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The map label for this gene is ppiD [H]

Identifier: 88608708

GI number: 88608708

Start: 564755

End: 566539

Strand: Reverse

Name: ppiD [H]

Synonym: NSE_0645

Alternate gene names: 88608708

Gene position: 566539-564755 (Counterclockwise)

Preceding gene: 88608005

Following gene: 88608853

Centisome position: 65.95

GC content: 40.11

Gene sequence:

>1785_bases
TTGTTTCGACCTTCATTGACTATGCGACTAAAGAAGCTTTTCTCTCCAAAATGGTTAATCCTTGTACTCCTGATTCTAGC
ACTCTTGGTTACTGCAATAAACGCGTCCATTACGGGTAGCAGGTCTGACGTGGTCGCTTCGGTTGGAAGGGAGAAAATCC
TGGTTGACGATTTTGTTTCTGAGTACAAGAAGCACGAGCGCTATTTTCAAAGTATGTTTGACTTTAGGCTCACAGATACC
CAGCTTAAAGATATCGGAGTTGGCAGGATTGTTCTCACGACTTTAATCCAAGACAAGGTGATAGAACAGCTCTTTAAGCA
GATGGGTCTCCATATTGATACCTCGATCGCAATTGACAAGATAAAGAAAAATCCTGTTTTTAATGAAAATGGAAAATTTG
ATCGAGCTAAGCTTGATGATTTCCTCGATCGTAACGATCTTACGGAAAGAGAATACATAAGAAAAGTGAAGCGTGAAATC
GGTAAAGACTTTGTTTTTGGTCCGTTTTTTAATATTCAAGGTGAGTATGGGAAGTTGGCTGAACTTTTCTACAATTTTGA
GTACGGACTAAAAGAGGTCAGTATTGCGAAAGTAGATAAAAATGCGTTGCCTACTCCTCCTGTACCAACCGAGAGTGAGC
TCGTATCTTTCTATGAAGAAAATAAGGATAAGTTTTTCAGTGATGAGTACAGAGCTGCTGCGTGTATTCTTATTTCGGAG
GATAATGTAAAGCCCGAGTTGGTCGAGGTAGCAGATGAAGATGTACAGAAAAGCTTTGAGAGTCTGCAATTAGGAAAAAG
GTATTACATCAATTACGTGGAGTTTGACTCACGTGACGAAGCGGAGCGCATGAAGAGATCTATTTCTGCAAACCCAGAGT
TCTACGCAAATGATCTAACTCGGATAGAGGGTTCAGTTAAGACAGATTTGCCAGCTTTTCTTCCGAAAAATATCCAATGG
GATGGAAATAAATGGCTCCTCGCAAAGTATATGGGCAAGTTTTACATTTACACAGTTGTGAAAATAGTTTCTGTTTCTCC
AGAGGAGAAAGAGAAAAATTTAAATGAGCTCCGGAAGTTCATGCGTTTGAACAAACTAAATCAGATAGTCGATGAAATAA
GAGATAAGGTTCATTTAGGTGAAGATTGGAAAGTAATAGTAGGAAAATACGGTGGAGAAATAGATTACCTTACTCCCATG
AGTCGACTTTCCTTGGATAAGGATGGGAAGAAAGTTAAAGTAAGTGAAGAGCTATTAGAGCAGGTTTTTTCAAGTAGCGA
AGGTGCTATAAGCGAAGTTATCACTGGCAAGAATGAGTTTATACTGTTTCGTGTTACTTCCGTTGAACCAGTGGCTAAGC
AACCTTTCAGTAAAGTTAGAAGCAAAGTGATGGAAGCATTGTCTAAAAAAAGACAAATGCAAGTTGCGCTTGAGCTTCTA
CAAAAGCAGCAGGAAAGGGGAGAAAAAACAGAAAAGGTGGCTCTGTACCGGCCAGGGATTGCGAAGCGTAAAGGGCTGAA
CTACCACTATCCTGATGAATTCATAGCAGAAGTATTCCAGATTGATTCCGGGGGCACAACAAAAGTTTTTGAGTCGGATG
TGGAATTCTTTTCTGGCAAGGTTCTGGGTAACAGAAATCCTGAGCTAGATAAGTCAATAGTTGCCGAAATTGAGGCTAAG
CTGCGCGAAGAGATTGGGTTTTCAATGCTAAGTGAGCTAACTCAAGCTGCGATGAAGCAGTTTAAGGTAAAGGTAAATTC
GGATCTTATAAAAGACCTTTTGTAA

Upstream 100 bases:

>100_bases
CTTCCTAAGAGCTGGTCCCGCACGCAGCCGCCAACGAATCTTGCTTCTCCGCCATTATTACGTATTATTTGAACGAGGGT
TCTTAAGTCCTCAGTCCAGC

Downstream 100 bases:

>100_bases
TGTGTAGCATAAACGCTTTCCTGTTCAGCGATTTGGCTTCAAAGCGGATTTTCCTTTTTGAGGGTCAGCTCGAGTTGATC
TATCTGGCCTATGTCAAGGA

Product: rotamase family protein

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MFRPSLTMRLKKLFSPKWLILVLLILALLVTAINASITGSRSDVVASVGREKILVDDFVSEYKKHERYFQSMFDFRLTDT
QLKDIGVGRIVLTTLIQDKVIEQLFKQMGLHIDTSIAIDKIKKNPVFNENGKFDRAKLDDFLDRNDLTEREYIRKVKREI
GKDFVFGPFFNIQGEYGKLAELFYNFEYGLKEVSIAKVDKNALPTPPVPTESELVSFYEENKDKFFSDEYRAAACILISE
DNVKPELVEVADEDVQKSFESLQLGKRYYINYVEFDSRDEAERMKRSISANPEFYANDLTRIEGSVKTDLPAFLPKNIQW
DGNKWLLAKYMGKFYIYTVVKIVSVSPEEKEKNLNELRKFMRLNKLNQIVDEIRDKVHLGEDWKVIVGKYGGEIDYLTPM
SRLSLDKDGKKVKVSEELLEQVFSSSEGAISEVITGKNEFILFRVTSVEPVAKQPFSKVRSKVMEALSKKRQMQVALELL
QKQQERGEKTEKVALYRPGIAKRKGLNYHYPDEFIAEVFQIDSGGTTKVFESDVEFFSGKVLGNRNPELDKSIVAEIEAK
LREEIGFSMLSELTQAAMKQFKVKVNSDLIKDLL

Sequences:

>Translated_594_residues
MFRPSLTMRLKKLFSPKWLILVLLILALLVTAINASITGSRSDVVASVGREKILVDDFVSEYKKHERYFQSMFDFRLTDT
QLKDIGVGRIVLTTLIQDKVIEQLFKQMGLHIDTSIAIDKIKKNPVFNENGKFDRAKLDDFLDRNDLTEREYIRKVKREI
GKDFVFGPFFNIQGEYGKLAELFYNFEYGLKEVSIAKVDKNALPTPPVPTESELVSFYEENKDKFFSDEYRAAACILISE
DNVKPELVEVADEDVQKSFESLQLGKRYYINYVEFDSRDEAERMKRSISANPEFYANDLTRIEGSVKTDLPAFLPKNIQW
DGNKWLLAKYMGKFYIYTVVKIVSVSPEEKEKNLNELRKFMRLNKLNQIVDEIRDKVHLGEDWKVIVGKYGGEIDYLTPM
SRLSLDKDGKKVKVSEELLEQVFSSSEGAISEVITGKNEFILFRVTSVEPVAKQPFSKVRSKVMEALSKKRQMQVALELL
QKQQERGEKTEKVALYRPGIAKRKGLNYHYPDEFIAEVFQIDSGGTTKVFESDVEFFSGKVLGNRNPELDKSIVAEIEAK
LREEIGFSMLSELTQAAMKQFKVKVNSDLIKDLL
>Mature_594_residues
MFRPSLTMRLKKLFSPKWLILVLLILALLVTAINASITGSRSDVVASVGREKILVDDFVSEYKKHERYFQSMFDFRLTDT
QLKDIGVGRIVLTTLIQDKVIEQLFKQMGLHIDTSIAIDKIKKNPVFNENGKFDRAKLDDFLDRNDLTEREYIRKVKREI
GKDFVFGPFFNIQGEYGKLAELFYNFEYGLKEVSIAKVDKNALPTPPVPTESELVSFYEENKDKFFSDEYRAAACILISE
DNVKPELVEVADEDVQKSFESLQLGKRYYINYVEFDSRDEAERMKRSISANPEFYANDLTRIEGSVKTDLPAFLPKNIQW
DGNKWLLAKYMGKFYIYTVVKIVSVSPEEKEKNLNELRKFMRLNKLNQIVDEIRDKVHLGEDWKVIVGKYGGEIDYLTPM
SRLSLDKDGKKVKVSEELLEQVFSSSEGAISEVITGKNEFILFRVTSVEPVAKQPFSKVRSKVMEALSKKRQMQVALELL
QKQQERGEKTEKVALYRPGIAKRKGLNYHYPDEFIAEVFQIDSGGTTKVFESDVEFFSGKVLGNRNPELDKSIVAEIEAK
LREEIGFSMLSELTQAAMKQFKVKVNSDLIKDLL

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=290, Percent_Identity=22.0689655172414, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68389; Mature: 68389

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPSLTMRLKKLFSPKWLILVLLILALLVTAINASITGSRSDVVASVGREKILVDDFVS
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHH
EYKKHERYFQSMFDFRLTDTQLKDIGVGRIVLTTLIQDKVIEQLFKQMGLHIDTSIAIDK
HHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IKKNPVFNENGKFDRAKLDDFLDRNDLTEREYIRKVKREIGKDFVFGPFFNIQGEYGKLA
HHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHH
ELFYNFEYGLKEVSIAKVDKNALPTPPVPTESELVSFYEENKDKFFSDEYRAAACILISE
HHHHHHHHCCHHHHHEEECCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCEEEEEEEEC
DNVKPELVEVADEDVQKSFESLQLGKRYYINYVEFDSRDEAERMKRSISANPEFYANDLT
CCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHH
RIEGSVKTDLPAFLPKNIQWDGNKWLLAKYMGKFYIYTVVKIVSVSPEEKEKNLNELRKF
HHCCCHHCCCHHHCCCCCEECCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
MRLNKLNQIVDEIRDKVHLGEDWKVIVGKYGGEIDYLTPMSRLSLDKDGKKVKVSEELLE
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCCCEEEHHHHHHH
QVFSSSEGAISEVITGKNEFILFRVTSVEPVAKQPFSKVRSKVMEALSKKRQMQVALELL
HHHCCCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKQQERGEKTEKVALYRPGIAKRKGLNYHYPDEFIAEVFQIDSGGTTKVFESDVEFFSGK
HHHHHCCCHHHEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
VLGNRNPELDKSIVAEIEAKLREEIGFSMLSELTQAAMKQFKVKVNSDLIKDLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRPSLTMRLKKLFSPKWLILVLLILALLVTAINASITGSRSDVVASVGREKILVDDFVS
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHH
EYKKHERYFQSMFDFRLTDTQLKDIGVGRIVLTTLIQDKVIEQLFKQMGLHIDTSIAIDK
HHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IKKNPVFNENGKFDRAKLDDFLDRNDLTEREYIRKVKREIGKDFVFGPFFNIQGEYGKLA
HHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHH
ELFYNFEYGLKEVSIAKVDKNALPTPPVPTESELVSFYEENKDKFFSDEYRAAACILISE
HHHHHHHHCCHHHHHEEECCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCEEEEEEEEC
DNVKPELVEVADEDVQKSFESLQLGKRYYINYVEFDSRDEAERMKRSISANPEFYANDLT
CCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHH
RIEGSVKTDLPAFLPKNIQWDGNKWLLAKYMGKFYIYTVVKIVSVSPEEKEKNLNELRKF
HHCCCHHCCCHHHCCCCCEECCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
MRLNKLNQIVDEIRDKVHLGEDWKVIVGKYGGEIDYLTPMSRLSLDKDGKKVKVSEELLE
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCCCEEEHHHHHHH
QVFSSSEGAISEVITGKNEFILFRVTSVEPVAKQPFSKVRSKVMEALSKKRQMQVALELL
HHHCCCCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKQQERGEKTEKVALYRPGIAKRKGLNYHYPDEFIAEVFQIDSGGTTKVFESDVEFFSGK
HHHHHCCCHHHEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
VLGNRNPELDKSIVAEIEAKLREEIGFSMLSELTQAAMKQFKVKVNSDLIKDLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]