Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 88608338

GI number: 88608338

Start: 733470

End: 734690

Strand: Direct

Name: hemA

Synonym: NSE_0826

Alternate gene names: 88608338

Gene position: 733470-734690 (Clockwise)

Preceding gene: 88608138

Following gene: 88608832

Centisome position: 85.39

GC content: 43.08

Gene sequence:

>1221_bases
ATGTCTAACTACAGTAGTGTCTTTGCTCGAGCTCTCGATACAATCAAGAATGAAAAGCGTTACCGTGAATTTGTCAACCT
TGCGCGAATCTCTGGTGAGTTCCCCTGTGCTATAAACGAGGAAACAAACGAAAAAATAGTCATATGGTGCAGCAATGACT
ATCTAGGAATGGGACAGAACTTTACAGTTTGTGACTCCATGAAAGAGACCATCGACAGGATGGGTGCCGGAGCTGGTGGT
ACTAGGAATATTTCCGGAAATAATAAGGAAGTGGTTCTCCTAGAAAAGACAATTGCGAAGTTACATCAGAAAGAGGCTGC
TTTGTCTTTTGTTTGTGGCTACGTTGCCAATCTTGCTTCGATATCCACAATTATCTCGCTCATGGAGAATTGTATCGCGT
TTTCTGATCAGTATAATCACTCATCGATAATAGAAGGTATCAGAACAAGTCGCTGCGAGAAGAGAATTTTTCGCCACAAC
GATGTCAATCACTTAGAAAAGTTGCTTTCACAGGTTCCTAAAGGGGCTTATAAGATAATAATTTTCGAGTCGGTATACTC
AATGGACGGGGACGTCGCACCAATAAAAAAGATTTGTGATCTTGCGGAGAAATATAATGCCCTTACGTACATCGACGAAG
TGCACGCCGTAGGGATGTATGGTAAACACGGTGGAGGAATCACAGAGGAAATGGATCTGGTGGATCGAGTAGATATAATC
CAGGGAACACTTGCAAAAGCATACGGCGTCATAGGCGGATATATAGCAGCTAAGGCTGATATAATCGACATCATCAGAAG
CCACGCGTCCGGATTCATTTTTACTACAGCACTTCCACCCGTAATCGCAAGCGCTGGCAGAGCAAGCATCACACATCTAT
ATGACAGTGATGAGGAAAGAAGAAAACAAAAGGAGAATGTTGCAAAACTCAAAGCGATGTTTAAAGCAAATGGTATCCCA
TATAAGGACGCCCCAACACACATAATACCTGTCATAATTGGGCACCCAGAGGAGTGCAAATACGCATCTAAAACTTTGCT
AGAAGAATTCAAGATTTTCATCCAGCACATAAACTATCCAACGGTTCCACGCGGCACAGAACGCCTGAGGATCACACCAA
CACCCCAGCATACCGATACAATGATGGAAGAACTTGTGTTCGCGCTAAAAGAAGTACTCGGGAGAATACAACACAAAAAA
AGCGCAAGGGGTGCAATTTAA

Upstream 100 bases:

>100_bases
TGCTCAATTCCAGGCGGAAGTAGTTCAGTTGGTAGAACGCAACCTTGCCAAGGTTGAGGCCGAGGGTTCGAGTCCCTTTT
TCCGCTCCCTTTTTTTGCAC

Downstream 100 bases:

>100_bases
CTGCGCACCCGGGCAGGGCGGAGCTGACTCAGTACGGCACCACACGGAGCTTCTGCTTTCTTATCTTGCGCCTAGTTTCT
ACAGCCCTCCTGTGCCTCTT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSNYSSVFARALDTIKNEKRYREFVNLARISGEFPCAINEETNEKIVIWCSNDYLGMGQNFTVCDSMKETIDRMGAGAGG
TRNISGNNKEVVLLEKTIAKLHQKEAALSFVCGYVANLASISTIISLMENCIAFSDQYNHSSIIEGIRTSRCEKRIFRHN
DVNHLEKLLSQVPKGAYKIIIFESVYSMDGDVAPIKKICDLAEKYNALTYIDEVHAVGMYGKHGGGITEEMDLVDRVDII
QGTLAKAYGVIGGYIAAKADIIDIIRSHASGFIFTTALPPVIASAGRASITHLYDSDEERRKQKENVAKLKAMFKANGIP
YKDAPTHIIPVIIGHPEECKYASKTLLEEFKIFIQHINYPTVPRGTERLRITPTPQHTDTMMEELVFALKEVLGRIQHKK
SARGAI

Sequences:

>Translated_406_residues
MSNYSSVFARALDTIKNEKRYREFVNLARISGEFPCAINEETNEKIVIWCSNDYLGMGQNFTVCDSMKETIDRMGAGAGG
TRNISGNNKEVVLLEKTIAKLHQKEAALSFVCGYVANLASISTIISLMENCIAFSDQYNHSSIIEGIRTSRCEKRIFRHN
DVNHLEKLLSQVPKGAYKIIIFESVYSMDGDVAPIKKICDLAEKYNALTYIDEVHAVGMYGKHGGGITEEMDLVDRVDII
QGTLAKAYGVIGGYIAAKADIIDIIRSHASGFIFTTALPPVIASAGRASITHLYDSDEERRKQKENVAKLKAMFKANGIP
YKDAPTHIIPVIIGHPEECKYASKTLLEEFKIFIQHINYPTVPRGTERLRITPTPQHTDTMMEELVFALKEVLGRIQHKK
SARGAI
>Mature_405_residues
SNYSSVFARALDTIKNEKRYREFVNLARISGEFPCAINEETNEKIVIWCSNDYLGMGQNFTVCDSMKETIDRMGAGAGGT
RNISGNNKEVVLLEKTIAKLHQKEAALSFVCGYVANLASISTIISLMENCIAFSDQYNHSSIIEGIRTSRCEKRIFRHND
VNHLEKLLSQVPKGAYKIIIFESVYSMDGDVAPIKKICDLAEKYNALTYIDEVHAVGMYGKHGGGITEEMDLVDRVDIIQ
GTLAKAYGVIGGYIAAKADIIDIIRSHASGFIFTTALPPVIASAGRASITHLYDSDEERRKQKENVAKLKAMFKANGIPY
KDAPTHIIPVIIGHPEECKYASKTLLEEFKIFIQHINYPTVPRGTERLRITPTPQHTDTMMEELVFALKEVLGRIQHKKS
ARGAI

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=390, Percent_Identity=43.0769230769231, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI83977440, Length=390, Percent_Identity=43.0769230769231, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI83977444, Length=390, Percent_Identity=43.0769230769231, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI4502025, Length=400, Percent_Identity=44.25, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI40316939, Length=400, Percent_Identity=44.25, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI7657118, Length=355, Percent_Identity=31.5492957746479, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI284448556, Length=355, Percent_Identity=31.5492957746479, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI119220554, Length=376, Percent_Identity=30.0531914893617, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=28.1842818428184, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=28.8065843621399, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=30.8571428571429, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1786993, Length=343, Percent_Identity=30.3206997084548, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=354, Percent_Identity=31.638418079096, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=371, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17560912, Length=371, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=27.9132791327913, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=28.4671532846715, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320438, Length=417, Percent_Identity=45.083932853717, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=28.3783783783784, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=270, Percent_Identity=25.1851851851852, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137420, Length=395, Percent_Identity=45.8227848101266, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24662918, Length=352, Percent_Identity=32.3863636363636, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17136286, Length=361, Percent_Identity=27.4238227146814, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24653280, Length=251, Percent_Identity=27.0916334661355, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653276, Length=251, Percent_Identity=27.0916334661355, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24653278, Length=251, Percent_Identity=27.0916334661355, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 45228; Mature: 45096

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYSSVFARALDTIKNEKRYREFVNLARISGEFPCAINEETNEKIVIWCSNDYLGMGQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCCCC
FTVCDSMKETIDRMGAGAGGTRNISGNNKEVVLLEKTIAKLHQKEAALSFVCGYVANLAS
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ISTIISLMENCIAFSDQYNHSSIIEGIRTSRCEKRIFRHNDVNHLEKLLSQVPKGAYKII
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEE
IFESVYSMDGDVAPIKKICDLAEKYNALTYIDEVHAVGMYGKHGGGITEEMDLVDRVDII
EEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
QGTLAKAYGVIGGYIAAKADIIDIIRSHASGFIFTTALPPVIASAGRASITHLYDSDEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCHHHHHHCCCCHHH
RKQKENVAKLKAMFKANGIPYKDAPTHIIPVIIGHPEECKYASKTLLEEFKIFIQHINYP
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
TVPRGTERLRITPTPQHTDTMMEELVFALKEVLGRIQHKKSARGAI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNYSSVFARALDTIKNEKRYREFVNLARISGEFPCAINEETNEKIVIWCSNDYLGMGQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCCCC
FTVCDSMKETIDRMGAGAGGTRNISGNNKEVVLLEKTIAKLHQKEAALSFVCGYVANLAS
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
ISTIISLMENCIAFSDQYNHSSIIEGIRTSRCEKRIFRHNDVNHLEKLLSQVPKGAYKII
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEE
IFESVYSMDGDVAPIKKICDLAEKYNALTYIDEVHAVGMYGKHGGGITEEMDLVDRVDII
EEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
QGTLAKAYGVIGGYIAAKADIIDIIRSHASGFIFTTALPPVIASAGRASITHLYDSDEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCHHHHHHCCCCHHH
RKQKENVAKLKAMFKANGIPYKDAPTHIIPVIIGHPEECKYASKTLLEEFKIFIQHINYP
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
TVPRGTERLRITPTPQHTDTMMEELVFALKEVLGRIQHKKSARGAI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]