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The map label for this gene is fabF [H]

Identifier: 88607520

GI number: 88607520

Start: 995981

End: 997252

Strand: Direct

Name: fabF [H]

Synonym: APH_0930

Alternate gene names: 88607520

Gene position: 995981-997252 (Clockwise)

Preceding gene: 88607643

Following gene: 88606978

Centisome position: 67.69

GC content: 46.23

Gene sequence:

>1272_bases
ATGGCCGAGCGAAAGAGGGTTGTGGTGACCGGCATGGGTTTGGTCACGCCTTTGGGTGTTGCGATCCCATCAGTTTGGGA
TAGACTCGTTAAGGGAGAATCTGGAATAAGGCAAGTAGTTAGTCGCTACGACGTGAGCGATTTGGACTGCAAGATCGGGG
GGCAAGTATTGCTCAAAGGAGAATCTGATGATTACGTATTTGATCCAGGGACTTGGTTAGAGGAAAAAGAAGTAAAAAAA
ATCGATCTCTTCATCTTGTTTGGCATTGCTGCATCTAGTATCGCTTTAGAAGATTCTGGCGCTTTAGAAAGTAACTTTGA
CCCTGAAAGGTTCGGTGTGTTACTTGGTTCTGGCATAGGGGGATTACCTAACATTGAGAGAAATGTAACTGCACTTAATG
CTCGCGGTCCTAGGAGGATCAGTCCGTTTTTCGTGCCTGGAAGTCTCATAAACTTGCTTCCTAGTCATGTATCCATGCGC
TACGGGCTTAAGGGATATTGCAATGCGGTCGTGGGAGCTTGTGCTACTGGTGCTATTGCGATTACGGAGGCAGCACGTGT
CATTGAGAGCGGCGTATGTGATATTGTAGTGGCTGGCGGTTCTGAGAGTGCGTTGTGTAGGTCAGGAATAGCTGGATTTA
GTATAATAAAGGCATTATCTACGAAATTTAATGATACTCCTCAAGTTGCTTCAAGACCCTGGGACAAGGACAGAGATGGG
TTCGTCATGGGTGAAGGCGCTGGTGTGGTGGTATTGGAAGACTACGAATACGCGAAGAAGCGGGGAGCTAGAATATACGC
AGAGCTAACCGGTTATGGTTTGACAGCTGATGCATATCATATAACAGCGCCGCATCCACAAGGCGAAGGCGGTATGCGCG
CTATGGAGATGGCTCTCAGGACAGCTAATATATCACCTAGTGAGATTGATTACATCAATGCTCATGGTACTTCGACTCCT
ACTGGCGACAGTGTGGAGATTGTTGCGATAAAGAATTTGTTCCAGGATCATGCTTATAAAGTAGCTATATCTTCGACGAA
ATCGTCGATAGGGCATCTTTTAGGTGCAGCTGGTAGCGTAGAAGCGATATTTTCTATGCTGGCATTGCAGCATGGTGTAC
TGCCACCTACTCTGAATCTGCACAATTCTACCGAGGATAGTAACGTGAACTTGGTACCGTTGGTAGCTGAGGAGCGTAAG
ATTTCTCATGTATTGAGTAATTCCTTCGGATTCGGTGGTGTAAATGCGTCTCTGATCTTTAGTAAGGTTTAA

Upstream 100 bases:

>100_bases
AATGGTAATCCGCGCTATTATTGCTACAAAGGCTGTGGTGCGTGGTTTTTGTGCCTAGTAAGTAGCTCAGGGTTGGTTGG
TATAGTTAGGGTATTTAGAG

Downstream 100 bases:

>100_bases
GCCCGGCTGGAGAACGTTATACCTTCTTGGTCGCAGAAGATAGGTGGTCTGAACCTAAGAGCAAGCCCTGCAACACATAG
AGGGATAGGGTTTTGCTTGT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MAERKRVVVTGMGLVTPLGVAIPSVWDRLVKGESGIRQVVSRYDVSDLDCKIGGQVLLKGESDDYVFDPGTWLEEKEVKK
IDLFILFGIAASSIALEDSGALESNFDPERFGVLLGSGIGGLPNIERNVTALNARGPRRISPFFVPGSLINLLPSHVSMR
YGLKGYCNAVVGACATGAIAITEAARVIESGVCDIVVAGGSESALCRSGIAGFSIIKALSTKFNDTPQVASRPWDKDRDG
FVMGEGAGVVVLEDYEYAKKRGARIYAELTGYGLTADAYHITAPHPQGEGGMRAMEMALRTANISPSEIDYINAHGTSTP
TGDSVEIVAIKNLFQDHAYKVAISSTKSSIGHLLGAAGSVEAIFSMLALQHGVLPPTLNLHNSTEDSNVNLVPLVAEERK
ISHVLSNSFGFGGVNASLIFSKV

Sequences:

>Translated_423_residues
MAERKRVVVTGMGLVTPLGVAIPSVWDRLVKGESGIRQVVSRYDVSDLDCKIGGQVLLKGESDDYVFDPGTWLEEKEVKK
IDLFILFGIAASSIALEDSGALESNFDPERFGVLLGSGIGGLPNIERNVTALNARGPRRISPFFVPGSLINLLPSHVSMR
YGLKGYCNAVVGACATGAIAITEAARVIESGVCDIVVAGGSESALCRSGIAGFSIIKALSTKFNDTPQVASRPWDKDRDG
FVMGEGAGVVVLEDYEYAKKRGARIYAELTGYGLTADAYHITAPHPQGEGGMRAMEMALRTANISPSEIDYINAHGTSTP
TGDSVEIVAIKNLFQDHAYKVAISSTKSSIGHLLGAAGSVEAIFSMLALQHGVLPPTLNLHNSTEDSNVNLVPLVAEERK
ISHVLSNSFGFGGVNASLIFSKV
>Mature_422_residues
AERKRVVVTGMGLVTPLGVAIPSVWDRLVKGESGIRQVVSRYDVSDLDCKIGGQVLLKGESDDYVFDPGTWLEEKEVKKI
DLFILFGIAASSIALEDSGALESNFDPERFGVLLGSGIGGLPNIERNVTALNARGPRRISPFFVPGSLINLLPSHVSMRY
GLKGYCNAVVGACATGAIAITEAARVIESGVCDIVVAGGSESALCRSGIAGFSIIKALSTKFNDTPQVASRPWDKDRDGF
VMGEGAGVVVLEDYEYAKKRGARIYAELTGYGLTADAYHITAPHPQGEGGMRAMEMALRTANISPSEIDYINAHGTSTPT
GDSVEIVAIKNLFQDHAYKVAISSTKSSIGHLLGAAGSVEAIFSMLALQHGVLPPTLNLHNSTEDSNVNLVPLVAEERKI
SHVLSNSFGFGGVNASLIFSKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=48.1042654028436, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=57.4324324324324, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI41872631, Length=299, Percent_Identity=25.752508361204, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=48.936170212766, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=38.5882352941176, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=425, Percent_Identity=39.2941176470588, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=268, Percent_Identity=43.6567164179104, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17550940, Length=403, Percent_Identity=26.302729528536, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI212642053, Length=432, Percent_Identity=23.8425925925926, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=36.9127516778523, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=44, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI19920632, Length=376, Percent_Identity=23.936170212766, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221330659, Length=372, Percent_Identity=24.1935483870968, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24581345, Length=438, Percent_Identity=23.7442922374429, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44842; Mature: 44710

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERKRVVVTGMGLVTPLGVAIPSVWDRLVKGESGIRQVVSRYDVSDLDCKIGGQVLLKG
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEECCCEEEEEC
ESDDYVFDPGTWLEEKEVKKIDLFILFGIAASSIALEDSGALESNFDPERFGVLLGSGIG
CCCCEEECCCCCCCCCCCCEEEEEEEEEEHHCEEEECCCCCCCCCCCHHHHHEEEECCCC
GLPNIERNVTALNARGPRRISPFFVPGSLINLLPSHVSMRYGLKGYCNAVVGACATGAIA
CCCCCCCCEEEEECCCCCCCCCEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
ITEAARVIESGVCDIVVAGGSESALCRSGIAGFSIIKALSTKFNDTPQVASRPWDKDRDG
HHHHHHHHHCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
FVMGEGAGVVVLEDYEYAKKRGARIYAELTGYGLTADAYHITAPHPQGEGGMRAMEMALR
EEEECCCCEEEECCCHHHHHCCCEEEEEEECCCEEECEEEEECCCCCCCCHHHHHHHHHH
TANISPSEIDYINAHGTSTPTGDSVEIVAIKNLFQDHAYKVAISSTKSSIGHLLGAAGSV
HCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHCCCEEEEEECCHHHHHHHHCCCCCH
EAIFSMLALQHGVLPPTLNLHNSTEDSNVNLVPLVAEERKISHVLSNSFGFGGVNASLIF
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCEEEE
SKV
ECC
>Mature Secondary Structure 
AERKRVVVTGMGLVTPLGVAIPSVWDRLVKGESGIRQVVSRYDVSDLDCKIGGQVLLKG
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEECCCEEEEEC
ESDDYVFDPGTWLEEKEVKKIDLFILFGIAASSIALEDSGALESNFDPERFGVLLGSGIG
CCCCEEECCCCCCCCCCCCEEEEEEEEEEHHCEEEECCCCCCCCCCCHHHHHEEEECCCC
GLPNIERNVTALNARGPRRISPFFVPGSLINLLPSHVSMRYGLKGYCNAVVGACATGAIA
CCCCCCCCEEEEECCCCCCCCCEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
ITEAARVIESGVCDIVVAGGSESALCRSGIAGFSIIKALSTKFNDTPQVASRPWDKDRDG
HHHHHHHHHCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
FVMGEGAGVVVLEDYEYAKKRGARIYAELTGYGLTADAYHITAPHPQGEGGMRAMEMALR
EEEECCCCEEEECCCHHHHHCCCEEEEEEECCCEEECEEEEECCCCCCCCHHHHHHHHHH
TANISPSEIDYINAHGTSTPTGDSVEIVAIKNLFQDHAYKVAISSTKSSIGHLLGAAGSV
HCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHCCCEEEEEECCHHHHHHHHCCCCCH
EAIFSMLALQHGVLPPTLNLHNSTEDSNVNLVPLVAEERKISHVLSNSFGFGGVNASLIF
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCEEEE
SKV
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]