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The map label for this gene is adk [H]

Identifier: 88658097

GI number: 88658097

Start: 408119

End: 408784

Strand: Direct

Name: adk [H]

Synonym: ECH_0429

Alternate gene names: 88658097

Gene position: 408119-408784 (Clockwise)

Preceding gene: 88658436

Following gene: 88658171

Centisome position: 34.7

GC content: 29.13

Gene sequence:

>666_bases
ATGGAAAATAAAATAAATATGTTAATTTTTGGTCCTCCTGGGTCTGGTAAAGGTACGCAATGTCATATTTTGTCAAAAAT
TTATAGTACTATTTCTGTAATTTCAACAGGTGATTTGTTAAGGAGTGAAGCAAAACTTGATACTGATGATGGTAGAAAAA
TTAGGCAGGTTATTGAATCTGGTGATTTAGTAAGTGATGATATAGTGTGTAAGATGTTTGCTAAGTCTATTAGTAGAGTA
AAGAGTGGATTTTTATTGGATGGATTTCCAAGAAATTTAAGTCAAGCAGAATTTTTAACGGAAATTCTAGAGGAATATAA
TAGCCGTATTGATATAGTGATACAGTTGCAATTAGATTTAGAGACGATAAAGAATAGGTTATATGGACGTATTGTGTGTA
AAAATTGTGGACAAGTTTCTAATTTAAATTTTTTTGATAGAGCAATAGATGAAATTGTTTGTAAGTTTTGTAAAAGTAGT
CAGTTAGATTATCGTTATGATGATAAAGTAGAAGTTATCATAAAAAGGGTTAATCAGTATGATAGAGAGATTAAAAAATT
AGAAAATTATTATCGTGATAAGATTGTGTGCATTGATGCAGGTAAGCCAATAGAAGAGGTTACTTGTGATATAAAAGACA
AAATAGCCCATTTAATTATTGGTTGA

Upstream 100 bases:

>100_bases
GTTTTTTGATAATAATCAACGTAATAATTGATACGTTTTCTCAGGTGCAGACACATTTGTATTCAAGCAGATATAGTACA
TTAATTAAAAAGTCTGAGTT

Downstream 100 bases:

>100_bases
CGTTAGTTTGCATATTTGCTATATTACAAAGCATTTATTATCTTGTGGAGGAAAGTTAGTGGCGCGTATAGCTGGAGTAA
ATATTCCTACAAATAAGCGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MENKINMLIFGPPGSGKGTQCHILSKIYSTISVISTGDLLRSEAKLDTDDGRKIRQVIESGDLVSDDIVCKMFAKSISRV
KSGFLLDGFPRNLSQAEFLTEILEEYNSRIDIVIQLQLDLETIKNRLYGRIVCKNCGQVSNLNFFDRAIDEIVCKFCKSS
QLDYRYDDKVEVIIKRVNQYDREIKKLENYYRDKIVCIDAGKPIEEVTCDIKDKIAHLIIG

Sequences:

>Translated_221_residues
MENKINMLIFGPPGSGKGTQCHILSKIYSTISVISTGDLLRSEAKLDTDDGRKIRQVIESGDLVSDDIVCKMFAKSISRV
KSGFLLDGFPRNLSQAEFLTEILEEYNSRIDIVIQLQLDLETIKNRLYGRIVCKNCGQVSNLNFFDRAIDEIVCKFCKSS
QLDYRYDDKVEVIIKRVNQYDREIKKLENYYRDKIVCIDAGKPIEEVTCDIKDKIAHLIIG
>Mature_221_residues
MENKINMLIFGPPGSGKGTQCHILSKIYSTISVISTGDLLRSEAKLDTDDGRKIRQVIESGDLVSDDIVCKMFAKSISRV
KSGFLLDGFPRNLSQAEFLTEILEEYNSRIDIVIQLQLDLETIKNRLYGRIVCKNCGQVSNLNFFDRAIDEIVCKFCKSS
QLDYRYDDKVEVIIKRVNQYDREIKKLENYYRDKIVCIDAGKPIEEVTCDIKDKIAHLIIG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=34.1836734693878, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=34.1836734693878, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=34.1836734693878, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=34.1836734693878, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI7524346, Length=202, Percent_Identity=30.6930693069307, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502013, Length=202, Percent_Identity=30.6930693069307, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=34.1708542713568, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502011, Length=201, Percent_Identity=28.8557213930348, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI28144897, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144899, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=220, Percent_Identity=30.4545454545455, Blast_Score=109, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=34.1121495327103, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=208, Percent_Identity=29.3269230769231, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=197, Percent_Identity=24.8730964467005, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=217, Percent_Identity=31.3364055299539, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321018, Length=190, Percent_Identity=34.2105263157895, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=28.7037037037037, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=34.1232227488152, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737899, Length=205, Percent_Identity=34.6341463414634, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=205, Percent_Identity=34.6341463414634, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17647141, Length=131, Percent_Identity=35.8778625954198, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24663208, Length=131, Percent_Identity=35.8778625954198, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 25227; Mature: 25227

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKINMLIFGPPGSGKGTQCHILSKIYSTISVISTGDLLRSEAKLDTDDGRKIRQVIES
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
GDLVSDDIVCKMFAKSISRVKSGFLLDGFPRNLSQAEFLTEILEEYNSRIDIVIQLQLDL
CCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECH
ETIKNRLYGRIVCKNCGQVSNLNFFDRAIDEIVCKFCKSSQLDYRYDDKVEVIIKRVNQY
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DREIKKLENYYRDKIVCIDAGKPIEEVTCDIKDKIAHLIIG
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MENKINMLIFGPPGSGKGTQCHILSKIYSTISVISTGDLLRSEAKLDTDDGRKIRQVIES
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
GDLVSDDIVCKMFAKSISRVKSGFLLDGFPRNLSQAEFLTEILEEYNSRIDIVIQLQLDL
CCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECH
ETIKNRLYGRIVCKNCGQVSNLNFFDRAIDEIVCKFCKSSQLDYRYDDKVEVIIKRVNQY
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DREIKKLENYYRDKIVCIDAGKPIEEVTCDIKDKIAHLIIG
HHHHHHHHHHHCCEEEEEECCCCHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA