Click here to switch to the map view.

The map label for this gene is alaS

Identifier: 88608446

GI number: 88608446

Start: 124722

End: 127268

Strand: Reverse

Name: alaS

Synonym: NSE_0156

Alternate gene names: 88608446

Gene position: 127268-124722 (Counterclockwise)

Preceding gene: 88608464

Following gene: 88608137

Centisome position: 14.82

GC content: 41.46

Gene sequence:

>2547_bases
ATGATAGACGGCCTCAGAAAAAAATTCATAGATTTTTTCGTCAAAAACGGACACACATACCTTCCTTCTGCATCCTTAGT
ACCGAAAGACGATCCTTCACTGATGTTCGTCAACGCGGGTATGGTTCCATTTAAGGAGTACTTTGTGGATGTCAGAAGAG
CACCATTCTCGAGCATCGTAACAGCACAAAAATGCGTGAGGGCTGGAGGTAAACACAATGACTTGGAAAACGTTGGATTT
ACAAAACGGCACCACACCTTTTTTGAGATGCTGGGAAATTTCAGCTTTGGCTGCTATTTCAAGGAAAGAGCAATAGAGTT
AGCTTGGAAATTTGTCACTGAAGAACTCACGTTAAGTAAGAAAAAACTGTACATTACAGTCTACCACGAGGACGATGAAG
CGTTCGAGATTTGGGATAAATTAACAGGCTTCGGGGAAAGAAAAATCAAGAGAATTAGCACAAGTGATAATTTCTGGCAG
ATGGGTGATATTGGCCCGTGTGGTCCCTGCTCAGAGATCTTTTATGACCATGGAGAACACTTATCCGGTGACATACCTGA
AGATAAAAAGGACCCCGGGGAAAGATACGTCGAGATATGGAACCTCGTTTTCATGCAGTACATAAGGGAACAAAGCGGAG
AACTGGCGCGCATGGAGTGTCCGTGTATAGATACAGGAATGGGGCTAGAAAGGGTGGCCGCAATTCTAGAGGGTACAGAT
GATAACTATAAAACAAAATTGTTCGAAGCCATTGTAAAGGAATCACAAAATGTTACCGGCAACAAAGACAATCAAGCTGC
GCACAAAGTAATAGCCGATCATTTACGTTCTGCTAGTTTTCTTATAGCGGATGGTGTTTTACCAGGTAATACTGGACGTG
AGTATGTCTTGAGGAGAATAATACGCAGAGCAGTACGGTACTCGCATGCACTTGGTTTTGATACGGTATTATTACCAAAG
CTTTTTTGGGTACTTAAGGAGTGGATGGGTAGTCATTACCAGGAACTCACAAGAGCTGAGAATCTCATTTTAGATACATT
AACACTAGAAGAACAATCTTTTCGAAACACACTCAAGTCAGGAATGAAATTACTCGAGGAAGTTTCAAGCTCTATGAAGG
AGGGCGATACATTATCTGGAGACATAGCATTCACACTATATGATACCCACGGATTCCCATTGGATATAACGGTAGACATC
TTAAAAGAGAGAAAAATTTCAGTCGATGAAGAAGGTTTTGCAGAAAGGATGAAAATGCAAAGGCTCCTTGCTCAAGCTTC
TCGGATGAAGGATATGGCACAAACCTCAAGTTATGAGGTAAAAGCAGTGTTCCTAGAGCACGGAAAAACACCTTTTATTG
GTTATGAAAATTTTACAGGATTAGCGCTTATCCTTGCGATAACAGAAAAAGAGGGATCTAACAAACTGACAATTATACTT
GACCAAACGATTTTCTACCCAGAATCAGGTGGTCAAGAGAGCGATCAAGGCATAATAGAAGGAGAAAATACCCTGCTGAA
GGTAGAAAAAGTCTACAAATCTACTGAGGGAGTTATCCTCCATGAGTGTACGATCATCAGGGGTCAAGTAACGAGTAGAG
GCGAGAAAGTAAACCTCAAGATAGATATAAATCGCAGAAACAGCCTAGCCAGGAACCACTCGGCAACGCATATACTACAT
CATGTTTTGAGAAAAAGGCTTGGTGCACATGTCTCGCAACGTGGCTCTCTCGTGGCACCGAGTAGGTTGCGTTTCGATTT
TAGTCACAGCCAATCTATCACGGAGGAAGAGCTTTCTAAAATAGAGGACTGTATAAACCTTATGATCTGGGATGATCATC
CTGTAATGACAGAAATCAAAAAGACTGATGAGGCTATAAGAGATGGCGCCATTGGATTGTTCGGAGAAAAGTACGACGAT
ACGGTTCGTGTTGTCTCAATAGGGGAAGCAGTAGAGCTATGCGGAGGTACGCACGTCAAAAAAAGTTCAGCCATTGGACT
AGTAAAGATTTTATCGGCGTCATCTGTGGCTCACGGTGTTCGCAGAATAGAGGCAGTAACGCATCTTACTGCCTTACAAT
ACATACGAGAAGCGGAACAAGCACAGCTTTATCAACTTACCGAACATCAAGCAAAGCTCAAAGCAATGCAAAAGAGCCAT
CAAAAAGAGATTACACGCGTATATCAGTCCATTGTCACAAATGCAGAAGCCCGAACAGAAAGATATGGCTCAGTGGAAAT
AATTACTAAAAATGTTCAGGGTATATCAAAAGAAATCCTGCTGAGTCTTGCATCAGAAATAAGACCCAAAACGGGGGTGC
TAATTGTTCACACAGAACTGAGCGAAGCCCTATATTCGCTCATCATACTCGATAAGGAGATTTTCAAAAACATAAGTTTT
ATAGATTCTATGAAAGAGACAATTGATAAATCGCACGGAAAAGTTACCCCTTCTGTACCATATGTCATTCAGGCCACATT
TTCTAAAAAAGAGGATCTGGATCGCTGCCTAAAAAATTTATCTGAATTAGTAGTATCTACCTTTTAG

Upstream 100 bases:

>100_bases
CCCTGCCTGCAAGACCTAGTAAGAAAATTGCTGTACTTTACTTTAAAGACCCGAAAACATATAACATTTACGTTCGTGTC
CTGTGCATTGGGGTTACTTT

Downstream 100 bases:

>100_bases
AAATCGTGTAAGTTCTAACCCTTTCCGCACAAAATTTCCAAAAAGTCTTGTGCTAAACGGGCCCTGCAATCTGAGCCTCT
TGGAAAGCAAAAGTCCTTTT

Product: alanyl-tRNA synthetase

Products: NA

Alternate protein names: Alanine--tRNA ligase; AlaRS

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MIDGLRKKFIDFFVKNGHTYLPSASLVPKDDPSLMFVNAGMVPFKEYFVDVRRAPFSSIVTAQKCVRAGGKHNDLENVGF
TKRHHTFFEMLGNFSFGCYFKERAIELAWKFVTEELTLSKKKLYITVYHEDDEAFEIWDKLTGFGERKIKRISTSDNFWQ
MGDIGPCGPCSEIFYDHGEHLSGDIPEDKKDPGERYVEIWNLVFMQYIREQSGELARMECPCIDTGMGLERVAAILEGTD
DNYKTKLFEAIVKESQNVTGNKDNQAAHKVIADHLRSASFLIADGVLPGNTGREYVLRRIIRRAVRYSHALGFDTVLLPK
LFWVLKEWMGSHYQELTRAENLILDTLTLEEQSFRNTLKSGMKLLEEVSSSMKEGDTLSGDIAFTLYDTHGFPLDITVDI
LKERKISVDEEGFAERMKMQRLLAQASRMKDMAQTSSYEVKAVFLEHGKTPFIGYENFTGLALILAITEKEGSNKLTIIL
DQTIFYPESGGQESDQGIIEGENTLLKVEKVYKSTEGVILHECTIIRGQVTSRGEKVNLKIDINRRNSLARNHSATHILH
HVLRKRLGAHVSQRGSLVAPSRLRFDFSHSQSITEEELSKIEDCINLMIWDDHPVMTEIKKTDEAIRDGAIGLFGEKYDD
TVRVVSIGEAVELCGGTHVKKSSAIGLVKILSASSVAHGVRRIEAVTHLTALQYIREAEQAQLYQLTEHQAKLKAMQKSH
QKEITRVYQSIVTNAEARTERYGSVEIITKNVQGISKEILLSLASEIRPKTGVLIVHTELSEALYSLIILDKEIFKNISF
IDSMKETIDKSHGKVTPSVPYVIQATFSKKEDLDRCLKNLSELVVSTF

Sequences:

>Translated_848_residues
MIDGLRKKFIDFFVKNGHTYLPSASLVPKDDPSLMFVNAGMVPFKEYFVDVRRAPFSSIVTAQKCVRAGGKHNDLENVGF
TKRHHTFFEMLGNFSFGCYFKERAIELAWKFVTEELTLSKKKLYITVYHEDDEAFEIWDKLTGFGERKIKRISTSDNFWQ
MGDIGPCGPCSEIFYDHGEHLSGDIPEDKKDPGERYVEIWNLVFMQYIREQSGELARMECPCIDTGMGLERVAAILEGTD
DNYKTKLFEAIVKESQNVTGNKDNQAAHKVIADHLRSASFLIADGVLPGNTGREYVLRRIIRRAVRYSHALGFDTVLLPK
LFWVLKEWMGSHYQELTRAENLILDTLTLEEQSFRNTLKSGMKLLEEVSSSMKEGDTLSGDIAFTLYDTHGFPLDITVDI
LKERKISVDEEGFAERMKMQRLLAQASRMKDMAQTSSYEVKAVFLEHGKTPFIGYENFTGLALILAITEKEGSNKLTIIL
DQTIFYPESGGQESDQGIIEGENTLLKVEKVYKSTEGVILHECTIIRGQVTSRGEKVNLKIDINRRNSLARNHSATHILH
HVLRKRLGAHVSQRGSLVAPSRLRFDFSHSQSITEEELSKIEDCINLMIWDDHPVMTEIKKTDEAIRDGAIGLFGEKYDD
TVRVVSIGEAVELCGGTHVKKSSAIGLVKILSASSVAHGVRRIEAVTHLTALQYIREAEQAQLYQLTEHQAKLKAMQKSH
QKEITRVYQSIVTNAEARTERYGSVEIITKNVQGISKEILLSLASEIRPKTGVLIVHTELSEALYSLIILDKEIFKNISF
IDSMKETIDKSHGKVTPSVPYVIQATFSKKEDLDRCLKNLSELVVSTF
>Mature_848_residues
MIDGLRKKFIDFFVKNGHTYLPSASLVPKDDPSLMFVNAGMVPFKEYFVDVRRAPFSSIVTAQKCVRAGGKHNDLENVGF
TKRHHTFFEMLGNFSFGCYFKERAIELAWKFVTEELTLSKKKLYITVYHEDDEAFEIWDKLTGFGERKIKRISTSDNFWQ
MGDIGPCGPCSEIFYDHGEHLSGDIPEDKKDPGERYVEIWNLVFMQYIREQSGELARMECPCIDTGMGLERVAAILEGTD
DNYKTKLFEAIVKESQNVTGNKDNQAAHKVIADHLRSASFLIADGVLPGNTGREYVLRRIIRRAVRYSHALGFDTVLLPK
LFWVLKEWMGSHYQELTRAENLILDTLTLEEQSFRNTLKSGMKLLEEVSSSMKEGDTLSGDIAFTLYDTHGFPLDITVDI
LKERKISVDEEGFAERMKMQRLLAQASRMKDMAQTSSYEVKAVFLEHGKTPFIGYENFTGLALILAITEKEGSNKLTIIL
DQTIFYPESGGQESDQGIIEGENTLLKVEKVYKSTEGVILHECTIIRGQVTSRGEKVNLKIDINRRNSLARNHSATHILH
HVLRKRLGAHVSQRGSLVAPSRLRFDFSHSQSITEEELSKIEDCINLMIWDDHPVMTEIKKTDEAIRDGAIGLFGEKYDD
TVRVVSIGEAVELCGGTHVKKSSAIGLVKILSASSVAHGVRRIEAVTHLTALQYIREAEQAQLYQLTEHQAKLKAMQKSH
QKEITRVYQSIVTNAEARTERYGSVEIITKNVQGISKEILLSLASEIRPKTGVLIVHTELSEALYSLIILDKEIFKNISF
IDSMKETIDKSHGKVTPSVPYVIQATFSKKEDLDRCLKNLSELVVSTF

Specific function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editin

COG id: COG0013

COG function: function code J; Alanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI109148542, Length=805, Percent_Identity=38.0124223602485, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI38569417, Length=889, Percent_Identity=31.1586051743532, Blast_Score=388, Evalue=1e-107,
Organism=Escherichia coli, GI1789048, Length=817, Percent_Identity=42.5948592411261, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506981, Length=840, Percent_Identity=34.4047619047619, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17536681, Length=740, Percent_Identity=32.7027027027027, Blast_Score=335, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6324911, Length=769, Percent_Identity=39.0117035110533, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6324288, Length=220, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24582809, Length=806, Percent_Identity=36.1042183622829, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45552267, Length=806, Percent_Identity=36.1042183622829, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24658214, Length=774, Percent_Identity=29.4573643410853, Blast_Score=306, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYA_NEOSM (Q2GEP2)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506054.1
- ProteinModelPortal:   Q2GEP2
- STRING:   Q2GEP2
- GeneID:   3931384
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0156
- TIGR:   NSE_0156
- eggNOG:   COG0013
- HOGENOM:   HBG354397
- OMA:   GESKTDQ
- PhylomeDB:   Q2GEP2
- ProtClustDB:   PRK00252
- BioCyc:   NSEN222891:NSE_0156-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00036_B
- InterPro:   IPR002318
- InterPro:   IPR018162
- InterPro:   IPR018165
- InterPro:   IPR018164
- InterPro:   IPR023033
- InterPro:   IPR018163
- InterPro:   IPR012947
- PRINTS:   PR00980
- SMART:   SM00863
- TIGRFAMs:   TIGR00344

Pfam domain/function: PF01411 tRNA-synt_2c; PF07973 tRNA_SAD; SSF101353 Ala-tRNA-synth_IIc_anticod-bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.7

Molecular weight: Translated: 95938; Mature: 95938

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50860 AA_TRNA_LIGASE_II_ALA; PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDGLRKKFIDFFVKNGHTYLPSASLVPKDDPSLMFVNAGMVPFKEYFVDVRRAPFSSIV
CCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHH
TAQKCVRAGGKHNDLENVGFTKRHHTFFEMLGNFSFGCYFKERAIELAWKFVTEELTLSK
HHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
KKLYITVYHEDDEAFEIWDKLTGFGERKIKRISTSDNFWQMGDIGPCGPCSEIFYDHGEH
EEEEEEEEECCCHHHHHHHHHCCCCHHHHHHCCCCCCCEECCCCCCCCCHHHHHHCCCCC
LSGDIPEDKKDPGERYVEIWNLVFMQYIREQSGELARMECPCIDTGMGLERVAAILEGTD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCC
DNYKTKLFEAIVKESQNVTGNKDNQAAHKVIADHLRSASFLIADGVLPGNTGREYVLRRI
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHH
IRRAVRYSHALGFDTVLLPKLFWVLKEWMGSHYQELTRAENLILDTLTLEEQSFRNTLKS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMKLLEEVSSSMKEGDTLSGDIAFTLYDTHGFPLDITVDILKERKISVDEEGFAERMKMQ
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEHHHHHCCCCCCCHHHHHHHHHHH
RLLAQASRMKDMAQTSSYEVKAVFLEHGKTPFIGYENFTGLALILAITEKEGSNKLTIIL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEECCCCCCCEEEEEEEECCCCCCEEEEEE
DQTIFYPESGGQESDQGIIEGENTLLKVEKVYKSTEGVILHECTIIRGQVTSRGEKVNLK
ECEEECCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEE
IDINRRNSLARNHSATHILHHVLRKRLGAHVSQRGSLVAPSRLRFDFSHSQSITEEELSK
EEECCCHHHHHCCHHHHHHHHHHHHHHCCCHHCCCCCCCCHHEEEECCCCCCCCHHHHHH
IEDCINLMIWDDHPVMTEIKKTDEAIRDGAIGLFGEKYDDTVRVVSIGEAVELCGGTHVK
HHHHHEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEHHHHHHHHCCCCCC
KSSAIGLVKILSASSVAHGVRRIEAVTHLTALQYIREAEQAQLYQLTEHQAKLKAMQKSH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKEITRVYQSIVTNAEARTERYGSVEIITKNVQGISKEILLSLASEIRPKTGVLIVHTEL
HHHHHHHHHHHHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEECHH
SEALYSLIILDKEIFKNISFIDSMKETIDKSHGKVTPSVPYVIQATFSKKEDLDRCLKNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
SELVVSTF
HHHHHHCC
>Mature Secondary Structure
MIDGLRKKFIDFFVKNGHTYLPSASLVPKDDPSLMFVNAGMVPFKEYFVDVRRAPFSSIV
CCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHH
TAQKCVRAGGKHNDLENVGFTKRHHTFFEMLGNFSFGCYFKERAIELAWKFVTEELTLSK
HHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
KKLYITVYHEDDEAFEIWDKLTGFGERKIKRISTSDNFWQMGDIGPCGPCSEIFYDHGEH
EEEEEEEEECCCHHHHHHHHHCCCCHHHHHHCCCCCCCEECCCCCCCCCHHHHHHCCCCC
LSGDIPEDKKDPGERYVEIWNLVFMQYIREQSGELARMECPCIDTGMGLERVAAILEGTD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCC
DNYKTKLFEAIVKESQNVTGNKDNQAAHKVIADHLRSASFLIADGVLPGNTGREYVLRRI
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHH
IRRAVRYSHALGFDTVLLPKLFWVLKEWMGSHYQELTRAENLILDTLTLEEQSFRNTLKS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMKLLEEVSSSMKEGDTLSGDIAFTLYDTHGFPLDITVDILKERKISVDEEGFAERMKMQ
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEHHHHHCCCCCCCHHHHHHHHHHH
RLLAQASRMKDMAQTSSYEVKAVFLEHGKTPFIGYENFTGLALILAITEKEGSNKLTIIL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEECCCCCCCEEEEEEEECCCCCCEEEEEE
DQTIFYPESGGQESDQGIIEGENTLLKVEKVYKSTEGVILHECTIIRGQVTSRGEKVNLK
ECEEECCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCEEEEE
IDINRRNSLARNHSATHILHHVLRKRLGAHVSQRGSLVAPSRLRFDFSHSQSITEEELSK
EEECCCHHHHHCCHHHHHHHHHHHHHHCCCHHCCCCCCCCHHEEEECCCCCCCCHHHHHH
IEDCINLMIWDDHPVMTEIKKTDEAIRDGAIGLFGEKYDDTVRVVSIGEAVELCGGTHVK
HHHHHEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEHHHHHHHHCCCCCC
KSSAIGLVKILSASSVAHGVRRIEAVTHLTALQYIREAEQAQLYQLTEHQAKLKAMQKSH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKEITRVYQSIVTNAEARTERYGSVEIITKNVQGISKEILLSLASEIRPKTGVLIVHTEL
HHHHHHHHHHHHHCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEECHH
SEALYSLIILDKEIFKNISFIDSMKETIDKSHGKVTPSVPYVIQATFSKKEDLDRCLKNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
SELVVSTF
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA