| Definition | Neorickettsia sennetsu str. Miyayama chromosome, complete genome. |
|---|---|
| Accession | NC_007798 |
| Length | 859,006 |
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The map label for this gene is topA
Identifier: 88608699
GI number: 88608699
Start: 514673
End: 517156
Strand: Reverse
Name: topA
Synonym: NSE_0594
Alternate gene names: 88608699
Gene position: 517156-514673 (Counterclockwise)
Preceding gene: 88608034
Following gene: 88608819
Centisome position: 60.2
GC content: 40.74
Gene sequence:
>2484_bases ATGAATGTCCTCATAGTAGAATCACCCACTAAAGGTAAGGCTATTGCTCAATATTTGGGTAAAGACTTTAGGGTACTGTC GTCCTTTGGTCATGTGCGAGCGCTTCCCAATAAAAAGGGCTCTGTTGATGTGACGGAGTCGTTCGAGATGCTCTATAAAC TTACCGATACCGGTGAGACAGTCGTGCCTCAGTTAATTAAGGATGTAAAAAAGGCGACAGCCCTCTATCTTGCTACAGAC CCTGATAGAGAAGGGGAAGCTATTTCTTGGCACCTTGTTGAGGTGTTTAAGGAGAATGATGTGCTTCCCAAAGACGTACA CAGGGTTGTGTTTCATGAAATTACAAAAACCGCTGTGCAAAATGCCATCGCTTCTCCAAGAAAGATAGATGAGAATCTTG TTCGCGCACAAAGGCTAAGACAGGCACTTGACTATCTTGTTGGGTTTAGTATTTCTCCAGTGCTATGGAAGAAATTACCT GGAAGTAAATCTGCTGGGAGAGTTCAATCTGTTGCCCTCAGGATCTTGTGCGATAGGGAAAACGAGATAGGTCTGTTTAC ACCAGAGGAATATTGGACGGTAACTGTGAATATGACCGATGGCGAAGCTCTTGTCCTTCCTACTCAACTTTCACACATGA ATGGTGAAAAACTCGAGAGAATGTCTATAAGAAGAGCAGAGGAAGCTGAAAAGATTGTTGAGGAGATCAGTGGACTTCCA TTTCTTGTTGAAGAAATCAAAAAGAAGGAACTTAAGCAGAAGCCTAGTCCCCCATTTATCACGTCCACTATGCAGCAAAC GGCATCAACCATACTTGGGTTTAGTGTAAAAAAAACTATGAGTCTAGCGCAAAAGCTGTATGAGGGTATCGAGATAGGTG GTGTGATTGAGGGCCTCATCACGTATATGAGGACAGATGCTACTCATCTTTCTGTTGAGAGTGTTGATGCTATAAGAGAG TTTATCCAAGAAAAATTTGGGCAAGAGTATTTGCCTGCATCTCCTGTTTTATTTAAGAAAAAAGTGAAAAACGCTCAGGA AGCACACGAAGCTATTCGTCCAACAAGCATTTTTCGTACACCTGAAGAAATTGAATCTTATCTCACACCAGATCAGTATA AGTTGTACAGGCTTATATGGGAGAGAGCACTTGCCTGTCAAATGAGTGATGCTATTACGAGTAGTCAGAACATCGTATTT GTTTCTCAAGACAAGAAGTTCAAAACTTCTGCGTCGGCATCACTGCTTATTTTTGATGGTTTCAATGCTGCTTTTTCGCA TGGTAAAAACAAAAATAAAAATCAGGATGTTATAGATTTTATAAAGAAGCATAAGGAAGGTGCTCAGGTAAAAGTAGGTG ATGTATTGCTTACACAAAACTTTACTGAGCCCCCACATCGCTACTCGGAAGCAGGGTTGGTCAAACATCTTGAGGAGTTG GGTATAGGGCGCCCTTCAACTTACGCTACTGTGGTTTCTGTTCTGCAGGAGAGGGGATATGCATCTATTGTCAACAAGTC GTTTATTCCAGAAAGCAGGGGAAGGCTAGTTTCTGAGTTTTTGGTACATTTTTTTAGCAAATATGTTGAGTATCATTTTA CTGCTGAATTGGAAGATAGACTGGACAAAGTCGCAGATGGAACAATTTTTTGGCTAGATGTAATTCAGGATTTCTGGGAC AGCTTTCATTCTAATGTAGAAGAGGTGGAAAAAGTTCCGATCACTGAGGTTCTAGCATTTGTAAATGGTGCCCTTGCAAG ACAAAAGCTTGTTTCGGCTGAGGTAAAGGTTGGTGACAAGTGTCCAAAATGTGAAAAAGGGTATATGCATTTAAATGTAA GTCGTTATGGAGTTTTCCTTGGCTGCACAGATTATCCGGTTTGTAGGTTTATAGTGAATAGTTATAGTACTGATAATGAT ACTGAATATCCTAAGCAAATTGCTCAGGATATTAGCCTCCACAAGGGTCCTTATGGTATCTACCTTAAATGCAAGGGCAA AAATAGTAGCATACCAAAAGATGTTGATCCCGTTTCTATAGATGAAGAGTTTGCTCATAAAATCGCTTCCTTACCAAAAA TTCTTGGTAAACACCCGATAGATGGTAAAGAAATCAAGATGGGTCTGGGCCCATATGGTCTGTATCTTTTTTGGAATGCA AAATATTACAACTTGCAGTTTTCCCAAATGGATGAAATGACACTAGACCAAGCTGTTCAGTTCATGGAGGACTATGTTAG TCATGACAAGAGTTTGCTCCGTGTGCTTGGATCCCATGAAGGTGAAGAGATACAAATTCGTGATGGGAGATACGGTCCGT ACATTAAGTATAGTAAGATGAATGTTCCTATACCGAAGGGGGAAAGTCCGGAGTCGTTGTCCCTTGAAACGGCGATTCTT CTCATTGAGAAAAAGAAAAATACCTCTAAGTCCGCAAGGAAAGTAACAACAAAGAGAAAGGTCTTCACAAAAGAGAAGAA ATAA
Upstream 100 bases:
>100_bases ACTATACTTGCCGAATTGTTCGGGGTAGCTTATCTCTTTATTGAAGCACTACGTTGTTTCTGAGTTTTTGTTATTTTCGT TCATAGAAAGTCTCTGAGAG
Downstream 100 bases:
>100_bases CGCTTTCAATATGCATTTCAAGGTTGATAAGAAAATGGATACAGCAACTTCGAGAGCGAAGAGGGGGTTTATCTTTTTTC AGTTTCCTTGAAAGTATCTT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 827; Mature: 827
Protein sequence:
>827_residues MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGETVVPQLIKDVKKATALYLATD PDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLP GSKSAGRVQSVALRILCDRENEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLP FLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLITYMRTDATHLSVESVDAIRE FIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVF VSQDKKFKTSASASLLIFDGFNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEEL GIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDRLDKVADGTIFWLDVIQDFWD SFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDKCPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDND TEYPKQIAQDISLHKGPYGIYLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNA KYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKMNVPIPKGESPESLSLETAIL LIEKKKNTSKSARKVTTKRKVFTKEKK
Sequences:
>Translated_827_residues MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGETVVPQLIKDVKKATALYLATD PDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLP GSKSAGRVQSVALRILCDRENEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLP FLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLITYMRTDATHLSVESVDAIRE FIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVF VSQDKKFKTSASASLLIFDGFNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEEL GIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDRLDKVADGTIFWLDVIQDFWD SFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDKCPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDND TEYPKQIAQDISLHKGPYGIYLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNA KYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKMNVPIPKGESPESLSLETAIL LIEKKKNTSKSARKVTTKRKVFTKEKK >Mature_827_residues MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGETVVPQLIKDVKKATALYLATD PDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLP GSKSAGRVQSVALRILCDRENEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLP FLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLITYMRTDATHLSVESVDAIRE FIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVF VSQDKKFKTSASASLLIFDGFNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEEL GIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDRLDKVADGTIFWLDVIQDFWD SFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDKCPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDND TEYPKQIAQDISLHKGPYGIYLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNA KYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKMNVPIPKGESPESLSLETAIL LIEKKKNTSKSARKVTTKRKVFTKEKK
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=639, Percent_Identity=24.8826291079812, Blast_Score=107, Evalue=4e-23, Organism=Homo sapiens, GI4507635, Length=569, Percent_Identity=23.3743409490334, Blast_Score=100, Evalue=5e-21, Organism=Escherichia coli, GI1787529, Length=667, Percent_Identity=38.0809595202399, Blast_Score=429, Evalue=1e-121, Organism=Escherichia coli, GI1788061, Length=676, Percent_Identity=22.189349112426, Blast_Score=94, Evalue=3e-20, Organism=Caenorhabditis elegans, GI32563869, Length=570, Percent_Identity=23.6842105263158, Blast_Score=108, Evalue=9e-24, Organism=Caenorhabditis elegans, GI17555378, Length=513, Percent_Identity=24.1715399610136, Blast_Score=90, Evalue=4e-18, Organism=Saccharomyces cerevisiae, GI6323263, Length=565, Percent_Identity=22.3008849557522, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24585251, Length=607, Percent_Identity=23.8879736408567, Blast_Score=113, Evalue=5e-25, Organism=Drosophila melanogaster, GI24640096, Length=569, Percent_Identity=24.0773286467487, Blast_Score=97, Evalue=4e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 93523; Mature: 93523
Theoretical pI: Translated: 8.07; Mature: 8.07
Prosite motif: PS00396 TOPOISOMERASE_I_PROK ; PS00223 ANNEXIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGET CCEEEEECCCCHHHHHHHHCHHHHHHHHCCCCEECCCCCCCEEHHHHHHHHHHHCCCCHH VVPQLIKDVKKATALYLATDPDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQ HHHHHHHHHHHHHEEEEEECCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH NAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLPGSKSAGRVQSVALRILCDRE HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHEECCC NEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLP CCCCEECCCCEEEEEEEECCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCH FLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLI HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH TYMRTDATHLSVESVDAIREFIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRT HHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHCCHHHCCC PEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVFVSQDKKFKTSASASLLIFDG HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEC FNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEEL CHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEECEEEEECCCCCCCHHHHHHHHHHHHHHH GIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDR CCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEHHHHH LDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDK HHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC CPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDNDTEYPKQIAQDISLHKGPYGI CCCCCCCCEEEEEEHEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEE YLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNA EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEC KYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKM EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCC NVPIPKGESPESLSLETAILLIEKKKNTSKSARKVTTKRKVFTKEKK CCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC >Mature Secondary Structure MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGET CCEEEEECCCCHHHHHHHHCHHHHHHHHCCCCEECCCCCCCEEHHHHHHHHHHHCCCCHH VVPQLIKDVKKATALYLATDPDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQ HHHHHHHHHHHHHEEEEEECCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH NAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLPGSKSAGRVQSVALRILCDRE HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHEECCC NEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLP CCCCEECCCCEEEEEEEECCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCH FLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLI HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH TYMRTDATHLSVESVDAIREFIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRT HHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHCCHHHCCC PEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVFVSQDKKFKTSASASLLIFDG HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEEEC FNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEEL CHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEECEEEEECCCCCCCHHHHHHHHHHHHHHH GIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDR CCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEHHHHH LDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDK HHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC CPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDNDTEYPKQIAQDISLHKGPYGI CCCCCCCCEEEEEEHEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEE YLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNA EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEC KYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKM EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCC NVPIPKGESPESLSLETAILLIEKKKNTSKSARKVTTKRKVFTKEKK CCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA