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The map label for this gene is mutL

Identifier: 88607715

GI number: 88607715

Start: 1002237

End: 1004141

Strand: Reverse

Name: mutL

Synonym: APH_0939

Alternate gene names: 88607715

Gene position: 1004141-1002237 (Counterclockwise)

Preceding gene: 88607477

Following gene: 88607273

Centisome position: 68.25

GC content: 43.2

Gene sequence:

>1905_bases
GTGCCGATAGTAGTTTTAAGTGCGCAGACGATCAATAAAATTGCCGCAGGTGAGGTAATAGATTGTCCAGCGAGCGTAGT
AAAAGAGCTGGTAGAGAATTCCATAGATGCGGGAGCCAAAACCATAAATGTGCATGTTGACAAAGGAGGTCGCAACTTAA
TTTCAGTGAGTGATGATGGTTGCGGAATCGCATGTGAAGAAATGGAAAAAGCGTTTATCGGTCATGCTACATCCAAGCTC
ATTGATGGGGATCTTGCAAATGTGAAAACCATGGGCTTCAGAGGAGAAGGTCTTACAGCAGTTGCATCGGTAGCCAGGGT
GAAGATGGTTTCTAAACATGTGGATGCAGAGAGAGCCTGGTCTATCACATTCGAAGGAGGAGAAAAAACCAGAGATTTAA
CACCGGGGGTTTTGTCTTGTGGTACACATGTGGAAGTGAGAGACTTGTTTTTCGCGACTCCTACGAGGCTGAAGTTTTTA
CGGACAGAAAAAGCTGAGATGCAAAATATTGTGGATTTGCTCAACAGGCTAGCCATGATAAACTATACCATAGCGTTTTC
TCTTACCATAGTTGAACGCCAGATCTTTAAATACTCAGCGCAGGAAAGCCTTATCGAGAGATTGAAGGAAATGAGAGCAT
TTGGCGAAGTTTTCTGTGAACAATCACTGGAGATAAATCACTCTATAGACCACGTAAGAGTATATGGGCACATAGGTCTG
CCGACGTTTAATAAGTCTAAGCCGGGGATGGTACACACTTTTGTGAATGGTCGGCCAATTTACAGTACTCTACTACTCGG
AGCAGTGAAGTCTGCTTATCATGGGTTAATCCCAAAGGATAGGCATCCTGTTGTTGTTTTAGCTCTGGATGTTATGCCTG
CTTACGTTGATGTTAACGTGCATCCTAGCAAAATGGAGGTCAGATTCCAGGACAAGCGCCTTGTATATAAGGCAGTGCTT
GATGCACTAGGTGAGGCTTTGTCTAGTAACGTATATGCCAGGTTTTCACCTGCCGCAACTACTTCGGAAGGACATGATCA
CTTCGCTATGGATAGTATTGAAAAGACCTACGGAAAGTTTTTCTCCGAAGATACAGAAGCAGCCTCAACTATGCAACTGC
AACCAGAGGTGTTAAATCATAACATACCGCTGCTGTTTGGCAGTAGTCACGTTGATGATTCCAAAGGAACGCATGATACG
AGGTTTTGTGCCGATCACACTCATCATAATGATACAAAAGGCTCGGTGCATACGAAAAGTTTTTCAGCAAGATCATCCTC
TTCTGCAGAAAGTAAGATGGAGCAGGGATGCATGCTGGAAGAGCCTCCTTTAGGTTATGCAGTTTGCCAACTATTTGAGA
GATATATCATTTCCAGAGCGGGAGATTACGTCATAATAGTTGATCAGCATGCTGCTCATGAGAGGCTTGTATGTGAATAT
ATAAAGAAGGTTACAGAACAAGAAGGAATAAAAAGACAGGTTCTGCTGATGCCAGAGTTTATAGAGCTTGGAAACGAGTA
CGAGCTGGAATTGCTGACTGAGTATCGGGAAAAATTAAGAGATCTAGGGCTTATAGTAGAGCCTATGGGTGACCTTACAG
TGGTAGTTAGAGAAGTTCCTGCTATCTTTGGTGTTGTAGATGCTAAGGCGCTAATTTCCAAGATATTAGAAAGCATAATG
GCAAAAGGTGACGAACTTTTTGTGAAAGGTAAGCTGAGCCATATTTGTGGTACAGTTGCATGCTATAGCTCCATAAGAAG
TGGCAGGATTATGAAATTGGAGGAAATGAACAGCCTACTCAGGCACATGGAGAGCACTCCGCATTCTGGTCAGTGTAACC
ACGGTAGGCCCACGTATGTGAAGCTTAAATTGTCAGAAATAGACAAGTTATTTGAACGTACGTAA

Upstream 100 bases:

>100_bases
TAGTAGTAATGCTGGTGTGCTTTAGACATAAGCACTTAGGGCATGGTGTTGTTCATCAACTTCGCGGCAACCGTGAAAAT
TGTTATTATGTGGTAATATT

Downstream 100 bases:

>100_bases
AGTGAACCGCATACATGGCTCAAAAAGATGTACAGTGCTTTTGATGCGTTGGTAGAACAACTGGTGGTGGGTTTTTCTGT
GTAAATCAGGATCATGTCAT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MPIVVLSAQTINKIAAGEVIDCPASVVKELVENSIDAGAKTINVHVDKGGRNLISVSDDGCGIACEEMEKAFIGHATSKL
IDGDLANVKTMGFRGEGLTAVASVARVKMVSKHVDAERAWSITFEGGEKTRDLTPGVLSCGTHVEVRDLFFATPTRLKFL
RTEKAEMQNIVDLLNRLAMINYTIAFSLTIVERQIFKYSAQESLIERLKEMRAFGEVFCEQSLEINHSIDHVRVYGHIGL
PTFNKSKPGMVHTFVNGRPIYSTLLLGAVKSAYHGLIPKDRHPVVVLALDVMPAYVDVNVHPSKMEVRFQDKRLVYKAVL
DALGEALSSNVYARFSPAATTSEGHDHFAMDSIEKTYGKFFSEDTEAASTMQLQPEVLNHNIPLLFGSSHVDDSKGTHDT
RFCADHTHHNDTKGSVHTKSFSARSSSSAESKMEQGCMLEEPPLGYAVCQLFERYIISRAGDYVIIVDQHAAHERLVCEY
IKKVTEQEGIKRQVLLMPEFIELGNEYELELLTEYREKLRDLGLIVEPMGDLTVVVREVPAIFGVVDAKALISKILESIM
AKGDELFVKGKLSHICGTVACYSSIRSGRIMKLEEMNSLLRHMESTPHSGQCNHGRPTYVKLKLSEIDKLFERT

Sequences:

>Translated_634_residues
MPIVVLSAQTINKIAAGEVIDCPASVVKELVENSIDAGAKTINVHVDKGGRNLISVSDDGCGIACEEMEKAFIGHATSKL
IDGDLANVKTMGFRGEGLTAVASVARVKMVSKHVDAERAWSITFEGGEKTRDLTPGVLSCGTHVEVRDLFFATPTRLKFL
RTEKAEMQNIVDLLNRLAMINYTIAFSLTIVERQIFKYSAQESLIERLKEMRAFGEVFCEQSLEINHSIDHVRVYGHIGL
PTFNKSKPGMVHTFVNGRPIYSTLLLGAVKSAYHGLIPKDRHPVVVLALDVMPAYVDVNVHPSKMEVRFQDKRLVYKAVL
DALGEALSSNVYARFSPAATTSEGHDHFAMDSIEKTYGKFFSEDTEAASTMQLQPEVLNHNIPLLFGSSHVDDSKGTHDT
RFCADHTHHNDTKGSVHTKSFSARSSSSAESKMEQGCMLEEPPLGYAVCQLFERYIISRAGDYVIIVDQHAAHERLVCEY
IKKVTEQEGIKRQVLLMPEFIELGNEYELELLTEYREKLRDLGLIVEPMGDLTVVVREVPAIFGVVDAKALISKILESIM
AKGDELFVKGKLSHICGTVACYSSIRSGRIMKLEEMNSLLRHMESTPHSGQCNHGRPTYVKLKLSEIDKLFERT
>Mature_633_residues
PIVVLSAQTINKIAAGEVIDCPASVVKELVENSIDAGAKTINVHVDKGGRNLISVSDDGCGIACEEMEKAFIGHATSKLI
DGDLANVKTMGFRGEGLTAVASVARVKMVSKHVDAERAWSITFEGGEKTRDLTPGVLSCGTHVEVRDLFFATPTRLKFLR
TEKAEMQNIVDLLNRLAMINYTIAFSLTIVERQIFKYSAQESLIERLKEMRAFGEVFCEQSLEINHSIDHVRVYGHIGLP
TFNKSKPGMVHTFVNGRPIYSTLLLGAVKSAYHGLIPKDRHPVVVLALDVMPAYVDVNVHPSKMEVRFQDKRLVYKAVLD
ALGEALSSNVYARFSPAATTSEGHDHFAMDSIEKTYGKFFSEDTEAASTMQLQPEVLNHNIPLLFGSSHVDDSKGTHDTR
FCADHTHHNDTKGSVHTKSFSARSSSSAESKMEQGCMLEEPPLGYAVCQLFERYIISRAGDYVIIVDQHAAHERLVCEYI
KKVTEQEGIKRQVLLMPEFIELGNEYELELLTEYREKLRDLGLIVEPMGDLTVVVREVPAIFGVVDAKALISKILESIMA
KGDELFVKGKLSHICGTVACYSSIRSGRIMKLEEMNSLLRHMESTPHSGQCNHGRPTYVKLKLSEIDKLFERT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=33.0128205128205, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI310128478, Length=355, Percent_Identity=29.2957746478873, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI4505913, Length=355, Percent_Identity=29.2957746478873, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI189458898, Length=345, Percent_Identity=27.2463768115942, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4505911, Length=345, Percent_Identity=27.2463768115942, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI189458896, Length=338, Percent_Identity=27.5147928994083, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI310128480, Length=308, Percent_Identity=28.2467532467532, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI263191589, Length=226, Percent_Identity=28.3185840707965, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI91992160, Length=276, Percent_Identity=28.6231884057971, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI91992162, Length=276, Percent_Identity=28.6231884057971, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1790612, Length=366, Percent_Identity=37.431693989071, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=315, Percent_Identity=32.3809523809524, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562796, Length=342, Percent_Identity=24.8538011695906, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323819, Length=347, Percent_Identity=31.9884726224784, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=444, Percent_Identity=26.1261261261261, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=360, Percent_Identity=26.3888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325093, Length=154, Percent_Identity=32.4675324675325, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=31.0030395136778, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17136970, Length=188, Percent_Identity=30.3191489361702, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_ANAPZ (Q2GJE2)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505509.1
- ProteinModelPortal:   Q2GJE2
- SMR:   Q2GJE2
- STRING:   Q2GJE2
- GeneID:   3931281
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0939
- NMPDR:   fig|212042.5.peg.888
- TIGR:   APH_0939
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q2GJE2
- ProtClustDB:   CLSK2465330
- BioCyc:   APHA212042:APH_0939-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70420; Mature: 70289

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVVLSAQTINKIAAGEVIDCPASVVKELVENSIDAGAKTINVHVDKGGRNLISVSDDG
CCEEEEEHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEECCCC
CGIACEEMEKAFIGHATSKLIDGDLANVKTMGFRGEGLTAVASVARVKMVSKHVDAERAW
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEE
SITFEGGEKTRDLTPGVLSCGTHVEVRDLFFATPTRLKFLRTEKAEMQNIVDLLNRLAMI
EEEECCCCCCCCCCCCHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NYTIAFSLTIVERQIFKYSAQESLIERLKEMRAFGEVFCEQSLEINHSIDHVRVYGHIGL
EEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECC
PTFNKSKPGMVHTFVNGRPIYSTLLLGAVKSAYHGLIPKDRHPVVVLALDVMPAYVDVNV
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEE
HPSKMEVRFQDKRLVYKAVLDALGEALSSNVYARFSPAATTSEGHDHFAMDSIEKTYGKF
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FSEDTEAASTMQLQPEVLNHNIPLLFGSSHVDDSKGTHDTRFCADHTHHNDTKGSVHTKS
HCCCHHHHHHEEECHHHHCCCCCEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEECC
FSARSSSSAESKMEQGCMLEEPPLGYAVCQLFERYIISRAGDYVIIVDQHAAHERLVCEY
CCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
IKKVTEQEGIKRQVLLMPEFIELGNEYELELLTEYREKLRDLGLIVEPMGDLTVVVREVP
HHHHHHHCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHH
AIFGVVDAKALISKILESIMAKGDELFVKGKLSHICGTVACYSSIRSGRIMKLEEMNSLL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEHHHHHHHH
RHMESTPHSGQCNHGRPTYVKLKLSEIDKLFERT
HHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
PIVVLSAQTINKIAAGEVIDCPASVVKELVENSIDAGAKTINVHVDKGGRNLISVSDDG
CEEEEEHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEECCCC
CGIACEEMEKAFIGHATSKLIDGDLANVKTMGFRGEGLTAVASVARVKMVSKHVDAERAW
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEE
SITFEGGEKTRDLTPGVLSCGTHVEVRDLFFATPTRLKFLRTEKAEMQNIVDLLNRLAMI
EEEECCCCCCCCCCCCHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NYTIAFSLTIVERQIFKYSAQESLIERLKEMRAFGEVFCEQSLEINHSIDHVRVYGHIGL
EEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECC
PTFNKSKPGMVHTFVNGRPIYSTLLLGAVKSAYHGLIPKDRHPVVVLALDVMPAYVDVNV
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEEEE
HPSKMEVRFQDKRLVYKAVLDALGEALSSNVYARFSPAATTSEGHDHFAMDSIEKTYGKF
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
FSEDTEAASTMQLQPEVLNHNIPLLFGSSHVDDSKGTHDTRFCADHTHHNDTKGSVHTKS
HCCCHHHHHHEEECHHHHCCCCCEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEECC
FSARSSSSAESKMEQGCMLEEPPLGYAVCQLFERYIISRAGDYVIIVDQHAAHERLVCEY
CCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
IKKVTEQEGIKRQVLLMPEFIELGNEYELELLTEYREKLRDLGLIVEPMGDLTVVVREVP
HHHHHHHCCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHH
AIFGVVDAKALISKILESIMAKGDELFVKGKLSHICGTVACYSSIRSGRIMKLEEMNSLL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCEEEHHHHHHHH
RHMESTPHSGQCNHGRPTYVKLKLSEIDKLFERT
HHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA