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The map label for this gene is hemC [H]

Identifier: 88607872

GI number: 88607872

Start: 791293

End: 792207

Strand: Reverse

Name: hemC [H]

Synonym: APH_0746

Alternate gene names: 88607872

Gene position: 792207-791293 (Counterclockwise)

Preceding gene: 88607153

Following gene: 88607276

Centisome position: 53.84

GC content: 39.78

Gene sequence:

>915_bases
TTGGGTATAGTTATGGTTATTAGAATAGGTACAAGAGGAAGCCTTCTAGCCATGCAGCAGGCTAGAATAGTGAAAACTGC
TATTGAAACCAATTATGCGGAGTTATCAACCCGTATAATTACCATAAAGACTTCTGGAGATATGAATACTCATGTACCTC
TTTATGATATTGGTGGTAAGGGGCTATTTATAAAGGAGATTGAGGAAGCTCTTTTGGATAATATAATAGATGTGGCTGTG
CATTCGGCTAAGGATGTTCCTGGCATATATTCCGAAGATCTAGATATTCCCTGTATTTTGCCCAGGGCATCAGCTTTAGA
TGCTTTTTTATCATCTAAATATGACAGTATAGCTTCTCTACCATTGAATGCAAAAATCGGTACTTCGTCGGTAAGGAGAA
AGGTGCAATTATTGACGATGAGGCCAGATTTAGAGATCATTCCCATGCGTGGCAATGTAGAAACAAGAATATCAAAAATG
CAGATGGGAGAGTGTGATGGTATTGTTTTGGCTGAAGCTGGTCTGTATAGGGTATCGAAAGATAATTTAATATCGGAAGT
ATTGCAGCCGGAAGTTATGTTGGGTGCAGTCGGTCAAGGAGCAATATGTGTTCAATGTCGCAGATATGATAGGAGGATAC
TTGAGATATTGAAGAAGTTAAACTGCCATAAGTCGTATACTACGGTATCAGCGGAGCGTAGCTTTATGAGGGCAGTAGAT
GGGTCTTGCAATACTCCCCTTGCTGCTATGGCGAAGTATATCGATATGGATATACTAACGATGAAGTGTATGTTAGCCGA
TGATGCCAGAAACATGGTATTTACAGAACGGGTTTTTGCAGAGCAAAATGCAGAAAGTGCAGGATATGAAATGGGGACAT
TGTTGAAAAATGAGTTACACCTTCACAGGTTATAA

Upstream 100 bases:

>100_bases
TATGGGGAAGATTTTGGGTGTATGTGCTTTATTTATTACATGTTTTATCCATCTTTCCCTAAAATAAGGATTCATCTGAT
TTATATGCCGTAGTGCTCCG

Downstream 100 bases:

>100_bases
ACTTCCTAAAGTTAGGGGAGTTTATAAAAGAAGCGTAAAAATGCATAGCATGACTTGGGTAGGCGTAGGTGGTGTTGCGC
CATTGCTATTCAAGCCAAAG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MGIVMVIRIGTRGSLLAMQQARIVKTAIETNYAELSTRIITIKTSGDMNTHVPLYDIGGKGLFIKEIEEALLDNIIDVAV
HSAKDVPGIYSEDLDIPCILPRASALDAFLSSKYDSIASLPLNAKIGTSSVRRKVQLLTMRPDLEIIPMRGNVETRISKM
QMGECDGIVLAEAGLYRVSKDNLISEVLQPEVMLGAVGQGAICVQCRRYDRRILEILKKLNCHKSYTTVSAERSFMRAVD
GSCNTPLAAMAKYIDMDILTMKCMLADDARNMVFTERVFAEQNAESAGYEMGTLLKNELHLHRL

Sequences:

>Translated_304_residues
MGIVMVIRIGTRGSLLAMQQARIVKTAIETNYAELSTRIITIKTSGDMNTHVPLYDIGGKGLFIKEIEEALLDNIIDVAV
HSAKDVPGIYSEDLDIPCILPRASALDAFLSSKYDSIASLPLNAKIGTSSVRRKVQLLTMRPDLEIIPMRGNVETRISKM
QMGECDGIVLAEAGLYRVSKDNLISEVLQPEVMLGAVGQGAICVQCRRYDRRILEILKKLNCHKSYTTVSAERSFMRAVD
GSCNTPLAAMAKYIDMDILTMKCMLADDARNMVFTERVFAEQNAESAGYEMGTLLKNELHLHRL
>Mature_303_residues
GIVMVIRIGTRGSLLAMQQARIVKTAIETNYAELSTRIITIKTSGDMNTHVPLYDIGGKGLFIKEIEEALLDNIIDVAVH
SAKDVPGIYSEDLDIPCILPRASALDAFLSSKYDSIASLPLNAKIGTSSVRRKVQLLTMRPDLEIIPMRGNVETRISKMQ
MGECDGIVLAEAGLYRVSKDNLISEVLQPEVMLGAVGQGAICVQCRRYDRRILEILKKLNCHKSYTTVSAERSFMRAVDG
SCNTPLAAMAKYIDMDILTMKCMLADDARNMVFTERVFAEQNAESAGYEMGTLLKNELHLHRL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=247, Percent_Identity=38.4615384615385, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI66933009, Length=247, Percent_Identity=38.4615384615385, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI48994974, Length=292, Percent_Identity=42.8082191780822, Blast_Score=229, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319996, Length=257, Percent_Identity=34.2412451361868, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI20130425, Length=251, Percent_Identity=39.8406374501992, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33647; Mature: 33516

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVMVIRIGTRGSLLAMQQARIVKTAIETNYAELSTRIITIKTSGDMNTHVPLYDIGGK
CCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEEECCCCCCCCEEEECCCC
GLFIKEIEEALLDNIIDVAVHSAKDVPGIYSEDLDIPCILPRASALDAFLSSKYDSIASL
CEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCHHHHCC
PLNAKIGTSSVRRKVQLLTMRPDLEIIPMRGNVETRISKMQMGECDGIVLAEAGLYRVSK
CCCCCCCHHHHHHEEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCEEEECH
DNLISEVLQPEVMLGAVGQGAICVQCRRYDRRILEILKKLNCHKSYTTVSAERSFMRAVD
HHHHHHHHCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
GSCNTPLAAMAKYIDMDILTMKCMLADDARNMVFTERVFAEQNAESAGYEMGTLLKNELH
CCCCCCHHHHHHHHHHHHHHHHHHECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LHRL
HCCC
>Mature Secondary Structure 
GIVMVIRIGTRGSLLAMQQARIVKTAIETNYAELSTRIITIKTSGDMNTHVPLYDIGGK
CEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEEECCCCCCCCEEEECCCC
GLFIKEIEEALLDNIIDVAVHSAKDVPGIYSEDLDIPCILPRASALDAFLSSKYDSIASL
CEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCHHHHCC
PLNAKIGTSSVRRKVQLLTMRPDLEIIPMRGNVETRISKMQMGECDGIVLAEAGLYRVSK
CCCCCCCHHHHHHEEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCEEEECH
DNLISEVLQPEVMLGAVGQGAICVQCRRYDRRILEILKKLNCHKSYTTVSAERSFMRAVD
HHHHHHHHCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHC
GSCNTPLAAMAKYIDMDILTMKCMLADDARNMVFTERVFAEQNAESAGYEMGTLLKNELH
CCCCCCHHHHHHHHHHHHHHHHHHECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LHRL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA