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The map label for this gene is aprE [H]

Identifier: 88607344

GI number: 88607344

Start: 1106232

End: 1107761

Strand: Direct

Name: aprE [H]

Synonym: APH_1043

Alternate gene names: 88607344

Gene position: 1106232-1107761 (Clockwise)

Preceding gene: 88607867

Following gene: 88607621

Centisome position: 75.19

GC content: 41.18

Gene sequence:

>1530_bases
ATGTATAGCAAGCTCTCAGGGGCTATCTCATTTCTGAAGATAGACCTTTCCCTTACTCGCCTTTTAGGACACAATTCCTT
AAACAAAGAGAAGGGGGGAGATTCTTGCAATTCTAAACTCCTCAGTGGATCTTTGGCAATTCTAGATGGGATGACATCCT
TCATATTCAGGCTACAAAAGAAAAGAAGTGGCAACGAGGCTTTGAAGGCTTCATGGGGCCCATTATTCATTGGTATTGTG
GCAGTAATAGGCTTTTTTGGATGTTTTGGCATATGGGCAGCATTAGCGCCTCTTGATGGAGCAGTTATAGCCCCTGGTGA
AGTGGTTTCATCACTCAATAGGCAGATTGTCCAACACCTAGAAGGAGGTATAGTAAAGAAAATTCTGGTTACGGAAGGTG
AAACAGTAGAAAAGGAGCAGCCTCTTGTATACCTGAATAGCACTGCTGCACAGGCAAACTTGGGCATAATAAAAGAAAAA
CTTTTAGTATTATTGGCTACAGAAGCACGTTTAAATGCAATAAAATCACATGCTACTACAGTGGAGTTTCCCGATGAAAT
ATTCAAACTTTCGAGTGAAGACGTAGTAAGTAAGGTGCTGGAAAATCAGAAAGAGCTGTTTTTCTCACAAAACAATAGCA
TCACGGGACAAATACAAATTTTGCGACAACGAATAAAGCAGCTGCATCAGGAGCTTGCGGGGCTTGCATCACAGCTCGAA
GCCGAAGAAAAACAATACCACCTTATAGATGAAGAGCTAGAAACAAAAAAGAGCCTATTGGATGCAGGTTATATTAGCAA
ACCATACCTGCTGAATCTTGAGAGATTGCATGCTAATGCAGAAGGAAAGCTAGGTCATATACGTGCTACTATCGCGAGCA
CTGAGCAAAAAATTGGTGAAAATAGGCTGGAAATTATAAATATAACTAACACAGTGATGGATAGAGCAAATGCCGAATTA
AAGGAAACTGCTTCTACCATTACAGATCTCAGGGAGCGTTTACGAGCTGCAGAAGACGTATTAGAACGCACAGTGATTAG
ATCGCCGCAACACGGTATAGTGACAGGATTAAAATACCATACAGAAGGAGGAGTGATACCTCCAGGCGGTGTTATTATGG
AAGTCGTACCTATAGATGATGATTTTATAATAGATGCTAAGATTTCAATACGAAACATAGAAGAGATACTCTCAGCACAA
ACAGTGGAAGAAAATCTTGTAACCAGTGGAGAATATAGGGGACTTAAAGCAAAGGTACGTCTAAGCGCCTTTAACATTCG
TAAGTTTGGTTTAGTAAATGGAATAGTTACTCAGGTGTCGGCCGATGCTCTGGCTGATCCACACGGTATGCGTTATTATT
CTTTACGTGTTGTTATCCCCAAGTCATCACATTCCGGGAAGTTTAAAAACCTAAAGTTGTACCATGGAATGCCTGCTGAA
GTCTTCGTAGTAACGCGCTCTCGCACACTGTTGGAGTACTTACTTACGCCTATTACCAGCACTTTTGAAAAGGCCTTTAA
AGAACGGTAA

Upstream 100 bases:

>100_bases
GTAGGTCAATAATGACATCTGTCGTACATACAAAAATAAATATCTGCGGTAATCTTTTCGTGCTATTAGTTTGTGGTCTG
TTGGTTCCATGCTCAGCATT

Downstream 100 bases:

>100_bases
AAAGCTGAGTGATTTGCGCTGCTTTACCTAACAAGTGAGCATTTGCTGTTCTTCGTTACCGCACGCCTAAATATTTTGAA
CTATGTATTAGCAGCTTGGA

Product: HlyD family type I secretion membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MYSKLSGAISFLKIDLSLTRLLGHNSLNKEKGGDSCNSKLLSGSLAILDGMTSFIFRLQKKRSGNEALKASWGPLFIGIV
AVIGFFGCFGIWAALAPLDGAVIAPGEVVSSLNRQIVQHLEGGIVKKILVTEGETVEKEQPLVYLNSTAAQANLGIIKEK
LLVLLATEARLNAIKSHATTVEFPDEIFKLSSEDVVSKVLENQKELFFSQNNSITGQIQILRQRIKQLHQELAGLASQLE
AEEKQYHLIDEELETKKSLLDAGYISKPYLLNLERLHANAEGKLGHIRATIASTEQKIGENRLEIINITNTVMDRANAEL
KETASTITDLRERLRAAEDVLERTVIRSPQHGIVTGLKYHTEGGVIPPGGVIMEVVPIDDDFIIDAKISIRNIEEILSAQ
TVEENLVTSGEYRGLKAKVRLSAFNIRKFGLVNGIVTQVSADALADPHGMRYYSLRVVIPKSSHSGKFKNLKLYHGMPAE
VFVVTRSRTLLEYLLTPITSTFEKAFKER

Sequences:

>Translated_509_residues
MYSKLSGAISFLKIDLSLTRLLGHNSLNKEKGGDSCNSKLLSGSLAILDGMTSFIFRLQKKRSGNEALKASWGPLFIGIV
AVIGFFGCFGIWAALAPLDGAVIAPGEVVSSLNRQIVQHLEGGIVKKILVTEGETVEKEQPLVYLNSTAAQANLGIIKEK
LLVLLATEARLNAIKSHATTVEFPDEIFKLSSEDVVSKVLENQKELFFSQNNSITGQIQILRQRIKQLHQELAGLASQLE
AEEKQYHLIDEELETKKSLLDAGYISKPYLLNLERLHANAEGKLGHIRATIASTEQKIGENRLEIINITNTVMDRANAEL
KETASTITDLRERLRAAEDVLERTVIRSPQHGIVTGLKYHTEGGVIPPGGVIMEVVPIDDDFIIDAKISIRNIEEILSAQ
TVEENLVTSGEYRGLKAKVRLSAFNIRKFGLVNGIVTQVSADALADPHGMRYYSLRVVIPKSSHSGKFKNLKLYHGMPAE
VFVVTRSRTLLEYLLTPITSTFEKAFKER
>Mature_509_residues
MYSKLSGAISFLKIDLSLTRLLGHNSLNKEKGGDSCNSKLLSGSLAILDGMTSFIFRLQKKRSGNEALKASWGPLFIGIV
AVIGFFGCFGIWAALAPLDGAVIAPGEVVSSLNRQIVQHLEGGIVKKILVTEGETVEKEQPLVYLNSTAAQANLGIIKEK
LLVLLATEARLNAIKSHATTVEFPDEIFKLSSEDVVSKVLENQKELFFSQNNSITGQIQILRQRIKQLHQELAGLASQLE
AEEKQYHLIDEELETKKSLLDAGYISKPYLLNLERLHANAEGKLGHIRATIASTEQKIGENRLEIINITNTVMDRANAEL
KETASTITDLRERLRAAEDVLERTVIRSPQHGIVTGLKYHTEGGVIPPGGVIMEVVPIDDDFIIDAKISIRNIEEILSAQ
TVEENLVTSGEYRGLKAKVRLSAFNIRKFGLVNGIVTQVSADALADPHGMRYYSLRVVIPKSSHSGKFKNLKLYHGMPAE
VFVVTRSRTLLEYLLTPITSTFEKAFKER

Specific function: Involved in the secretion of alkaline protease [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 56180; Mature: 56180

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKLSGAISFLKIDLSLTRLLGHNSLNKEKGGDSCNSKLLSGSLAILDGMTSFIFRLQK
CCCCHHHHHHHEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
KRSGNEALKASWGPLFIGIVAVIGFFGCFGIWAALAPLDGAVIAPGEVVSSLNRQIVQHL
HCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHH
EGGIVKKILVTEGETVEKEQPLVYLNSTAAQANLGIIKEKLLVLLATEARLNAIKSHATT
CCCCEEEHEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCE
VEFPDEIFKLSSEDVVSKVLENQKELFFSQNNSITGQIQILRQRIKQLHQELAGLASQLE
ECCCHHHHHCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AEEKQYHLIDEELETKKSLLDAGYISKPYLLNLERLHANAEGKLGHIRATIASTEQKIGE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHCCCCCCCCEEEEHHHHHHHHHHCC
NRLEIINITNTVMDRANAELKETASTITDLRERLRAAEDVLERTVIRSPQHGIVTGLKYH
CCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECEEEE
TEGGVIPPGGVIMEVVPIDDDFIIDAKISIRNIEEILSAQTVEENLVTSGEYRGLKAKVR
CCCCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
LSAFNIRKFGLVNGIVTQVSADALADPHGMRYYSLRVVIPKSSHSGKFKNLKLYHGMPAE
EEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEEECCCCCE
VFVVTRSRTLLEYLLTPITSTFEKAFKER
EEEEECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYSKLSGAISFLKIDLSLTRLLGHNSLNKEKGGDSCNSKLLSGSLAILDGMTSFIFRLQK
CCCCHHHHHHHEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
KRSGNEALKASWGPLFIGIVAVIGFFGCFGIWAALAPLDGAVIAPGEVVSSLNRQIVQHL
HCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHH
EGGIVKKILVTEGETVEKEQPLVYLNSTAAQANLGIIKEKLLVLLATEARLNAIKSHATT
CCCCEEEHEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCE
VEFPDEIFKLSSEDVVSKVLENQKELFFSQNNSITGQIQILRQRIKQLHQELAGLASQLE
ECCCHHHHHCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AEEKQYHLIDEELETKKSLLDAGYISKPYLLNLERLHANAEGKLGHIRATIASTEQKIGE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHCCCCCCCCEEEEHHHHHHHHHHCC
NRLEIINITNTVMDRANAELKETASTITDLRERLRAAEDVLERTVIRSPQHGIVTGLKYH
CCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECEEEE
TEGGVIPPGGVIMEVVPIDDDFIIDAKISIRNIEEILSAQTVEENLVTSGEYRGLKAKVR
CCCCCCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
LSAFNIRKFGLVNGIVTQVSADALADPHGMRYYSLRVVIPKSSHSGKFKNLKLYHGMPAE
EEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEEECCCCCE
VFVVTRSRTLLEYLLTPITSTFEKAFKER
EEEEECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1427098; 10984043 [H]