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The map label for this gene is sdhA

Identifier: 88608201

GI number: 88608201

Start: 309273

End: 311066

Strand: Direct

Name: sdhA

Synonym: NSE_0376

Alternate gene names: 88608201

Gene position: 309273-311066 (Clockwise)

Preceding gene: 88608365

Following gene: 88608374

Centisome position: 36.0

GC content: 45.54

Gene sequence:

>1794_bases
ATGGCTCTCAGTAGTTACCCAATTGTTGAACATGAATATGATGTTGTCGTTGTAGGGGCTGGTGGTTCTGGGCTCAGGGC
TACTTTGGGTATGGCGAGTCAGGGTTTGAAGGTTGCATGTCTTTCTAAGGTCTTTCCAACTAGGAGTCATACCGTAGCGG
CTCAAGGAGGAATCAGTGCTGCATTGGGGAATATCAGTGAAGATGATTGGAGATGGCACGCCTATGATACTGTCAAGGGT
TCTGATTGGCTTGGTGATCAGGATGCAATTGAATACATGTGTAAAAATGCTTCCAGTTCAGTAATAGAATTAGAGAATTT
CGGTGTGCCATTTTCACGGACGTCTGAAGGTAAAATATATCAGCGTCCATTTGGTGGTATGACGACGCATTATGGGAAGG
GTCGTGCTATTCGAACATGTGCTGCTGAGGATAAAACAGGCCACGCCATACTACACGCTCTTTATCAACAGTCTATAAAG
CTGGATACGGAATTTTTTGTGGAATATATAGTCCTTGATTTACTCATGGATGATGAAGGTTGTAAGGGAGTCATTGCTTG
GGATCTCAAAGATGGCTCATTACATAGGTTCAGAGCTCATATTGTGGTGATAGCAACTGGTGGCTACGGTCGTATTTACT
TTTCAGCCACAGGTGCGCATACCTGTACGGGCGATGGAAATGCATTTGTCCTGAGAGCTGGTTTGCCGCTCCAAGACATG
GAATTTGTGCAATTTCACCCAACCGGTATTTATGGAGCTGGTTGTTTAATCAGTGAGGCGGTTCGTGGTGAGGGTGGCTA
TCTTATAAATTCAGAAGGGGAAAGGTTTATGGCTAAGTATGCTCCTTCTGCAATAGATCTTGCGTCCAGAGATGTTGTGA
GTCGTGCAATCACTATGGAGATCCGTGCTGGTAGAGGTGTTGGCCCAAAGAAAGATCACATTTACCTTCAAGTTTCACAT
TTAGGTTCTAAGGTTATAGAACAACGGCTTCCGGGTATAAGCGAAACTGCACGTATCTTTGCAAATGTGGATGTGACGAA
AGAGCCTATTCCGGTACTTCCGACTGTCCACTATAACATGGGAGGGATTCCAGCAAATTATCATGGGGAGGTCCTTACCG
TCGATGATGAGAATGTAGAGAAAGTTGTTCCAGGTTTGATGGCTATAGGGGAAGCTGCTTGTATTTCAGTACATGGCGCG
AATAGACTTGGCTCAAATTCTTTACTGGATCTTGTCGTTTTTGGTAGGACGGCTGCTATTAGGGCCAGAGAGGTCATAAA
GGCCAATACGAAGCACTCTCCTATCGATAAGGAGTTGACAGAGCGGGTTCTGGCGCGCTTCGATAGGTTCCGTTACGCAG
ACGGTGGGCTTCCTACAGCTGTGCTAAGAAGAAAAATGCAATTGATAATGCAGGAGCATGCTGCCGTTTTTAGGACTCAG
GAGGTCCTGGATGAAGGGTGTAAAAAAATGCGGGAGTTCCTCCGTGAAATGGATGAGATCAATGTAACTGACCGTTCACT
TGTCTGGAATACTGACCTCGTAGAAACGCTTGAGCTCGATAATATGGTGAGCCAGGCTGTTGCAACAATAGAGTCAGCTG
CAAATAGGAAAGAAAGTAGAGGCAGCCATGCTAGAGAAGATTATCCTGAAAGAGATGATGAGAACTGGCTCCGTCACACG
CTGTTTTGGTTCCTACCAGACGGTAATGAGACAAAGTTTGGCTACAGGCCAGTACGTCTGCAGCCAATGACTAATGAAAT
AGAATCATTTCCTCCTCAGAAGAGGGTCTACTAG

Upstream 100 bases:

>100_bases
CTTAATGTTTAGAAACACCATTTGTAAATGAGGTAATGGATTTCCTCCGTTGCCTGGACTACAATTCGGGTTTGGTCTTT
GTGTCTTTTGCACGTGGTTT

Downstream 100 bases:

>100_bases
TCTGTTTTCTGCTCATATCTGTTAGCTTTTCAGTTAGTGTTTTATGAGTAGTTTTTTGGAAAGGTCAGCTGTGAGCGTGG
CCTGCGTGTGTCTATTATCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MALSSYPIVEHEYDVVVVGAGGSGLRATLGMASQGLKVACLSKVFPTRSHTVAAQGGISAALGNISEDDWRWHAYDTVKG
SDWLGDQDAIEYMCKNASSSVIELENFGVPFSRTSEGKIYQRPFGGMTTHYGKGRAIRTCAAEDKTGHAILHALYQQSIK
LDTEFFVEYIVLDLLMDDEGCKGVIAWDLKDGSLHRFRAHIVVIATGGYGRIYFSATGAHTCTGDGNAFVLRAGLPLQDM
EFVQFHPTGIYGAGCLISEAVRGEGGYLINSEGERFMAKYAPSAIDLASRDVVSRAITMEIRAGRGVGPKKDHIYLQVSH
LGSKVIEQRLPGISETARIFANVDVTKEPIPVLPTVHYNMGGIPANYHGEVLTVDDENVEKVVPGLMAIGEAACISVHGA
NRLGSNSLLDLVVFGRTAAIRAREVIKANTKHSPIDKELTERVLARFDRFRYADGGLPTAVLRRKMQLIMQEHAAVFRTQ
EVLDEGCKKMREFLREMDEINVTDRSLVWNTDLVETLELDNMVSQAVATIESAANRKESRGSHAREDYPERDDENWLRHT
LFWFLPDGNETKFGYRPVRLQPMTNEIESFPPQKRVY

Sequences:

>Translated_597_residues
MALSSYPIVEHEYDVVVVGAGGSGLRATLGMASQGLKVACLSKVFPTRSHTVAAQGGISAALGNISEDDWRWHAYDTVKG
SDWLGDQDAIEYMCKNASSSVIELENFGVPFSRTSEGKIYQRPFGGMTTHYGKGRAIRTCAAEDKTGHAILHALYQQSIK
LDTEFFVEYIVLDLLMDDEGCKGVIAWDLKDGSLHRFRAHIVVIATGGYGRIYFSATGAHTCTGDGNAFVLRAGLPLQDM
EFVQFHPTGIYGAGCLISEAVRGEGGYLINSEGERFMAKYAPSAIDLASRDVVSRAITMEIRAGRGVGPKKDHIYLQVSH
LGSKVIEQRLPGISETARIFANVDVTKEPIPVLPTVHYNMGGIPANYHGEVLTVDDENVEKVVPGLMAIGEAACISVHGA
NRLGSNSLLDLVVFGRTAAIRAREVIKANTKHSPIDKELTERVLARFDRFRYADGGLPTAVLRRKMQLIMQEHAAVFRTQ
EVLDEGCKKMREFLREMDEINVTDRSLVWNTDLVETLELDNMVSQAVATIESAANRKESRGSHAREDYPERDDENWLRHT
LFWFLPDGNETKFGYRPVRLQPMTNEIESFPPQKRVY
>Mature_596_residues
ALSSYPIVEHEYDVVVVGAGGSGLRATLGMASQGLKVACLSKVFPTRSHTVAAQGGISAALGNISEDDWRWHAYDTVKGS
DWLGDQDAIEYMCKNASSSVIELENFGVPFSRTSEGKIYQRPFGGMTTHYGKGRAIRTCAAEDKTGHAILHALYQQSIKL
DTEFFVEYIVLDLLMDDEGCKGVIAWDLKDGSLHRFRAHIVVIATGGYGRIYFSATGAHTCTGDGNAFVLRAGLPLQDME
FVQFHPTGIYGAGCLISEAVRGEGGYLINSEGERFMAKYAPSAIDLASRDVVSRAITMEIRAGRGVGPKKDHIYLQVSHL
GSKVIEQRLPGISETARIFANVDVTKEPIPVLPTVHYNMGGIPANYHGEVLTVDDENVEKVVPGLMAIGEAACISVHGAN
RLGSNSLLDLVVFGRTAAIRAREVIKANTKHSPIDKELTERVLARFDRFRYADGGLPTAVLRRKMQLIMQEHAAVFRTQE
VLDEGCKKMREFLREMDEINVTDRSLVWNTDLVETLELDNMVSQAVATIESAANRKESRGSHAREDYPERDDENWLRHTL
FWFLPDGNETKFGYRPVRLQPMTNEIESFPPQKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=615, Percent_Identity=58.8617886178862, Blast_Score=707, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=51.7006802721088, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=41.522491349481, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=32.258064516129, Blast_Score=224, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17550100, Length=614, Percent_Identity=56.8403908794788, Blast_Score=693, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=616, Percent_Identity=55.1948051948052, Blast_Score=672, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=595, Percent_Identity=62.5210084033613, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=61.8090452261307, Blast_Score=753, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=482, Percent_Identity=28.2157676348548, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322511, Length=492, Percent_Identity=25.609756097561, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137288, Length=610, Percent_Identity=59.1803278688525, Blast_Score=738, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=610, Percent_Identity=59.1803278688525, Blast_Score=738, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=610, Percent_Identity=59.1803278688525, Blast_Score=738, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=55.5555555555556, Blast_Score=698, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66065; Mature: 65934

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSSYPIVEHEYDVVVVGAGGSGLRATLGMASQGLKVACLSKVFPTRSHTVAAQGGISA
CCCCCCCCEECCCCEEEEECCCCCCHHHHHHCCCCCEEEEHHHHCCCCCCEEEECCCCHH
ALGNISEDDWRWHAYDTVKGSDWLGDQDAIEYMCKNASSSVIELENFGVPFSRTSEGKIY
HHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCCEE
QRPFGGMTTHYGKGRAIRTCAAEDKTGHAILHALYQQSIKLDTEFFVEYIVLDLLMDDEG
ECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
CKGVIAWDLKDGSLHRFRAHIVVIATGGYGRIYFSATGAHTCTGDGNAFVLRAGLPLQDM
CCEEEEEECCCCCEEEEEEEEEEEEECCCEEEEEEECCCEEECCCCCEEEEECCCCCCCC
EFVQFHPTGIYGAGCLISEAVRGEGGYLINSEGERFMAKYAPSAIDLASRDVVSRAITME
CEEEECCCCCEECHHHHHHHHCCCCCEEECCCCCHHHHHHCCCHHHHHHHHHHHHEEEEE
IRAGRGVGPKKDHIYLQVSHLGSKVIEQRLPGISETARIFANVDVTKEPIPVLPTVHYNM
EECCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCCCCCCCEEECCC
GGIPANYHGEVLTVDDENVEKVVPGLMAIGEAACISVHGANRLGSNSLLDLVVFGRTAAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEECCHHHH
RAREVIKANTKHSPIDKELTERVLARFDRFRYADGGLPTAVLRRKMQLIMQEHAAVFRTQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVLDEGCKKMREFLREMDEINVTDRSLVWNTDLVETLELDNMVSQAVATIESAANRKESR
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSHAREDYPERDDENWLRHTLFWFLPDGNETKFGYRPVRLQPMTNEIESFPPQKRVY
CCCCHHCCCCCCCHHHHEEEEEEEEECCCCCCCCCCCEEECCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
ALSSYPIVEHEYDVVVVGAGGSGLRATLGMASQGLKVACLSKVFPTRSHTVAAQGGISA
CCCCCCCEECCCCEEEEECCCCCCHHHHHHCCCCCEEEEHHHHCCCCCCEEEECCCCHH
ALGNISEDDWRWHAYDTVKGSDWLGDQDAIEYMCKNASSSVIELENFGVPFSRTSEGKIY
HHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCCEE
QRPFGGMTTHYGKGRAIRTCAAEDKTGHAILHALYQQSIKLDTEFFVEYIVLDLLMDDEG
ECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
CKGVIAWDLKDGSLHRFRAHIVVIATGGYGRIYFSATGAHTCTGDGNAFVLRAGLPLQDM
CCEEEEEECCCCCEEEEEEEEEEEEECCCEEEEEEECCCEEECCCCCEEEEECCCCCCCC
EFVQFHPTGIYGAGCLISEAVRGEGGYLINSEGERFMAKYAPSAIDLASRDVVSRAITME
CEEEECCCCCEECHHHHHHHHCCCCCEEECCCCCHHHHHHCCCHHHHHHHHHHHHEEEEE
IRAGRGVGPKKDHIYLQVSHLGSKVIEQRLPGISETARIFANVDVTKEPIPVLPTVHYNM
EECCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCCCCCCCEEECCC
GGIPANYHGEVLTVDDENVEKVVPGLMAIGEAACISVHGANRLGSNSLLDLVVFGRTAAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEECCHHHH
RAREVIKANTKHSPIDKELTERVLARFDRFRYADGGLPTAVLRRKMQLIMQEHAAVFRTQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVLDEGCKKMREFLREMDEINVTDRSLVWNTDLVETLELDNMVSQAVATIESAANRKESR
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSHAREDYPERDDENWLRHTLFWFLPDGNETKFGYRPVRLQPMTNEIESFPPQKRVY
CCCCHHCCCCCCCHHHHEEEEEEEEECCCCCCCCCCCEEECCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA