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The map label for this gene is map

Identifier: 88608522

GI number: 88608522

Start: 277355

End: 278143

Strand: Reverse

Name: map

Synonym: NSE_0337

Alternate gene names: 88608522

Gene position: 278143-277355 (Counterclockwise)

Preceding gene: 88608577

Following gene: 88608174

Centisome position: 32.38

GC content: 41.7

Gene sequence:

>789_bases
ATGGTCACAGACATAAAAATACATTCAGAGAAAGATTTTGAATCCATGAGAAAAGCTGGCCACTTAGCCGCGGAAGTACT
GGATTACATTACCGATTATGTAAAACCAGGTGTTACAACTGATGAACTAAACAAGTTATGTCACGAGTTTATAGTTGCTG
CAGGTGCTATTCCGGCACCATTGCATTACAAAGGCTTTCCAAAATCGATATGCACCTCAAAAAATAATGTTGTCTGTCAC
GGCATCCCAGATGCTGTACCCCTAAGAGATGGAGATATACTCAATATAGATGTCACAGTTATTCTGAATGGCTGGCACGG
TGATACAAGTCGGATGTATTTCGTTGGAACACCTTCAATCAAAGCGGTGAGACTGTGTAAAGCCACTTATGAAGCAATGA
TGGCCGGCATTGCAGTGGTTAAACCAGGCGTACCATTTAATGCAATTGGTCACGCAATAAGCACACACACCTCGCAATAC
GAATACTCAATAGTCCACCAATATTGTGGCCATGGTATAGGACAAACATTTCACGCACCACCAAATGTTGTACATTACGC
ATCGGATGAAAATAGCGACCTTATTATGCTACCTGGAATGTTTTTCACCATCGAGCCAATGATAAACGCGGGTAGAGCTA
ATGTAATACTCGATCGGAGGGATGGATGGACCGTTAGAACTAAGGATTTGTCCTTGTCAGCACAATTTGAACACACTATT
GGAGTAACCCAAACCGGATATGAAATCTTTACTCTTTCACCAGCTGGATTACATACTCCAAACTTTTAG

Upstream 100 bases:

>100_bases
GCGGTTGTATAGTTATGTCGCATAGCAAAAAGAGGTTAATAGTTCGGTACATAATCATGAATTAACAGAACTCACAATTG
GGAGAAGATCTACTAAGCTT

Downstream 100 bases:

>100_bases
AGCTGTGAAACAGCTACACGTTAAATGTATTTCACGTCCCACCAGCGTGCAACACTATAATAAAGCACAGTTCTCAAAAT
AACGTGCGCGCACTTGCGTA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVTDIKIHSEKDFESMRKAGHLAAEVLDYITDYVKPGVTTDELNKLCHEFIVAAGAIPAPLHYKGFPKSICTSKNNVVCH
GIPDAVPLRDGDILNIDVTVILNGWHGDTSRMYFVGTPSIKAVRLCKATYEAMMAGIAVVKPGVPFNAIGHAISTHTSQY
EYSIVHQYCGHGIGQTFHAPPNVVHYASDENSDLIMLPGMFFTIEPMINAGRANVILDRRDGWTVRTKDLSLSAQFEHTI
GVTQTGYEIFTLSPAGLHTPNF

Sequences:

>Translated_262_residues
MVTDIKIHSEKDFESMRKAGHLAAEVLDYITDYVKPGVTTDELNKLCHEFIVAAGAIPAPLHYKGFPKSICTSKNNVVCH
GIPDAVPLRDGDILNIDVTVILNGWHGDTSRMYFVGTPSIKAVRLCKATYEAMMAGIAVVKPGVPFNAIGHAISTHTSQY
EYSIVHQYCGHGIGQTFHAPPNVVHYASDENSDLIMLPGMFFTIEPMINAGRANVILDRRDGWTVRTKDLSLSAQFEHTI
GVTQTGYEIFTLSPAGLHTPNF
>Mature_262_residues
MVTDIKIHSEKDFESMRKAGHLAAEVLDYITDYVKPGVTTDELNKLCHEFIVAAGAIPAPLHYKGFPKSICTSKNNVVCH
GIPDAVPLRDGDILNIDVTVILNGWHGDTSRMYFVGTPSIKAVRLCKATYEAMMAGIAVVKPGVPFNAIGHAISTHTSQY
EYSIVHQYCGHGIGQTFHAPPNVVHYASDENSDLIMLPGMFFTIEPMINAGRANVILDRRDGWTVRTKDLSLSAQFEHTI
GVTQTGYEIFTLSPAGLHTPNF

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=47.4103585657371, Blast_Score=228, Evalue=3e-60,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=44, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=54.8, Blast_Score=274, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71996291, Length=250, Percent_Identity=45.2, Blast_Score=209, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6323273, Length=260, Percent_Identity=43.4615384615385, Blast_Score=225, Evalue=6e-60,
Organism=Drosophila melanogaster, GI21355531, Length=261, Percent_Identity=45.9770114942529, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=45.1219512195122, Blast_Score=218, Evalue=3e-57,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28727; Mature: 28727

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTDIKIHSEKDFESMRKAGHLAAEVLDYITDYVKPGVTTDELNKLCHEFIVAAGAIPAP
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
LHYKGFPKSICTSKNNVVCHGIPDAVPLRDGDILNIDVTVILNGWHGDTSRMYFVGTPSI
CCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCCH
KAVRLCKATYEAMMAGIAVVKPGVPFNAIGHAISTHTSQYEYSIVHQYCGHGIGQTFHAP
HHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCC
PNVVHYASDENSDLIMLPGMFFTIEPMINAGRANVILDRRDGWTVRTKDLSLSAQFEHTI
CCEEEECCCCCCCEEEECCCEEEEECHHCCCCCEEEEECCCCCEEEEECCEEEEEEEEEE
GVTQTGYEIFTLSPAGLHTPNF
CCEECCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MVTDIKIHSEKDFESMRKAGHLAAEVLDYITDYVKPGVTTDELNKLCHEFIVAAGAIPAP
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
LHYKGFPKSICTSKNNVVCHGIPDAVPLRDGDILNIDVTVILNGWHGDTSRMYFVGTPSI
CCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCCH
KAVRLCKATYEAMMAGIAVVKPGVPFNAIGHAISTHTSQYEYSIVHQYCGHGIGQTFHAP
HHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCC
PNVVHYASDENSDLIMLPGMFFTIEPMINAGRANVILDRRDGWTVRTKDLSLSAQFEHTI
CCEEEECCCCCCCEEEECCCEEEEECHHCCCCCEEEEECCCCCEEEEECCEEEEEEEEEE
GVTQTGYEIFTLSPAGLHTPNF
CCEECCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]