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The map label for this gene is uvrD [H]

Identifier: 88606993

GI number: 88606993

Start: 959318

End: 961297

Strand: Direct

Name: uvrD [H]

Synonym: APH_0903

Alternate gene names: 88606993

Gene position: 959318-961297 (Clockwise)

Preceding gene: 88607466

Following gene: 88607569

Centisome position: 65.2

GC content: 40.71

Gene sequence:

>1980_bases
ATGGAATATCGCGATTTTCCGCAAGCAAACTGCACATCTCAGCAGGTCGAAGAACATTACCCTGAAGACTTCATGCTCAA
CCTAAATGCCGAACAAAAAGAAGCAGTGCTGCAAGTAGCAGGCCCAGTCTTGATCTTGGCAGGCGCAGGTACTGGGAAAA
CTCGCACAATAACCGCTAGAATGGGGCATATAATAAAAGAGGGATATGCACAACCTCACGAAATTCTCGCAGTTACATTC
ACAAATAAGGCTGCAAAAGAAATGCTCTCTCGAGTTAATAATATTGTTACTGCTTCTGGCATATGGCTCGGAACATTTCA
CGCAATAGCTGCGCGTATTTTGCGTAGCCACGCAGAATTGGTAGGATTAAGCAGCAATTTCACGATAATAAGCCCTGATG
ATCAGCTACAGATCACAAAGACAATAGCGGCGGATATGCAACAAGGTTATCCAGCCACAGAATGCAAAGGCATTCTCCAT
ACTATACAGAGGTGGAAAGAGAAAGGACTATTGCCTCATGATATTACTGAAACAGAATTACAAAGATCTTCTAACAGTTT
TGCTCTTAGAGTATACGAAGAATACCAAGAACGCCTTAAAGCCCTAAATTGTGCCGATTTTGGTGATTTATTACTCCACA
ACGTTACTATACTTAGTGCAAATCCTGATGTCCTTGCGCATTATCAAGAACACCTTAGATATGTTATGGTTGATGAGTAT
CAAGACATCAACACAATACAATATCTGTGGCTTCGCTTACTAGTGCGTCGACATAAAAACCTATGCTGCGTAGGAGATGA
TGATCAATCCATATATAACTGGAGAGGAGCAGAAGTCGGCAACATACTCAGATTTTCAGATGATTTCCCAGACGCTAAAG
TAATAAGGCTGGAATGTAATTATAGGTCAACGTCTAACATATTAGCCTCAGCATCAGCGATAATTGATAATAATAAATCC
CGCCTTAAAAAAACATTATGGACGCACAATCAGGCAGGACAAAAAGTTGGTTTAATGAAGTTCTTCGATGGACGGCTCGA
AGCTCAATACATTAGTGAGCATATTAAGAGCTCTTACGATTATAAATTTAGTGAAACTGCTGTTCTAGTAAGAGCCAGCT
TTCAGACTAGAGTCTTCGAGGAGTTCTTCGTAAGATATGGTATACCTTACAAAATTATCGGCGGAACCAAGTTCTATGAT
AGGGTAGAAATCCGCGATCTTGTTGCATATCTCAAAGTAGTAGTCAACCCCAATAACGACATAGCGTTTGAGAAAATTAT
AAATAAGCCCAAACGCAAGCTCGGAACTTCTACTGTCAATAAGCTTCGTGCATATGGGAGAAAGCACAGTATTTCCCTAA
CTGAAGCCGGACACTCAATGATAAAAGATGGATTACTATCTGATAATACATCCAACATTCTGCAAGATCTTCTCAAGCAG
TTTGATGATTGGAGAGAAATGTTAAGTAGAGATTCATCCGTCAATGTACTAAAAGCTATTGCTCATGACTCTGGATATAT
AGAATCTCTAAAAAAAGACGGGGAATCAGGTCTATCAAGAATAGAGAACATAAAGGAACTCTTCTCAGCCGTATCAGGAT
TCGATGATGTGTCGAAGTTTTTAGAACACATTAGCTTAGTGGCAGAAAATGATTCTTTAGAAGAAGACAATAACTACGTA
CACGTTATGACATTACATGCCGCAAAGGGGTTGGAGTTCCCGTTGGTTTTCCTCCCCGGATGGGAGGAAGGAGTCTTCCC
ACACGAAAAATCCATGAATGACATAACTGGAAACGCTCTGGAAGAAGAGAGGCGCTTAGCCTATGTTGGCATAACAAGAG
CTAGAGAGCAGCTATACATATCATGTGCTGCAATGAGAGAAATCAATAACTGGAGCCAATCCATGAAAATGTCTCGTTTC
ATAAAGGAACTCCCCAGAGAACATGTACAGGTGCTGCATAATATGACTGGTTACGCGTAG

Upstream 100 bases:

>100_bases
CTATTTTAATCCTTGTTTTTGTTGATTGTATGCTCCTTTAAGTTACTATAAACAGACACCGCGTCTGTACGGCAATCTAC
ATCTCTAGGAGCGTTAAGTT

Downstream 100 bases:

>100_bases
TATATCTGTGAGTCTGGTATATAATTAGCTAATGTTAAGAAAAATCCAGGCAATGTGGAGCTGTTGCGTGCAAGGCAACG
CTTAAGTACCCCACATATGT

Product: UvrD/Rep family helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MEYRDFPQANCTSQQVEEHYPEDFMLNLNAEQKEAVLQVAGPVLILAGAGTGKTRTITARMGHIIKEGYAQPHEILAVTF
TNKAAKEMLSRVNNIVTASGIWLGTFHAIAARILRSHAELVGLSSNFTIISPDDQLQITKTIAADMQQGYPATECKGILH
TIQRWKEKGLLPHDITETELQRSSNSFALRVYEEYQERLKALNCADFGDLLLHNVTILSANPDVLAHYQEHLRYVMVDEY
QDINTIQYLWLRLLVRRHKNLCCVGDDDQSIYNWRGAEVGNILRFSDDFPDAKVIRLECNYRSTSNILASASAIIDNNKS
RLKKTLWTHNQAGQKVGLMKFFDGRLEAQYISEHIKSSYDYKFSETAVLVRASFQTRVFEEFFVRYGIPYKIIGGTKFYD
RVEIRDLVAYLKVVVNPNNDIAFEKIINKPKRKLGTSTVNKLRAYGRKHSISLTEAGHSMIKDGLLSDNTSNILQDLLKQ
FDDWREMLSRDSSVNVLKAIAHDSGYIESLKKDGESGLSRIENIKELFSAVSGFDDVSKFLEHISLVAENDSLEEDNNYV
HVMTLHAAKGLEFPLVFLPGWEEGVFPHEKSMNDITGNALEEERRLAYVGITRAREQLYISCAAMREINNWSQSMKMSRF
IKELPREHVQVLHNMTGYA

Sequences:

>Translated_659_residues
MEYRDFPQANCTSQQVEEHYPEDFMLNLNAEQKEAVLQVAGPVLILAGAGTGKTRTITARMGHIIKEGYAQPHEILAVTF
TNKAAKEMLSRVNNIVTASGIWLGTFHAIAARILRSHAELVGLSSNFTIISPDDQLQITKTIAADMQQGYPATECKGILH
TIQRWKEKGLLPHDITETELQRSSNSFALRVYEEYQERLKALNCADFGDLLLHNVTILSANPDVLAHYQEHLRYVMVDEY
QDINTIQYLWLRLLVRRHKNLCCVGDDDQSIYNWRGAEVGNILRFSDDFPDAKVIRLECNYRSTSNILASASAIIDNNKS
RLKKTLWTHNQAGQKVGLMKFFDGRLEAQYISEHIKSSYDYKFSETAVLVRASFQTRVFEEFFVRYGIPYKIIGGTKFYD
RVEIRDLVAYLKVVVNPNNDIAFEKIINKPKRKLGTSTVNKLRAYGRKHSISLTEAGHSMIKDGLLSDNTSNILQDLLKQ
FDDWREMLSRDSSVNVLKAIAHDSGYIESLKKDGESGLSRIENIKELFSAVSGFDDVSKFLEHISLVAENDSLEEDNNYV
HVMTLHAAKGLEFPLVFLPGWEEGVFPHEKSMNDITGNALEEERRLAYVGITRAREQLYISCAAMREINNWSQSMKMSRF
IKELPREHVQVLHNMTGYA
>Mature_659_residues
MEYRDFPQANCTSQQVEEHYPEDFMLNLNAEQKEAVLQVAGPVLILAGAGTGKTRTITARMGHIIKEGYAQPHEILAVTF
TNKAAKEMLSRVNNIVTASGIWLGTFHAIAARILRSHAELVGLSSNFTIISPDDQLQITKTIAADMQQGYPATECKGILH
TIQRWKEKGLLPHDITETELQRSSNSFALRVYEEYQERLKALNCADFGDLLLHNVTILSANPDVLAHYQEHLRYVMVDEY
QDINTIQYLWLRLLVRRHKNLCCVGDDDQSIYNWRGAEVGNILRFSDDFPDAKVIRLECNYRSTSNILASASAIIDNNKS
RLKKTLWTHNQAGQKVGLMKFFDGRLEAQYISEHIKSSYDYKFSETAVLVRASFQTRVFEEFFVRYGIPYKIIGGTKFYD
RVEIRDLVAYLKVVVNPNNDIAFEKIINKPKRKLGTSTVNKLRAYGRKHSISLTEAGHSMIKDGLLSDNTSNILQDLLKQ
FDDWREMLSRDSSVNVLKAIAHDSGYIESLKKDGESGLSRIENIKELFSAVSGFDDVSKFLEHISLVAENDSLEEDNNYV
HVMTLHAAKGLEFPLVFLPGWEEGVFPHEKSMNDITGNALEEERRLAYVGITRAREQLYISCAAMREINNWSQSMKMSRF
IKELPREHVQVLHNMTGYA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=642, Percent_Identity=39.0965732087227, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI48994965, Length=650, Percent_Identity=36.3076923076923, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1787196, Length=336, Percent_Identity=27.0833333333333, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=734, Percent_Identity=26.9754768392371, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324477, Length=655, Percent_Identity=24.4274809160305, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 75049; Mature: 75049

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRDFPQANCTSQQVEEHYPEDFMLNLNAEQKEAVLQVAGPVLILAGAGTGKTRTITAR
CCCCCCCCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHCCCEEEEEECCCCCCEEEHHH
MGHIIKEGYAQPHEILAVTFTNKAAKEMLSRVNNIVTASGIWLGTFHAIAARILRSHAEL
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHH
VGLSSNFTIISPDDQLQITKTIAADMQQGYPATECKGILHTIQRWKEKGLLPHDITETEL
EECCCCEEEECCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
QRSSNSFALRVYEEYQERLKALNCADFGDLLLHNVTILSANPDVLAHYQEHLRYVMVDEY
HHCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCHHHHHHHHHCCEEEECCC
QDINTIQYLWLRLLVRRHKNLCCVGDDDQSIYNWRGAEVGNILRFSDDFPDAKVIRLECN
CCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCEEEECCCCCCCEEEEEEEC
YRSTSNILASASAIIDNNKSRLKKTLWTHNQAGQKVGLMKFFDGRLEAQYISEHIKSSYD
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCC
YKFSETAVLVRASFQTRVFEEFFVRYGIPYKIIGGTKFYDRVEIRDLVAYLKVVVNPNND
CCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHEEECCCCC
IAFEKIINKPKRKLGTSTVNKLRAYGRKHSISLTEAGHSMIKDGLLSDNTSNILQDLLKQ
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FDDWREMLSRDSSVNVLKAIAHDSGYIESLKKDGESGLSRIENIKELFSAVSGFDDVSKF
HHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHH
LEHISLVAENDSLEEDNNYVHVMTLHAAKGLEFPLVFLPGWEEGVFPHEKSMNDITGNAL
HHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHH
EEERRLAYVGITRAREQLYISCAAMREINNWSQSMKMSRFIKELPREHVQVLHNMTGYA
HHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEYRDFPQANCTSQQVEEHYPEDFMLNLNAEQKEAVLQVAGPVLILAGAGTGKTRTITAR
CCCCCCCCCCCCHHHHHHHCCCCEEEECCCHHHHHHHHHCCCEEEEEECCCCCCEEEHHH
MGHIIKEGYAQPHEILAVTFTNKAAKEMLSRVNNIVTASGIWLGTFHAIAARILRSHAEL
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHH
VGLSSNFTIISPDDQLQITKTIAADMQQGYPATECKGILHTIQRWKEKGLLPHDITETEL
EECCCCEEEECCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
QRSSNSFALRVYEEYQERLKALNCADFGDLLLHNVTILSANPDVLAHYQEHLRYVMVDEY
HHCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCHHHHHHHHHCCEEEECCC
QDINTIQYLWLRLLVRRHKNLCCVGDDDQSIYNWRGAEVGNILRFSDDFPDAKVIRLECN
CCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCEEEECCCCCCCEEEEEEEC
YRSTSNILASASAIIDNNKSRLKKTLWTHNQAGQKVGLMKFFDGRLEAQYISEHIKSSYD
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCC
YKFSETAVLVRASFQTRVFEEFFVRYGIPYKIIGGTKFYDRVEIRDLVAYLKVVVNPNND
CCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHEEECCCCC
IAFEKIINKPKRKLGTSTVNKLRAYGRKHSISLTEAGHSMIKDGLLSDNTSNILQDLLKQ
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FDDWREMLSRDSSVNVLKAIAHDSGYIESLKKDGESGLSRIENIKELFSAVSGFDDVSKF
HHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHH
LEHISLVAENDSLEEDNNYVHVMTLHAAKGLEFPLVFLPGWEEGVFPHEKSMNDITGNAL
HHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHH
EEERRLAYVGITRAREQLYISCAAMREINNWSQSMKMSRFIKELPREHVQVLHNMTGYA
HHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA