIHI
HHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHH
KDIISNFHNDFNVRNIIREVMYIPPSMKAVNLFIKMQSSHIHVAVVVDEYGGTEGLVTMA
HHHHHHHCCCCCHHHHHHHHHHCCCCHHEEEEEEEEECCCEEEEEEEECCCCCCHHHHHH
DLIEEIVGDIDDEHDVPTVPSIVNISDNKIEVNARVLVKNLEEIFNIDFRDCKEDDYVTI
HHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEH
GGLILSMIGRVPMTNEVFKHKSGAVFSIKEADDRCIYKIVIDLSDVKKVDLKIDY
HHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
SDKLSDNSDSEDRLSLKESLSAKLVSFMIERMPKLKRVVENNLIDDNECFTNSRMFYNL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHEEEH
RKFNDCLVRDVMIPRTEIYAIDITDVPDSKNLIDKVVSGQYTRIPAYENNLDNIIGFIHI
HHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHH
KDIISNFHNDFNVRNIIREVMYIPPSMKAVNLFIKMQSSHIHVAVVVDEYGGTEGLVTMA
HHHHHHHCCCCCHHHHHHHHHHCCCCHHEEEEEEEEECCCEEEEEEEECCCCCCHHHHHH
DLIEEIVGDIDDEHDVPTVPSIVNISDNKIEVNARVLVKNLEEIFNIDFRDCKEDDYVTI
HHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEH
GGLILSMIGRVPMTNEVFKHKSGAVFSIKEADDRCIYKIVIDLSDVKKVDLKIDY
HHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA