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The map label for this gene is ccmE

Identifier: 88658278

GI number: 88658278

Start: 805603

End: 806004

Strand: Reverse

Name: ccmE

Synonym: ECH_0789

Alternate gene names: 88658278

Gene position: 806004-805603 (Counterclockwise)

Preceding gene: 88657789

Following gene: 88657562

Centisome position: 68.52

GC content: 25.62

Gene sequence:

>402_bases
ATGAAAAGAAAACATAAAAGATTGCTTTTTACTGTTGTAACATTTGCTATATTTGGGATGTCAGTTGTTGTTGTCTTAAA
TAAGTTACAAAATAATATATCATTTTTTTTTACTCCGACTGAGGTTCTATCAAATGCTATATATAATAATAATCGTGATA
TTAGAATAGGGGGTATGATAATAAAAGGTAGCGTAGAAAAACATGATGATTTTATTTCTTTTTATATAACAGATTTGGAA
AATCATATGAAAATATTATATAAAGGAATATTACCTCCTTTATTCTCAGAAGGTAGTTGGATAGTAGCAAAAGGAAAAAT
GGTAAGCAGTGAATTTATTGCAGATGAAATTTTAGCTAAGCATGATGAAAATTATAAACCTAGTAAGTATAAAACAAAAT
AA

Upstream 100 bases:

>100_bases
GCGTATACTGTAAGTTTTGGTTTATTGGTTGGGTTAAGCTGTTTTATCATTTTTAGTTATAGTAAAAGTAAGAGAATTCT
AGAGAGTATTGATCGAAGAG

Downstream 100 bases:

>100_bases
ATTGTCAAAGTTTCTAAAGTTAAATGTTGTGTTTGTGTAATATCAAAAATTTATTGAAATTTGTTATTCATGATAATGTT
AATAAACTTGATGGAATAAT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MKRKHKRLLFTVVTFAIFGMSVVVVLNKLQNNISFFFTPTEVLSNAIYNNNRDIRIGGMIIKGSVEKHDDFISFYITDLE
NHMKILYKGILPPLFSEGSWIVAKGKMVSSEFIADEILAKHDENYKPSKYKTK

Sequences:

>Translated_133_residues
MKRKHKRLLFTVVTFAIFGMSVVVVLNKLQNNISFFFTPTEVLSNAIYNNNRDIRIGGMIIKGSVEKHDDFISFYITDLE
NHMKILYKGILPPLFSEGSWIVAKGKMVSSEFIADEILAKHDENYKPSKYKTK
>Mature_133_residues
MKRKHKRLLFTVVTFAIFGMSVVVVLNKLQNNISFFFTPTEVLSNAIYNNNRDIRIGGMIIKGSVEKHDDFISFYITDLE
NHMKILYKGILPPLFSEGSWIVAKGKMVSSEFIADEILAKHDENYKPSKYKTK

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=135, Percent_Identity=35.5555555555556, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_EHRCR (Q2GG46)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507587.1
- ProteinModelPortal:   Q2GG46
- SMR:   Q2GG46
- STRING:   Q2GG46
- GeneID:   3927957
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0789
- TIGR:   ECH_0789
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q2GG46
- ProtClustDB:   PRK13254
- BioCyc:   ECHA205920:ECH_0789-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 15321; Mature: 15321

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: BINDING 121-121

Signals:

None

Transmembrane regions:

HASH(0x1bebde68)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKHKRLLFTVVTFAIFGMSVVVVLNKLQNNISFFFTPTEVLSNAIYNNNRDIRIGGMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCEEEECCEE
IKGSVEKHDDFISFYITDLENHMKILYKGILPPLFSEGSWIVAKGKMVSSEFIADEILAK
EECCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
HDENYKPSKYKTK
CCCCCCCCCCCCH
>Mature Secondary Structure
MKRKHKRLLFTVVTFAIFGMSVVVVLNKLQNNISFFFTPTEVLSNAIYNNNRDIRIGGMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCEEEECCEE
IKGSVEKHDDFISFYITDLENHMKILYKGILPPLFSEGSWIVAKGKMVSSEFIADEILAK
EECCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
HDENYKPSKYKTK
CCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA