| Definition | Neorickettsia sennetsu str. Miyayama chromosome, complete genome. |
|---|---|
| Accession | NC_007798 |
| Length | 859,006 |
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The map label for this gene is virB4-1
Identifier: 88608288
GI number: 88608288
Start: 683112
End: 685364
Strand: Reverse
Name: virB4-1
Synonym: NSE_0766
Alternate gene names: 88608288
Gene position: 685364-683112 (Counterclockwise)
Preceding gene: 88608473
Following gene: 88608696
Centisome position: 79.79
GC content: 41.32
Gene sequence:
>2253_bases ATGGTAAGTGATTTGTATACGAAGGAAGTCTCGCGGAATGTTCAGGCCTCTTGTTTTTACGACTCGAGCAGCGTTTTGAA TGCGAATGGTACTCTGGTAAGGGTGGTGAAGCTATCGGACTTTAGGTTCACCACATCTTCTTTGGAGAGGATGCGTTCTT TGTGCAAAAAGGTCCTTTACTCGGGTGAATTCAGGTGTTTAGGTCTCTGGATCAATGTGGTACGCTCGCCTATTGGTTCT GTTCGTGCTGAGAATGTGAGTATGGACGGATTCGCAGCGGGTCTATCTGATACCTACCATAAATTTGTGGAAAAAGAGAA TAGATTTTCAAACGAGGTATTCATATCGATTGTATCGGAGTCAGCTCTTGAGTGTGCAGTCGGGCAGGTCGACTTTCTGC TTAGGAGTCTGCTAAAGAGGTTTGATGAGTTTGCCTCCAAGGTAATCGTAAAAAGTTTGGAAGATGCGGTTGCAGTGGTT TGTACGGAATTGGCAGAATACCAGCCCGTGCTGCTCTGTGAAGCAGAGGTAATGAATTTTCTTTCCGCATTACTTGGGAT TTCAAAAACCGGTCTCGAGAGTGGTGTTAGAGATATATCAACAGAACTACTTTCTGATAGAAAGGTGTTTTTCGGTTTTA ATACTTTTGAGATACATGGAGACAAAAGGACTTTTGGTACGAGCTTTTCGGTAAAGAGTTTTAGGAACCTTGAGGATGTT CAGTTTGTAGCGAGGTTTCTGGGCGCCCAAAACAGGATGGTAATCACAGAAGTCATAACAAGGACTACGGAAGAGGATAT TAGAGATACCTTTGAGGAAAGTCTTGAACTAACAGGGGTTGTGAATGATACGGCTTATCAAAGTGCTTCTTCTAAAGATA TTATCGCGGAGCATATAAATGAGAAGAGGAAGGAAGAGTTCTGTAAGCGCTCCTTCAAGGTGACACTTTTTGCAGATTCT TTAGAGGAGCTTGGTCTTGTTGTTGCAAATTGTGAAAAGCTTTTCTCACATCGAGGTTTCATGATTGTACGTGACGACCT GCTTTTAGAAGACACTTTCTGGGGTAACTTGCCCGGAAATTTCTCTAGAATGAGAAAATGGGAGATAGTCTTACTGAAGG AAATCAGTTCATTTGCCTTTACGCATGCGCATTTTCGTTCTCTTTTGGCTGATGTGAATAAATGTCTTACCAAATTTGTT TCCCTTGAAGGAGAGTTGCACTACTTTAGTTTTCCTGACGCTAAAAGCAAGAGCCACGCTATTATCTTTGGTAAAGAGAA ATCTAGTAGGATCGAGCTGCAAAATTTTCTCTTATTAGAGTCGGTTGTGAGGCTCGGTGCTGAGTTTTTAATAGTGGATG ATCAGAGTCTTTCAGAAGTATTTGTACATGCGTTGGAAGGTTCATACATAGAGGTTTCAGATGGGGCATTTAGGTGCAAC TTGCTCGACGTAGCAGATGTTGATGTTTTATATGATATTCTGTCGTCATTCTGTTCCAAAGACGTCAAAAGCGAGGAAAT TGCAGGAGTAGCGAAAAAGATATCTGAAATTCCGCTAGGTAAAAGAAGTCTGACTGACTGTGCTGTGCATCTTCAGCCTA TTTTTGGGGAGCTTTCAATATTGCAAAAAAGTTATGGACACCTTTTTACCAGTGACGCCGAAAATGGCTGGTTACTTGAG GACAAACTTGGTTTTTCAGTAGATAAGTTATCTTTGCCTGAAAAAGTTATTTCCTCTGTCACGTCTTACGTGATTGCAAG GTACATTGAAGTGCGCAAGAAATCCGGTAAGCCGTTTATAATTGTGATACAGAGCCCGACTCGTTTTAAGAGGCTCTTTT CTTCGTTGTCAAAGTGCGAGTCGTTTTTGTGTGAAGTGAGTGAATGCGGTGGTATGATTCTGTTCTCATCTGAGAACACA GCTTTTCTCGAAAAGTTGGGTGAAGTAGGGACAAAGTACATCACCACGAGGATGTTTTTGCCATTAAGTGATACTTTGCC AGTAGAGTATAATAAATTTTTTACTAGCTCTGCTTCTGTCATGCGTACACTTGATGATGCATCTCTTTTCGGAAAATGTT TCTTCCTTAATCAAGGTGGTAACTCTGTAATTCTTAAGTTTGATTCTTTGTTATTTGAGGAGATGAAAATTTTGTCATCT TGTGGAAGAATTGAGAAAATGAGGGCTGCCATGCGGGAAGCAGGCAATAATCCCGCTATTTGGTTACCGATATTTTGCCG CGAATGCAACTGA
Upstream 100 bases:
>100_bases AAAAAGTACCTAATGTCTGTGAAAGTGTATGGTTTACATTGTGAGTTCTTCCTTAATCCTTTTCAAGGTGTGTTTGTTTC ACTCATCGGTTTGATGGGTC
Downstream 100 bases:
>100_bases AGAAATTTCTCTTGCTTTTGTTTTTTCTATGTCTTTGCTCCCCGAAGGAGGCTTTTTGTAAGTCTAAGCAGCCAGTTTCG TTACCTGAATACGATCCAGA
Product: type IV secretion system protein VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 750; Mature: 750
Protein sequence:
>750_residues MVSDLYTKEVSRNVQASCFYDSSSVLNANGTLVRVVKLSDFRFTTSSLERMRSLCKKVLYSGEFRCLGLWINVVRSPIGS VRAENVSMDGFAAGLSDTYHKFVEKENRFSNEVFISIVSESALECAVGQVDFLLRSLLKRFDEFASKVIVKSLEDAVAVV CTELAEYQPVLLCEAEVMNFLSALLGISKTGLESGVRDISTELLSDRKVFFGFNTFEIHGDKRTFGTSFSVKSFRNLEDV QFVARFLGAQNRMVITEVITRTTEEDIRDTFEESLELTGVVNDTAYQSASSKDIIAEHINEKRKEEFCKRSFKVTLFADS LEELGLVVANCEKLFSHRGFMIVRDDLLLEDTFWGNLPGNFSRMRKWEIVLLKEISSFAFTHAHFRSLLADVNKCLTKFV SLEGELHYFSFPDAKSKSHAIIFGKEKSSRIELQNFLLLESVVRLGAEFLIVDDQSLSEVFVHALEGSYIEVSDGAFRCN LLDVADVDVLYDILSSFCSKDVKSEEIAGVAKKISEIPLGKRSLTDCAVHLQPIFGELSILQKSYGHLFTSDAENGWLLE DKLGFSVDKLSLPEKVISSVTSYVIARYIEVRKKSGKPFIIVIQSPTRFKRLFSSLSKCESFLCEVSECGGMILFSSENT AFLEKLGEVGTKYITTRMFLPLSDTLPVEYNKFFTSSASVMRTLDDASLFGKCFFLNQGGNSVILKFDSLLFEEMKILSS CGRIEKMRAAMREAGNNPAIWLPIFCRECN
Sequences:
>Translated_750_residues MVSDLYTKEVSRNVQASCFYDSSSVLNANGTLVRVVKLSDFRFTTSSLERMRSLCKKVLYSGEFRCLGLWINVVRSPIGS VRAENVSMDGFAAGLSDTYHKFVEKENRFSNEVFISIVSESALECAVGQVDFLLRSLLKRFDEFASKVIVKSLEDAVAVV CTELAEYQPVLLCEAEVMNFLSALLGISKTGLESGVRDISTELLSDRKVFFGFNTFEIHGDKRTFGTSFSVKSFRNLEDV QFVARFLGAQNRMVITEVITRTTEEDIRDTFEESLELTGVVNDTAYQSASSKDIIAEHINEKRKEEFCKRSFKVTLFADS LEELGLVVANCEKLFSHRGFMIVRDDLLLEDTFWGNLPGNFSRMRKWEIVLLKEISSFAFTHAHFRSLLADVNKCLTKFV SLEGELHYFSFPDAKSKSHAIIFGKEKSSRIELQNFLLLESVVRLGAEFLIVDDQSLSEVFVHALEGSYIEVSDGAFRCN LLDVADVDVLYDILSSFCSKDVKSEEIAGVAKKISEIPLGKRSLTDCAVHLQPIFGELSILQKSYGHLFTSDAENGWLLE DKLGFSVDKLSLPEKVISSVTSYVIARYIEVRKKSGKPFIIVIQSPTRFKRLFSSLSKCESFLCEVSECGGMILFSSENT AFLEKLGEVGTKYITTRMFLPLSDTLPVEYNKFFTSSASVMRTLDDASLFGKCFFLNQGGNSVILKFDSLLFEEMKILSS CGRIEKMRAAMREAGNNPAIWLPIFCRECN >Mature_750_residues MVSDLYTKEVSRNVQASCFYDSSSVLNANGTLVRVVKLSDFRFTTSSLERMRSLCKKVLYSGEFRCLGLWINVVRSPIGS VRAENVSMDGFAAGLSDTYHKFVEKENRFSNEVFISIVSESALECAVGQVDFLLRSLLKRFDEFASKVIVKSLEDAVAVV CTELAEYQPVLLCEAEVMNFLSALLGISKTGLESGVRDISTELLSDRKVFFGFNTFEIHGDKRTFGTSFSVKSFRNLEDV QFVARFLGAQNRMVITEVITRTTEEDIRDTFEESLELTGVVNDTAYQSASSKDIIAEHINEKRKEEFCKRSFKVTLFADS LEELGLVVANCEKLFSHRGFMIVRDDLLLEDTFWGNLPGNFSRMRKWEIVLLKEISSFAFTHAHFRSLLADVNKCLTKFV SLEGELHYFSFPDAKSKSHAIIFGKEKSSRIELQNFLLLESVVRLGAEFLIVDDQSLSEVFVHALEGSYIEVSDGAFRCN LLDVADVDVLYDILSSFCSKDVKSEEIAGVAKKISEIPLGKRSLTDCAVHLQPIFGELSILQKSYGHLFTSDAENGWLLE DKLGFSVDKLSLPEKVISSVTSYVIARYIEVRKKSGKPFIIVIQSPTRFKRLFSSLSKCESFLCEVSECGGMILFSSENT AFLEKLGEVGTKYITTRMFLPLSDTLPVEYNKFFTSSASVMRTLDDASLFGKCFFLNQGGNSVILKFDSLLFEEMKILSS CGRIEKMRAAMREAGNNPAIWLPIFCRECN
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 84360; Mature: 84360
Theoretical pI: Translated: 5.44; Mature: 5.44
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.5 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 2.5 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVSDLYTKEVSRNVQASCFYDSSSVLNANGTLVRVVKLSDFRFTTSSLERMRSLCKKVLY CCCCHHHHHHHCCCEEEEEECCCCEEECCCCEEEEEEECCCEECHHHHHHHHHHHHHHHH SGEFRCLGLWINVVRSPIGSVRAENVSMDGFAAGLSDTYHKFVEKENRFSNEVFISIVSE CCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCCHHEEEEHHH SALECAVGQVDFLLRSLLKRFDEFASKVIVKSLEDAVAVVCTELAEYQPVLLCEAEVMNF HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHH LSALLGISKTGLESGVRDISTELLSDRKVFFGFNTFEIHGDKRTFGTSFSVKSFRNLEDV HHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECEEEEEECCCCCCCCCCCHHHHCCHHHH QFVARFLGAQNRMVITEVITRTTEEDIRDTFEESLELTGVVNDTAYQSASSKDIIAEHIN HHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHEEEEEECHHHHCCCCCCHHHHHHHH EKRKEEFCKRSFKVTLFADSLEELGLVVANCEKLFSHRGFMIVRDDLLLEDTFWGNLPGN HHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCCCCCC FSRMRKWEIVLLKEISSFAFTHAHFRSLLADVNKCLTKFVSLEGELHYFSFPDAKSKSHA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCE IIFGKEKSSRIELQNFLLLESVVRLGAEFLIVDDQSLSEVFVHALEGSYIEVSDGAFRCN EEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCEEEECCCEEEEE LLDVADVDVLYDILSSFCSKDVKSEEIAGVAKKISEIPLGKRSLTDCAVHLQPIFGELSI EECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH LQKSYGHLFTSDAENGWLLEDKLGFSVDKLSLPEKVISSVTSYVIARYIEVRKKSGKPFI HHHHHCCEEECCCCCCEEEECCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE IVIQSPTRFKRLFSSLSKCESFLCEVSECGGMILFSSENTAFLEKLGEVGTKYITTRMFL EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHEEEE PLSDTLPVEYNKFFTSSASVMRTLDDASLFGKCFFLNQGGNSVILKFDSLLFEEMKILSS ECCCCCCCCHHHHHCCHHHHHHHHHHHHHEEEEEEEECCCCEEEEEHHHHHHHHHHHHHH CGRIEKMRAAMREAGNNPAIWLPIFCRECN CCHHHHHHHHHHHCCCCCEEEEEEEEECCC >Mature Secondary Structure MVSDLYTKEVSRNVQASCFYDSSSVLNANGTLVRVVKLSDFRFTTSSLERMRSLCKKVLY CCCCHHHHHHHCCCEEEEEECCCCEEECCCCEEEEEEECCCEECHHHHHHHHHHHHHHHH SGEFRCLGLWINVVRSPIGSVRAENVSMDGFAAGLSDTYHKFVEKENRFSNEVFISIVSE CCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCCHHEEEEHHH SALECAVGQVDFLLRSLLKRFDEFASKVIVKSLEDAVAVVCTELAEYQPVLLCEAEVMNF HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHH LSALLGISKTGLESGVRDISTELLSDRKVFFGFNTFEIHGDKRTFGTSFSVKSFRNLEDV HHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECEEEEEECCCCCCCCCCCHHHHCCHHHH QFVARFLGAQNRMVITEVITRTTEEDIRDTFEESLELTGVVNDTAYQSASSKDIIAEHIN HHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHEEEEEECHHHHCCCCCCHHHHHHHH EKRKEEFCKRSFKVTLFADSLEELGLVVANCEKLFSHRGFMIVRDDLLLEDTFWGNLPGN HHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCCCCCC FSRMRKWEIVLLKEISSFAFTHAHFRSLLADVNKCLTKFVSLEGELHYFSFPDAKSKSHA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCE IIFGKEKSSRIELQNFLLLESVVRLGAEFLIVDDQSLSEVFVHALEGSYIEVSDGAFRCN EEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCEEEECCCEEEEE LLDVADVDVLYDILSSFCSKDVKSEEIAGVAKKISEIPLGKRSLTDCAVHLQPIFGELSI EECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH LQKSYGHLFTSDAENGWLLEDKLGFSVDKLSLPEKVISSVTSYVIARYIEVRKKSGKPFI HHHHHCCEEECCCCCCEEEECCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE IVIQSPTRFKRLFSSLSKCESFLCEVSECGGMILFSSENTAFLEKLGEVGTKYITTRMFL EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHEEEE PLSDTLPVEYNKFFTSSASVMRTLDDASLFGKCFFLNQGGNSVILKFDSLLFEEMKILSS ECCCCCCCCHHHHHCCHHHHHHHHHHHHHEEEEEEEECCCCEEEEEHHHHHHHHHHHHHH CGRIEKMRAAMREAGNNPAIWLPIFCRECN CCHHHHHHHHHHHCCCCCEEEEEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]