Click here to switch to the map view.

The map label for this gene is fabD

Identifier: 88608410

GI number: 88608410

Start: 846297

End: 847226

Strand: Reverse

Name: fabD

Synonym: NSE_0960

Alternate gene names: 88608410

Gene position: 847226-846297 (Counterclockwise)

Preceding gene: 88608559

Following gene: 88608771

Centisome position: 98.63

GC content: 42.9

Gene sequence:

>930_bases
ATGAATATGTTTTTATTTCCCGGACAAGGTTCCCAGCGTGTCGGTATGGGCAAAAGTTTGTACGAGAATTTCTCTGTTGC
CCGTGAGGTTTTTTCCGAAGTCGATGAATCTCTGGGTATGAAGTTATCAAAAGTAATATTTGAGGGACCGGAACTTTCGA
ATACTGAGAATGCTCAGCCTGCCCTTATGGCAACCTCTATGGCGGCACTTAAGGTTCTTTTATCAGAGTCTGGAAAAAGT
GTTTCGGAATTGTCCAAGTACTTAGCTGGACATTCACTTGGGGAATACACAGCACTGTGTGCGTCTGGTGCCATTACGAT
CTCTCAAGTTGCCAGAATCTTAAAAATTAGAGGAAAGTCGATGCAAGAAGCTGTGCCTATGGGTGAAGGTGGCATGCTTG
CTCTGCTTAAAGTAACTTTTGAGGAAGTACAGGATCTCATAGTGGAGTCAAAGGCAAACTGTGAGATTTCGAATGACAAT
AGTAATGAGCAGGTTGTTGTTAGCGGTTTGACTACTGAGATAGAAAAGATTGAACAGTATGCAAAACAAAAAGGTATAAA
GCGCGTGGTGCGGTTGAATGTGAGTGCGCCGTTTCACTGCAAGTTAATGCAGCCCGCTGTTATGCCAGTGAAAGATGCCC
TCGATACTGCAGAAATTGTCACACCTTCTGTTCCAATCGTGTCGAATGTTACAGCAAGTCCAGTAACGGAGGTTCAAAAA
ATAAAGGAGCTTCTAGTGCAGCAAATCACAGGCTGCGTACGATGGAGGGAGAGCATGCTTTTTGCAATAGGAGCAGGTGT
AAAAACTTTCATAGAAGTGGGATCAGGCAATGTTTTGAGCAAAATGCTCTCTCGAATGAATCCAAATGTAACAACATTAA
ATCTCGAAGGGGTAGATGATCTAGACAGAATTATTGCTACAATTGGATGA

Upstream 100 bases:

>100_bases
TTCGGGAGGCAGAAAAAGAATGAAGTTCATCTAAATTTGACTGCCATTTCTGTAGGGTATAAGTTTTGGTATTGCAGATC
AGATCCTATTTAAAGTCTCT

Downstream 100 bases:

>100_bases
GCTAAGTCGGAGATCTACCGATTTGCATGTATTCTGTTATGAAAGTCCCCTTTTCAAAAAGTCTCAATGAGTAGTCCCGA
GTATAATAGCAGCGATTGCC

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNMFLFPGQGSQRVGMGKSLYENFSVAREVFSEVDESLGMKLSKVIFEGPELSNTENAQPALMATSMAALKVLLSESGKS
VSELSKYLAGHSLGEYTALCASGAITISQVARILKIRGKSMQEAVPMGEGGMLALLKVTFEEVQDLIVESKANCEISNDN
SNEQVVVSGLTTEIEKIEQYAKQKGIKRVVRLNVSAPFHCKLMQPAVMPVKDALDTAEIVTPSVPIVSNVTASPVTEVQK
IKELLVQQITGCVRWRESMLFAIGAGVKTFIEVGSGNVLSKMLSRMNPNVTTLNLEGVDDLDRIIATIG

Sequences:

>Translated_309_residues
MNMFLFPGQGSQRVGMGKSLYENFSVAREVFSEVDESLGMKLSKVIFEGPELSNTENAQPALMATSMAALKVLLSESGKS
VSELSKYLAGHSLGEYTALCASGAITISQVARILKIRGKSMQEAVPMGEGGMLALLKVTFEEVQDLIVESKANCEISNDN
SNEQVVVSGLTTEIEKIEQYAKQKGIKRVVRLNVSAPFHCKLMQPAVMPVKDALDTAEIVTPSVPIVSNVTASPVTEVQK
IKELLVQQITGCVRWRESMLFAIGAGVKTFIEVGSGNVLSKMLSRMNPNVTTLNLEGVDDLDRIIATIG
>Mature_309_residues
MNMFLFPGQGSQRVGMGKSLYENFSVAREVFSEVDESLGMKLSKVIFEGPELSNTENAQPALMATSMAALKVLLSESGKS
VSELSKYLAGHSLGEYTALCASGAITISQVARILKIRGKSMQEAVPMGEGGMLALLKVTFEEVQDLIVESKANCEISNDN
SNEQVVVSGLTTEIEKIEQYAKQKGIKRVVRLNVSAPFHCKLMQPAVMPVKDALDTAEIVTPSVPIVSNVTASPVTEVQK
IKELLVQQITGCVRWRESMLFAIGAGVKTFIEVGSGNVLSKMLSRMNPNVTTLNLEGVDDLDRIIATIG

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=304, Percent_Identity=34.5394736842105, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI27477045, Length=110, Percent_Identity=38.1818181818182, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787334, Length=311, Percent_Identity=36.0128617363344, Blast_Score=171, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=31.0580204778157, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=294, Percent_Identity=25.8503401360544, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24665753, Length=304, Percent_Identity=35.8552631578947, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33346; Mature: 33346

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMFLFPGQGSQRVGMGKSLYENFSVAREVFSEVDESLGMKLSKVIFEGPELSNTENAQP
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCH
ALMATSMAALKVLLSESGKSVSELSKYLAGHSLGEYTALCASGAITISQVARILKIRGKS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEHHHHHHHHHHCCCH
MQEAVPMGEGGMLALLKVTFEEVQDLIVESKANCEISNDNSNEQVVVSGLTTEIEKIEQY
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECHHHHHHHHHHH
AKQKGIKRVVRLNVSAPFHCKLMQPAVMPVKDALDTAEIVTPSVPIVSNVTASPVTEVQK
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
IKELLVQQITGCVRWRESMLFAIGAGVKTFIEVGSGNVLSKMLSRMNPNVTTLNLEGVDD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCHH
LDRIIATIG
HHHHHHHCC
>Mature Secondary Structure
MNMFLFPGQGSQRVGMGKSLYENFSVAREVFSEVDESLGMKLSKVIFEGPELSNTENAQP
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCH
ALMATSMAALKVLLSESGKSVSELSKYLAGHSLGEYTALCASGAITISQVARILKIRGKS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEHHHHHHHHHHCCCH
MQEAVPMGEGGMLALLKVTFEEVQDLIVESKANCEISNDNSNEQVVVSGLTTEIEKIEQY
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECHHHHHHHHHHH
AKQKGIKRVVRLNVSAPFHCKLMQPAVMPVKDALDTAEIVTPSVPIVSNVTASPVTEVQK
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
IKELLVQQITGCVRWRESMLFAIGAGVKTFIEVGSGNVLSKMLSRMNPNVTTLNLEGVDD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCHH
LDRIIATIG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]