Click here to switch to the map view.

The map label for this gene is htpG

Identifier: 88607782

GI number: 88607782

Start: 948535

End: 950448

Strand: Reverse

Name: htpG

Synonym: APH_0893

Alternate gene names: 88607782

Gene position: 950448-948535 (Counterclockwise)

Preceding gene: 88607077

Following gene: 88607703

Centisome position: 64.6

GC content: 42.11

Gene sequence:

>1914_bases
GTGGCGGATATTGAAGAGTTAAAATTTGATGCGGAAGTAGGGAAGGTATTGAGTCTTGTTGTACATTCTCTGTACACAAA
TAAAGATATATTTCTAAGGGAGTTGCTCTCTAATGCTTCAGACGCCTGTGATAAGTTACGGCATGAGTTTTTGTCTAATC
ACGACCTTATGGAGGAAGGTGAAGAGCTAAAGGTGGTGATTAGCGTAGACAAGGATAGTAAGCAGCTTTCCATTTGTGAC
AATGGAATAGGTATGAATCGTGATGAGCTCATAGCAAATCTGGGTACTATTGCAAGTTCAGGTACGCAGCGGTTTTTGGA
AGCTCTGGGTGGTGATAAGGCCAAGGGGTATGATCTCATCGGGAAGTTCGGTGTGGGTTTTTATTCCGTCTTTATGGTTG
CTAGCGAGGTAGTGGTTGATACTTGCAGGGCAGGGGAAAGCGTTGGTTATAGGTGGAGATCTTCTGGTGATGGGGGATTT
ACTATAGAGAAGCTGGGTGAAGATGTTCCCAGAGGCACAAAGATAACTTTGACTCTTAAGGAAGACGAGTCAGGATTTTT
GGATAAGTTCAGAATAGAGCATGTAGTTACTACATATTCTGATCATTTGGGTTATCCGGTATATTTTCTGGATGAGAAGG
GTGAAGAGGAGAAGCTGAATAGTGGTATTGCTATTTGGACTAAGCCTAAGGCTGAAGTTACTGCTGCTGAGCATTTGGAG
TTTTTCCGCTCTGTTGCCCATATAGGCAGCGAACCATGGATGGTGATTCACAATAAAAATGAGGGTGCTATTGAATATAC
TAACTTGCTGTATATTCCGTCGGTCAAGCCCTTTGATCTTTTTCACCCCGATAGAAGATGCTCTGTGAAGTTATATGTGA
ATAGAGTATTCATTACTGAGGACAACGTGCAAATCATACCTCAATATCTGAGGTTTATAAGGGGTGTGATAGATTCTTCT
GATTTGCCTTTGAATATCAGCAGGGAAACTTTACAAAATAATCGCATAGTAGAGAAAATTAAGACTTCCGTTACTAAGAA
AGTCTTGTCTGCTTTGAAAGAAAAGGCGGAAAGTGATCATGAGAGCTATAGCAAATTCTGGGAGAATTTCGGTCCTGTTC
TCAAGGAGGGTTTGTGTGAAGCTATGGACACGGAATCACGCGAAGGTGTGCTTTCGGTCTGTAAGTTCCATACTAGTGCT
TGTGCTGCGGGGGAGCTTGTAAGTTTGGCTGACTATATTTCCAGAATGAAGCCAGGGCAGGAGAGTATTTTCTATCTTTC
AGGTGATGACTTAGAATCTACTAAAAGGAGCCCTCAGATTGAAAAGCTCGTGAGTAGCGGAATAGAGGTTATCCTGCTTG
TTGATCCTGTAGATGATTTTTGGACTAGTGTTGTCTCCGAATATAAGGGGGTGCCGTTCAAGTCTGTTATGCGTGTTGGT
GAGAAGGATCTTGAGAAGTGCATAGGTGCTAGTGACGACAGTGGTGATAAAACTAGTGAAGATAGTGGTGAATCTGCGTC
AGATAAGGAGAGTATAGGTTCTTTTATCGAGTATTTGAAGAAGGTGCTCGATGGGGTAGTGAGTGATGTACGCGTTTCTA
AGAAGCTTACTACAAGTTTGGTTTGTCTCGCAGTGCCTGATAATTCAATGGACATTCGAATGGAGAGGTTCTTAAGGGAG
CAGAAGCAGCTGAATTACAAGGGTAACAGGATTTTGGAGATTAATATTGATCATCCTATAGCTAAGAGTCTCCTGAAAGA
ACATGAAGCGCGTGGCGAAAGTGAGCTTCTGAATGGAATAGTGCATTTGTTATATGACGAAGCGTGTATAATTGAGGGTG
AGGAGATAAGAAGTACCGTTGATTTTGCGAGTCGTATAAATGGGGTGCTTGCTAAAATATTTTCTAGCAAGTAG

Upstream 100 bases:

>100_bases
ATGGCCATAAGTAAAGTTTTCATGCCTCTAATCCTTGAAACAAGGGTATTGAATGATTAGTTAGAGGTAAGATTCGGTTT
GTAGTGTCGTGGAGTTTGTT

Downstream 100 bases:

>100_bases
GCATTTGTTTCTGGGGGAGAAGGGCTACTATGTGCGAGCTCTTTTCCCTTACGGAAGTGCATTAATGAACTCCGTGTTCT
ATTCTCCAATCTGAGTTCTG

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MADIEELKFDAEVGKVLSLVVHSLYTNKDIFLRELLSNASDACDKLRHEFLSNHDLMEEGEELKVVISVDKDSKQLSICD
NGIGMNRDELIANLGTIASSGTQRFLEALGGDKAKGYDLIGKFGVGFYSVFMVASEVVVDTCRAGESVGYRWRSSGDGGF
TIEKLGEDVPRGTKITLTLKEDESGFLDKFRIEHVVTTYSDHLGYPVYFLDEKGEEEKLNSGIAIWTKPKAEVTAAEHLE
FFRSVAHIGSEPWMVIHNKNEGAIEYTNLLYIPSVKPFDLFHPDRRCSVKLYVNRVFITEDNVQIIPQYLRFIRGVIDSS
DLPLNISRETLQNNRIVEKIKTSVTKKVLSALKEKAESDHESYSKFWENFGPVLKEGLCEAMDTESREGVLSVCKFHTSA
CAAGELVSLADYISRMKPGQESIFYLSGDDLESTKRSPQIEKLVSSGIEVILLVDPVDDFWTSVVSEYKGVPFKSVMRVG
EKDLEKCIGASDDSGDKTSEDSGESASDKESIGSFIEYLKKVLDGVVSDVRVSKKLTTSLVCLAVPDNSMDIRMERFLRE
QKQLNYKGNRILEINIDHPIAKSLLKEHEARGESELLNGIVHLLYDEACIIEGEEIRSTVDFASRINGVLAKIFSSK

Sequences:

>Translated_637_residues
MADIEELKFDAEVGKVLSLVVHSLYTNKDIFLRELLSNASDACDKLRHEFLSNHDLMEEGEELKVVISVDKDSKQLSICD
NGIGMNRDELIANLGTIASSGTQRFLEALGGDKAKGYDLIGKFGVGFYSVFMVASEVVVDTCRAGESVGYRWRSSGDGGF
TIEKLGEDVPRGTKITLTLKEDESGFLDKFRIEHVVTTYSDHLGYPVYFLDEKGEEEKLNSGIAIWTKPKAEVTAAEHLE
FFRSVAHIGSEPWMVIHNKNEGAIEYTNLLYIPSVKPFDLFHPDRRCSVKLYVNRVFITEDNVQIIPQYLRFIRGVIDSS
DLPLNISRETLQNNRIVEKIKTSVTKKVLSALKEKAESDHESYSKFWENFGPVLKEGLCEAMDTESREGVLSVCKFHTSA
CAAGELVSLADYISRMKPGQESIFYLSGDDLESTKRSPQIEKLVSSGIEVILLVDPVDDFWTSVVSEYKGVPFKSVMRVG
EKDLEKCIGASDDSGDKTSEDSGESASDKESIGSFIEYLKKVLDGVVSDVRVSKKLTTSLVCLAVPDNSMDIRMERFLRE
QKQLNYKGNRILEINIDHPIAKSLLKEHEARGESELLNGIVHLLYDEACIIEGEEIRSTVDFASRINGVLAKIFSSK
>Mature_636_residues
ADIEELKFDAEVGKVLSLVVHSLYTNKDIFLRELLSNASDACDKLRHEFLSNHDLMEEGEELKVVISVDKDSKQLSICDN
GIGMNRDELIANLGTIASSGTQRFLEALGGDKAKGYDLIGKFGVGFYSVFMVASEVVVDTCRAGESVGYRWRSSGDGGFT
IEKLGEDVPRGTKITLTLKEDESGFLDKFRIEHVVTTYSDHLGYPVYFLDEKGEEEKLNSGIAIWTKPKAEVTAAEHLEF
FRSVAHIGSEPWMVIHNKNEGAIEYTNLLYIPSVKPFDLFHPDRRCSVKLYVNRVFITEDNVQIIPQYLRFIRGVIDSSD
LPLNISRETLQNNRIVEKIKTSVTKKVLSALKEKAESDHESYSKFWENFGPVLKEGLCEAMDTESREGVLSVCKFHTSAC
AAGELVSLADYISRMKPGQESIFYLSGDDLESTKRSPQIEKLVSSGIEVILLVDPVDDFWTSVVSEYKGVPFKSVMRVGE
KDLEKCIGASDDSGDKTSEDSGESASDKESIGSFIEYLKKVLDGVVSDVRVSKKLTTSLVCLAVPDNSMDIRMERFLREQ
KQLNYKGNRILEINIDHPIAKSLLKEHEARGESELLNGIVHLLYDEACIIEGEEIRSTVDFASRINGVLAKIFSSK

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI4507677, Length=688, Percent_Identity=31.9767441860465, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI155722983, Length=637, Percent_Identity=33.2810047095761, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI154146191, Length=419, Percent_Identity=33.6515513126492, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI153792590, Length=419, Percent_Identity=33.6515513126492, Blast_Score=224, Evalue=3e-58,
Organism=Homo sapiens, GI20149594, Length=419, Percent_Identity=33.1742243436754, Blast_Score=219, Evalue=6e-57,
Organism=Escherichia coli, GI1786679, Length=638, Percent_Identity=43.2601880877743, Blast_Score=498, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17559162, Length=675, Percent_Identity=34.6666666666667, Blast_Score=377, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17542208, Length=679, Percent_Identity=33.4315169366716, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI115535205, Length=646, Percent_Identity=31.733746130031, Blast_Score=314, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI115535167, Length=423, Percent_Identity=36.6430260047281, Blast_Score=265, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6323840, Length=688, Percent_Identity=32.9941860465116, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6325016, Length=423, Percent_Identity=31.6784869976359, Blast_Score=224, Evalue=4e-59,
Organism=Drosophila melanogaster, GI21357739, Length=692, Percent_Identity=34.393063583815, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24586016, Length=629, Percent_Identity=31.9554848966614, Blast_Score=306, Evalue=4e-83,
Organism=Drosophila melanogaster, GI17647529, Length=419, Percent_Identity=35.0835322195704, Blast_Score=242, Evalue=6e-64,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_ANAPZ (Q2GJI3)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505468.1
- ProteinModelPortal:   Q2GJI3
- STRING:   Q2GJI3
- GeneID:   3930959
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0893
- NMPDR:   fig|212042.5.peg.843
- TIGR:   APH_0893
- eggNOG:   COG0326
- HOGENOM:   HBG631012
- OMA:   KYIANAY
- PhylomeDB:   Q2GJI3
- ProtClustDB:   PRK05218
- BioCyc:   APHA212042:APH_0893-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71168; Mature: 71037

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIEELKFDAEVGKVLSLVVHSLYTNKDIFLRELLSNASDACDKLRHEFLSNHDLMEEG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
EELKVVISVDKDSKQLSICDNGIGMNRDELIANLGTIASSGTQRFLEALGGDKAKGYDLI
CEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHH
GKFGVGFYSVFMVASEVVVDTCRAGESVGYRWRSSGDGGFTIEKLGEDVPRGTKITLTLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEHHHHCCCCCCCCEEEEEEE
EDESGFLDKFRIEHVVTTYSDHLGYPVYFLDEKGEEEKLNSGIAIWTKPKAEVTAAEHLE
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCEEEEECCCCHHHHHHHHH
FFRSVAHIGSEPWMVIHNKNEGAIEYTNLLYIPSVKPFDLFHPDRRCSVKLYVNRVFITE
HHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEC
DNVQIIPQYLRFIRGVIDSSDLPLNISRETLQNNRIVEKIKTSVTKKVLSALKEKAESDH
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCH
ESYSKFWENFGPVLKEGLCEAMDTESREGVLSVCKFHTSACAAGELVSLADYISRMKPGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ESIFYLSGDDLESTKRSPQIEKLVSSGIEVILLVDPVDDFWTSVVSEYKGVPFKSVMRVG
CCEEEEECCCHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHC
EKDLEKCIGASDDSGDKTSEDSGESASDKESIGSFIEYLKKVLDGVVSDVRVSKKLTTSL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VCLAVPDNSMDIRMERFLREQKQLNYKGNRILEINIDHPIAKSLLKEHEARGESELLNGI
EEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHH
VHLLYDEACIIEGEEIRSTVDFASRINGVLAKIFSSK
HHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADIEELKFDAEVGKVLSLVVHSLYTNKDIFLRELLSNASDACDKLRHEFLSNHDLMEEG
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
EELKVVISVDKDSKQLSICDNGIGMNRDELIANLGTIASSGTQRFLEALGGDKAKGYDLI
CEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHH
GKFGVGFYSVFMVASEVVVDTCRAGESVGYRWRSSGDGGFTIEKLGEDVPRGTKITLTLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEHHHHCCCCCCCCEEEEEEE
EDESGFLDKFRIEHVVTTYSDHLGYPVYFLDEKGEEEKLNSGIAIWTKPKAEVTAAEHLE
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCEEEEECCCCHHHHHHHHH
FFRSVAHIGSEPWMVIHNKNEGAIEYTNLLYIPSVKPFDLFHPDRRCSVKLYVNRVFITE
HHHHHHHCCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEC
DNVQIIPQYLRFIRGVIDSSDLPLNISRETLQNNRIVEKIKTSVTKKVLSALKEKAESDH
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCH
ESYSKFWENFGPVLKEGLCEAMDTESREGVLSVCKFHTSACAAGELVSLADYISRMKPGQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ESIFYLSGDDLESTKRSPQIEKLVSSGIEVILLVDPVDDFWTSVVSEYKGVPFKSVMRVG
CCEEEEECCCHHHHCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHC
EKDLEKCIGASDDSGDKTSEDSGESASDKESIGSFIEYLKKVLDGVVSDVRVSKKLTTSL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VCLAVPDNSMDIRMERFLREQKQLNYKGNRILEINIDHPIAKSLLKEHEARGESELLNGI
EEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHH
VHLLYDEACIIEGEEIRSTVDFASRINGVLAKIFSSK
HHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA