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The map label for this gene is ndk

Identifier: 88607736

GI number: 88607736

Start: 1286645

End: 1287067

Strand: Reverse

Name: ndk

Synonym: APH_1217

Alternate gene names: 88607736

Gene position: 1287067-1286645 (Counterclockwise)

Preceding gene: 88607102

Following gene: 88606886

Centisome position: 87.48

GC content: 43.74

Gene sequence:

>423_bases
GTGCAAGAGAGGACGCTTTCTATCTTAAAGCCTGATGTCGTTGAGCGTGGCATAATAGGTAATGTTATTTCCTATATAGA
GGCTGCGGGGCTTAAAGTTGTTGCGCAAAGGATGTGTAGATTAACTGTCTCTCAGGCCGAAGAGTTTTATGATGTGCATC
GTGACAGGCCGTTTTTTCCTGAGCTTGTTAAGTTTATGACTTCAGGACCCGTCGTAGTGCAGGTACTGGAAGGGGAATCG
GCTATAGCTGTATACAGAGATGTTATGGGTGCTACGAATCCTAAAGAGGCTGCAAAAGGGACCATAAGGGCTGATTTTGC
TGAGAGCATAGATGCAAATTGTGTGCATGGATCGGATAATGCAGATAATGCGAAGAGGGAAATCATGTTTTTCTTTGGAG
AATGTGAGATTTTTAAACGGTAG

Upstream 100 bases:

>100_bases
CGCAAGCATAGGTTATAGCAGTTGTTTATTGCGTTATACACTTGCGATAATGTACTGTTGCGTGTTAACATATTTGGTTG
AATATAAAGGGGGCACAAGA

Downstream 100 bases:

>100_bases
CCAGTAATTGGGCAGCGCTTTGTTCCAGAAGTGTCTAAGAAGTAGAGGTAGGCTTTTCTTCGAGTAATCTCTTAGCGGTA
GTTAGCAGTTGATCACGAGA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MQERTLSILKPDVVERGIIGNVISYIEAAGLKVVAQRMCRLTVSQAEEFYDVHRDRPFFPELVKFMTSGPVVVQVLEGES
AIAVYRDVMGATNPKEAAKGTIRADFAESIDANCVHGSDNADNAKREIMFFFGECEIFKR

Sequences:

>Translated_140_residues
MQERTLSILKPDVVERGIIGNVISYIEAAGLKVVAQRMCRLTVSQAEEFYDVHRDRPFFPELVKFMTSGPVVVQVLEGES
AIAVYRDVMGATNPKEAAKGTIRADFAESIDANCVHGSDNADNAKREIMFFFGECEIFKR
>Mature_140_residues
MQERTLSILKPDVVERGIIGNVISYIEAAGLKVVAQRMCRLTVSQAEEFYDVHRDRPFFPELVKFMTSGPVVVQVLEGES
AIAVYRDVMGATNPKEAAKGTIRADFAESIDANCVHGSDNADNAKREIMFFFGECEIFKR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI37693993, Length=131, Percent_Identity=41.2213740458015, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI4557797, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=9e-26,
Organism=Homo sapiens, GI38045913, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=9e-26,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=33.0935251798561, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=33.0935251798561, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=34.0740740740741, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI5031951, Length=132, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.8518518518519, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=29.9270072992701, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=54.3478260869565, Blast_Score=163, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.962962962963, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=41.4814814814815, Blast_Score=121, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=41.9117647058824, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ANAPZ (Q2GIQ3)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505748.1
- ProteinModelPortal:   Q2GIQ3
- SMR:   Q2GIQ3
- STRING:   Q2GIQ3
- GeneID:   3931219
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1217
- NMPDR:   fig|212042.5.peg.1167
- TIGR:   APH_1217
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q2GIQ3
- ProtClustDB:   PRK00668
- BioCyc:   APHA212042:APH_1217-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15620; Mature: 15620

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERTLSILKPDVVERGIIGNVISYIEAAGLKVVAQRMCRLTVSQAEEFYDVHRDRPFFP
CCCCHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELVKFMTSGPVVVQVLEGESAIAVYRDVMGATNPKEAAKGTIRADFAESIDANCVHGSDN
HHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCEECCCCC
ADNAKREIMFFFGECEIFKR
CCCHHHHEEHEECCEEECCC
>Mature Secondary Structure
MQERTLSILKPDVVERGIIGNVISYIEAAGLKVVAQRMCRLTVSQAEEFYDVHRDRPFFP
CCCCHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELVKFMTSGPVVVQVLEGESAIAVYRDVMGATNPKEAAKGTIRADFAESIDANCVHGSDN
HHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCCCEECCCCC
ADNAKREIMFFFGECEIFKR
CCCHHHHEEHEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA