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The map label for this gene is dxr

Identifier: 88658276

GI number: 88658276

Start: 558851

End: 560011

Strand: Direct

Name: dxr

Synonym: ECH_0557

Alternate gene names: 88658276

Gene position: 558851-560011 (Clockwise)

Preceding gene: 88657624

Following gene: 88657823

Centisome position: 47.51

GC content: 30.84

Gene sequence:

>1161_bases
GTGAAAACAGTTTCAATATTTGGCTCGACTGGTGCTATTGGTCAAATGATTATTGATATAATATTTGCTGACCTTGATAA
GTATCAGGTAAAAGTATTAGTTGCAAAATCAAATGTTCAGTTATTAGCATTTCAGGCTAAGTTAATTAATGCAGAAAGGG
TTGTTATTGCTAATGTTGATTTATATCAGGAGTTAAAAGATTTATTAGTTGGTACTAATATTAAAGTTAGTGCAGGGGAT
TCCGGAATGGTTATGGCTACATCTTTAGATGTGGATTATGCAATGATGGCTATTGTAGGGATGGCAGCGCTTATACCGAT
GACTTATTTAATTAATTCTGGTATTAAAGTTATTGCATTAGCAAATAAAGAGAGCATAGTCTGTGGGGGTACACTATTGC
TTAGTTTAGCAAAAGAAAAAAATGTTAATATTGTTCCTGTAGATTCAGAGCATAATGCTATATATCAAATACTTTCTAGT
AGTAAAAAAAATTTAGAAAAAATTACCTTAACTGCATCTGGTGGTCCATTGTTATCAATGGATTATGATCAAATAAAAAA
TGTTACAGTTCAGGATACGGTTAAGCATCCTATTTGGAAAATGGGAAAAAAAATCTCTGTTGATAGTGCAACCATGATTA
ATAAGTCTCTTGAAATTATAGAAGCTTATTATTTTTTTTCAATAAAAGCTGAGAAGTTAGATATAATCATACATCCTGAG
TCTATAATACATGCAATAGTATCTTATGTAGATGGCGCATCTATTGCTTTCATGTCTGTGCCAGATATGAAGATTCCAAT
TATGTATACATTGTCCTGGCCCGATAGGTCAGCTATTTTATGTAAAAAACTAAATTTGGCATCATGTAATCAATTAACAT
TTATAAAGCCTGACGTTTATAAATTTCCTGGTATAAAGTTAGGGTTTGAAGTATTAAAAACGTCTAATGTTCATGCTAAT
AGCATTATTTTAAATGCTGCAAATGAAGTTGCTGTTGATGCTTTTTTAAATAAGAAGATAAGATTTCTTGATATTGTAAG
TGTGGTATGTGAGACGTTAAACTTAGTCAATTATGGACGCATTAATTCTCTATCAAGTATTCTTGATTGTGATCTGGTAA
GTAGAAGAGTAGCAAGTAGTGCTATTGATAAGTTATATTAA

Upstream 100 bases:

>100_bases
GGCGTTTAATAGGTTATTTTTTTACATTTTAATTTTTTTAATGGATAATAATCTGAATATTCGATATATAATGTAATAAA
TTTATTGAATATTAAAGCAT

Downstream 100 bases:

>100_bases
TATATTAAATTATTTACTATATTGTGTAATTAGTGTATTATCCTTTCTACTTGATTGTTGGGTTAAATGTGTATTTTTCA
GTTGTTATAGTTAGTATTGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKTVSIFGSTGAIGQMIIDIIFADLDKYQVKVLVAKSNVQLLAFQAKLINAERVVIANVDLYQELKDLLVGTNIKVSAGD
SGMVMATSLDVDYAMMAIVGMAALIPMTYLINSGIKVIALANKESIVCGGTLLLSLAKEKNVNIVPVDSEHNAIYQILSS
SKKNLEKITLTASGGPLLSMDYDQIKNVTVQDTVKHPIWKMGKKISVDSATMINKSLEIIEAYYFFSIKAEKLDIIIHPE
SIIHAIVSYVDGASIAFMSVPDMKIPIMYTLSWPDRSAILCKKLNLASCNQLTFIKPDVYKFPGIKLGFEVLKTSNVHAN
SIILNAANEVAVDAFLNKKIRFLDIVSVVCETLNLVNYGRINSLSSILDCDLVSRRVASSAIDKLY

Sequences:

>Translated_386_residues
MKTVSIFGSTGAIGQMIIDIIFADLDKYQVKVLVAKSNVQLLAFQAKLINAERVVIANVDLYQELKDLLVGTNIKVSAGD
SGMVMATSLDVDYAMMAIVGMAALIPMTYLINSGIKVIALANKESIVCGGTLLLSLAKEKNVNIVPVDSEHNAIYQILSS
SKKNLEKITLTASGGPLLSMDYDQIKNVTVQDTVKHPIWKMGKKISVDSATMINKSLEIIEAYYFFSIKAEKLDIIIHPE
SIIHAIVSYVDGASIAFMSVPDMKIPIMYTLSWPDRSAILCKKLNLASCNQLTFIKPDVYKFPGIKLGFEVLKTSNVHAN
SIILNAANEVAVDAFLNKKIRFLDIVSVVCETLNLVNYGRINSLSSILDCDLVSRRVASSAIDKLY
>Mature_386_residues
MKTVSIFGSTGAIGQMIIDIIFADLDKYQVKVLVAKSNVQLLAFQAKLINAERVVIANVDLYQELKDLLVGTNIKVSAGD
SGMVMATSLDVDYAMMAIVGMAALIPMTYLINSGIKVIALANKESIVCGGTLLLSLAKEKNVNIVPVDSEHNAIYQILSS
SKKNLEKITLTASGGPLLSMDYDQIKNVTVQDTVKHPIWKMGKKISVDSATMINKSLEIIEAYYFFSIKAEKLDIIIHPE
SIIHAIVSYVDGASIAFMSVPDMKIPIMYTLSWPDRSAILCKKLNLASCNQLTFIKPDVYKFPGIKLGFEVLKTSNVHAN
SIILNAANEVAVDAFLNKKIRFLDIVSVVCETLNLVNYGRINSLSSILDCDLVSRRVASSAIDKLY

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=399, Percent_Identity=37.34335839599, Blast_Score=249, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_EHRCR (Q2GGR4)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507369.1
- ProteinModelPortal:   Q2GGR4
- SMR:   Q2GGR4
- STRING:   Q2GGR4
- GeneID:   3927955
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0557
- TIGR:   ECH_0557
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   GLLPTIE
- PhylomeDB:   Q2GGR4
- ProtClustDB:   PRK05447
- BioCyc:   ECHA205920:ECH_0557-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42235; Mature: 42235

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVSIFGSTGAIGQMIIDIIFADLDKYQVKVLVAKSNVQLLAFQAKLINAERVVIANVD
CCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEEECCCCCEEEEECCH
LYQELKDLLVGTNIKVSAGDSGMVMATSLDVDYAMMAIVGMAALIPMTYLINSGIKVIAL
HHHHHHHHHHCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ANKESIVCGGTLLLSLAKEKNVNIVPVDSEHNAIYQILSSSKKNLEKITLTASGGPLLSM
ECCCCEEECHHHEEEEHHCCCCEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCEEEE
DYDQIKNVTVQDTVKHPIWKMGKKISVDSATMINKSLEIIEAYYFFSIKAEKLDIIIHPE
CHHHHCCCCHHHHHCCHHHHCCCEECCCHHHHHHHHHHHEEEEEEEEEEECEEEEEECCH
SIIHAIVSYVDGASIAFMSVPDMKIPIMYTLSWPDRSAILCKKLNLASCNQLTFIKPDVY
HHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEECCCCE
KFPGIKLGFEVLKTSNVHANSIILNAANEVAVDAFLNKKIRFLDIVSVVCETLNLVNYGR
ECCCCCCCHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
INSLSSILDCDLVSRRVASSAIDKLY
CHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTVSIFGSTGAIGQMIIDIIFADLDKYQVKVLVAKSNVQLLAFQAKLINAERVVIANVD
CCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEEEEECCCCCEEEEECCH
LYQELKDLLVGTNIKVSAGDSGMVMATSLDVDYAMMAIVGMAALIPMTYLINSGIKVIAL
HHHHHHHHHHCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ANKESIVCGGTLLLSLAKEKNVNIVPVDSEHNAIYQILSSSKKNLEKITLTASGGPLLSM
ECCCCEEECHHHEEEEHHCCCCEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCEEEE
DYDQIKNVTVQDTVKHPIWKMGKKISVDSATMINKSLEIIEAYYFFSIKAEKLDIIIHPE
CHHHHCCCCHHHHHCCHHHHCCCEECCCHHHHHHHHHHHEEEEEEEEEEECEEEEEECCH
SIIHAIVSYVDGASIAFMSVPDMKIPIMYTLSWPDRSAILCKKLNLASCNQLTFIKPDVY
HHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEECCCCE
KFPGIKLGFEVLKTSNVHANSIILNAANEVAVDAFLNKKIRFLDIVSVVCETLNLVNYGR
ECCCCCCCHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
INSLSSILDCDLVSRRVASSAIDKLY
CHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA