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The map label for this gene is pyrE

Identifier: 88608864

GI number: 88608864

Start: 467107

End: 467727

Strand: Direct

Name: pyrE

Synonym: NSE_0538

Alternate gene names: 88608864

Gene position: 467107-467727 (Clockwise)

Preceding gene: 88608052

Following gene: 88608236

Centisome position: 54.38

GC content: 41.87

Gene sequence:

>621_bases
ATGAGGGTTTCTAGGAAAGGCCAGGTGGAAGAAGCACTACTTGATGAGCTTTACGCCTCTGGCGCCATACTAAAGGGACA
TTTCGTCCTTTCTTCCGGACTGCACAGCGATACATATGTGCAGTGCGCTCTTTTACTGCAAAATCCACGACGTGTCTTTA
AGTTTGCATCGGCTTTGGTGCAACTCATCCCTGAAAAAATCAAGAGTGTGGTCGACTTAATCGTCGCACCAGCACTCGGT
GGATTGATCATTGGATACGAGGTAGCGCGCTTATTGGATAAAGATTTTGTGTTTTTTGAAAGGTTTAATGGTGAACTTAC
TCTAAGGCGCGGTTTTAAAGTAGAGAGTGGACAAAACGTTCTGCTCATAGAGGATGTAGTCACAACAGCTGGCTCTTCTA
TAGATGTTATACAAAAAGTCCATGACCGTGGTGCAAATGTTATCTTTGCAGCTTCAATAATAGATAGATCTGAAGGAGCT
GCAGAAAAACGTTTTAAAAAGCATAGTTGCGAGTTTCTTAGTGTCGTGAAATTAAATTGTGTCACATTTGATGCAGCAAA
TATCCCAAAAGAATTGAGCAATGTTCCTTGCATAAAGCCCGGTTCCAATAATCTCAATTGA

Upstream 100 bases:

>100_bases
GATCAAATAATTTCTCTGATTGCTCATTTATCGAAGAGATTTCACAAGAAATAAAAATTGGTATAATGAGGGAGGATGGC
GCATGCGGATATAGCTGATA

Downstream 100 bases:

>100_bases
CGGACGCGTACTGAATATAAATTCTAGCCAATAGTATCGATCTGCGTAATATCTCATCATTTATTTTCCATAAGCAAAAT
TATGTGTACAAACGCTTAAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRVSRKGQVEEALLDELYASGAILKGHFVLSSGLHSDTYVQCALLLQNPRRVFKFASALVQLIPEKIKSVVDLIVAPALG
GLIIGYEVARLLDKDFVFFERFNGELTLRRGFKVESGQNVLLIEDVVTTAGSSIDVIQKVHDRGANVIFAASIIDRSEGA
AEKRFKKHSCEFLSVVKLNCVTFDAANIPKELSNVPCIKPGSNNLN

Sequences:

>Translated_206_residues
MRVSRKGQVEEALLDELYASGAILKGHFVLSSGLHSDTYVQCALLLQNPRRVFKFASALVQLIPEKIKSVVDLIVAPALG
GLIIGYEVARLLDKDFVFFERFNGELTLRRGFKVESGQNVLLIEDVVTTAGSSIDVIQKVHDRGANVIFAASIIDRSEGA
AEKRFKKHSCEFLSVVKLNCVTFDAANIPKELSNVPCIKPGSNNLN
>Mature_206_residues
MRVSRKGQVEEALLDELYASGAILKGHFVLSSGLHSDTYVQCALLLQNPRRVFKFASALVQLIPEKIKSVVDLIVAPALG
GLIIGYEVARLLDKDFVFFERFNGELTLRRGFKVESGQNVLLIEDVVTTAGSSIDVIQKVHDRGANVIFAASIIDRSEGA
AEKRFKKHSCEFLSVVKLNCVTFDAANIPKELSNVPCIKPGSNNLN

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22587; Mature: 22587

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSRKGQVEEALLDELYASGAILKGHFVLSSGLHSDTYVQCALLLQNPRRVFKFASALV
CCCCCCCCHHHHHHHHHHHCCCEEEEHEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHH
QLIPEKIKSVVDLIVAPALGGLIIGYEVARLLDKDFVFFERFNGELTLRRGFKVESGQNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECEEECCCCCE
LLIEDVVTTAGSSIDVIQKVHDRGANVIFAASIIDRSEGAAEKRFKKHSCEFLSVVKLNC
EEEHHHHHHCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHEEHEE
VTFDAANIPKELSNVPCIKPGSNNLN
EEECCCCCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRVSRKGQVEEALLDELYASGAILKGHFVLSSGLHSDTYVQCALLLQNPRRVFKFASALV
CCCCCCCCHHHHHHHHHHHCCCEEEEHEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHH
QLIPEKIKSVVDLIVAPALGGLIIGYEVARLLDKDFVFFERFNGELTLRRGFKVESGQNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECEEECCCCCE
LLIEDVVTTAGSSIDVIQKVHDRGANVIFAASIIDRSEGAAEKRFKKHSCEFLSVVKLNC
EEEHHHHHHCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHEEHEE
VTFDAANIPKELSNVPCIKPGSNNLN
EEECCCCCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA