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The map label for this gene is ndk

Identifier: 88195202

GI number: 88195202

Start: 1442371

End: 1442802

Strand: Reverse

Name: ndk

Synonym: SAOUHSC_01485

Alternate gene names: 88195202

Gene position: 1442802-1442371 (Counterclockwise)

Preceding gene: 88195203

Following gene: 88195201

Centisome position: 51.14

GC content: 34.03

Gene sequence:

>432_bases
ATGATTAAACCAGATGCAGTACAAAGAAATCTAATTGGTGAAGTAATTTCAAGAATTGAAAGAAAAGGACTAAAACTTGT
CGGTGGTAAATTAATGCAAGTACCAATGGAACTTGCTGAAACACATTATGGTGAACACCAAGGTAAACCATTTTATAATG
ATTTAATTTCATTTATTACATCAGCACCAGTGTTCGCAATGGTAGTTGAAGGTGAAGATGCAGTTAATGTATCTAGACAT
ATTATTGGCAGCACCAATCCTTCAGAAGCTTCACCAGGATCAATTAGAGGTGATTTAGGTTTAACTGTTGGTAGAAATAT
CATTCACGGTTCAGATTCATTAGAGTCTGCTGAACGTGAAATTAATCTATGGTTTAATGAAAATGAAATTACTAGCTATG
CTTCACCACGTGATGCATGGTTATATGAATAA

Upstream 100 bases:

>100_bases
AAAGTATTGAAAGCGCTTTACCAACCTGTTAATATATAATAGTAATATACATAAACCTATTAAACACAGGGGGATACATA
AAGTGGAACGTACATTTTTA

Downstream 100 bases:

>100_bases
AATATAAACTGTAAACCTTTACGATTTATTTATAAAGGTAGAAAGGGTTTTGTTATGTGGTTAGTCATTATGATTATACA
TAACAAGGCCCGTTTTTTAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRH
IIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE

Sequences:

>Translated_143_residues
MIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRH
IIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE
>Mature_143_residues
MIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFITSAPVFAMVVEGEDAVNVSRH
IIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAEREINLWFNENEITSYASPRDAWLYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=142, Percent_Identity=52.8169014084507, Blast_Score=167, Evalue=4e-42,
Organism=Homo sapiens, GI4557797, Length=142, Percent_Identity=51.4084507042254, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI38045913, Length=142, Percent_Identity=51.4084507042254, Blast_Score=161, Evalue=1e-40,
Organism=Homo sapiens, GI66392203, Length=142, Percent_Identity=48.5915492957746, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI66392227, Length=142, Percent_Identity=48.5915492957746, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI66392205, Length=142, Percent_Identity=48.5915492957746, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI4505409, Length=142, Percent_Identity=48.5915492957746, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI66392192, Length=142, Percent_Identity=48.5915492957746, Blast_Score=153, Evalue=4e-38,
Organism=Homo sapiens, GI4826862, Length=133, Percent_Identity=51.1278195488722, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.7777777777778, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7019465, Length=128, Percent_Identity=36.71875, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI37574614, Length=128, Percent_Identity=36.71875, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4505413, Length=130, Percent_Identity=31.5384615384615, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI148839372, Length=134, Percent_Identity=32.089552238806, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=45.0381679389313, Blast_Score=131, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=143, Percent_Identity=48.2517482517483, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71995094, Length=128, Percent_Identity=33.59375, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=142, Percent_Identity=51.4084507042254, Blast_Score=168, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45549037, Length=143, Percent_Identity=48.951048951049, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI18860097, Length=130, Percent_Identity=33.8461538461538, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_STAA1 (A7X2H3)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442047.1
- ProteinModelPortal:   A7X2H3
- SMR:   A7X2H3
- STRING:   A7X2H3
- EnsemblBacteria:   EBSTAT00000003246
- GeneID:   5559968
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1457
- eggNOG:   COG0105
- GeneTree:   EBGT00050000025527
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   SAUR418127:SAHV_1457-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15797; Mature: 15797

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFIT
CCCCHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAERE
CCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCEEECCCCHHHHHHHH
INLWFNENEITSYASPRDAWLYE
EEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKPDAVQRNLIGEVISRIERKGLKLVGGKLMQVPMELAETHYGEHQGKPFYNDLISFIT
CCCCHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SAPVFAMVVEGEDAVNVSRHIIGSTNPSEASPGSIRGDLGLTVGRNIIHGSDSLESAERE
CCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCEEECCCCHHHHHHHH
INLWFNENEITSYASPRDAWLYE
EEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA