BacMap

Definition	Neorickettsia sennetsu str. Miyayama chromosome, complete genome.
Accession	NC_007798
Length	859,006

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The map label for this gene is ppiB [C]

Identifier: 88608333

GI number: 88608333

Start: 753497

End: 754156

Strand: Reverse

Name: ppiB [C]

Synonym: NSE_0851

Alternate gene names: 88608333

Gene position: 754156-753497 (Counterclockwise)

Preceding gene: 88608255

Following gene: 88608064

Centisome position: 87.79

GC content: 42.27

Gene sequence:

>660_bases
ATGATGAGGGCCAGTGTCACAACTATTACTGCGTTTGTTCTGTTCTTTTGTGGTGTTTGTTGCTCACATGCCTCTGTGGT
ATTCCTGCAGTCTCAAGAAGGTGTATTATCATATCCTGAGCACGTGAGTTTTAATAAGATTCAGCAAATGAAAGAGAAGA
ATGCAAATCCCGTAGTAGGTCTCGAGATAGGTGCTGGTGCTGAGATGTTGGGTGAGATAGAGATTGAGCTCGCAGCAGAT
GTGGTACCTAGAACTGCAGAAAACTTTCTTCAACTCTGTACTGGTAAGAATGGGTTCGGCTACAAAGGTTCTATATTTCA
TAGGATAATACCTTCCTTCATGATACAAGGCGGTGACTTTACTCAGGGTAATGGTACAGGTGGCCACTCGATATACAACA
ATGATGTTTTTCCCGATGAAAACTTTGTCATAAAACACACTGGTCCCGGAAAGGTCTCAATGGCCAACCGTGGTCCGAAT
ACCAATGGATCACAATTCTTTATTACTACAGTAGAGACCCCCTGGTTGGATGGTAAACACGTTGTTTTTGGACAGGTTAT
TAGGGGAATGTCAGTTGTGAAAAAAATAGAAAGTTATGGTTCCAGCAACGGGAGACCATCAAGAATTATAAAGATATTGG
ATTGTTGGCAGGTGTCGTAG

Upstream 100 bases:

>100_bases
CGTGTGGGCCAGTGTTATAGGCTTATCGGATCTGGATTTTCTGTTAATAGCTTTTTATTTAATTGCGAGTACTACCATAT
AGTACTTTCAATTTTAGAGT

Downstream 100 bases:

>100_bases
CTATGCAATAAAATAGAGAAGATCGAGGTTAGCCAGTAAGCTGCAGCTGTTGGTTCAGTCTCCTAACTTTTCAGGTGCTT
GTAAAGCACTTCGACCGCGA

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase slr1251; Rotamase slr1251 [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MMRASVTTITAFVLFFCGVCCSHASVVFLQSQEGVLSYPEHVSFNKIQQMKEKNANPVVGLEIGAGAEMLGEIEIELAAD
VVPRTAENFLQLCTGKNGFGYKGSIFHRIIPSFMIQGGDFTQGNGTGGHSIYNNDVFPDENFVIKHTGPGKVSMANRGPN
TNGSQFFITTVETPWLDGKHVVFGQVIRGMSVVKKIESYGSSNGRPSRIIKILDCWQVS

Sequences:

>Translated_219_residues
MMRASVTTITAFVLFFCGVCCSHASVVFLQSQEGVLSYPEHVSFNKIQQMKEKNANPVVGLEIGAGAEMLGEIEIELAAD
VVPRTAENFLQLCTGKNGFGYKGSIFHRIIPSFMIQGGDFTQGNGTGGHSIYNNDVFPDENFVIKHTGPGKVSMANRGPN
TNGSQFFITTVETPWLDGKHVVFGQVIRGMSVVKKIESYGSSNGRPSRIIKILDCWQVS
>Mature_219_residues
MMRASVTTITAFVLFFCGVCCSHASVVFLQSQEGVLSYPEHVSFNKIQQMKEKNANPVVGLEIGAGAEMLGEIEIELAAD
VVPRTAENFLQLCTGKNGFGYKGSIFHRIIPSFMIQGGDFTQGNGTGGHSIYNNDVFPDENFVIKHTGPGKVSMANRGPN
TNGSQFFITTVETPWLDGKHVVFGQVIRGMSVVKKIESYGSSNGRPSRIIKILDCWQVS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI5031987, Length=164, Percent_Identity=67.0731707317073, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI10863927, Length=163, Percent_Identity=63.1901840490798, Blast_Score=212, Evalue=2e-55,
Organism=Homo sapiens, GI5174637, Length=165, Percent_Identity=59.3939393939394, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI310129267, Length=160, Percent_Identity=60.625, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI310120620, Length=160, Percent_Identity=60.625, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI310110104, Length=160, Percent_Identity=58.75, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI150418007, Length=166, Percent_Identity=59.0361445783133, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI303305009, Length=161, Percent_Identity=59.0062111801242, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI45439316, Length=152, Percent_Identity=60.5263157894737, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI4758950, Length=173, Percent_Identity=54.9132947976879, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI310132444, Length=165, Percent_Identity=55.7575757575758, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI310113152, Length=165, Percent_Identity=55.7575757575758, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI169214050, Length=163, Percent_Identity=56.441717791411, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI239751853, Length=163, Percent_Identity=56.441717791411, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI113428306, Length=163, Percent_Identity=56.441717791411, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI310127646, Length=163, Percent_Identity=55.2147239263804, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI310114371, Length=163, Percent_Identity=55.2147239263804, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI310119221, Length=163, Percent_Identity=55.2147239263804, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI256017253, Length=162, Percent_Identity=57.4074074074074, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI221139811, Length=162, Percent_Identity=57.4074074074074, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI256017251, Length=162, Percent_Identity=57.4074074074074, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI178057341, Length=162, Percent_Identity=56.1728395061728, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI169163387, Length=163, Percent_Identity=54.601226993865, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI169164185, Length=163, Percent_Identity=54.601226993865, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI169163623, Length=163, Percent_Identity=54.601226993865, Blast_Score=181, Evalue=5e-46,
Organism=Homo sapiens, GI209417936, Length=162, Percent_Identity=56.1728395061728, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI30102944, Length=162, Percent_Identity=56.1728395061728, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI219842199, Length=162, Percent_Identity=56.1728395061728, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI4826932, Length=180, Percent_Identity=52.7777777777778, Blast_Score=177, Evalue=7e-45,
Organism=Homo sapiens, GI5454154, Length=169, Percent_Identity=53.8461538461538, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI310127745, Length=160, Percent_Identity=53.75, Blast_Score=170, Evalue=8e-43,
Organism=Homo sapiens, GI310119290, Length=160, Percent_Identity=53.75, Blast_Score=170, Evalue=8e-43,
Organism=Homo sapiens, GI310114540, Length=160, Percent_Identity=53.75, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4505991, Length=179, Percent_Identity=51.9553072625698, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI6631100, Length=168, Percent_Identity=48.8095238095238, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI42560244, Length=178, Percent_Identity=47.1910112359551, Blast_Score=161, Evalue=3e-40,
Organism=Homo sapiens, GI27735045, Length=163, Percent_Identity=46.0122699386503, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI289803023, Length=188, Percent_Identity=39.3617021276596, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI310132372, Length=163, Percent_Identity=42.9447852760736, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI310113085, Length=163, Percent_Identity=42.9447852760736, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI310123632, Length=163, Percent_Identity=42.9447852760736, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI24308049, Length=128, Percent_Identity=52.34375, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI7706339, Length=152, Percent_Identity=44.7368421052632, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI19557636, Length=147, Percent_Identity=44.8979591836735, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI22547212, Length=145, Percent_Identity=42.0689655172414, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI7657473, Length=145, Percent_Identity=42.0689655172414, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI22547215, Length=145, Percent_Identity=42.0689655172414, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI64276486, Length=117, Percent_Identity=44.4444444444444, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI20911035, Length=152, Percent_Identity=40.1315789473684, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI14277126, Length=149, Percent_Identity=35.5704697986577, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786736, Length=144, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=32.6923076923077, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=178, Percent_Identity=60.1123595505618, Blast_Score=212, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17539498, Length=163, Percent_Identity=58.8957055214724, Blast_Score=202, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17559074, Length=165, Percent_Identity=61.8181818181818, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17566266, Length=171, Percent_Identity=59.0643274853801, Blast_Score=198, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17552782, Length=166, Percent_Identity=60.2409638554217, Blast_Score=184, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17532643, Length=182, Percent_Identity=52.1978021978022, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17506307, Length=148, Percent_Identity=57.4324324324324, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17552780, Length=154, Percent_Identity=53.8961038961039, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17551284, Length=165, Percent_Identity=51.5151515151515, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17551282, Length=165, Percent_Identity=51.5151515151515, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552784, Length=173, Percent_Identity=45.0867052023121, Blast_Score=146, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17539496, Length=149, Percent_Identity=52.3489932885906, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI115533296, Length=166, Percent_Identity=40.9638554216867, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17506311, Length=148, Percent_Identity=50, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71980594, Length=139, Percent_Identity=47.4820143884892, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71980590, Length=139, Percent_Identity=47.4820143884892, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17532641, Length=137, Percent_Identity=44.5255474452555, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71997782, Length=149, Percent_Identity=42.2818791946309, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32563659, Length=152, Percent_Identity=38.8157894736842, Blast_Score=90, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71996029, Length=177, Percent_Identity=28.2485875706215, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=153, Percent_Identity=61.437908496732, Blast_Score=191, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6323562, Length=149, Percent_Identity=63.0872483221477, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6323246, Length=170, Percent_Identity=54.1176470588235, Blast_Score=174, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6321848, Length=160, Percent_Identity=55.625, Blast_Score=168, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320510, Length=163, Percent_Identity=52.1472392638037, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322492, Length=195, Percent_Identity=38.974358974359, Blast_Score=116, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319914, Length=159, Percent_Identity=31.4465408805031, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45549139, Length=158, Percent_Identity=65.8227848101266, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24664125, Length=159, Percent_Identity=64.7798742138365, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21357783, Length=159, Percent_Identity=64.7798742138365, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17647301, Length=168, Percent_Identity=57.7380952380952, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24586038, Length=182, Percent_Identity=51.0989010989011, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20130249, Length=156, Percent_Identity=55.7692307692308, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24650807, Length=171, Percent_Identity=50.8771929824561, Blast_Score=166, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24661775, Length=175, Percent_Identity=45.7142857142857, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355237, Length=175, Percent_Identity=45.7142857142857, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24661771, Length=175, Percent_Identity=45.7142857142857, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=41.9753086419753, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17986117, Length=147, Percent_Identity=48.2993197278912, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19922376, Length=151, Percent_Identity=45.6953642384106, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19922912, Length=147, Percent_Identity=52.3809523809524, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24652460, Length=145, Percent_Identity=42.0689655172414, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357249, Length=118, Percent_Identity=45.7627118644068, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24650101, Length=163, Percent_Identity=30.6748466257669, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355677, Length=152, Percent_Identity=33.5526315789474, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 23858; Mature: 23858

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRASVTTITAFVLFFCGVCCSHASVVFLQSQEGVLSYPEHVSFNKIQQMKEKNANPVVG
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEE
LEIGAGAEMLGEIEIELAADVVPRTAENFLQLCTGKNGFGYKGSIFHRIIPSFMIQGGDF
EEECCCCHHHHEEEEEEEHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
TQGNGTGGHSIYNNDVFPDENFVIKHTGPGKVSMANRGPNTNGSQFFITTVETPWLDGKH
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCC
VVFGQVIRGMSVVKKIESYGSSNGRPSRIIKILDCWQVS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEHHCCCC
>Mature Secondary Structure
MMRASVTTITAFVLFFCGVCCSHASVVFLQSQEGVLSYPEHVSFNKIQQMKEKNANPVVG
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEE
LEIGAGAEMLGEIEIELAADVVPRTAENFLQLCTGKNGFGYKGSIFHRIIPSFMIQGGDF
EEECCCCHHHHEEEEEEEHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
TQGNGTGGHSIYNNDVFPDENFVIKHTGPGKVSMANRGPNTNGSQFFITTVETPWLDGKH
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCC
VVFGQVIRGMSVVKKIESYGSSNGRPSRIIKILDCWQVS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]