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The map label for this gene is tpiA [H]

Identifier: 88607189

GI number: 88607189

Start: 650446

End: 651252

Strand: Direct

Name: tpiA [H]

Synonym: APH_0624

Alternate gene names: 88607189

Gene position: 650446-651252 (Clockwise)

Preceding gene: 88606887

Following gene: 88607856

Centisome position: 44.21

GC content: 44.61

Gene sequence:

>807_bases
TTGGTAGAGCGCCTGACTTGTAATCAGGATGTTGTCGGTTCGAGTCCGGCAGTCGGCTCTCTCTGTGTAATTATTATGGA
TGATATGTCCTTTCTTGTTGTTGCGAATTGGAAGGCTAACGGTAATGCAAGGCTAGCTGAAAGTTTCTTGGATGTTCTGT
CTTCTCAAAACTCATTATCAGGTGGTTCTACGTGCAGCGTGGTGTTGTGTCCTCCATATACTGCTATGCCTTCATTAAGG
GGGCGAAGTTGTGTAGTTAGGTTAGGTGGGCAGGACTGTTTTGCTGGGGTGAGTCGTGGTTGTACCGGTGAAATCACTGC
TAAAATGCTGCGGGAATGTGGCTGTGAATATGTAATACTAGGGCACTCTGACCGGCGGACTCTACTTAATGAGAGTGACT
CTTTGATAAAGCTTAAGGCTGAGAGTGCTATAGGAGAATGCCTTATTCCGATAATATGTGTGGGAGAAAATAGGGAAGAG
CGAGAAAGTGGTGCTACTGGAAGGGTTTTATTGGAGCAATGCCGAAGTTGTCTTCCTGAAGAGGGGGAGTTTTTTGTTGC
GTATGAACCTATATGGGCTATAGGTGGTTCTGTTATCCCTGATATTGCGATGATAGAGGAGGCTTTTTCTATCATTAAGT
CGCATAATCCTGGGCTTCGTATCATATATGGTGGTTCTGTAAATGAGAGTAACATACGCTCGCTGAAAACAGGTGTTAGT
GGTATCGCTGGGGTATTAGTGGGTAGTGCTAGTCTAGATGCTGATGGATTTGCTAGAATGTTGGATAATGTGATGGAATG
CTTATAG

Upstream 100 bases:

>100_bases
ATGTTTTAGTGTATTGACTTTTATCCTAACATGTATATCATAGCTACCGCTAGCTGTTATAGGATTTAGTTTTCGCGATG
GTTGGCCGGCTTAGCTATAA

Downstream 100 bases:

>100_bases
GTCATATATGCTAAGGGGAATAGTTACCTGCTTTGTTGCGCTTTGTAGCCTTTCTTTTTTGTTTTTTACTAATGTAGCTC
TCTCTGCAGATGCTCCGTCT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MVERLTCNQDVVGSSPAVGSLCVIIMDDMSFLVVANWKANGNARLAESFLDVLSSQNSLSGGSTCSVVLCPPYTAMPSLR
GRSCVVRLGGQDCFAGVSRGCTGEITAKMLRECGCEYVILGHSDRRTLLNESDSLIKLKAESAIGECLIPIICVGENREE
RESGATGRVLLEQCRSCLPEEGEFFVAYEPIWAIGGSVIPDIAMIEEAFSIIKSHNPGLRIIYGGSVNESNIRSLKTGVS
GIAGVLVGSASLDADGFARMLDNVMECL

Sequences:

>Translated_268_residues
MVERLTCNQDVVGSSPAVGSLCVIIMDDMSFLVVANWKANGNARLAESFLDVLSSQNSLSGGSTCSVVLCPPYTAMPSLR
GRSCVVRLGGQDCFAGVSRGCTGEITAKMLRECGCEYVILGHSDRRTLLNESDSLIKLKAESAIGECLIPIICVGENREE
RESGATGRVLLEQCRSCLPEEGEFFVAYEPIWAIGGSVIPDIAMIEEAFSIIKSHNPGLRIIYGGSVNESNIRSLKTGVS
GIAGVLVGSASLDADGFARMLDNVMECL
>Mature_268_residues
MVERLTCNQDVVGSSPAVGSLCVIIMDDMSFLVVANWKANGNARLAESFLDVLSSQNSLSGGSTCSVVLCPPYTAMPSLR
GRSCVVRLGGQDCFAGVSRGCTGEITAKMLRECGCEYVILGHSDRRTLLNESDSLIKLKAESAIGECLIPIICVGENREE
RESGATGRVLLEQCRSCLPEEGEFFVAYEPIWAIGGSVIPDIAMIEEAFSIIKSHNPGLRIIYGGSVNESNIRSLKTGVS
GIAGVLVGSASLDADGFARMLDNVMECL

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=239, Percent_Identity=33.4728033472803, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI226529917, Length=236, Percent_Identity=33.8983050847458, Blast_Score=121, Evalue=6e-28,
Organism=Escherichia coli, GI1790353, Length=242, Percent_Identity=36.3636363636364, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17536593, Length=248, Percent_Identity=33.8709677419355, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320255, Length=238, Percent_Identity=34.0336134453782, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28572008, Length=238, Percent_Identity=38.2352941176471, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28572006, Length=238, Percent_Identity=38.2352941176471, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28572004, Length=238, Percent_Identity=38.2352941176471, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 28496; Mature: 28496

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERLTCNQDVVGSSPAVGSLCVIIMDDMSFLVVANWKANGNARLAESFLDVLSSQNSLS
CCCCCCCCCCCCCCCCCHHHEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
GGSTCSVVLCPPYTAMPSLRGRSCVVRLGGQDCFAGVSRGCTGEITAKMLRECGCEYVIL
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEE
GHSDRRTLLNESDSLIKLKAESAIGECLIPIICVGENREERESGATGRVLLEQCRSCLPE
ECCCCHHHHCCCCCEEEEECHHHHHHEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCC
EGEFFVAYEPIWAIGGSVIPDIAMIEEAFSIIKSHNPGLRIIYGGSVNESNIRSLKTGVS
CCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
GIAGVLVGSASLDADGFARMLDNVMECL
HHHHHHCCCCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MVERLTCNQDVVGSSPAVGSLCVIIMDDMSFLVVANWKANGNARLAESFLDVLSSQNSLS
CCCCCCCCCCCCCCCCCHHHEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCC
GGSTCSVVLCPPYTAMPSLRGRSCVVRLGGQDCFAGVSRGCTGEITAKMLRECGCEYVIL
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHCCCCEEEE
GHSDRRTLLNESDSLIKLKAESAIGECLIPIICVGENREERESGATGRVLLEQCRSCLPE
ECCCCHHHHCCCCCEEEEECHHHHHHEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHCCC
EGEFFVAYEPIWAIGGSVIPDIAMIEEAFSIIKSHNPGLRIIYGGSVNESNIRSLKTGVS
CCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHH
GIAGVLVGSASLDADGFARMLDNVMECL
HHHHHHCCCCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA