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The map label for this gene is pyrD [H]

Identifier: 88607083

GI number: 88607083

Start: 1071160

End: 1072212

Strand: Direct

Name: pyrD [H]

Synonym: APH_1013

Alternate gene names: 88607083

Gene position: 1071160-1072212 (Clockwise)

Preceding gene: 88607448

Following gene: 88607377

Centisome position: 72.8

GC content: 43.59

Gene sequence:

>1053_bases
ATGTCGCTTTTCAGGTTTAATAATCCGCTTTTTCTTATACCACCTAAAGTTGCACACAGCCTAACGCTCTTTGCGCTGCA
GCAGGGTTTATATAGCTCTAGTGTACGTAAAATGCCTGAATGTTTGAGCGCTCAGCCTCTGAATTTCAAAGTACGCACTC
CCATCGGTCTGGCTGCAGGGTTTGATAAAAACGCTGAGGTAATACGTCCAGTGCTTTCACTTGGATTTGGGTTCACAGAG
GTTGGCACTGTGACAAAATATCCTCAATCTGGGAATAAAGGGCCTCGTCTTTTCCGCATGCATAAACAGAAGGCCGTAAT
AAATCGTCTGGGGTTCAATAATAAGGGTCTGACGCGTTTGTTAAAGAAGGTAGACTCTAAAGACTTGAACAACCTGGTAT
TTGGCATAAACGTAGGTATGTATAAAGGGTGTTCTGACCCTCCTGCCGAATATGCAGAGTTAGTACAGAAGGTTTACGGG
CTTTCTAGCTATATAACAATCAACCTCTCTTCTCCAAATACTGCTGGATTGAGGGAGTTGCAAAAAAGAAACTCTCTGAA
CGAAATACTAGCATCCGTGAGAAAGGCTAGGTACGCGGTTGATCACGCAGAATCTGTGCCTATTCTCTTAAAAATAGATC
CTGATCTCTCGGATGAAGTATTGCAAGACGTAGTAGATGAGGTTTTAAGGCATAAGATAAACGGAATAATAGTCAGTAAT
ACTACGACCAATTTCAAGCTTTTAGGTACAAAAGCACCTATCTCTAGGGGTGGTTTGAGCGGCCAGCCCTTGTTTTCCTT
ATCCACGAGAGTGCTAGCAGATGTATATTCTCAAACTCGAGGAAGAGTGGTGCTCGTGGGTTGCGGTGGTGTTAGTAGCG
GAGCCCAAGCTCTGGAAAAGATTAGAGCTGGTGCATCCCTGGTGCAATTATACACTGCTATAGTTTATGGGGGTTTTGGT
ATTATTGACAAAATCAACATGGAGCTTGCTGATTTGCTCACACGCGATGGGTTCAATAAAGTGGAGCAAGCCGTAGGAAT
AGATGTACATTGA

Upstream 100 bases:

>100_bases
AATAGTTGTTGTAAGAACTGCAGAAAATCCTATTGTGTGGGGTTTTGTTATTTTTAGCGACTGTGGTATAATCGCAAAGA
TTTAGTGAAATTTAGAGATA

Downstream 100 bases:

>100_bases
CGAGCAATATGCTAGCTATAGTTGATGTTGGAAATACCAACATAAAATTCACTTTATATGTCGATGGGGAGTTTTCAGAG
AGCTGGTATATATCGACTTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSLFRFNNPLFLIPPKVAHSLTLFALQQGLYSSSVRKMPECLSAQPLNFKVRTPIGLAAGFDKNAEVIRPVLSLGFGFTE
VGTVTKYPQSGNKGPRLFRMHKQKAVINRLGFNNKGLTRLLKKVDSKDLNNLVFGINVGMYKGCSDPPAEYAELVQKVYG
LSSYITINLSSPNTAGLRELQKRNSLNEILASVRKARYAVDHAESVPILLKIDPDLSDEVLQDVVDEVLRHKINGIIVSN
TTTNFKLLGTKAPISRGGLSGQPLFSLSTRVLADVYSQTRGRVVLVGCGGVSSGAQALEKIRAGASLVQLYTAIVYGGFG
IIDKINMELADLLTRDGFNKVEQAVGIDVH

Sequences:

>Translated_350_residues
MSLFRFNNPLFLIPPKVAHSLTLFALQQGLYSSSVRKMPECLSAQPLNFKVRTPIGLAAGFDKNAEVIRPVLSLGFGFTE
VGTVTKYPQSGNKGPRLFRMHKQKAVINRLGFNNKGLTRLLKKVDSKDLNNLVFGINVGMYKGCSDPPAEYAELVQKVYG
LSSYITINLSSPNTAGLRELQKRNSLNEILASVRKARYAVDHAESVPILLKIDPDLSDEVLQDVVDEVLRHKINGIIVSN
TTTNFKLLGTKAPISRGGLSGQPLFSLSTRVLADVYSQTRGRVVLVGCGGVSSGAQALEKIRAGASLVQLYTAIVYGGFG
IIDKINMELADLLTRDGFNKVEQAVGIDVH
>Mature_349_residues
SLFRFNNPLFLIPPKVAHSLTLFALQQGLYSSSVRKMPECLSAQPLNFKVRTPIGLAAGFDKNAEVIRPVLSLGFGFTEV
GTVTKYPQSGNKGPRLFRMHKQKAVINRLGFNNKGLTRLLKKVDSKDLNNLVFGINVGMYKGCSDPPAEYAELVQKVYGL
SSYITINLSSPNTAGLRELQKRNSLNEILASVRKARYAVDHAESVPILLKIDPDLSDEVLQDVVDEVLRHKINGIIVSNT
TTNFKLLGTKAPISRGGLSGQPLFSLSTRVLADVYSQTRGRVVLVGCGGVSSGAQALEKIRAGASLVQLYTAIVYGGFGI
IDKINMELADLLTRDGFNKVEQAVGIDVH

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=346, Percent_Identity=40.7514450867052, Blast_Score=252, Evalue=3e-67,
Organism=Escherichia coli, GI1787177, Length=327, Percent_Identity=39.7553516819572, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17509475, Length=343, Percent_Identity=41.1078717201166, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI281361352, Length=343, Percent_Identity=41.6909620991254, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI17137316, Length=343, Percent_Identity=41.6909620991254, Blast_Score=251, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38118; Mature: 37987

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFRFNNPLFLIPPKVAHSLTLFALQQGLYSSSVRKMPECLSAQPLNFKVRTPIGLAAG
CCCEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEECC
FDKNAEVIRPVLSLGFGFTEVGTVTKYPQSGNKGPRLFRMHKQKAVINRLGFNNKGLTRL
CCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LKKVDSKDLNNLVFGINVGMYKGCSDPPAEYAELVQKVYGLSSYITINLSSPNTAGLREL
HHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
QKRNSLNEILASVRKARYAVDHAESVPILLKIDPDLSDEVLQDVVDEVLRHKINGIIVSN
HHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEC
TTTNFKLLGTKAPISRGGLSGQPLFSLSTRVLADVYSQTRGRVVLVGCGGVSSGAQALEK
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
IRAGASLVQLYTAIVYGGFGIIDKINMELADLLTRDGFNKVEQAVGIDVH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SLFRFNNPLFLIPPKVAHSLTLFALQQGLYSSSVRKMPECLSAQPLNFKVRTPIGLAAG
CCEEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEECC
FDKNAEVIRPVLSLGFGFTEVGTVTKYPQSGNKGPRLFRMHKQKAVINRLGFNNKGLTRL
CCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LKKVDSKDLNNLVFGINVGMYKGCSDPPAEYAELVQKVYGLSSYITINLSSPNTAGLREL
HHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
QKRNSLNEILASVRKARYAVDHAESVPILLKIDPDLSDEVLQDVVDEVLRHKINGIIVSN
HHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEC
TTTNFKLLGTKAPISRGGLSGQPLFSLSTRVLADVYSQTRGRVVLVGCGGVSSGAQALEK
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
IRAGASLVQLYTAIVYGGFGIIDKINMELADLLTRDGFNKVEQAVGIDVH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA