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The map label for this gene is bcr [H]

Identifier: 88608332

GI number: 88608332

Start: 56119

End: 57312

Strand: Direct

Name: bcr [H]

Synonym: NSE_0064

Alternate gene names: 88608332

Gene position: 56119-57312 (Clockwise)

Preceding gene: 88608594

Following gene: 88608037

Centisome position: 6.53

GC content: 39.53

Gene sequence:

>1194_bases
GTGAATCGTTTTTTGCACGTGGTTTTGATCACGTTTGTCGTCTTCGTAGCAGATGTCGCAGTGGAAATTTATGTTCCTGC
GCTGCCAAGTATTGGTGTTTTTTTTTCGGCAACAGCAATGGCTGTGAAGGCAAGTATAAGTAGTAATATATTGGGTCTAG
CTCTTTCTAGCCTCTTTTGGGGTACGGTTTCTGATTTATGGGGAAGAAAACTTGCTTTGCTTTTAGGTTCGTTAGTTTTT
GTTGTTTCTAGTGTTCTTTGTATTTTTTCTGCTTCGATCGATGCATTGGTTTTCTTCAGGTTTCTACAAGGTATTGGGCA
AGGTGTTGCAGTAGTTGTAGGTTTCGCTAGCGTGAAAGATTTTTATTCTGGTGAAAAATGTGCGCAGGTTATTTCTAAAT
TATCTTCTGTGGTTGCGGTCTCTCCGACGTTTGCGCCTATTTTAGGTACTGTTATCCTTTTTTATTTCAGTTGGCACTAT
ATTTTCTTGTTTCTTGCCTCACTAGGATTGGTGTGTCTGTTGCTATTAGTTTTCTTTTTTCAAGATACGCTAAAGGAGAG
AAATCCCGCTTCACTAAGGGGTCTTCTTAATTCTTATATTCGAATAGCGACTAATAAAAGTTACGTCCTTTATTCTGCCA
TAACAGTGATTACTTTCATGTGGCTCTGGAATGTTATCAGTTCTGCTCCTTTTTTATTACTCGAAGATATGGGTGTTACA
ATCCAGGAATACGGGTATCTGGTAGCAATTAACGTGATGGGTTTCTTACTGGGTACAATCTTAAACAGTAAATATATTCC
AAAGGTAGGGCTCAAGAAGTTGGTAGCATTTGGATTAGCTCTTCCGCTACTTAGTGAGGTGTTGCTTATTCTTCTTCATT
ACACTACTGGGTTTTCACCACTTATACTTGAATGTATATGGTTTTTCAGCGCTATGGGACTTGCGTTCGTAATTGGGAAT
TCAACTACGCTTGCTCTTGACCAAGTTGGTGAATCTAACAATGGCAAAGCTACTGCACTCCTAGTATGTTCGGAAATGGC
GCTGGGTTCATTGAGTGTCTACTTAAATGCACCTTTTTATGATGGGACAATAGTTCCGCTGTCGTTATTCACAATTGTGT
CAGTTCTTGCAAGTATGATAGTGTTCTACTATGCAGTGAGGAATCCCGGTAATACCGTAAAACCAGCTAGATAG

Upstream 100 bases:

>100_bases
CATACGGCTACCTAAGGGCTGTTGGTATGGTTCCGATGCCAAATCAGGAGCTAGGTGTCATTAGAGAAAAGGTTGCATCT
TTGTCTTCTTGAGTTAGTTT

Downstream 100 bases:

>100_bases
ATACCAGGTTGGTTCTCATCCGCACGTTAGTTTTGCTTCCTCTGGTTCCTTTTATATTTCTTGTTTTTGTACTCGCAGCA
TGCAATGTAACTGGTGCCAC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNRFLHVVLITFVVFVADVAVEIYVPALPSIGVFFSATAMAVKASISSNILGLALSSLFWGTVSDLWGRKLALLLGSLVF
VVSSVLCIFSASIDALVFFRFLQGIGQGVAVVVGFASVKDFYSGEKCAQVISKLSSVVAVSPTFAPILGTVILFYFSWHY
IFLFLASLGLVCLLLLVFFFQDTLKERNPASLRGLLNSYIRIATNKSYVLYSAITVITFMWLWNVISSAPFLLLEDMGVT
IQEYGYLVAINVMGFLLGTILNSKYIPKVGLKKLVAFGLALPLLSEVLLILLHYTTGFSPLILECIWFFSAMGLAFVIGN
STTLALDQVGESNNGKATALLVCSEMALGSLSVYLNAPFYDGTIVPLSLFTIVSVLASMIVFYYAVRNPGNTVKPAR

Sequences:

>Translated_397_residues
MNRFLHVVLITFVVFVADVAVEIYVPALPSIGVFFSATAMAVKASISSNILGLALSSLFWGTVSDLWGRKLALLLGSLVF
VVSSVLCIFSASIDALVFFRFLQGIGQGVAVVVGFASVKDFYSGEKCAQVISKLSSVVAVSPTFAPILGTVILFYFSWHY
IFLFLASLGLVCLLLLVFFFQDTLKERNPASLRGLLNSYIRIATNKSYVLYSAITVITFMWLWNVISSAPFLLLEDMGVT
IQEYGYLVAINVMGFLLGTILNSKYIPKVGLKKLVAFGLALPLLSEVLLILLHYTTGFSPLILECIWFFSAMGLAFVIGN
STTLALDQVGESNNGKATALLVCSEMALGSLSVYLNAPFYDGTIVPLSLFTIVSVLASMIVFYYAVRNPGNTVKPAR
>Mature_397_residues
MNRFLHVVLITFVVFVADVAVEIYVPALPSIGVFFSATAMAVKASISSNILGLALSSLFWGTVSDLWGRKLALLLGSLVF
VVSSVLCIFSASIDALVFFRFLQGIGQGVAVVVGFASVKDFYSGEKCAQVISKLSSVVAVSPTFAPILGTVILFYFSWHY
IFLFLASLGLVCLLLLVFFFQDTLKERNPASLRGLLNSYIRIATNKSYVLYSAITVITFMWLWNVISSAPFLLLEDMGVT
IQEYGYLVAINVMGFLLGTILNSKYIPKVGLKKLVAFGLALPLLSEVLLILLHYTTGFSPLILECIWFFSAMGLAFVIGN
STTLALDQVGESNNGKATALLVCSEMALGSLSVYLNAPFYDGTIVPLSLFTIVSVLASMIVFYYAVRNPGNTVKPAR

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=263, Percent_Identity=30.7984790874525, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI48994889, Length=241, Percent_Identity=32.3651452282158, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790146, Length=252, Percent_Identity=29.3650793650794, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790794, Length=234, Percent_Identity=20.9401709401709, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787065, Length=280, Percent_Identity=21.0714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790195, Length=160, Percent_Identity=28.125, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082312, Length=197, Percent_Identity=26.9035532994924, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788068, Length=148, Percent_Identity=30.4054054054054, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43128; Mature: 43128

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFLHVVLITFVVFVADVAVEIYVPALPSIGVFFSATAMAVKASISSNILGLALSSLFW
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTVSDLWGRKLALLLGSLVFVVSSVLCIFSASIDALVFFRFLQGIGQGVAVVVGFASVKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FYSGEKCAQVISKLSSVVAVSPTFAPILGTVILFYFSWHYIFLFLASLGLVCLLLLVFFF
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDTLKERNPASLRGLLNSYIRIATNKSYVLYSAITVITFMWLWNVISSAPFLLLEDMGVT
HHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCH
IQEYGYLVAINVMGFLLGTILNSKYIPKVGLKKLVAFGLALPLLSEVLLILLHYTTGFSP
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LILECIWFFSAMGLAFVIGNSTTLALDQVGESNNGKATALLVCSEMALGSLSVYLNAPFY
HHHHHHHHHHHHHHHHEECCCCEEEHHHCCCCCCCCEEEEEEEHHHHHCCEEEEEECCCC
DGTIVPLSLFTIVSVLASMIVFYYAVRNPGNTVKPAR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNRFLHVVLITFVVFVADVAVEIYVPALPSIGVFFSATAMAVKASISSNILGLALSSLFW
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTVSDLWGRKLALLLGSLVFVVSSVLCIFSASIDALVFFRFLQGIGQGVAVVVGFASVKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FYSGEKCAQVISKLSSVVAVSPTFAPILGTVILFYFSWHYIFLFLASLGLVCLLLLVFFF
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDTLKERNPASLRGLLNSYIRIATNKSYVLYSAITVITFMWLWNVISSAPFLLLEDMGVT
HHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCH
IQEYGYLVAINVMGFLLGTILNSKYIPKVGLKKLVAFGLALPLLSEVLLILLHYTTGFSP
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LILECIWFFSAMGLAFVIGNSTTLALDQVGESNNGKATALLVCSEMALGSLSVYLNAPFY
HHHHHHHHHHHHHHHHEECCCCEEEHHHCCCCCCCCEEEEEEEHHHHHCCEEEEEECCCC
DGTIVPLSLFTIVSVLASMIVFYYAVRNPGNTVKPAR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]