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The map label for this gene is clpP

Identifier: 87201067

GI number: 87201067

Start: 3271222

End: 3271929

Strand: Reverse

Name: clpP

Synonym: Saro_3055

Alternate gene names: 87201067

Gene position: 3271929-3271222 (Counterclockwise)

Preceding gene: 87201068

Following gene: 87201066

Centisome position: 91.87

GC content: 64.83

Gene sequence:

>708_bases
ATGCTCGACCTGTTCGGCGCATCCAGCGCCCCCACTTTTGGCAATCAGGGGAAGTTCACCACCGATCCCGTCACCGGCGC
GCTGATCCCGGTCGTGGTCGAACAGTCGAGCCGCGGCGAACGCAGCTTCGACATCTATTCGCGCCTCCTGCGCGAACGCA
TCATTTTCGTGACTGGCGAAGTCGAGGACCACATGGCCTCGGTGATCATCGCGCAGCTCCTGTTCCTCGAGTCGGAAAAT
CCCTCGAAGGACATCTCGATGTACATCAACTCGCCGGGCGGCGTGGTGACGGCAGGTCTCGCGATCTACGACACCATGCA
GTACATTCGCCCCCGCGTGTCGACCGTGTGCATCGGCCAGGCAGCCTCGATGGGCTCGTTCCTGCTCGCCGCCGGTGAGC
CGGGCATGCGCATCGCCCTGCCCAACGCGCGCATCATGATCCACCAGCCTTCGGGCGGTGCCCGCGGCATGGCGTCCGAC
ATCGAGATCCAGGCGCGCGAGATCCTGCGCATCCGCAAGCGGATGAACGACCTCTACGTCAAGTTCACCGGCCGCTCGCT
CGACGAGATCGAGAAGGCGATGGACCGCGACACCTTCCTCGAAGCCGAGGAAGCGATGAAGTTCGGCCTGGTCGACAAGG
TGTTCGAATCGCGCCCCGCGACCGATTCGGTCGGCGAGGGCGAAGGTTCGGGCGGCGCGCCGGCCTGA

Upstream 100 bases:

>100_bases
CCACCTATTACCCACGGGTTTGCCCGGATTTGCGGTTAACGCACTTGAACATCCCGCCATGGCACGCGACATAGGCCGCC
TAAGCCATATGAGGATTCCC

Downstream 100 bases:

>100_bases
TCGGGGACTCCCCCGCCGTCTTAAGCCTGGCGAAAGGCTGGCGGGGGTAAGGACCTGTTACCTGTTTTCGAGTCCGGTTG
ATTAATGCCCTTGCGGTAGT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MLDLFGASSAPTFGNQGKFTTDPVTGALIPVVVEQSSRGERSFDIYSRLLRERIIFVTGEVEDHMASVIIAQLLFLESEN
PSKDISMYINSPGGVVTAGLAIYDTMQYIRPRVSTVCIGQAASMGSFLLAAGEPGMRIALPNARIMIHQPSGGARGMASD
IEIQAREILRIRKRMNDLYVKFTGRSLDEIEKAMDRDTFLEAEEAMKFGLVDKVFESRPATDSVGEGEGSGGAPA

Sequences:

>Translated_235_residues
MLDLFGASSAPTFGNQGKFTTDPVTGALIPVVVEQSSRGERSFDIYSRLLRERIIFVTGEVEDHMASVIIAQLLFLESEN
PSKDISMYINSPGGVVTAGLAIYDTMQYIRPRVSTVCIGQAASMGSFLLAAGEPGMRIALPNARIMIHQPSGGARGMASD
IEIQAREILRIRKRMNDLYVKFTGRSLDEIEKAMDRDTFLEAEEAMKFGLVDKVFESRPATDSVGEGEGSGGAPA
>Mature_235_residues
MLDLFGASSAPTFGNQGKFTTDPVTGALIPVVVEQSSRGERSFDIYSRLLRERIIFVTGEVEDHMASVIIAQLLFLESEN
PSKDISMYINSPGGVVTAGLAIYDTMQYIRPRVSTVCIGQAASMGSFLLAAGEPGMRIALPNARIMIHQPSGGARGMASD
IEIQAREILRIRKRMNDLYVKFTGRSLDEIEKAMDRDTFLEAEEAMKFGLVDKVFESRPATDSVGEGEGSGGAPA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=64.5833333333333, Blast_Score=264, Evalue=4e-71,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=65.625, Blast_Score=282, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=63.4408602150538, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=59.6938775510204, Blast_Score=258, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_NOVAD (Q2G3T3)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_498324.1
- ProteinModelPortal:   Q2G3T3
- SMR:   Q2G3T3
- STRING:   Q2G3T3
- MEROPS:   S14.001
- GeneID:   3916668
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_3055
- NMPDR:   fig|48935.1.peg.1494
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   DTFLEAE
- PhylomeDB:   Q2G3T3
- ProtClustDB:   PRK00277
- BioCyc:   NARO279238:SARO_3055-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 25472; Mature: 25472

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 123-123 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLFGASSAPTFGNQGKFTTDPVTGALIPVVVEQSSRGERSFDIYSRLLRERIIFVTGE
CCCCCCCCCCCCCCCCCCEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEEEEECC
VEDHMASVIIAQLLFLESENPSKDISMYINSPGGVVTAGLAIYDTMQYIRPRVSTVCIGQ
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHEEEECC
AASMGSFLLAAGEPGMRIALPNARIMIHQPSGGARGMASDIEIQAREILRIRKRMNDLYV
HHCCCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
KFTGRSLDEIEKAMDRDTFLEAEEAMKFGLVDKVFESRPATDSVGEGEGSGGAPA
EECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDLFGASSAPTFGNQGKFTTDPVTGALIPVVVEQSSRGERSFDIYSRLLRERIIFVTGE
CCCCCCCCCCCCCCCCCCEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEEEEECC
VEDHMASVIIAQLLFLESENPSKDISMYINSPGGVVTAGLAIYDTMQYIRPRVSTVCIGQ
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHEEEECC
AASMGSFLLAAGEPGMRIALPNARIMIHQPSGGARGMASDIEIQAREILRIRKRMNDLYV
HHCCCCEEEECCCCCCEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEE
KFTGRSLDEIEKAMDRDTFLEAEEAMKFGLVDKVFESRPATDSVGEGEGSGGAPA
EECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA