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The map label for this gene is panB

Identifier: 88196546

GI number: 88196546

Start: 2683527

End: 2684318

Strand: Reverse

Name: panB

Synonym: SAOUHSC_02919

Alternate gene names: 88196546

Gene position: 2684318-2683527 (Counterclockwise)

Preceding gene: 88196548

Following gene: 88196545

Centisome position: 95.14

GC content: 36.74

Gene sequence:

>792_bases
ATGAAACAAAAGCAAACTAAAATTTCTATGGTAACAGCTTATGATTTTCCAAGTGCTAAACAAGTGGAAGCAGCGGGTAT
TGATATGATTCTTGTTGGGGATTCACTTGGTATGACTGTATTAGGTTATGAAAGTACCGTACAAGTGACGTTAGCAGATA
TGATTCATCACGGTCGTGCAGTAAGAAGAGGCGCACCAAATACATTTGTAGTTGTTGATATGCCGATTGGTGCAGTAGGC
ATCTCTATGACACAAGACTTAAATCATGCTCTAAAGCTTTATCAGGAGACGAATGCAAATGCAATTAAAGCAGAAGGAGC
GCATATTACACCATTTATTGAAAAAGCAACGGCAATTGGTATTCCTGTTGTTGCACATTTAGGATTAACACCTCAAAGTG
TTGGCGTTATGGGGTATAAATTACAAGGTGCAACGAAAGAAGCAGCGGAGCAACTTATTTTAGACGCGAAAAATGTAGAA
CAAGCTGGTGCAGTTGCGTTAGTACTTGAAGCAATTCCAAATGATTTAGCAGAAGAAATTAGCAAGCACTTAACAATTCC
AGTCATTGGTATTGGTGCAGGAAAAGGTACAGATGGTCAAGTATTGGTTTATCACGATATGTTAAATTATGGTGTTGAAC
ATAAAGCGAAATTTGTGAAGCAATTTGCTGATTTTAGTGTTGGTGTGGATGGTTTAAAACAATACGATCAAGAAGTTAAA
TCTGGTGCATTTCCATCAGAAGAATATACGTATAAAAAGAAAATTATGAATGAGGTTAATAACAATGACTAA

Upstream 100 bases:

>100_bases
TCTTCTTCTTTCCTTTCTATAAAAGATTCATTATACTATTTCTAATAATACTGCAAAAAGAGGTTGAATAACATTGAAAA
CAGTAAGTCAATTAATAGAT

Downstream 100 bases:

>100_bases
GCTGATTACTACGGTAAAAGAGATGCAACACATTGTTAAAGCAGCCAAACGCTCAGGCACAACGATTGGTTTTATCCCAA
CAATGGGTGCCTTACATGAT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRAVRRGAPNTFVVVDMPIGAVG
ISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVE
QAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVK
SGAFPSEEYTYKKKIMNEVNNND

Sequences:

>Translated_263_residues
MKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRAVRRGAPNTFVVVDMPIGAVG
ISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVE
QAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVK
SGAFPSEEYTYKKKIMNEVNNND
>Mature_263_residues
MKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRAVRRGAPNTFVVVDMPIGAVG
ISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVE
QAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVK
SGAFPSEEYTYKKKIMNEVNNND

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=256, Percent_Identity=44.53125, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319653, Length=266, Percent_Identity=37.593984962406, Blast_Score=176, Evalue=5e-45,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_STAA1 (A7X6X7)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001443173.1
- ProteinModelPortal:   A7X6X7
- SMR:   A7X6X7
- STRING:   A7X6X7
- EnsemblBacteria:   EBSTAT00000003098
- GeneID:   5560899
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2583
- eggNOG:   COG0413
- GeneTree:   EBGT00050000025039
- HOGENOM:   HBG299908
- OMA:   YATPEQT
- ProtClustDB:   PRK00311
- BioCyc:   SAUR418127:SAHV_2583-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 28240; Mature: 28240

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: ACT_SITE 179-179 BINDING 82-82 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRA
CCCCCCEEEEEEEECCCCCCCHHHCCEEEEEECCCCCEEEEECCCEEEHHHHHHHHCCHH
VRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIG
HHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCEECHHHHHHHHCC
IPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEQAGAVALVLEAIPNDLAEEI
CHHHHHCCCCCHHCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHH
SKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVK
HHCCEEEEEEEECCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SGAFPSEEYTYKKKIMNEVNNND
HCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRA
CCCCCCEEEEEEEECCCCCCCHHHCCEEEEEECCCCCEEEEECCCEEEHHHHHHHHCCHH
VRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIG
HHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCEECHHHHHHHHCC
IPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEQAGAVALVLEAIPNDLAEEI
CHHHHHCCCCCHHCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHH
SKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVK
HHCCEEEEEEEECCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SGAFPSEEYTYKKKIMNEVNNND
HCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA