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The map label for this gene is lolC [H]

Identifier: 88658053

GI number: 88658053

Start: 116375

End: 117607

Strand: Direct

Name: lolC [H]

Synonym: ECH_0127

Alternate gene names: 88658053

Gene position: 116375-117607 (Clockwise)

Preceding gene: 88658400

Following gene: 88657708

Centisome position: 9.89

GC content: 29.85

Gene sequence:

>1233_bases
ATGTTACTTAAATTTGAATTAATGTTAGCACTGCGTTATTTACGATCTAGTAGTAGTAAATTCTTATGTTCTATGATTAC
TATGTTATCTTTAGTAGGGATTACGTTAGGAGTTGCTACGTTAATTGTAGTTATGTCTGTCATGAATGGGTTTGGAGAAA
AGCTATTAAATTGTGTAGTAGGGTTAAATGGTCATATAGTAATTTATTTTAATGATAGTGTTGATTACGATTACCGTAGT
ATTGCAGAGTCAATTAAGGGTATTTCTGGAGTAAAGGATGCTGTGCCTATTACTGAAAATCAAGCTATGATTAAATCTAA
TAGTAATGTATCTGGAGTGGTAGTTCGAGGTATAGAAAAACAAGATATAGAGCGTAATAATATAATAGTAAATAATATAG
TAAGAGGTAGTATTGATGAATTTAATGACGGTATTGCTATAGGTATCAAATTGGCTGAAATTCTACATGTCAATTATGGA
GATAAACTAACTATTGTATCATCAGAAAGTATATCTACGGTTATAGGTAATATACCACGTATGAAGACCTATAAAATTGC
TGCAGTATTTGATGTTGGAATGTATGAGTATGACAGTACGTTGGTATATATGCCTTTGCATGCTTCACAATTGTTTTTCC
ATTATGATAATCGAGTAAAAAGTATAGAGGTGTCAATTCTTGATGTTAATAAATCATCAGAAATGTTAGAGATAATAGAA
AGTAAGACAAATATGAAAGGAGAAGATTGGAAAATGCAGCAGGGAAGTTATTTTCATGCATTAAAAATCGAAAGTAATGT
AATGTTTTTTATATTGACTTTAATTATAATAGTTGCAACATTTAATATTATTTCAAGCTTGTCTATATTAGTACAAGATA
AAAAAGGAGCAATTGCTATAATGCGTACGTTAGGTGTAACACGTTGTGGTATACTCAGAATATTTTGTATGTGTGGGTTT
TTTATAGGATTGATAGGTACAATACTAGGTTGTGTATTAGGCATAGTAGTTTCTCTGAATATTGATGGAATAAAAAATAT
GTTAGAGAAAATAAGTGATAGTAATATTTTTGATCCTGTAATTTACTTTTTTGATACTTTGCCTTCTGTTTTATTAGTAG
AGGATGTGGTAAAAATATCTTTGTTATCTTTATTTCTATCTTTAGTTGCAGCTATTCTTCCTGCTAGAAAAGCTGCTTGT
CAAGATCCAGCAGATGTTTTACGACATGAATAG

Upstream 100 bases:

>100_bases
ATTTATCTATAAATGTTTATAATTATTAGCAATGTAGTTTTGTAATATCATATTGATATGATAAATTAGTGACATTATTT
TGTTCTGTTGGTGTAATGCG

Downstream 100 bases:

>100_bases
TAGGGGTTAATATGCTAGCAAAAGAAGTTTGGGGATGGTTTTTTATGATGTTGATAACCACTTCTTGCTCTATATGTGCT
GTTTTTTCTTATTTAGATGT

Product: LolC/E family lipoprotein releasing system transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLLKFELMLALRYLRSSSSKFLCSMITMLSLVGITLGVATLIVVMSVMNGFGEKLLNCVVGLNGHIVIYFNDSVDYDYRS
IAESIKGISGVKDAVPITENQAMIKSNSNVSGVVVRGIEKQDIERNNIIVNNIVRGSIDEFNDGIAIGIKLAEILHVNYG
DKLTIVSSESISTVIGNIPRMKTYKIAAVFDVGMYEYDSTLVYMPLHASQLFFHYDNRVKSIEVSILDVNKSSEMLEIIE
SKTNMKGEDWKMQQGSYFHALKIESNVMFFILTLIIIVATFNIISSLSILVQDKKGAIAIMRTLGVTRCGILRIFCMCGF
FIGLIGTILGCVLGIVVSLNIDGIKNMLEKISDSNIFDPVIYFFDTLPSVLLVEDVVKISLLSLFLSLVAAILPARKAAC
QDPADVLRHE

Sequences:

>Translated_410_residues
MLLKFELMLALRYLRSSSSKFLCSMITMLSLVGITLGVATLIVVMSVMNGFGEKLLNCVVGLNGHIVIYFNDSVDYDYRS
IAESIKGISGVKDAVPITENQAMIKSNSNVSGVVVRGIEKQDIERNNIIVNNIVRGSIDEFNDGIAIGIKLAEILHVNYG
DKLTIVSSESISTVIGNIPRMKTYKIAAVFDVGMYEYDSTLVYMPLHASQLFFHYDNRVKSIEVSILDVNKSSEMLEIIE
SKTNMKGEDWKMQQGSYFHALKIESNVMFFILTLIIIVATFNIISSLSILVQDKKGAIAIMRTLGVTRCGILRIFCMCGF
FIGLIGTILGCVLGIVVSLNIDGIKNMLEKISDSNIFDPVIYFFDTLPSVLLVEDVVKISLLSLFLSLVAAILPARKAAC
QDPADVLRHE
>Mature_410_residues
MLLKFELMLALRYLRSSSSKFLCSMITMLSLVGITLGVATLIVVMSVMNGFGEKLLNCVVGLNGHIVIYFNDSVDYDYRS
IAESIKGISGVKDAVPITENQAMIKSNSNVSGVVVRGIEKQDIERNNIIVNNIVRGSIDEFNDGIAIGIKLAEILHVNYG
DKLTIVSSESISTVIGNIPRMKTYKIAAVFDVGMYEYDSTLVYMPLHASQLFFHYDNRVKSIEVSILDVNKSSEMLEIIE
SKTNMKGEDWKMQQGSYFHALKIESNVMFFILTLIIIVATFNIISSLSILVQDKKGAIAIMRTLGVTRCGILRIFCMCGF
FIGLIGTILGCVLGIVVSLNIDGIKNMLEKISDSNIFDPVIYFFDTLPSVLLVEDVVKISLLSLFLSLVAAILPARKAAC
QDPADVLRHE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=417, Percent_Identity=29.4964028776978, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1787360, Length=415, Percent_Identity=28.6746987951807, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45286; Mature: 45286

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKFELMLALRYLRSSSSKFLCSMITMLSLVGITLGVATLIVVMSVMNGFGEKLLNCVV
CEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLNGHIVIYFNDSVDYDYRSIAESIKGISGVKDAVPITENQAMIKSNSNVSGVVVRGIEK
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCCH
QDIERNNIIVNNIVRGSIDEFNDGIAIGIKLAEILHVNYGDKLTIVSSESISTVIGNIPR
HCCCCCCEEEEHHHHCCCHHCCCCEEEHEEEEHHEEECCCCEEEEEECCHHHHHHCCCCC
MKTYKIAAVFDVGMYEYDSTLVYMPLHASQLFFHYDNRVKSIEVSILDVNKSSEMLEIIE
CCEEEEEEEEECCCEEECCEEEEEECCHHHHHEEECCCEEEEEEEEEECCCCHHHHHHHH
SKTNMKGEDWKMQQGSYFHALKIESNVMFFILTLIIIVATFNIISSLSILVQDKKGAIAI
HHCCCCCCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHH
MRTLGVTRCGILRIFCMCGFFIGLIGTILGCVLGIVVSLNIDGIKNMLEKISDSNIFDPV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHH
IYFFDTLPSVLLVEDVVKISLLSLFLSLVAAILPARKAACQDPADVLRHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure
MLLKFELMLALRYLRSSSSKFLCSMITMLSLVGITLGVATLIVVMSVMNGFGEKLLNCVV
CEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLNGHIVIYFNDSVDYDYRSIAESIKGISGVKDAVPITENQAMIKSNSNVSGVVVRGIEK
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCCH
QDIERNNIIVNNIVRGSIDEFNDGIAIGIKLAEILHVNYGDKLTIVSSESISTVIGNIPR
HCCCCCCEEEEHHHHCCCHHCCCCEEEHEEEEHHEEECCCCEEEEEECCHHHHHHCCCCC
MKTYKIAAVFDVGMYEYDSTLVYMPLHASQLFFHYDNRVKSIEVSILDVNKSSEMLEIIE
CCEEEEEEEEECCCEEECCEEEEEECCHHHHHEEECCCEEEEEEEEEECCCCHHHHHHHH
SKTNMKGEDWKMQQGSYFHALKIESNVMFFILTLIIIVATFNIISSLSILVQDKKGAIAI
HHCCCCCCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHH
MRTLGVTRCGILRIFCMCGFFIGLIGTILGCVLGIVVSLNIDGIKNMLEKISDSNIFDPV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHH
IYFFDTLPSVLLVEDVVKISLLSLFLSLVAAILPARKAACQDPADVLRHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]