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The map label for this gene is thiL [H]

Identifier: 88607240

GI number: 88607240

Start: 780131

End: 781087

Strand: Direct

Name: thiL [H]

Synonym: APH_0735

Alternate gene names: 88607240

Gene position: 780131-781087 (Clockwise)

Preceding gene: 88607053

Following gene: 88607051

Centisome position: 53.02

GC content: 37.72

Gene sequence:

>957_bases
ATGGATGAGTTTCAGTGTATAGAAAAATATATACGTCCTTTACTTCGCAGTGGGTTTGCATCTGAAAATGACGATGCTGC
GCATGTATCCTCCCCTACATCGTCTTTTATCATGACAAAAGATGTATTAGTTGAAAATGTTCATTTCTTAAATCATAGCG
ATCCTTTCTTACTCGCTAAAAAGGCGCTACGAGTTAACCTATCAGATATAGCTTCTATGGGAGCTACACCGCATTCTTAT
CTTTTGGGATTATCGCTTCCAAAATTTATTGATGAAGAATGGTGGAAAAGCTTTTGCGCCGGTTTACAAGAAGATAACAG
TATTTTTTCCATCAAGCTAACAGGTGGTGATACAACCAATAATTTAGCAGATATCATCGTAATAAGCATAACCGCCTTGG
GAATTCCATCTGCAAATATTCTTACTAGATCTAATGCAAAAGTAGGAGATTATCTATATGTTAGTGGAACTATTGGTGAT
GCTGCTTTAGGATTGCTAGCATACAATAAAAAGCTAATTGGTGAGTTTTCCTATCTCAAGCAAAGATATGATTTACCTCA
GCCTAGAGTTATGTTAGGCACCAGTATTAGCAATGTAGCTTCTGCATGCATAGATGTTTCTGATGGATTATTACAGGATA
TTGGGCTGTTGTGTAAGCTTTCCGGTGTTGGTGCAAATTTATACGCTTATGAAGTACCACTATCACACGAAGCCGCAGCT
GCTATAATGCAAAATCACGATCTTTTAGAAAACGTACTGGCAGGAGGAGATGATTACGAACTGGCATTTACGGTCCCTCC
CAAATACTGTCCAGAAGTTGAGCAAATTGCCACGAATATAAAAATCCCCGTAAAAAGAATAGGAGTCATTACTCGTGAAC
AAGGAATACGTGTATACGACAGAAATAACAACCTTATGAAAATATCAAAAGAGGGCTATAGTCACACCTTTTCTTAA

Upstream 100 bases:

>100_bases
AATATTAGGCAGCATTTTTACAAAATATTACTGTTGGCACATTTATTTTTTGAAAGGAACGCTTTATATAGACGGAACGC
AGAACGCTGTTGGATGAATT

Downstream 100 bases:

>100_bases
GTTAATGACTTTGCAGGAAAAACACCTCTATGGCTTGAATAACCTGTAGAACTGCCACTTCAGTAAGCGTTTTTTTCAGC
GTTCTTATAAATACAATTAC

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDEFQCIEKYIRPLLRSGFASENDDAAHVSSPTSSFIMTKDVLVENVHFLNHSDPFLLAKKALRVNLSDIASMGATPHSY
LLGLSLPKFIDEEWWKSFCAGLQEDNSIFSIKLTGGDTTNNLADIIVISITALGIPSANILTRSNAKVGDYLYVSGTIGD
AALGLLAYNKKLIGEFSYLKQRYDLPQPRVMLGTSISNVASACIDVSDGLLQDIGLLCKLSGVGANLYAYEVPLSHEAAA
AIMQNHDLLENVLAGGDDYELAFTVPPKYCPEVEQIATNIKIPVKRIGVITREQGIRVYDRNNNLMKISKEGYSHTFS

Sequences:

>Translated_318_residues
MDEFQCIEKYIRPLLRSGFASENDDAAHVSSPTSSFIMTKDVLVENVHFLNHSDPFLLAKKALRVNLSDIASMGATPHSY
LLGLSLPKFIDEEWWKSFCAGLQEDNSIFSIKLTGGDTTNNLADIIVISITALGIPSANILTRSNAKVGDYLYVSGTIGD
AALGLLAYNKKLIGEFSYLKQRYDLPQPRVMLGTSISNVASACIDVSDGLLQDIGLLCKLSGVGANLYAYEVPLSHEAAA
AIMQNHDLLENVLAGGDDYELAFTVPPKYCPEVEQIATNIKIPVKRIGVITREQGIRVYDRNNNLMKISKEGYSHTFS
>Mature_318_residues
MDEFQCIEKYIRPLLRSGFASENDDAAHVSSPTSSFIMTKDVLVENVHFLNHSDPFLLAKKALRVNLSDIASMGATPHSY
LLGLSLPKFIDEEWWKSFCAGLQEDNSIFSIKLTGGDTTNNLADIIVISITALGIPSANILTRSNAKVGDYLYVSGTIGD
AALGLLAYNKKLIGEFSYLKQRYDLPQPRVMLGTSISNVASACIDVSDGLLQDIGLLCKLSGVGANLYAYEVPLSHEAAA
AIMQNHDLLENVLAGGDDYELAFTVPPKYCPEVEQIATNIKIPVKRIGVITREQGIRVYDRNNNLMKISKEGYSHTFS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=325, Percent_Identity=35.6923076923077, Blast_Score=167, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34813; Mature: 34813

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEFQCIEKYIRPLLRSGFASENDDAAHVSSPTSSFIMTKDVLVENVHFLNHSDPFLLAK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHCCCCCCCHHHHH
KALRVNLSDIASMGATPHSYLLGLSLPKFIDEEWWKSFCAGLQEDNSIFSIKLTGGDTTN
HHHHCCHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCC
NLADIIVISITALGIPSANILTRSNAKVGDYLYVSGTIGDAALGLLAYNKKLIGEFSYLK
CHHHEEEEEEECCCCCCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QRYDLPQPRVMLGTSISNVASACIDVSDGLLQDIGLLCKLSGVGANLYAYEVPLSHEAAA
HHCCCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHEEECCCCCEEEEEECCCCHHHHH
AIMQNHDLLENVLAGGDDYELAFTVPPKYCPEVEQIATNIKIPVKRIGVITREQGIRVYD
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCHHHHCEEECCCCEEEEE
RNNNLMKISKEGYSHTFS
CCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MDEFQCIEKYIRPLLRSGFASENDDAAHVSSPTSSFIMTKDVLVENVHFLNHSDPFLLAK
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHCCCCCCCHHHHH
KALRVNLSDIASMGATPHSYLLGLSLPKFIDEEWWKSFCAGLQEDNSIFSIKLTGGDTTN
HHHHCCHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCC
NLADIIVISITALGIPSANILTRSNAKVGDYLYVSGTIGDAALGLLAYNKKLIGEFSYLK
CHHHEEEEEEECCCCCCCCEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QRYDLPQPRVMLGTSISNVASACIDVSDGLLQDIGLLCKLSGVGANLYAYEVPLSHEAAA
HHCCCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHEEECCCCCEEEEEECCCCHHHHH
AIMQNHDLLENVLAGGDDYELAFTVPPKYCPEVEQIATNIKIPVKRIGVITREQGIRVYD
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCHHHHCEEECCCCEEEEE
RNNNLMKISKEGYSHTFS
CCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]