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The map label for this gene is pyrG

Identifier: 88607103

GI number: 88607103

Start: 34514

End: 36139

Strand: Reverse

Name: pyrG

Synonym: APH_0038

Alternate gene names: 88607103

Gene position: 36139-34514 (Counterclockwise)

Preceding gene: 88607260

Following gene: 88607566

Centisome position: 2.46

GC content: 44.59

Gene sequence:

>1626_bases
ATGGTGGGTAAGTTAAATCCAACACGTTTTATATTTGTTACTGGTGGAGTGGTCTCTTCGCTAGGTAAGGGTCTTGCCGC
AGCATCTATAGGTGCGCTGCTGCAGGCACGCGGGTTTAGTGTGCGCTTAAGAAAGCTCGATCCGTATTTAAACGTGGACC
CTGGCACTATGAGTCCTGCCCAGCACGGTGAGGTATTTGTGACCTCTGATGGTGGCGAGACGGACTTAGACCTCGGACAT
TACGAACGTTTCACTGGCGTAATGAAGACAAGGGCAGATAACGTAACTGCTGGTAAAATATACCATGAGCTTATAGTAAA
GGAACGTCGGGGAGATTATCTTGGGCAGACGGTACAGGTGATACCGCATGTGATAGATTTGATAATCTCATGTATCCTTC
ATAATGATGCAGGGGCTGACTTTGTTATATGTGAAATAGGCGGTACTGTTGGTGATATAGAAAGTCAACCGTTTCTGGAA
GCGATACGTCAGGTCAGTTACAGGTTGAGTAAGAATCTAACGATTTTTGTACACCTAACGCTAGTGCCGTATATAGGTGC
TGTCGGGGAGCTAAAAACAAAACCTACTCAGCACTCTGTAAAGGAGTTGAGTTCTTTGGGGATACAGCCAGATATTGTTT
TGTATCGTAGTAGGGCGCAGTTGCCGCAGTACCAGTGTGCTAAAATAGCCAACTTCTGTAATGTGGCAGAGGACAACATC
ATAGCTGCTCTTGATGTTAGTAACATTTACATGTTGCCTGTGATGTATCATGAGCATAGGCTTGATACGCAAATTCTCAA
ACATTTTGATGTAGACAGTCCTGAACCTGATCTTACGCAGTGGGAAAATGTGCTAAGAATGTCTGAGACTGCGTCAGACA
GGATTGTCATTGCTATAGTTGGTAAGTATGTTACCTCCTTGGATGCTTATACCTCTTTGGAGGAAGCTTTGCGTCATGCA
GGGTTGCATAGTGGTATCCGTGTAGAGATAAAGTGGGTAGATGCGCGTTTGCCTGCTTCTGAAATTGATCTTACCGATGC
GGATGCAATATTAATTCCTGGTGGATTTGGTGACAACGGTATAGGGACAAAGATTTGCGCTATAGAATACGCTCGCGTGA
ACAATATTCCGATGTTGGGAATATGTTTGGGGATGCAGTTAGCAGTAATTGAATTTGCCCTTAACGTTGCAGGAATTGAA
GATGCGAATTCTACTGAATTCAAGTCTGATTGTAAAAACCCCGTGGTTTGTGAATTGCCGGGTTTGCAAGTGGGAGATGA
GTATAAGATGGGCGGAAGTATGCGTCTGGGATCTTACACATGCAATTTAGCGCCGGGTTCTCGTATAATGTCTATATACG
ATTCTTCAACAGTTGTGGAGCGTCGTAGGCATAGGTATGGGATAAACCCTGAGTATAGGGATGTGCTTTCTAAGTGTGGC
CTTGCGTTTACTGGTGCTGCCGAAGATCGAGATTTGCCTGAGGTACTTGAGTTGCCTGATCATCCTTGGTTTATTGGTGT
ACAGTTTCATCCGGAGTTTCAATCTACTCCTTTTAAATCTCATCCTCTGTTCCTTTCTTTTGTAACCAGCACTTTGCAGG
TGAAAAAGGCTTCGTCCCGGAGTTAG

Upstream 100 bases:

>100_bases
TCAGGGTGTGCCTGGGGTTGATTTTGCTGGAGAGTCCGAATTGGTTTCAGGCCAGGATGCTGGTATTGGTGAAGTTCCCT
CTGAGTAGTAGCGTTTACAT

Downstream 100 bases:

>100_bases
GAAGTTCCTCAACGAACACAGGAGTTCTTGTGGCTATTCTTAATTTTTGTCATTTAGTGTCTCTTAGAGGTTGCTTCCTA
ATTGAGTGTATTTAACATCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MVGKLNPTRFIFVTGGVVSSLGKGLAAASIGALLQARGFSVRLRKLDPYLNVDPGTMSPAQHGEVFVTSDGGETDLDLGH
YERFTGVMKTRADNVTAGKIYHELIVKERRGDYLGQTVQVIPHVIDLIISCILHNDAGADFVICEIGGTVGDIESQPFLE
AIRQVSYRLSKNLTIFVHLTLVPYIGAVGELKTKPTQHSVKELSSLGIQPDIVLYRSRAQLPQYQCAKIANFCNVAEDNI
IAALDVSNIYMLPVMYHEHRLDTQILKHFDVDSPEPDLTQWENVLRMSETASDRIVIAIVGKYVTSLDAYTSLEEALRHA
GLHSGIRVEIKWVDARLPASEIDLTDADAILIPGGFGDNGIGTKICAIEYARVNNIPMLGICLGMQLAVIEFALNVAGIE
DANSTEFKSDCKNPVVCELPGLQVGDEYKMGGSMRLGSYTCNLAPGSRIMSIYDSSTVVERRRHRYGINPEYRDVLSKCG
LAFTGAAEDRDLPEVLELPDHPWFIGVQFHPEFQSTPFKSHPLFLSFVTSTLQVKKASSRS

Sequences:

>Translated_541_residues
MVGKLNPTRFIFVTGGVVSSLGKGLAAASIGALLQARGFSVRLRKLDPYLNVDPGTMSPAQHGEVFVTSDGGETDLDLGH
YERFTGVMKTRADNVTAGKIYHELIVKERRGDYLGQTVQVIPHVIDLIISCILHNDAGADFVICEIGGTVGDIESQPFLE
AIRQVSYRLSKNLTIFVHLTLVPYIGAVGELKTKPTQHSVKELSSLGIQPDIVLYRSRAQLPQYQCAKIANFCNVAEDNI
IAALDVSNIYMLPVMYHEHRLDTQILKHFDVDSPEPDLTQWENVLRMSETASDRIVIAIVGKYVTSLDAYTSLEEALRHA
GLHSGIRVEIKWVDARLPASEIDLTDADAILIPGGFGDNGIGTKICAIEYARVNNIPMLGICLGMQLAVIEFALNVAGIE
DANSTEFKSDCKNPVVCELPGLQVGDEYKMGGSMRLGSYTCNLAPGSRIMSIYDSSTVVERRRHRYGINPEYRDVLSKCG
LAFTGAAEDRDLPEVLELPDHPWFIGVQFHPEFQSTPFKSHPLFLSFVTSTLQVKKASSRS
>Mature_541_residues
MVGKLNPTRFIFVTGGVVSSLGKGLAAASIGALLQARGFSVRLRKLDPYLNVDPGTMSPAQHGEVFVTSDGGETDLDLGH
YERFTGVMKTRADNVTAGKIYHELIVKERRGDYLGQTVQVIPHVIDLIISCILHNDAGADFVICEIGGTVGDIESQPFLE
AIRQVSYRLSKNLTIFVHLTLVPYIGAVGELKTKPTQHSVKELSSLGIQPDIVLYRSRAQLPQYQCAKIANFCNVAEDNI
IAALDVSNIYMLPVMYHEHRLDTQILKHFDVDSPEPDLTQWENVLRMSETASDRIVIAIVGKYVTSLDAYTSLEEALRHA
GLHSGIRVEIKWVDARLPASEIDLTDADAILIPGGFGDNGIGTKICAIEYARVNNIPMLGICLGMQLAVIEFALNVAGIE
DANSTEFKSDCKNPVVCELPGLQVGDEYKMGGSMRLGSYTCNLAPGSRIMSIYDSSTVVERRRHRYGINPEYRDVLSKCG
LAFTGAAEDRDLPEVLELPDHPWFIGVQFHPEFQSTPFKSHPLFLSFVTSTLQVKKASSRS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=41.6363636363636, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=40.8679927667269, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=40.8679927667269, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=40.8679927667269, Blast_Score=422, Evalue=1e-118,
Organism=Escherichia coli, GI1789142, Length=544, Percent_Identity=51.8382352941177, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25148299, Length=614, Percent_Identity=36.6449511400651, Blast_Score=383, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=41.4285714285714, Blast_Score=409, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=40.8199643493761, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24664469, Length=550, Percent_Identity=40.9090909090909, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=39.5959595959596, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_ANAPZ (Q2GLS9)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504672.1
- HSSP:   P17812
- ProteinModelPortal:   Q2GLS9
- SMR:   Q2GLS9
- STRING:   Q2GLS9
- GeneID:   3930011
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0038
- NMPDR:   fig|212042.5.peg.33
- TIGR:   APH_0038
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   TEWLRGN
- ProtClustDB:   PRK05380
- BioCyc:   APHA212042:APH_0038-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59455; Mature: 59455

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 382-382 ACT_SITE 510-510 ACT_SITE 512-512

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGKLNPTRFIFVTGGVVSSLGKGLAAASIGALLQARGFSVRLRKLDPYLNVDPGTMSPA
CCCCCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCC
QHGEVFVTSDGGETDLDLGHYERFTGVMKTRADNVTAGKIYHELIVKERRGDYLGQTVQV
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
IPHVIDLIISCILHNDAGADFVICEIGGTVGDIESQPFLEAIRQVSYRLSKNLTIFVHLT
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
LVPYIGAVGELKTKPTQHSVKELSSLGIQPDIVLYRSRAQLPQYQCAKIANFCNVAEDNI
EHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCE
IAALDVSNIYMLPVMYHEHRLDTQILKHFDVDSPEPDLTQWENVLRMSETASDRIVIAIV
EEEEECCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
GKYVTSLDAYTSLEEALRHAGLHSGIRVEIKWVDARLPASEIDLTDADAILIPGGFGDNG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHCCCCCCCEEEECCCCCCCC
IGTKICAIEYARVNNIPMLGICLGMQLAVIEFALNVAGIEDANSTEFKSDCKNPVVCELP
CCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEECC
GLQVGDEYKMGGSMRLGSYTCNLAPGSRIMSIYDSSTVVERRRHRYGINPEYRDVLSKCG
CCCCCCCCCCCCCEEECCEEEECCCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCC
LAFTGAAEDRDLPEVLELPDHPWFIGVQFHPEFQSTPFKSHPLFLSFVTSTLQVKKASSR
CEEECCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
S
C
>Mature Secondary Structure
MVGKLNPTRFIFVTGGVVSSLGKGLAAASIGALLQARGFSVRLRKLDPYLNVDPGTMSPA
CCCCCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCC
QHGEVFVTSDGGETDLDLGHYERFTGVMKTRADNVTAGKIYHELIVKERRGDYLGQTVQV
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
IPHVIDLIISCILHNDAGADFVICEIGGTVGDIESQPFLEAIRQVSYRLSKNLTIFVHLT
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
LVPYIGAVGELKTKPTQHSVKELSSLGIQPDIVLYRSRAQLPQYQCAKIANFCNVAEDNI
EHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCE
IAALDVSNIYMLPVMYHEHRLDTQILKHFDVDSPEPDLTQWENVLRMSETASDRIVIAIV
EEEEECCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
GKYVTSLDAYTSLEEALRHAGLHSGIRVEIKWVDARLPASEIDLTDADAILIPGGFGDNG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHCCCCCCCEEEECCCCCCCC
IGTKICAIEYARVNNIPMLGICLGMQLAVIEFALNVAGIEDANSTEFKSDCKNPVVCELP
CCCEEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEECC
GLQVGDEYKMGGSMRLGSYTCNLAPGSRIMSIYDSSTVVERRRHRYGINPEYRDVLSKCG
CCCCCCCCCCCCCEEECCEEEECCCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCC
LAFTGAAEDRDLPEVLELPDHPWFIGVQFHPEFQSTPFKSHPLFLSFVTSTLQVKKASSR
CEEECCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA