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The map label for this gene is msrA [H]

Identifier: 87201107

GI number: 87201107

Start: 3315106

End: 3315642

Strand: Direct

Name: msrA [H]

Synonym: Saro_3095

Alternate gene names: 87201107

Gene position: 3315106-3315642 (Clockwise)

Preceding gene: 87201102

Following gene: 87201109

Centisome position: 93.08

GC content: 64.25

Gene sequence:

>537_bases
ATGAGCGAACAAGCAACGGCCATCCTCGCGGGCGGATGCTTCTGGTGCACCGAAGCGGTCTTTCGCGACGTGATCGGGGT
CAGCAACGTCGAGAGCGGCTATATCGGCGGCACGGTCGAGAGCCCGACCTACAAGCAGGTCTGCTCCGGCAGCACCGGCC
ATGCCGAAGCGATCCGCGTGACCTTCGACCCGCAGGTCATCGGGTATGGCCAGATCCTCGACATCTTTTTCGCGACACAC
GATCCGACCCAGCTCAACCGCCAGGGCAACGACATCGGCACCCAGTACCGCTCGGCCCTGTTCCCGCTGGACGACGAACA
GCGCAGCGAGGCCAAAGCCGCCATTGGACGCGCGCAGCCCGACTGGCCGCGGCCCATCGTGACGACGATCGAAGGCCCCG
CCACATGGTATCCGGCCGAGGACTATCACCAGGAATACTGGGAAGGCGAAGGCCAGCGGAACCCCTACTGCCTGGCGGTG
ATCCCGCCCAAGCTGATGAAGTTGCGCAAGAGCTTCGCCAACAAGGTGAAGGCCTAG

Upstream 100 bases:

>100_bases
CAGGGCGAGGACTCTACGCATCCGGCGATTCTCCTTGGGCAACCGATGACAAGCGCGGGGCGCCTGCCTATCTCTGGGCG
ATCCAAGGAGAATAAGACGC

Downstream 100 bases:

>100_bases
CCCTTCACCCAGCGGGCGGCGAAGAAACCGTCGATGCCGCCCGCATCGGCAAGCATCCCGGGGTCGGAACGGAACCAGCC
GTCCGCCGCCTTCAAACCCC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSEQATAILAGGCFWCTEAVFRDVIGVSNVESGYIGGTVESPTYKQVCSGSTGHAEAIRVTFDPQVIGYGQILDIFFATH
DPTQLNRQGNDIGTQYRSALFPLDDEQRSEAKAAIGRAQPDWPRPIVTTIEGPATWYPAEDYHQEYWEGEGQRNPYCLAV
IPPKLMKLRKSFANKVKA

Sequences:

>Translated_178_residues
MSEQATAILAGGCFWCTEAVFRDVIGVSNVESGYIGGTVESPTYKQVCSGSTGHAEAIRVTFDPQVIGYGQILDIFFATH
DPTQLNRQGNDIGTQYRSALFPLDDEQRSEAKAAIGRAQPDWPRPIVTTIEGPATWYPAEDYHQEYWEGEGQRNPYCLAV
IPPKLMKLRKSFANKVKA
>Mature_177_residues
SEQATAILAGGCFWCTEAVFRDVIGVSNVESGYIGGTVESPTYKQVCSGSTGHAEAIRVTFDPQVIGYGQILDIFFATHD
PTQLNRQGNDIGTQYRSALFPLDDEQRSEAKAAIGRAQPDWPRPIVTTIEGPATWYPAEDYHQEYWEGEGQRNPYCLAVI
PPKLMKLRKSFANKVKA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=42.6751592356688, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=42.6751592356688, Blast_Score=126, Evalue=8e-30,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=42.8571428571429, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=48.7012987012987, Blast_Score=145, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17533973, Length=205, Percent_Identity=31.7073170731707, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=152, Percent_Identity=40.1315789473684, Blast_Score=112, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24664627, Length=168, Percent_Identity=31.547619047619, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=31.25, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664631, Length=168, Percent_Identity=30.952380952381, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19690; Mature: 19559

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQATAILAGGCFWCTEAVFRDVIGVSNVESGYIGGTVESPTYKQVCSGSTGHAEAIRV
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEE
TFDPQVIGYGQILDIFFATHDPTQLNRQGNDIGTQYRSALFPLDDEQRSEAKAAIGRAQP
EECCCEECHHHEEEHHHCCCCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
DWPRPIVTTIEGPATWYPAEDYHQEYWEGEGQRNPYCLAVIPPKLMKLRKSFANKVKA
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQATAILAGGCFWCTEAVFRDVIGVSNVESGYIGGTVESPTYKQVCSGSTGHAEAIRV
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEE
TFDPQVIGYGQILDIFFATHDPTQLNRQGNDIGTQYRSALFPLDDEQRSEAKAAIGRAQP
EECCCEECHHHEEEHHHCCCCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
DWPRPIVTTIEGPATWYPAEDYHQEYWEGEGQRNPYCLAVIPPKLMKLRKSFANKVKA
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA