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The map label for this gene is capL [H]

Identifier: 87201162

GI number: 87201162

Start: 3361673

End: 3362998

Strand: Direct

Name: capL [H]

Synonym: Saro_3150

Alternate gene names: 87201162

Gene position: 3361673-3362998 (Clockwise)

Preceding gene: 87201159

Following gene: 87201163

Centisome position: 94.39

GC content: 67.35

Gene sequence:

>1326_bases
GTGACCGTACAGTTCCCGTCGATCAACGCCGCTCCGCTGAAGGGCCTCGACCCGCTGGTCTGCGCGACCACCCGCGTCAC
CGTGCTAGGTCTCGGCTATGTCGGCCTGCCGCTGGCCGTAGCGCTGGCCAAGCGATTCTTCGTCACCGGCTTCGACATCG
ACGTCGAACGCATTTCCGAGCTGTCCGAAGGCCACGACCGCACCCGCGAGATCGAACCCGCGCTGCTGTCGATGTCGAGC
CTGGGCCTTACCTGCGATGCCGGGGTCTGTCCGCCAAGCGATTTCTACATCGTCACCGTGCCCACCCCTATCGACGCCGC
CAACCGCCCCAACCTGCGCCTGGTCGAGGCCGCTTCGCGCACGGTCGGCCAGATGCTTCCCCGGGCCGTGGCCGAAGGCC
GCCAGCCCATCGTCGTCTACGAAAGCACCGTCTATCCCGGCGTCACCGAGGACATCTGCGGCCCGATCCTCGAGCAGGTC
TCCGGCCTCAGGTGCGGCACGGACTTCTTCCTCGGCTACAGCCCGGAACGCATCAACCCGGGCGACCGCGAACACACCAT
CGAGCGGATAACCAAGGTCGTCTCGGGCCAGACACCCGAAGTGCTCGACCGCGTGGCCGACCTCTATGGCGCGATCACTT
CGGGCGGCGTCTTCCGCGCCGCCTCGATCAAGGCCGCCGAGGCCGCCAAGGTCATCGAGAACGCCCAGCGCGACATCAAC
ATCGCCTTCATGAACGAGATCACGCAAATCTTCTCGCGCATGGACCTTTCGGTCTGGGACGTGCTCGCGGCGGCGGGCAC
CAAATGGAACTTCCTGCCCTTCACCCCCGGCCTCGTCGGCGGACACTGCATCGGCGTCGATCCCTACTACCTCTCCGCGC
GCGCCGAAGCGCTGGGCCATGACCCGCAGGTGATCCTCGCCGGTCGCGGCGTGAACGACGGCATGGCGAAATGGGTCGCG
GGCGAGCTTCACGCGCGGCGCGGCGGCAAGCCCGGCTCGGTCCTCGTGCTGGGCCTGACGTTCAAGGAAAACGTGCCCGA
CCTGCGCAATTCCAAGGTGGCCGACGTCATCGCCGAACTGAAGGCCCTGGGCCATGCGGTCGACGTGCACGATCCCCACG
CCGATACCGCCGAGGCTCTGCTCGAATATGGCCTCGAACTCGCCGGCGACGCGTTCGAGCAGACCTACGATCTCGTGTTC
CTCGCCGTGCCGCACAAGTACTACCTGGCAGCAGGCGCGGACCGTATCGCTGCGCTCGTCGCGCCCGGCGGCACGCTGGC
CGATCTCAAGGGCGTCCTGGGCGAGGCCGCCGACTGGCGTCTCTGA

Upstream 100 bases:

>100_bases
CCAATAATCGGCGAGTGTTAACCGTGAAATAAGAGCCTCGCTTTAAGCCGACGGCAAAGTCGGCGCGCATGCGCGTCAAC
CATGAAAGGCCGCCTGCACA

Downstream 100 bases:

>100_bases
CCCTGCCCGGTCATCTGGCCCGGTCGTCTGGCCCGGACGGGCAGGCAATGACGTGCTAGGCCTGAAACGCGAATCGAAGA
CCTGCGAATTTCCGGAGAAA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTVQFPSINAAPLKGLDPLVCATTRVTVLGLGYVGLPLAVALAKRFFVTGFDIDVERISELSEGHDRTREIEPALLSMSS
LGLTCDAGVCPPSDFYIVTVPTPIDAANRPNLRLVEAASRTVGQMLPRAVAEGRQPIVVYESTVYPGVTEDICGPILEQV
SGLRCGTDFFLGYSPERINPGDREHTIERITKVVSGQTPEVLDRVADLYGAITSGGVFRAASIKAAEAAKVIENAQRDIN
IAFMNEITQIFSRMDLSVWDVLAAAGTKWNFLPFTPGLVGGHCIGVDPYYLSARAEALGHDPQVILAGRGVNDGMAKWVA
GELHARRGGKPGSVLVLGLTFKENVPDLRNSKVADVIAELKALGHAVDVHDPHADTAEALLEYGLELAGDAFEQTYDLVF
LAVPHKYYLAAGADRIAALVAPGGTLADLKGVLGEAADWRL

Sequences:

>Translated_441_residues
MTVQFPSINAAPLKGLDPLVCATTRVTVLGLGYVGLPLAVALAKRFFVTGFDIDVERISELSEGHDRTREIEPALLSMSS
LGLTCDAGVCPPSDFYIVTVPTPIDAANRPNLRLVEAASRTVGQMLPRAVAEGRQPIVVYESTVYPGVTEDICGPILEQV
SGLRCGTDFFLGYSPERINPGDREHTIERITKVVSGQTPEVLDRVADLYGAITSGGVFRAASIKAAEAAKVIENAQRDIN
IAFMNEITQIFSRMDLSVWDVLAAAGTKWNFLPFTPGLVGGHCIGVDPYYLSARAEALGHDPQVILAGRGVNDGMAKWVA
GELHARRGGKPGSVLVLGLTFKENVPDLRNSKVADVIAELKALGHAVDVHDPHADTAEALLEYGLELAGDAFEQTYDLVF
LAVPHKYYLAAGADRIAALVAPGGTLADLKGVLGEAADWRL
>Mature_440_residues
TVQFPSINAAPLKGLDPLVCATTRVTVLGLGYVGLPLAVALAKRFFVTGFDIDVERISELSEGHDRTREIEPALLSMSSL
GLTCDAGVCPPSDFYIVTVPTPIDAANRPNLRLVEAASRTVGQMLPRAVAEGRQPIVVYESTVYPGVTEDICGPILEQVS
GLRCGTDFFLGYSPERINPGDREHTIERITKVVSGQTPEVLDRVADLYGAITSGGVFRAASIKAAEAAKVIENAQRDINI
AFMNEITQIFSRMDLSVWDVLAAAGTKWNFLPFTPGLVGGHCIGVDPYYLSARAEALGHDPQVILAGRGVNDGMAKWVAG
ELHARRGGKPGSVLVLGLTFKENVPDLRNSKVADVIAELKALGHAVDVHDPHADTAEALLEYGLELAGDAFEQTYDLVFL
AVPHKYYLAAGADRIAALVAPGGTLADLKGVLGEAADWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=419, Percent_Identity=30.3102625298329, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47081; Mature: 46950

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQFPSINAAPLKGLDPLVCATTRVTVLGLGYVGLPLAVALAKRFFVTGFDIDVERISE
CEEECCCCCCCCCCCCCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LSEGHDRTREIEPALLSMSSLGLTCDAGVCPPSDFYIVTVPTPIDAANRPNLRLVEAASR
HHHCCHHHHHCCHHHHHHHHCCCEECCCCCCCCCEEEEEECCCCCCCCCCCEEEEHHHHH
TVGQMLPRAVAEGRQPIVVYESTVYPGVTEDICGPILEQVSGLRCGTDFFLGYSPERINP
HHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
GDREHTIERITKVVSGQTPEVLDRVADLYGAITSGGVFRAASIKAAEAAKVIENAQRDIN
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCEE
IAFMNEITQIFSRMDLSVWDVLAAAGTKWNFLPFTPGLVGGHCIGVDPYYLSARAEALGH
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCC
DPQVILAGRGVNDGMAKWVAGELHARRGGKPGSVLVLGLTFKENVPDLRNSKVADVIAEL
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
KALGHAVDVHDPHADTAEALLEYGLELAGDAFEQTYDLVFLAVPHKYYLAAGADRIAALV
HHHCCEECCCCCCCHHHHHHHHHCHHHCCHHHHHCCCEEEEEECCCEEECCCCHHEEEEE
APGGTLADLKGVLGEAADWRL
CCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TVQFPSINAAPLKGLDPLVCATTRVTVLGLGYVGLPLAVALAKRFFVTGFDIDVERISE
EEECCCCCCCCCCCCCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LSEGHDRTREIEPALLSMSSLGLTCDAGVCPPSDFYIVTVPTPIDAANRPNLRLVEAASR
HHHCCHHHHHCCHHHHHHHHCCCEECCCCCCCCCEEEEEECCCCCCCCCCCEEEEHHHHH
TVGQMLPRAVAEGRQPIVVYESTVYPGVTEDICGPILEQVSGLRCGTDFFLGYSPERINP
HHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCC
GDREHTIERITKVVSGQTPEVLDRVADLYGAITSGGVFRAASIKAAEAAKVIENAQRDIN
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCEE
IAFMNEITQIFSRMDLSVWDVLAAAGTKWNFLPFTPGLVGGHCIGVDPYYLSARAEALGH
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCC
DPQVILAGRGVNDGMAKWVAGELHARRGGKPGSVLVLGLTFKENVPDLRNSKVADVIAEL
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
KALGHAVDVHDPHADTAEALLEYGLELAGDAFEQTYDLVFLAVPHKYYLAAGADRIAALV
HHHCCEECCCCCCCHHHHHHHHHCHHHCCHHHHHCCCEEEEEECCCEEECCCCHHEEEEE
APGGTLADLKGVLGEAADWRL
CCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]