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The map label for this gene is trxA

Identifier: 88608595

GI number: 88608595

Start: 799237

End: 799545

Strand: Reverse

Name: trxA

Synonym: NSE_0894

Alternate gene names: 88608595

Gene position: 799545-799237 (Counterclockwise)

Preceding gene: 88608669

Following gene: 88608254

Centisome position: 93.08

GC content: 43.04

Gene sequence:

>309_bases
ATGGATGAACTGAAAGATTTTTCAACACAGGTTTCTGGGGTTTCAGGGCTTGTTCTTTTGGATTTTTGGGCGGATTGGTG
TGCGCCATGTAAGCAGTTAATTCCTATACTTGAGGCTTTTGCGGAATCCGCTGAAAATGTGAAGGTATATAAAGTCAATA
TAGATGGTCCTGGTCAGGATTTGGCTGTCTCTAATGGTGTAAGGGCTGTTCCAACGTTGATCCTGTTTAAAGATGGGAAA
ATCGTGGATCGTAAAGTTGGGTCTCTTTCGTTGTCGCAACTCAAAGAATGGGTTGCCACGTTCTCTTAG

Upstream 100 bases:

>100_bases
GAGAGAGGGTAAAGTGAGAAGGGCTAAGCTTTACTATATTAGGGCTCTAACTGGAAAGGCAACGAGAATAAGGAAAGAAT
ATCGTAGTTAAGAGTCTCTT

Downstream 100 bases:

>100_bases
TCTTGTTTCCCTCTGTATTTGTGGAGTTACAACAACTATTGGTGTTTTCTGAACAGTGGTGAGGCCGGCAGCTTGATCTG
TGTGCCGGGTCTTATACGTG

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MDELKDFSTQVSGVSGLVLLDFWADWCAPCKQLIPILEAFAESAENVKVYKVNIDGPGQDLAVSNGVRAVPTLILFKDGK
IVDRKVGSLSLSQLKEWVATFS

Sequences:

>Translated_102_residues
MDELKDFSTQVSGVSGLVLLDFWADWCAPCKQLIPILEAFAESAENVKVYKVNIDGPGQDLAVSNGVRAVPTLILFKDGK
IVDRKVGSLSLSQLKEWVATFS
>Mature_102_residues
MDELKDFSTQVSGVSGLVLLDFWADWCAPCKQLIPILEAFAESAENVKVYKVNIDGPGQDLAVSNGVRAVPTLILFKDGK
IVDRKVGSLSLSQLKEWVATFS

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=94, Percent_Identity=46.8085106382979, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI1788936, Length=82, Percent_Identity=36.5853658536585, Blast_Score=68, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=99, Percent_Identity=36.3636363636364, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=72, Percent_Identity=47.2222222222222, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=95, Percent_Identity=35.7894736842105, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573567, Length=95, Percent_Identity=38.9473684210526, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=39.7590361445783, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11129; Mature: 11129

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELKDFSTQVSGVSGLVLLDFWADWCAPCKQLIPILEAFAESAENVKVYKVNIDGPGQD
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCC
LAVSNGVRAVPTLILFKDGKIVDRKVGSLSLSQLKEWVATFS
CCCCCCCCHHCEEEEECCCCEECHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDELKDFSTQVSGVSGLVLLDFWADWCAPCKQLIPILEAFAESAENVKVYKVNIDGPGQD
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCC
LAVSNGVRAVPTLILFKDGKIVDRKVGSLSLSQLKEWVATFS
CCCCCCCCHHCEEEEECCCCEECHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]