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The map label for this gene is uppS

Identifier: 88608842

GI number: 88608842

Start: 832470

End: 833162

Strand: Reverse

Name: uppS

Synonym: NSE_0944

Alternate gene names: 88608842

Gene position: 833162-832470 (Counterclockwise)

Preceding gene: 88608154

Following gene: 88608425

Centisome position: 96.99

GC content: 41.13

Gene sequence:

>693_bases
ATGATTGGAAAAGAGCTTCCTGTTCATATTGCAATAATAATGGACGGGAACGCGAGATGGGCCAGAGCGAGAGGTCTGTG
TAACTCCGATGGATACAAGATGGGTGTCGAGGCTGCATTCTCGGCTGTGAGGGCATCTTGTAATGCTGGGATTCGTTACC
TTACGCTTTTCCTTTTTTCGACTGAAAATTGGAAAAGAAATCCAGACGATGTGCACCTTGTCTTTAGCATTTTTGAAAAA
GCTAGTGTTACTGCGTTGGACGAACTATGCGATGCTAATATAAAAGTAAAAGTCATAGGGGAACAGGTAGGTTTAGGTGA
AAGCGCAAAGCAAGTGATAAAAAACCTAGAGTCGGGAACGGCAAAAAATAGTGGTATGTATTTGTGTTTTGCCCTAAATT
ATGGTGGCAGATCTGAGATCATAAATGCGGTTTCAAGAATGATAAGTGATGGTCTAAGGGCTGAGGAAGTGGATGTACAG
AAATTTGCAAGCTATTTATACACAGATGGCATTCCTGATCCAGATTTGATTATAAGGACAGCTGGTGAAAAACGACTTAG
CAACTTTCTCTTGTGGCAGAGTTCGTACTCTGAATTGTATTTTTGCGATACGCTTTGGCCAGATTTTACAGAAAAAGATT
TAGAGATAGCGATGGAAGCTTATAAGGCTAGGTGTCGCAGATATGGGAAATAA

Upstream 100 bases:

>100_bases
ATATGCACGCTTTGCTCAAGAAGATAGATAAAATTATTTCTGAAGAAGATGCTAGAATTGATGATGCTGTGAGCAAAAAG
GAAACCGACATCTTGAAGGT

Downstream 100 bases:

>100_bases
ATTCTTACGTTTTATTTCTCATGATCTGAGATTGGTACCTCTACTACTCGGCACATTTTTTCTATCCTTTTTGGGTGTTG
TTCTTGCCTAAGCGTTCCGT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MIGKELPVHIAIIMDGNARWARARGLCNSDGYKMGVEAAFSAVRASCNAGIRYLTLFLFSTENWKRNPDDVHLVFSIFEK
ASVTALDELCDANIKVKVIGEQVGLGESAKQVIKNLESGTAKNSGMYLCFALNYGGRSEIINAVSRMISDGLRAEEVDVQ
KFASYLYTDGIPDPDLIIRTAGEKRLSNFLLWQSSYSELYFCDTLWPDFTEKDLEIAMEAYKARCRRYGK

Sequences:

>Translated_230_residues
MIGKELPVHIAIIMDGNARWARARGLCNSDGYKMGVEAAFSAVRASCNAGIRYLTLFLFSTENWKRNPDDVHLVFSIFEK
ASVTALDELCDANIKVKVIGEQVGLGESAKQVIKNLESGTAKNSGMYLCFALNYGGRSEIINAVSRMISDGLRAEEVDVQ
KFASYLYTDGIPDPDLIIRTAGEKRLSNFLLWQSSYSELYFCDTLWPDFTEKDLEIAMEAYKARCRRYGK
>Mature_230_residues
MIGKELPVHIAIIMDGNARWARARGLCNSDGYKMGVEAAFSAVRASCNAGIRYLTLFLFSTENWKRNPDDVHLVFSIFEK
ASVTALDELCDANIKVKVIGEQVGLGESAKQVIKNLESGTAKNSGMYLCFALNYGGRSEIINAVSRMISDGLRAEEVDVQ
KFASYLYTDGIPDPDLIIRTAGEKRLSNFLLWQSSYSELYFCDTLWPDFTEKDLEIAMEAYKARCRRYGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=212, Percent_Identity=33.0188679245283, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI45580742, Length=212, Percent_Identity=33.0188679245283, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=38.5593220338983, Blast_Score=180, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=214, Percent_Identity=31.7757009345794, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=32.5358851674641, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=26.605504587156, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI18857969, Length=223, Percent_Identity=33.6322869955157, Blast_Score=137, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25757; Mature: 25757

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKELPVHIAIIMDGNARWARARGLCNSDGYKMGVEAAFSAVRASCNAGIRYLTLFLFS
CCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEHEEEEE
TENWKRNPDDVHLVFSIFEKASVTALDELCDANIKVKVIGEQVGLGESAKQVIKNLESGT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCC
AKNSGMYLCFALNYGGRSEIINAVSRMISDGLRAEEVDVQKFASYLYTDGIPDPDLIIRT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEC
AGEKRLSNFLLWQSSYSELYFCDTLWPDFTEKDLEIAMEAYKARCRRYGK
CCHHHHHHHHHEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIGKELPVHIAIIMDGNARWARARGLCNSDGYKMGVEAAFSAVRASCNAGIRYLTLFLFS
CCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHEEHEEEEE
TENWKRNPDDVHLVFSIFEKASVTALDELCDANIKVKVIGEQVGLGESAKQVIKNLESGT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCC
AKNSGMYLCFALNYGGRSEIINAVSRMISDGLRAEEVDVQKFASYLYTDGIPDPDLIIRT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEC
AGEKRLSNFLLWQSSYSELYFCDTLWPDFTEKDLEIAMEAYKARCRRYGK
CCHHHHHHHHHEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]