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The map label for this gene is fadA [H]

Identifier: 88194005

GI number: 88194005

Start: 214246

End: 215430

Strand: Reverse

Name: fadA [H]

Synonym: SAOUHSC_00195

Alternate gene names: 88194005

Gene position: 215430-214246 (Counterclockwise)

Preceding gene: 88194006

Following gene: 88194004

Centisome position: 7.64

GC content: 43.29

Gene sequence:

>1185_bases
ATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCAAAGCAAGGCGCATTATTCCACGAAAGACC
TGATGATGTCGCAGCCAAAGTATTACAAGGCGTATTGAAACGTATTGACGGAAAATTCAATAAGAATATGATTGAAGATG
TCATTGTTGGTACGGCTTTTCCAGAAGGATTACAAGGCCAAAACATTGCACGAACGATTGCATTGCGTGCGGGATTATCT
GACACGGTACCGGGTCAAACAGTGAATCGCTACTGCTCATCAGGATTACAAACCATCGCGATTGCAGCCAATCAAATTAT
GGCTGGTCAAGGAGATATACTTGTAGCTGGTGGCGTTGAATTGATGAGTGCCGTACCAATGGGTGGCAACGAGCCCACAA
ACAATCCAACCTTACAATATGATGATATAGGTGCGTCATATCCTATGGGTTTAACTGCTGAAAATGTAGCATCCCAATTT
GACGTATCACGCGAAGATCAAGATGCTTATGCTGTCAGAAGTCATCAACGTGCCTATGACGCACAACGTGATGGTCGGTT
CAAAGATGAAATTATTCCAATACAAGTAAACTCAGTTGAATATACAAACGCAGGACCAAAAGTACACACAAATATCTTTG
ACCAAGATGAATTTATACGCCCTGACACCACGATGGAGGCATTAGCCAAATTACGTACAGTATTTAAAGCTGACGGCACT
ATGACTGCAGGAACATCTGCCCCACTTTCTGATGGTGCAGGATTTGTAGTTTTAATGTCTGGAGATAAAGTGAAAGAACT
CGGCGTGACACCTATTGCACGATTCGTTGGTTTTAAGGCAGTAGGCGTTGACCCGAAAATTATGGGTATTGGGCCTGCAT
ATGCGATTCCTGAAGTATTGTCACTCAGCAATCTATCTGTTGAAGACATTGATTTGATCGAATTGAACGAAGCATTTGCT
TCTCAAACGATTGCATCTATTAAAGAAGTAGGTCTAGATATATCACGTACGAATGTGAATGGTGGCGCTATTGCTTTAGG
TCATCCATTAGGTGCTACAGGCGCAATGTTAACCGCGCGTTTACTTAATGAAATGGGTAGACGTCCCGATAGCCGTTACG
GCATGGTTACGATGTGTATTGGTGTCGGCATGGGTGCAGCTGCTATATTTGAATATGTGCGTTAG

Upstream 100 bases:

>100_bases
TACTAAAATCTAAAAAATCATATGAAAGAATTGCACATATGTTAAAAACTGGTAAGCCATTACGTAATTAAAAGATAGTC
ATTAAGAGAGGATGATAACC

Downstream 100 bases:

>100_bases
AATGGTTGATTTTGGATGAAGCGGATTCGTTTTGTTATTGAATGAAGTAGGCTGAAGTTGAAGCCAGTTGAAGTTGAAGC
GGGTTGAAGCAATTTCGTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
MTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Sequences:

>Translated_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
MTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
>Mature_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
MTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=43.9897698209719, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI167614485, Length=360, Percent_Identity=40.5555555555556, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI148539872, Length=387, Percent_Identity=39.2764857881137, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4557237, Length=354, Percent_Identity=36.4406779661017, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI4504327, Length=412, Percent_Identity=33.7378640776699, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI194353979, Length=240, Percent_Identity=35.8333333333333, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.8491484184915, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=42.0654911838791, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=39.8514851485149, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082165, Length=355, Percent_Identity=40, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=32.5242718446602, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=357, Percent_Identity=40.0560224089636, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=31.2342569269521, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=354, Percent_Identity=34.7457627118644, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=394, Percent_Identity=28.6802030456853, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=321, Percent_Identity=27.4143302180685, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=40.2469135802469, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=31.0679611650485, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.8514851485149, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI17648125, Length=356, Percent_Identity=41.2921348314607, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24640423, Length=356, Percent_Identity=35.3932584269663, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI17137578, Length=412, Percent_Identity=33.495145631068, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41837; Mature: 41837

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
MTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHC
>Mature Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
MTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]