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The map label for this gene is guaA

Identifier: 88608428

GI number: 88608428

Start: 790828

End: 792387

Strand: Reverse

Name: guaA

Synonym: NSE_0887

Alternate gene names: 88608428

Gene position: 792387-790828 (Counterclockwise)

Preceding gene: 88608350

Following gene: 88608512

Centisome position: 92.24

GC content: 43.78

Gene sequence:

>1560_bases
ATGATGCCCGAAATAGCCATCATTGATCTAGGATCGCAGTTTACCCAGCTGATAGCTCGAAAGTTAAGGGAAAATGGATG
CTGCTCGTGTATCTATAACCCCTCTGGCTTTACTTTCTCCAATGACATAAAGGGTGTTATATTATCCGGTAGCCACCAGT
CTACCAGTGAGTATGCGAACTACAGAGACCTAATCGCAATGGTTCTGAGCCTGAATTCTACGCATGGTATACCAGTGTTA
GGAATCTGCTACGGAAAGCAACTCCTAAGCGATTTCTTAGGTGCTAGTGTGGTCTCTGGTAAAAACCGCGAATATGGAAG
GGCTAGACTCCAGATCGTTGCAGAAAGCCCGATTGTGAGCAACATCAGTGCCTCGGATTTTACGGTCTGGATGAGTCACG
GTGATGCGGTTGTGACGCTTCCTTGTGGTTTTAAATGTGTCGCAAAGACAGACGATTGCCAATTTGCACTAATTGCTGAT
GAAAACAGGAAGATATATGGCTTTCAGTTTCATCCTGAGGTCTCACACACTGAGAATGGTGGTGTCTTACTACGCAATTT
CATATCAATTGCAGGAGTTGAAAATACCTGGGATCTACAAGTTTTTTCCGAAGAAGAAAAACGCATGGTAGTTGCTACCA
CTGGTGATGCAGGTGTTCTTGCTGCAGTCAGCGGAGGTGTTGATTCAACAGTTGCAGCGAAATTTATGCACGGAGCAATA
GGTGAAAGGCTTCATTGCATTTTTGTAGATACAGGACTTCTAAGAAAAAATGAAGCTAATGAAGTGAAGGAATCATTTTC
ATCGTTGGGAATACCGCTGAAGATTGTTTTTGCAGCTGATAGGTTCTTTAAAAAGCTTGCTGGAGTTGCAGATCCCGAAC
AGAAGAGAAGAATTGTTGGAGAGACTTTTATTCAAGTATTTGAAGAAGAGGCTCTAAAAATCCAGGGTGTGGAATTTCTT
TTACAGGGCACTTTGTACCCCGACGTTATCGAATCGGGTGGTGGAGGTTCCCATACAATTAAATCTCACCACAATGTGGG
TGGGCTGCCCAAGAAAATGGGGTTAAAGTTGCTTGAGCCTTTTAGATTGCTCTTTAAAGATGAGGTGAGAGCAATTGGGC
GTCAGTTAGGTGTGAGTGAGGTCCTTTTAATGCGGCATCCGTCACCAGGACCTGCTCTGGCGATACGAATCCTAGGAGAA
GTAACTCAAGAAAAAGTGGCTGTGCTTCAGGATATCGATGAGATATACATCTCGACAATGAAGGAATACAATCTGTATTC
TCACATATGGCAGGCTTTCAGCGTATTATTACCAGTTTGTTCCGTTGGTGTGATGGGTGATAAGCGCTCTTATAACTATG
TTTGTGCGCTACGCGCTATTGTTTCTCACGATGGAATGACAGCTAGTGCCTATCCATTTGAGGCTCATGATGATGATAAA
TTGCGCTTTCTTTCCTTTCTGAATGAGGTTGCAACCAAAATACCCAATCGTGTGAGCGCAGTCTCTCGTGTAGTATATGA
CATTACATCCAAACCGCCAGCCACAGTTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
ATTCACACGGCAAGGTGTATTTCTTTACTTTTAACTGTGCTTCACTAGATTTTGTTATCTATCAGCAATATAATCTGCCT
GTGTACTCCCGTAAAGCGAG

Downstream 100 bases:

>100_bases
ACCTTGATATCACAGCGCTTTGTGCATACGGGCTAAGCTCTCGGTACTTGTGCGTGTGGTCTCTAAGAAGGTGGTTCCTC
TTCTTTGGCGATGCTTTTTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MMPEIAIIDLGSQFTQLIARKLRENGCCSCIYNPSGFTFSNDIKGVILSGSHQSTSEYANYRDLIAMVLSLNSTHGIPVL
GICYGKQLLSDFLGASVVSGKNREYGRARLQIVAESPIVSNISASDFTVWMSHGDAVVTLPCGFKCVAKTDDCQFALIAD
ENRKIYGFQFHPEVSHTENGGVLLRNFISIAGVENTWDLQVFSEEEKRMVVATTGDAGVLAAVSGGVDSTVAAKFMHGAI
GERLHCIFVDTGLLRKNEANEVKESFSSLGIPLKIVFAADRFFKKLAGVADPEQKRRIVGETFIQVFEEEALKIQGVEFL
LQGTLYPDVIESGGGGSHTIKSHHNVGGLPKKMGLKLLEPFRLLFKDEVRAIGRQLGVSEVLLMRHPSPGPALAIRILGE
VTQEKVAVLQDIDEIYISTMKEYNLYSHIWQAFSVLLPVCSVGVMGDKRSYNYVCALRAIVSHDGMTASAYPFEAHDDDK
LRFLSFLNEVATKIPNRVSAVSRVVYDITSKPPATVEWE

Sequences:

>Translated_519_residues
MMPEIAIIDLGSQFTQLIARKLRENGCCSCIYNPSGFTFSNDIKGVILSGSHQSTSEYANYRDLIAMVLSLNSTHGIPVL
GICYGKQLLSDFLGASVVSGKNREYGRARLQIVAESPIVSNISASDFTVWMSHGDAVVTLPCGFKCVAKTDDCQFALIAD
ENRKIYGFQFHPEVSHTENGGVLLRNFISIAGVENTWDLQVFSEEEKRMVVATTGDAGVLAAVSGGVDSTVAAKFMHGAI
GERLHCIFVDTGLLRKNEANEVKESFSSLGIPLKIVFAADRFFKKLAGVADPEQKRRIVGETFIQVFEEEALKIQGVEFL
LQGTLYPDVIESGGGGSHTIKSHHNVGGLPKKMGLKLLEPFRLLFKDEVRAIGRQLGVSEVLLMRHPSPGPALAIRILGE
VTQEKVAVLQDIDEIYISTMKEYNLYSHIWQAFSVLLPVCSVGVMGDKRSYNYVCALRAIVSHDGMTASAYPFEAHDDDK
LRFLSFLNEVATKIPNRVSAVSRVVYDITSKPPATVEWE
>Mature_519_residues
MMPEIAIIDLGSQFTQLIARKLRENGCCSCIYNPSGFTFSNDIKGVILSGSHQSTSEYANYRDLIAMVLSLNSTHGIPVL
GICYGKQLLSDFLGASVVSGKNREYGRARLQIVAESPIVSNISASDFTVWMSHGDAVVTLPCGFKCVAKTDDCQFALIAD
ENRKIYGFQFHPEVSHTENGGVLLRNFISIAGVENTWDLQVFSEEEKRMVVATTGDAGVLAAVSGGVDSTVAAKFMHGAI
GERLHCIFVDTGLLRKNEANEVKESFSSLGIPLKIVFAADRFFKKLAGVADPEQKRRIVGETFIQVFEEEALKIQGVEFL
LQGTLYPDVIESGGGGSHTIKSHHNVGGLPKKMGLKLLEPFRLLFKDEVRAIGRQLGVSEVLLMRHPSPGPALAIRILGE
VTQEKVAVLQDIDEIYISTMKEYNLYSHIWQAFSVLLPVCSVGVMGDKRSYNYVCALRAIVSHDGMTASAYPFEAHDDDK
LRFLSFLNEVATKIPNRVSAVSRVVYDITSKPPATVEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=578, Percent_Identity=33.7370242214533, Blast_Score=255, Evalue=6e-68,
Organism=Escherichia coli, GI1788854, Length=532, Percent_Identity=44.7368421052632, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71992710, Length=590, Percent_Identity=32.3728813559322, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI71992717, Length=590, Percent_Identity=32.7118644067797, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI133901714, Length=590, Percent_Identity=32.7118644067797, Blast_Score=234, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6323873, Length=536, Percent_Identity=49.2537313432836, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=32.3214285714286, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 56952; Mature: 56952

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPEIAIIDLGSQFTQLIARKLRENGCCSCIYNPSGFTFSNDIKGVILSGSHQSTSEYAN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCEEEEECCCCCHHHHHH
YRDLIAMVLSLNSTHGIPVLGICYGKQLLSDFLGASVVSGKNREYGRARLQIVAESPIVS
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEEECCCCCC
NISASDFTVWMSHGDAVVTLPCGFKCVAKTDDCQFALIADENRKIYGFQFHPEVSHTENG
CCCCCCEEEEEECCCEEEEECCCCEEEECCCCCCEEEEECCCCEEEEEEECCCCCCCCCC
GVLLRNFISIAGVENTWDLQVFSEEEKRMVVATTGDAGVLAAVSGGVDSTVAAKFMHGAI
CHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHH
GERLHCIFVDTGLLRKNEANEVKESFSSLGIPLKIVFAADRFFKKLAGVADPEQKRRIVG
CCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHH
ETFIQVFEEEALKIQGVEFLLQGTLYPDVIESGGGGSHTIKSHHNVGGLPKKMGLKLLEP
HHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
FRLLFKDEVRAIGRQLGVSEVLLMRHPSPGPALAIRILGEVTQEKVAVLQDIDEIYISTM
HHHHHHHHHHHHHHHCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEYNLYSHIWQAFSVLLPVCSVGVMGDKRSYNYVCALRAIVSHDGMTASAYPFEAHDDDK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCH
LRFLSFLNEVATKIPNRVSAVSRVVYDITSKPPATVEWE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MMPEIAIIDLGSQFTQLIARKLRENGCCSCIYNPSGFTFSNDIKGVILSGSHQSTSEYAN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCEEEEECCCCCHHHHHH
YRDLIAMVLSLNSTHGIPVLGICYGKQLLSDFLGASVVSGKNREYGRARLQIVAESPIVS
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEEECCCCCC
NISASDFTVWMSHGDAVVTLPCGFKCVAKTDDCQFALIADENRKIYGFQFHPEVSHTENG
CCCCCCEEEEEECCCEEEEECCCCEEEECCCCCCEEEEECCCCEEEEEEECCCCCCCCCC
GVLLRNFISIAGVENTWDLQVFSEEEKRMVVATTGDAGVLAAVSGGVDSTVAAKFMHGAI
CHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHH
GERLHCIFVDTGLLRKNEANEVKESFSSLGIPLKIVFAADRFFKKLAGVADPEQKRRIVG
CCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHH
ETFIQVFEEEALKIQGVEFLLQGTLYPDVIESGGGGSHTIKSHHNVGGLPKKMGLKLLEP
HHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
FRLLFKDEVRAIGRQLGVSEVLLMRHPSPGPALAIRILGEVTQEKVAVLQDIDEIYISTM
HHHHHHHHHHHHHHHCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEYNLYSHIWQAFSVLLPVCSVGVMGDKRSYNYVCALRAIVSHDGMTASAYPFEAHDDDK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCH
LRFLSFLNEVATKIPNRVSAVSRVVYDITSKPPATVEWE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA