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The map label for this gene is nuoL

Identifier: 88608767

GI number: 88608767

Start: 10355

End: 12322

Strand: Direct

Name: nuoL

Synonym: NSE_0014

Alternate gene names: 88608767

Gene position: 10355-12322 (Clockwise)

Preceding gene: 88608443

Following gene: 88608294

Centisome position: 1.21

GC content: 40.55

Gene sequence:

>1968_bases
ATGTCGAACATTTTGCGTATGTTGAGTTATTCGATAGTTTTCCTGCCCTTGTTGTCATGTTTGTTATGCTGTTTTTTTAT
CAGGTGTAGGGAATCGGTCTGCCTACAGCTATTGAGCTCGTTCTTGATAGGTCTTGCTGCCATTTCTTCTTGGAGTCTGT
TTTTTACACTTGAAGATGGTGAAGCTTTTTTGCTTCCTCTTTTTGAATGGATTTCCGTTGGATCATTGCAAGCCCTTTTT
AGGGTGAACATAGATAAATTAACGGTGCTGATGTTCGTAGTTGTTAATACCGTTTCGTTTGTCGTGCACTGTTACTCAAT
CGCGTACATGAAGAATGATCCTTGCAAGTCCAGGTTTTTCGCATACCTCTCCCTCTTTACTTTCGCCATGCTTGTCCTTG
TTTCCGCGGGTGATTTGCTACAGCTCTTTTTAGGGTGGGAAGGCGTCGGAGTTTGTTCCTACCTTCTTATAGGATTTTGG
TTCAGGAAGGAGTCTGCCAATGTTGCTTCTATGAAGGCTTTTCTCGTTAACAGAGTTGGAGATTTTTGTTTCTTAATAGG
AATTTTCTCAGTATACAAAATTTTCGGAACACTAGAGTTAAAGGGGATTATTTCAGATGTTGGTTTCCACTCAGGTGAAA
CAATTTTGGGTTTTGATTCTCTTACCTTTATCTGTTTGATGCTCTTTATTGGTTGCATGAGTAAATCCGCTCAGCTGGGC
TTACATACCTGGCTTCCTGATGCAATGGAGGGTCCTACACCAGTATCGGCACTTATCCATGCAGCAACTATGGTTACTGC
TGGTGTATTTCTTCTAGCAAGATTGTCTCCACTGTTTGAGTGTACTGAACTGGTAAGGCACATAATTATGTGGGTTGGTG
TGTCTACAGCCGCTTTTGGATCTGTAGTTGCGCTTTGTCAGGATGATATAAAAAGAATTATAGCCTACTCAACTTGCAGT
CAGCTTGGGTATATGTTTGCTGCATGTGGTGCATCGGCGTATGGATTGGCTATCTTCCATTTATCCACACATGCTTTCTT
TAAAGCACTACTCTTTTTGTGTGCCGGTAACGTAATTCATTCCGTTGGTGGGGAACAAGATGTGCATAAAATGGGTGCAT
TGAGAAATAAAATCTTCTCCACCTATTGCATGATGATTATAGGAAGTCTCGCTTTGTGTGGAATTTTTCCATTTGCTGGG
TTCTATTCAAAAGACTTAATAATTTCCTCCCTCTCCCATGCGGAGATCCCGTTTATTTTGTTAATACTCACAGCTTTTTG
CACTTCTGTATATTCATGCAGGCTGCTTATGCTTGTGTTCTTTGGTGAACAGAACTTCAGTCTTAAGAAGTTTCACTCTC
CTCCTGTGGGCATGGTTTTGCCGCTTGCGCCGCTGGTTCTCCTTTCGCTTATTTCTGGTTATCTTGGGGTGAAGCTTTTA
GTAAACTCTTCATTTTGGGTGCAAACTGGCTTAGTTTTCCGGCAAGTTACGGAAATGCATGGGTTGGTGCATTTCCTTCC
TTTGATTTTTGCTTTAGCTGGTTTCTTTGTGGTTTTTGTTCTTGAGGGTAGAAGAATTTCCTTGCCCAGAATATTTGTTT
GTTTGTCGCTCTTTACACTCTTGTCATTTCTTTTAAATTTTTATTTAGGTGTGGTGTCATTTATTTTCTCGATCGGACTT
ATATTAGTTAATCGCAGTGGCGTTATTCTAAACCTTTTCAAAAGGGTCCTGAGTTGCGGATTTTACTTTGACAAAATATA
TAGAGTTTTATTTGTTGGTCCGTTAACACACTGTAGTAGGTTCTTCTGGAAGGTGATTGACATTGGGTGTATTAACCTCG
TACCTGCACTGCTTGCTAGGCTTTCACAGAAACTTTCATCTGGCGTTCTGGCATTGCAAACTGGTCTTTTATGCCACACC
GTGCTCTTTTTCTTTCTAGGTATACTGTTTTTATTTTGGGTTATGTAA

Upstream 100 bases:

>100_bases
TCATTATCTATGATAATTGGTTGTCCGCCCTGAGAAGTGGTGTGTATTCTTGTTCTCTTTGAGCAAGTTTCTGTGCGCTT
GTCTATGTTCTCTGGATTAA

Downstream 100 bases:

>100_bases
CCATCTCCATGTTCTTTTGTCGTGTAGTTGGATGGACAGAGGAGAAGACTCTACTTTACTTTCACACGTAATTATAAGAA
TTTATACTAATTTAGACTAC

Product: NADH dehydrogenase I subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MSNILRMLSYSIVFLPLLSCLLCCFFIRCRESVCLQLLSSFLIGLAAISSWSLFFTLEDGEAFLLPLFEWISVGSLQALF
RVNIDKLTVLMFVVVNTVSFVVHCYSIAYMKNDPCKSRFFAYLSLFTFAMLVLVSAGDLLQLFLGWEGVGVCSYLLIGFW
FRKESANVASMKAFLVNRVGDFCFLIGIFSVYKIFGTLELKGIISDVGFHSGETILGFDSLTFICLMLFIGCMSKSAQLG
LHTWLPDAMEGPTPVSALIHAATMVTAGVFLLARLSPLFECTELVRHIIMWVGVSTAAFGSVVALCQDDIKRIIAYSTCS
QLGYMFAACGASAYGLAIFHLSTHAFFKALLFLCAGNVIHSVGGEQDVHKMGALRNKIFSTYCMMIIGSLALCGIFPFAG
FYSKDLIISSLSHAEIPFILLILTAFCTSVYSCRLLMLVFFGEQNFSLKKFHSPPVGMVLPLAPLVLLSLISGYLGVKLL
VNSSFWVQTGLVFRQVTEMHGLVHFLPLIFALAGFFVVFVLEGRRISLPRIFVCLSLFTLLSFLLNFYLGVVSFIFSIGL
ILVNRSGVILNLFKRVLSCGFYFDKIYRVLFVGPLTHCSRFFWKVIDIGCINLVPALLARLSQKLSSGVLALQTGLLCHT
VLFFFLGILFLFWVM

Sequences:

>Translated_655_residues
MSNILRMLSYSIVFLPLLSCLLCCFFIRCRESVCLQLLSSFLIGLAAISSWSLFFTLEDGEAFLLPLFEWISVGSLQALF
RVNIDKLTVLMFVVVNTVSFVVHCYSIAYMKNDPCKSRFFAYLSLFTFAMLVLVSAGDLLQLFLGWEGVGVCSYLLIGFW
FRKESANVASMKAFLVNRVGDFCFLIGIFSVYKIFGTLELKGIISDVGFHSGETILGFDSLTFICLMLFIGCMSKSAQLG
LHTWLPDAMEGPTPVSALIHAATMVTAGVFLLARLSPLFECTELVRHIIMWVGVSTAAFGSVVALCQDDIKRIIAYSTCS
QLGYMFAACGASAYGLAIFHLSTHAFFKALLFLCAGNVIHSVGGEQDVHKMGALRNKIFSTYCMMIIGSLALCGIFPFAG
FYSKDLIISSLSHAEIPFILLILTAFCTSVYSCRLLMLVFFGEQNFSLKKFHSPPVGMVLPLAPLVLLSLISGYLGVKLL
VNSSFWVQTGLVFRQVTEMHGLVHFLPLIFALAGFFVVFVLEGRRISLPRIFVCLSLFTLLSFLLNFYLGVVSFIFSIGL
ILVNRSGVILNLFKRVLSCGFYFDKIYRVLFVGPLTHCSRFFWKVIDIGCINLVPALLARLSQKLSSGVLALQTGLLCHT
VLFFFLGILFLFWVM
>Mature_654_residues
SNILRMLSYSIVFLPLLSCLLCCFFIRCRESVCLQLLSSFLIGLAAISSWSLFFTLEDGEAFLLPLFEWISVGSLQALFR
VNIDKLTVLMFVVVNTVSFVVHCYSIAYMKNDPCKSRFFAYLSLFTFAMLVLVSAGDLLQLFLGWEGVGVCSYLLIGFWF
RKESANVASMKAFLVNRVGDFCFLIGIFSVYKIFGTLELKGIISDVGFHSGETILGFDSLTFICLMLFIGCMSKSAQLGL
HTWLPDAMEGPTPVSALIHAATMVTAGVFLLARLSPLFECTELVRHIIMWVGVSTAAFGSVVALCQDDIKRIIAYSTCSQ
LGYMFAACGASAYGLAIFHLSTHAFFKALLFLCAGNVIHSVGGEQDVHKMGALRNKIFSTYCMMIIGSLALCGIFPFAGF
YSKDLIISSLSHAEIPFILLILTAFCTSVYSCRLLMLVFFGEQNFSLKKFHSPPVGMVLPLAPLVLLSLISGYLGVKLLV
NSSFWVQTGLVFRQVTEMHGLVHFLPLIFALAGFFVVFVLEGRRISLPRIFVCLSLFTLLSFLLNFYLGVVSFIFSIGLI
LVNRSGVILNLFKRVLSCGFYFDKIYRVLFVGPLTHCSRFFWKVIDIGCINLVPALLARLSQKLSSGVLALQTGLLCHTV
LFFFLGILFLFWVM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=415, Percent_Identity=40, Blast_Score=289, Evalue=6e-78,
Organism=Escherichia coli, GI1788614, Length=479, Percent_Identity=42.7974947807933, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788829, Length=493, Percent_Identity=29.2089249492901, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788827, Length=344, Percent_Identity=29.0697674418605, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=26.647564469914, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788613, Length=331, Percent_Identity=28.0966767371601, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=219, Percent_Identity=27.8538812785388, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI2367154, Length=347, Percent_Identity=24.4956772334294, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 72715; Mature: 72584

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNILRMLSYSIVFLPLLSCLLCCFFIRCRESVCLQLLSSFLIGLAAISSWSLFFTLEDG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
EAFLLPLFEWISVGSLQALFRVNIDKLTVLMFVVVNTVSFVVHCYSIAYMKNDPCKSRFF
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AYLSLFTFAMLVLVSAGDLLQLFLGWEGVGVCSYLLIGFWFRKESANVASMKAFLVNRVG
HHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DFCFLIGIFSVYKIFGTLELKGIISDVGFHSGETILGFDSLTFICLMLFIGCMSKSAQLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCC
LHTWLPDAMEGPTPVSALIHAATMVTAGVFLLARLSPLFECTELVRHIIMWVGVSTAAFG
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVVALCQDDIKRIIAYSTCSQLGYMFAACGASAYGLAIFHLSTHAFFKALLFLCAGNVIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGGEQDVHKMGALRNKIFSTYCMMIIGSLALCGIFPFAGFYSKDLIISSLSHAEIPFIL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LILTAFCTSVYSCRLLMLVFFGEQNFSLKKFHSPPVGMVLPLAPLVLLSLISGYLGVKLL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VNSSFWVQTGLVFRQVTEMHGLVHFLPLIFALAGFFVVFVLEGRRISLPRIFVCLSLFTL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LSFLLNFYLGVVSFIFSIGLILVNRSGVILNLFKRVLSCGFYFDKIYRVLFVGPLTHCSR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFWKVIDIGCINLVPALLARLSQKLSSGVLALQTGLLCHTVLFFFLGILFLFWVM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SNILRMLSYSIVFLPLLSCLLCCFFIRCRESVCLQLLSSFLIGLAAISSWSLFFTLEDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC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HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]