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The map label for this gene is nhaA2

Identifier: 87200658

GI number: 87200658

Start: 2882210

End: 2883382

Strand: Direct

Name: nhaA2

Synonym: Saro_2645

Alternate gene names: 87200658

Gene position: 2882210-2883382 (Clockwise)

Preceding gene: 87200652

Following gene: 87200659

Centisome position: 80.92

GC content: 68.37

Gene sequence:

>1173_bases
ATGGCTGGAATTGAGGGCTTTGCAGCGATTCGTGGCAAACTGGCGCAGAGCGAGGCCGCGCCCGGCATCGTCCTCATCGC
ATGCGCGGCGCTGGCGCTCCTGATCGCCAATTCGCCCCTCGCCGCGGCGTGGCATGCCCTGTTCCATCACCCGCTTCCAT
GGACGCCGGTCGCCAAGCTCGACACGCTTCACCTGTGGATCAACGACGGCCTGATGGCGGTGTTCTTCTTCGTCGTCGGC
CTCGAGATCAAGCGCGAAGTCCTTGCCGGCGAACTGTCGGACGCCCGCCGCCGCAGGTTGCCTGTCCTTGCCGCAGTGGC
CGGGATGGCCGTGCCCGCGCTCATCTATCTCGCGATCACGGCTGGCCAGCCCGCCCTGCATCGCGGCTGGGCGATCCCGT
CTGCGACCGACATCGCCTTTGCGATCGGCGTACTGGCTCTCGTCGGCCGGGGGCTGCCGCCTTCGCTCCGGCTGTTCCTG
CTGACCGTCGCCATCGTCGACGATCTCGGCGCGGTGGTCGTGATCGCGCTGTTCTACACCTCGGGCCTCAAGCTCGCCTG
GCTCGGCGCGAGCGCGCTGATCCTCGCGGCGCTCGTCCTGGTCAACCGCATGGGCGTCCGCGCCCTCCTGCCCTACCTCG
CCGGAGCCGTGGCGCTGTGGTACACAGTGCTGCATTCCGGCATCCACGCGACGGTCGCCGGCGTCCTTGCCGCAATGACT
GTCCCGCTTGCGCTCAACCGCCGTCACGACAGTCCGCTGCTCCGGCTCGAGCATGCCCTCGTCGCACCGAACGGGTTCGT
CATCGTGCCTCTGTTCGGCCTTGCGAACGCCGGCGTGGCGCTTGGGGCGGACTTCGGTGAAAGCCCCGCCCTCCCCCTCG
GGATCGCGATGGGTCTTCTGCTGGGCAAGCAGTTCGGCATTCTCGGCAGCATCCTCGTTGCCGAACGCCTGGGCTTCGCG
CACCGGCCCGAAGGGGCAAGCCTGCGCCATCTCTGGGGAATCGCCCTCCTGTGCGGGATTGGCTTCACGATGAGCCTGTT
CATCGCCGGGCTCGCGTTCCCCGAAACGCCGATGCTGGTCGAGGAAGCCAAGCTCGGCATCCTCGGCGGCTCGCTTGTCT
CCGCCCTTGCCGGGCTCCTGGTCCTGCGCGGCTCCGGCCGGCCGGTAGTTTGA

Upstream 100 bases:

>100_bases
CGACGCTGGCGGCAGCGGTTTGACCCGCCCCCCTCCAGTGGGCACAAGAGCCAAGGTATGCCCATTTGGCGCGTTTCGTG
AACCAGGGAATAATTCGAGA

Downstream 100 bases:

>100_bases
TCGATAAATTCGATCAAACTACGCATGACGTTGCGTGAAACCTTTCAGACCGGACGGCGTATAAACAGCGCATCCAACCG
GAATCATGAAAGGGGAACAC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAGIEGFAAIRGKLAQSEAAPGIVLIACAALALLIANSPLAAAWHALFHHPLPWTPVAKLDTLHLWINDGLMAVFFFVVG
LEIKREVLAGELSDARRRRLPVLAAVAGMAVPALIYLAITAGQPALHRGWAIPSATDIAFAIGVLALVGRGLPPSLRLFL
LTVAIVDDLGAVVVIALFYTSGLKLAWLGASALILAALVLVNRMGVRALLPYLAGAVALWYTVLHSGIHATVAGVLAAMT
VPLALNRRHDSPLLRLEHALVAPNGFVIVPLFGLANAGVALGADFGESPALPLGIAMGLLLGKQFGILGSILVAERLGFA
HRPEGASLRHLWGIALLCGIGFTMSLFIAGLAFPETPMLVEEAKLGILGGSLVSALAGLLVLRGSGRPVV

Sequences:

>Translated_390_residues
MAGIEGFAAIRGKLAQSEAAPGIVLIACAALALLIANSPLAAAWHALFHHPLPWTPVAKLDTLHLWINDGLMAVFFFVVG
LEIKREVLAGELSDARRRRLPVLAAVAGMAVPALIYLAITAGQPALHRGWAIPSATDIAFAIGVLALVGRGLPPSLRLFL
LTVAIVDDLGAVVVIALFYTSGLKLAWLGASALILAALVLVNRMGVRALLPYLAGAVALWYTVLHSGIHATVAGVLAAMT
VPLALNRRHDSPLLRLEHALVAPNGFVIVPLFGLANAGVALGADFGESPALPLGIAMGLLLGKQFGILGSILVAERLGFA
HRPEGASLRHLWGIALLCGIGFTMSLFIAGLAFPETPMLVEEAKLGILGGSLVSALAGLLVLRGSGRPVV
>Mature_389_residues
AGIEGFAAIRGKLAQSEAAPGIVLIACAALALLIANSPLAAAWHALFHHPLPWTPVAKLDTLHLWINDGLMAVFFFVVGL
EIKREVLAGELSDARRRRLPVLAAVAGMAVPALIYLAITAGQPALHRGWAIPSATDIAFAIGVLALVGRGLPPSLRLFLL
TVAIVDDLGAVVVIALFYTSGLKLAWLGASALILAALVLVNRMGVRALLPYLAGAVALWYTVLHSGIHATVAGVLAAMTV
PLALNRRHDSPLLRLEHALVAPNGFVIVPLFGLANAGVALGADFGESPALPLGIAMGLLLGKQFGILGSILVAERLGFAH
RPEGASLRHLWGIALLCGIGFTMSLFIAGLAFPETPMLVEEAKLGILGGSLVSALAGLLVLRGSGRPVV

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=388, Percent_Identity=47.9381443298969, Blast_Score=281, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA2_NOVAD (Q2G4Z2)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497915.1
- ProteinModelPortal:   Q2G4Z2
- SMR:   Q2G4Z2
- STRING:   Q2G4Z2
- GeneID:   3918419
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2645
- NMPDR:   fig|48935.1.peg.1988
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   HIINDGL
- PhylomeDB:   Q2G4Z2
- BioCyc:   NARO279238:SARO_2645-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 40446; Mature: 40315

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x174768b0)-; HASH(0x1704f8d4)-; HASH(0x170a72b8)-; HASH(0x17f3c170)-; HASH(0x17f4d85c)-; HASH(0x17dc9d24)-; HASH(0x17f36804)-; HASH(0x17dc8420)-; HASH(0x17823834)-; HASH(0x17d92c6c)-; HASH(0x17dace88)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIEGFAAIRGKLAQSEAAPGIVLIACAALALLIANSPLAAAWHALFHHPLPWTPVAKL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
DTLHLWINDGLMAVFFFVVGLEIKREVLAGELSDARRRRLPVLAAVAGMAVPALIYLAIT
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
AGQPALHRGWAIPSATDIAFAIGVLALVGRGLPPSLRLFLLTVAIVDDLGAVVVIALFYT
CCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLKLAWLGASALILAALVLVNRMGVRALLPYLAGAVALWYTVLHSGIHATVAGVLAAMT
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLALNRRHDSPLLRLEHALVAPNGFVIVPLFGLANAGVALGADFGESPALPLGIAMGLL
HHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEHHCCCCCEEECCCCCCCCCCHHHHHHHHH
LGKQFGILGSILVAERLGFAHRPEGASLRHLWGIALLCGIGFTMSLFIAGLAFPETPMLV
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EEAKLGILGGSLVSALAGLLVLRGSGRPVV
HHHHHHHCCHHHHHHHHHHHEECCCCCCCH
>Mature Secondary Structure 
AGIEGFAAIRGKLAQSEAAPGIVLIACAALALLIANSPLAAAWHALFHHPLPWTPVAKL
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
DTLHLWINDGLMAVFFFVVGLEIKREVLAGELSDARRRRLPVLAAVAGMAVPALIYLAIT
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
AGQPALHRGWAIPSATDIAFAIGVLALVGRGLPPSLRLFLLTVAIVDDLGAVVVIALFYT
CCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLKLAWLGASALILAALVLVNRMGVRALLPYLAGAVALWYTVLHSGIHATVAGVLAAMT
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPLALNRRHDSPLLRLEHALVAPNGFVIVPLFGLANAGVALGADFGESPALPLGIAMGLL
HHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEHHCCCCCEEECCCCCCCCCCHHHHHHHHH
LGKQFGILGSILVAERLGFAHRPEGASLRHLWGIALLCGIGFTMSLFIAGLAFPETPMLV
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EEAKLGILGGSLVSALAGLLVLRGSGRPVV
HHHHHHHCCHHHHHHHHHHHEECCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA