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The map label for this gene is lolC [H]

Identifier: 88606867

GI number: 88606867

Start: 1404364

End: 1405563

Strand: Reverse

Name: lolC [H]

Synonym: APH_1341

Alternate gene names: 88606867

Gene position: 1405563-1404364 (Counterclockwise)

Preceding gene: 88607207

Following gene: 88607601

Centisome position: 95.53

GC content: 43.08

Gene sequence:

>1200_bases
ATGGGTTTAGAGTGGTTACTCGCGCGTAGGTATCTGAGTTCTAAAAAAGGGCGATTCTTGTGTTCTCCCATGAGCGTATT
TTCCATCCTGGGAATCTCTATAGGAGTAGCTACCCTAGTCTCAGTCATGGCAGTTATGAGCGGTTTCTCTGCTAAGTTAT
TGCATAACATTCTTGGGATGAATGGACACATTACTGTTCATTGTCAGGATGTGGATTATCACACAGTCATCCCTGAAGTA
GAGAGCACAGCGGGTGTAGTGTCTGCCGTAGCTGTGTTGGAAGGACAGGTTATGGTGAAATCAGAACATGCAGCAGTCGG
TGCAGTGCTTAGGGGCATGGAAATGCCTGATATTAGCGATAAACTGTCGCAATATGTAGTCAGTGGAGATACCGAAGAGT
TAGAAGCAGGAATAATCATAGGCTCTAGACTAGCTGAAAGCTTAAATGTTTACTACGGTGATGAGGTGGTTGTGATTTCC
TCGTCCAGCTTCTCGACTATGCCACGAACGCATGAGTATAAAGTTACGGGGATTTTCAATGTGGGTATGTACGAGTATGA
TAGCGCATTTGTGTATGTGCCCCTAGAAAGTGCTCAGACTCTCTTAGGATACGATGGCGGAATGCAATATGTAGAGGTTA
GAGTAGATGATGCCTTGCACTCTTCTAATATCGTAAAAGAACTCATTGAGAAGACAAAGATGCGAGTGGAAGATTGGAAA
GTCCAGCATGGACAGTACTTCTACGCATTGGAATTAGAGCGTGATGCCATGTTTTTTATTCTGACGTTAATTATTGTTGT
GGCTGCCTTTAATATAATTTCAGGAATTTCTGTGTTAGTACAGGATAAGACAAAGGCTGTGGCTGTGATGCGTACTATGG
GATTGAGTAAGTTTGCGGTGGCTAGGATATTCTGCATGTGTGGTGTGTGTATAGGTGCTATAGGCACTGGAATAGGATGT
TGCTTGGGTGTCTTGTTTTCTTTAAACATGGAGAGGGTGAGTGACTTTTTGATGATGTTCGGCCAGGGTGCATTTTTTGA
ATCTATCGCATATTGTTTGGAAGGTATTCCGTCCAAGATGGTGTTCTTAGATGTTGTGCGAGTGGCATCTTTGTCGTTGT
GTATTTCACTAATAGCAGCGTTGCTCCCAGCGCTTAGAGCAGCGTATCAAAATCCTGTAGATATTCTTAAATATGAGTAA

Upstream 100 bases:

>100_bases
TTTTTGGGAAGGTATCTGTAGTATTCGGATATACAGGGAAAATTGTAACCATACTGGAAGCATGATATAGATGGTTCTGC
AATGTACAATAACAACGCCA

Downstream 100 bases:

>100_bases
GCAAATGCGAAGAGAAACATGTTGTTGGATGAGTATATTCTGTATTTTTGCGTTATGGATGGGAGGAATTGTATACTTTG
TTCTTGATATGAGGCAAAAT

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MGLEWLLARRYLSSKKGRFLCSPMSVFSILGISIGVATLVSVMAVMSGFSAKLLHNILGMNGHITVHCQDVDYHTVIPEV
ESTAGVVSAVAVLEGQVMVKSEHAAVGAVLRGMEMPDISDKLSQYVVSGDTEELEAGIIIGSRLAESLNVYYGDEVVVIS
SSSFSTMPRTHEYKVTGIFNVGMYEYDSAFVYVPLESAQTLLGYDGGMQYVEVRVDDALHSSNIVKELIEKTKMRVEDWK
VQHGQYFYALELERDAMFFILTLIIVVAAFNIISGISVLVQDKTKAVAVMRTMGLSKFAVARIFCMCGVCIGAIGTGIGC
CLGVLFSLNMERVSDFLMMFGQGAFFESIAYCLEGIPSKMVFLDVVRVASLSLCISLIAALLPALRAAYQNPVDILKYE

Sequences:

>Translated_399_residues
MGLEWLLARRYLSSKKGRFLCSPMSVFSILGISIGVATLVSVMAVMSGFSAKLLHNILGMNGHITVHCQDVDYHTVIPEV
ESTAGVVSAVAVLEGQVMVKSEHAAVGAVLRGMEMPDISDKLSQYVVSGDTEELEAGIIIGSRLAESLNVYYGDEVVVIS
SSSFSTMPRTHEYKVTGIFNVGMYEYDSAFVYVPLESAQTLLGYDGGMQYVEVRVDDALHSSNIVKELIEKTKMRVEDWK
VQHGQYFYALELERDAMFFILTLIIVVAAFNIISGISVLVQDKTKAVAVMRTMGLSKFAVARIFCMCGVCIGAIGTGIGC
CLGVLFSLNMERVSDFLMMFGQGAFFESIAYCLEGIPSKMVFLDVVRVASLSLCISLIAALLPALRAAYQNPVDILKYE
>Mature_398_residues
GLEWLLARRYLSSKKGRFLCSPMSVFSILGISIGVATLVSVMAVMSGFSAKLLHNILGMNGHITVHCQDVDYHTVIPEVE
STAGVVSAVAVLEGQVMVKSEHAAVGAVLRGMEMPDISDKLSQYVVSGDTEELEAGIIIGSRLAESLNVYYGDEVVVISS
SSFSTMPRTHEYKVTGIFNVGMYEYDSAFVYVPLESAQTLLGYDGGMQYVEVRVDDALHSSNIVKELIEKTKMRVEDWKV
QHGQYFYALELERDAMFFILTLIIVVAAFNIISGISVLVQDKTKAVAVMRTMGLSKFAVARIFCMCGVCIGAIGTGIGCC
LGVLFSLNMERVSDFLMMFGQGAFFESIAYCLEGIPSKMVFLDVVRVASLSLCISLIAALLPALRAAYQNPVDILKYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=411, Percent_Identity=29.683698296837, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787362, Length=415, Percent_Identity=26.9879518072289, Blast_Score=137, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43538; Mature: 43406

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLEWLLARRYLSSKKGRFLCSPMSVFSILGISIGVATLVSVMAVMSGFSAKLLHNILGM
CCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
NGHITVHCQDVDYHTVIPEVESTAGVVSAVAVLEGQVMVKSEHAAVGAVLRGMEMPDISD
CCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCHHH
KLSQYVVSGDTEELEAGIIIGSRLAESLNVYYGDEVVVISSSSFSTMPRTHEYKVTGIFN
HHHHHHHCCCHHHHHHHEEEHHHHHHHCCEEECCEEEEEECCCCCCCCCCCEEEEEEEEE
VGMYEYDSAFVYVPLESAQTLLGYDGGMQYVEVRVDDALHSSNIVKELIEKTKMRVEDWK
CCEEEECCEEEEEECCCCHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHE
VQHGQYFYALELERDAMFFILTLIIVVAAFNIISGISVLVQDKTKAVAVMRTMGLSKFAV
EECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHCCHHHHH
ARIFCMCGVCIGAIGTGIGCCLGVLFSLNMERVSDFLMMFGQGAFFESIAYCLEGIPSKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
VFLDVVRVASLSLCISLIAALLPALRAAYQNPVDILKYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECC
>Mature Secondary Structure 
GLEWLLARRYLSSKKGRFLCSPMSVFSILGISIGVATLVSVMAVMSGFSAKLLHNILGM
CHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
NGHITVHCQDVDYHTVIPEVESTAGVVSAVAVLEGQVMVKSEHAAVGAVLRGMEMPDISD
CCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCHHH
KLSQYVVSGDTEELEAGIIIGSRLAESLNVYYGDEVVVISSSSFSTMPRTHEYKVTGIFN
HHHHHHHCCCHHHHHHHEEEHHHHHHHCCEEECCEEEEEECCCCCCCCCCCEEEEEEEEE
VGMYEYDSAFVYVPLESAQTLLGYDGGMQYVEVRVDDALHSSNIVKELIEKTKMRVEDWK
CCEEEECCEEEEEECCCCHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHE
VQHGQYFYALELERDAMFFILTLIIVVAAFNIISGISVLVQDKTKAVAVMRTMGLSKFAV
EECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHCCHHHHH
ARIFCMCGVCIGAIGTGIGCCLGVLFSLNMERVSDFLMMFGQGAFFESIAYCLEGIPSKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHH
VFLDVVRVASLSLCISLIAALLPALRAAYQNPVDILKYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]