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The map label for this gene is ubiE

Identifier: 88195204

GI number: 88195204

Start: 1443873

End: 1444475

Strand: Reverse

Name: ubiE

Synonym: SAOUHSC_01487

Alternate gene names: 88195204

Gene position: 1444475-1443873 (Counterclockwise)

Preceding gene: 88195205

Following gene: 88195203

Centisome position: 51.2

GC content: 35.32

Gene sequence:

>603_bases
ATGAAAGACATGGGTGTTAGAAAAGGGACGAAAGCATTAGATGTTTGTTGTGGTACTGGTGATTGGACAATCGCATTAAG
CAAAGCTGTAGGACCAACAGGTGAAGTTACTGGTATTGACTTTAGTGAGAATATGTTAGAAGTAGGAAAAGAAAAAACTG
CTTCAATGGAAAATGTTAAACTTGTTCATGGTGATGCAATGGAATTGCCGTTTGAAGACAATTCTTTTGATTATGTAACA
ATTGGGTTTGGATTAAGAAATGTGCCAGACTATTTAGTCGCGTTAAAAGAAATGAATAGAGTACTTAAACCAGGTGGTAT
GGTGGTATGTCTTGAAACGAGCCAACCAACTTTGCCAGTCTTTAAACAAATGTATGCACTATACTTTAAATTTGTTATGC
CTATTTTTGGAAAATTATTTGCAAAATCAAAAGAAGAATATGAATGGTTACAGCAATCTACGTTTAATTTTCCTGGAAAA
GAAGAGTTGAAGCGCATGTTTGAAGAAGCAGGTTTCATAAATGTAAGAGTACGTAGTTTTACAGGGGGCGTTGCTGCAAT
GCACCTTGGCTATAAAGAAAAAGATAATACCAAAGGTGATTAA

Upstream 100 bases:

>100_bases
AGAGCAAGTACATCGCGTTTTTCAAAATATTTCAAAAAAATATGATAGATTAAATAATATTATTAGTTTTGAGCAGCATA
AAGTATGGAGAAAACGCGTC

Downstream 100 bases:

>100_bases
CGTGGCAAAGTTAAACATGAACAATGAAATTAAGAAAGTGGAACAACGACTTGAAAAGGCAATAAAAAGTAAAGATTCTG
TATTAGAACAGGCATCATTA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYVT
IGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPVFKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGK
EELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKGD

Sequences:

>Translated_200_residues
MKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYVT
IGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPVFKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGK
EELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKGD
>Mature_200_residues
MKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVKLVHGDAMELPFEDNSFDYVT
IGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPVFKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGK
EELKRMFEEAGFINVRVRSFTGGVAAMHLGYKEKDNTKGD

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=160, Percent_Identity=43.75, Blast_Score=134, Evalue=4e-32,
Organism=Escherichia coli, GI48994983, Length=191, Percent_Identity=43.979057591623, Blast_Score=159, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17557039, Length=196, Percent_Identity=34.1836734693878, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25143945, Length=109, Percent_Identity=31.1926605504587, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323526, Length=195, Percent_Identity=32.3076923076923, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24641702, Length=208, Percent_Identity=35.5769230769231, Blast_Score=116, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_STAA1 (A7X2H6)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442049.1
- ProteinModelPortal:   A7X2H6
- STRING:   A7X2H6
- EnsemblBacteria:   EBSTAT00000004549
- GeneID:   5559333
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1459
- eggNOG:   COG2226
- GeneTree:   EBGT00050000024451
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   SAUR418127:SAHV_1459-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 22371; Mature: 22371

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVK
CCCCCCCCCCHHHEEEECCCCEEEEEECCCCCCCCEECCCCHHHHHHHCHHHHCCCCCEE
LVHGDAMELPFEDNSFDYVTIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPV
EEECCEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
FKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEEC
TGGVAAMHLGYKEKDNTKGD
CCCCHHEECCCCCCCCCCCC
>Mature Secondary Structure
MKDMGVRKGTKALDVCCGTGDWTIALSKAVGPTGEVTGIDFSENMLEVGKEKTASMENVK
CCCCCCCCCCHHHEEEECCCCEEEEEECCCCCCCCEECCCCHHHHHHHCHHHHCCCCCEE
LVHGDAMELPFEDNSFDYVTIGFGLRNVPDYLVALKEMNRVLKPGGMVVCLETSQPTLPV
EEECCEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
FKQMYALYFKFVMPIFGKLFAKSKEEYEWLQQSTFNFPGKEELKRMFEEAGFINVRVRSF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEEC
TGGVAAMHLGYKEKDNTKGD
CCCCHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA