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The map label for this gene is czcD [H]

Identifier: 87201064

GI number: 87201064

Start: 3267702

End: 3268658

Strand: Direct

Name: czcD [H]

Synonym: Saro_3052

Alternate gene names: 87201064

Gene position: 3267702-3268658 (Clockwise)

Preceding gene: 87201063

Following gene: 87201065

Centisome position: 91.75

GC content: 67.82

Gene sequence:

>957_bases
ATGTCCGGCGGCCATCATCATCATCACCATAACCACGACCACGACCATCATCACGGGCACGGGCATGGGCATGGGCACGC
CCCAGCCAACTTCGGCCGCGCCTTCGCCATCGGCATTGCGCTGAACCTGGCCTTCGTGATCGTCGAGGCGGCCTACGGCA
TCGTCGCCGGCTCGATGGCGCTGGTCGCCGATGCGGGGCACAATCTGTCCGACGTGCTCGGCCTGGTCATTGCCTGGGGC
GCGAGCTTGCTGGCAGCGCGGCCGCCTTCGGCGCGCTTCACCTATGGCTTCAAGTCCAGCTCGATCCTTGCCGCGCTCGC
CAACGCCGCGTTCCTGCTGGTCGCGCTGGGCGCGATCCTGCTCGAGACGATCCGCCGCCTGGTCGATCCGCAACCGGTCG
ACGGCGCGCCGGTGATGATCGTGGCGGGCATCGGCATCGCCATAAACACGGCCACGGCGCTGATGTTCATGCGCGGACGC
AAGCACGACATCAACATCCGCGGCGCCTATCTGCACATGGCGGCGGACGCGGCAGTATCGGCAGGCGTGGTCCTGGCGGG
CCTCGCCATCAGCCTGACCGGCTGGCAATGGATCGACCCCGCCACCAGCCTGGCCATCGTCGGCGTGATCGCCATCGGCA
CCTGGGGCCTGCTGAAGGACTCCCTGAAGATGAGCCTGCACGCGGTGCCGCCCGGCATCGACGAGGGCAAGGTCCGGACG
TTCCTGACAGGCCAACCCGGAGTCGAGGCGGTGCACGACCTGCACATCTGGCCGATGAGCACGACCGAGACCGCGCTGAC
CGCGCACCTCGTCATGCCCAGCGGCTACCCGGGTGACACCTTCCTCCACCACCTGGCGCAGGAACTGCACGACAGGTTCC
GCATCGGCCACCCGACCATCCAGGTCGAGACGCTGGACGGGGCGGAATGCATCCTGGCGAGCGACCAGACCGTCTGA

Upstream 100 bases:

>100_bases
GTCCACTCGTGGGATACCGTCGGCGCTACAGAACCCGGCTTACAGGCCCCCTGGCACTTCGCTTGTTTCCTGCCCGCCTG
CGACGCGTTAGGAATGGCCC

Downstream 100 bases:

>100_bases
GGGGGCCCACCTGACCTTGTGGACATGAGTCCAAAGGACACCTCGCGCGGGCTGTGGAGCGCGATCATATTGCCTGCCGG
AGACGTTCCAACCGGGCCGG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSGGHHHHHHNHDHDHHHGHGHGHGHAPANFGRAFAIGIALNLAFVIVEAAYGIVAGSMALVADAGHNLSDVLGLVIAWG
ASLLAARPPSARFTYGFKSSSILAALANAAFLLVALGAILLETIRRLVDPQPVDGAPVMIVAGIGIAINTATALMFMRGR
KHDINIRGAYLHMAADAAVSAGVVLAGLAISLTGWQWIDPATSLAIVGVIAIGTWGLLKDSLKMSLHAVPPGIDEGKVRT
FLTGQPGVEAVHDLHIWPMSTTETALTAHLVMPSGYPGDTFLHHLAQELHDRFRIGHPTIQVETLDGAECILASDQTV

Sequences:

>Translated_318_residues
MSGGHHHHHHNHDHDHHHGHGHGHGHAPANFGRAFAIGIALNLAFVIVEAAYGIVAGSMALVADAGHNLSDVLGLVIAWG
ASLLAARPPSARFTYGFKSSSILAALANAAFLLVALGAILLETIRRLVDPQPVDGAPVMIVAGIGIAINTATALMFMRGR
KHDINIRGAYLHMAADAAVSAGVVLAGLAISLTGWQWIDPATSLAIVGVIAIGTWGLLKDSLKMSLHAVPPGIDEGKVRT
FLTGQPGVEAVHDLHIWPMSTTETALTAHLVMPSGYPGDTFLHHLAQELHDRFRIGHPTIQVETLDGAECILASDQTV
>Mature_317_residues
SGGHHHHHHNHDHDHHHGHGHGHGHAPANFGRAFAIGIALNLAFVIVEAAYGIVAGSMALVADAGHNLSDVLGLVIAWGA
SLLAARPPSARFTYGFKSSSILAALANAAFLLVALGAILLETIRRLVDPQPVDGAPVMIVAGIGIAINTATALMFMRGRK
HDINIRGAYLHMAADAAVSAGVVLAGLAISLTGWQWIDPATSLAIVGVIAIGTWGLLKDSLKMSLHAVPPGIDEGKVRTF
LTGQPGVEAVHDLHIWPMSTTETALTAHLVMPSGYPGDTFLHHLAQELHDRFRIGHPTIQVETLDGAECILASDQTV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=322, Percent_Identity=24.5341614906832, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI64762489, Length=327, Percent_Identity=25.9938837920489, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI289803013, Length=288, Percent_Identity=27.4305555555556, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI289803009, Length=288, Percent_Identity=27.4305555555556, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI289803007, Length=288, Percent_Identity=27.4305555555556, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI289803003, Length=288, Percent_Identity=27.4305555555556, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI20070323, Length=314, Percent_Identity=26.1146496815287, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI21361112, Length=312, Percent_Identity=25.9615384615385, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI21359890, Length=302, Percent_Identity=23.841059602649, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI14210520, Length=225, Percent_Identity=24, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI52351208, Length=179, Percent_Identity=26.8156424581006, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=32.6315789473684, Blast_Score=130, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=27.1341463414634, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=330, Percent_Identity=28.1818181818182, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564488, Length=293, Percent_Identity=27.9863481228669, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17555794, Length=270, Percent_Identity=26.2962962962963, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=120, Percent_Identity=32.5, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=118, Percent_Identity=33.8983050847458, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583858, Length=330, Percent_Identity=26.0606060606061, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=28.8732394366197, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=28.8732394366197, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585900, Length=156, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585898, Length=156, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585896, Length=156, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921672, Length=156, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24645863, Length=106, Percent_Identity=33.0188679245283, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33433; Mature: 33302

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGHHHHHHNHDHDHHHGHGHGHGHAPANFGRAFAIGIALNLAFVIVEAAYGIVAGSMA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LVADAGHNLSDVLGLVIAWGASLLAARPPSARFTYGFKSSSILAALANAAFLLVALGAIL
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LETIRRLVDPQPVDGAPVMIVAGIGIAINTATALMFMRGRKHDINIRGAYLHMAADAAVS
HHHHHHHCCCCCCCCCCEEEEECCCEEHHHHHHHHHHCCCCCCCEEEEEEEEEEHHHHHH
AGVVLAGLAISLTGWQWIDPATSLAIVGVIAIGTWGLLKDSLKMSLHAVPPGIDEGKVRT
HHHHHHHHEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEE
FLTGQPGVEAVHDLHIWPMSTTETALTAHLVMPSGYPGDTFLHHLAQELHDRFRIGHPTI
EECCCCCCHHHHEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEE
QVETLDGAECILASDQTV
EEEECCCCEEEEECCCCC
>Mature Secondary Structure 
SGGHHHHHHNHDHDHHHGHGHGHGHAPANFGRAFAIGIALNLAFVIVEAAYGIVAGSMA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LVADAGHNLSDVLGLVIAWGASLLAARPPSARFTYGFKSSSILAALANAAFLLVALGAIL
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LETIRRLVDPQPVDGAPVMIVAGIGIAINTATALMFMRGRKHDINIRGAYLHMAADAAVS
HHHHHHHCCCCCCCCCCEEEEECCCEEHHHHHHHHHHCCCCCCCEEEEEEEEEEHHHHHH
AGVVLAGLAISLTGWQWIDPATSLAIVGVIAIGTWGLLKDSLKMSLHAVPPGIDEGKVRT
HHHHHHHHEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEE
FLTGQPGVEAVHDLHIWPMSTTETALTAHLVMPSGYPGDTFLHHLAQELHDRFRIGHPTI
EECCCCCCHHHHEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEE
QVETLDGAECILASDQTV
EEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA