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The map label for this gene is hemN [H]

Identifier: 87200582

GI number: 87200582

Start: 2773551

End: 2774900

Strand: Reverse

Name: hemN [H]

Synonym: Saro_2569

Alternate gene names: 87200582

Gene position: 2774900-2773551 (Counterclockwise)

Preceding gene: 87200583

Following gene: 87200581

Centisome position: 77.91

GC content: 66.07

Gene sequence:

>1350_bases
ATGTCGCCTGATCTGATGATACGCCCTGAAACCGTTGCCGACTGGACCTATTACCCCGAACTGCTCGAACGCCCGGTCCC
ACGCTACACCAGCTATCCGACCGCGGCAGAGTTCGTCGAGGAGAGCTTCGAGGAGCGCCAGCGTCAGGCGCTGCAGTCCT
TGCGCGGACCGGTCTCGCTCTACCTGCACATCCCCTACTGCCAGGAAATCTGCTGGTACTGCGGGTGCAACACCGGGGCG
GCGAACAAGACCCAGCGGCTGGGCGCCTATCTCGAAGCGCTCCATCATGAGATCGAGCTGGTCGCGCGCAACCTCCACTC
CTCGGTGCGGATCTCGCGCATTGCCTTCGGCGGTGGCAGCCCCAACGCGATCAAGCCGACCGACTTCGTGCGCCTTGTCG
ACCGGCTGACCGTCAACTTCCGTCTCGCGAGCCCGGTGCTGTCGATCGAACTCGATCCGCGCAGCCTGGAACCCGGCTGG
TTCCTCGCCATTCGCGGCATCGGCGTCATCAAGGCGAGCCTTGGCGTCCAGACGCTCGACCCGCGCGTCCAGGCGGCCAT
CGGTCGGGTCCAGCCGCGCGAACACATCGAGCGCGCGGTCGACGGCCTGCGCAAGGCGGGTGTCGACTCGATCAACTTCG
ACCTGATGTACGGACTTCCGTTCCAGGACGACGCGATCCTTGCCGATACGCTCGACCAGTCCGTGGCCATGGGCGCGGAC
CGCATTGCGCTGTTCGGCTATGCCCACGTGCCGCACATGATCCCGCGACAGAAGCGGATCGACGTCAGCCAGCTTCCCGA
CCAGCGCGCCCGCTTCCGCATGGCTGCGCAAGGACATGCGCAGCTGGTCGATGCAGGATACCGCGCCATCGGTTTCGATC
ACTTCGCCCTGCCTGGCGACGATCTTGCGCTTGCGGCGGAGAGGGGCGCCCTTCGCCGCAACTTCCAGGGTTTCACCGAT
GATCCCGCGCCGGTCCTCATCGGTCTGGGCGCATCCTCGATCAGCGAGTTTCCCGACCTTTTCGTCCAGAACGAGAAGAA
CGCCGGCCGCTATCGCATGCTGGTCGGCGCGAGCCAGCTTACCGGGCGCAAGGGCGTCGTCCGCACGGCGGAAGACCGTC
GGCGCGGGGCGATCATCACCGATCTGCTGTGCCAGGGCGGCGCCCGGATCGACGCTGACCTTCTGGCCATGAACCGCGAC
CGGCTGGTGCCCTTCATCGAACGCGGCCTGGCAAGGCTCGACGGCAACGTCCTGGCGCTTCTCGCGGGCAGCGAACCCTA
TGCCCGTTCCATCGCCGCGGTATTCGATGCCTATCGCGCCGGGCCTCACCAGTTCAGCTCTGCGGTCTGA

Upstream 100 bases:

>100_bases
GACGACGGCGGCAAAAATCTACCCTGTTGTAAAATTTGCCATATCTCAATGCGCAAGCGCCTCGCCGCCGATAGCTGTTG
CGACGAGGAGGACGACCCGG

Downstream 100 bases:

>100_bases
CAAGGAGCGAAGAATAGCTATGCGCCCTGCCTGAGCAGGTGCACAATAAGGCTGAGTCGCGTTAAGCCACCATCCGCAAC
GGAGTGCGCACCAGTCGGGT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSPDLMIRPETVADWTYYPELLERPVPRYTSYPTAAEFVEESFEERQRQALQSLRGPVSLYLHIPYCQEICWYCGCNTGA
ANKTQRLGAYLEALHHEIELVARNLHSSVRISRIAFGGGSPNAIKPTDFVRLVDRLTVNFRLASPVLSIELDPRSLEPGW
FLAIRGIGVIKASLGVQTLDPRVQAAIGRVQPREHIERAVDGLRKAGVDSINFDLMYGLPFQDDAILADTLDQSVAMGAD
RIALFGYAHVPHMIPRQKRIDVSQLPDQRARFRMAAQGHAQLVDAGYRAIGFDHFALPGDDLALAAERGALRRNFQGFTD
DPAPVLIGLGASSISEFPDLFVQNEKNAGRYRMLVGASQLTGRKGVVRTAEDRRRGAIITDLLCQGGARIDADLLAMNRD
RLVPFIERGLARLDGNVLALLAGSEPYARSIAAVFDAYRAGPHQFSSAV

Sequences:

>Translated_449_residues
MSPDLMIRPETVADWTYYPELLERPVPRYTSYPTAAEFVEESFEERQRQALQSLRGPVSLYLHIPYCQEICWYCGCNTGA
ANKTQRLGAYLEALHHEIELVARNLHSSVRISRIAFGGGSPNAIKPTDFVRLVDRLTVNFRLASPVLSIELDPRSLEPGW
FLAIRGIGVIKASLGVQTLDPRVQAAIGRVQPREHIERAVDGLRKAGVDSINFDLMYGLPFQDDAILADTLDQSVAMGAD
RIALFGYAHVPHMIPRQKRIDVSQLPDQRARFRMAAQGHAQLVDAGYRAIGFDHFALPGDDLALAAERGALRRNFQGFTD
DPAPVLIGLGASSISEFPDLFVQNEKNAGRYRMLVGASQLTGRKGVVRTAEDRRRGAIITDLLCQGGARIDADLLAMNRD
RLVPFIERGLARLDGNVLALLAGSEPYARSIAAVFDAYRAGPHQFSSAV
>Mature_448_residues
SPDLMIRPETVADWTYYPELLERPVPRYTSYPTAAEFVEESFEERQRQALQSLRGPVSLYLHIPYCQEICWYCGCNTGAA
NKTQRLGAYLEALHHEIELVARNLHSSVRISRIAFGGGSPNAIKPTDFVRLVDRLTVNFRLASPVLSIELDPRSLEPGWF
LAIRGIGVIKASLGVQTLDPRVQAAIGRVQPREHIERAVDGLRKAGVDSINFDLMYGLPFQDDAILADTLDQSVAMGADR
IALFGYAHVPHMIPRQKRIDVSQLPDQRARFRMAAQGHAQLVDAGYRAIGFDHFALPGDDLALAAERGALRRNFQGFTDD
PAPVLIGLGASSISEFPDLFVQNEKNAGRYRMLVGASQLTGRKGVVRTAEDRRRGAIITDLLCQGGARIDADLLAMNRDR
LVPFIERGLARLDGNVLALLAGSEPYARSIAAVFDAYRAGPHQFSSAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=244, Percent_Identity=26.2295081967213, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87082341, Length=441, Percent_Identity=34.9206349206349, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789325, Length=285, Percent_Identity=27.3684210526316, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49575; Mature: 49444

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPDLMIRPETVADWTYYPELLERPVPRYTSYPTAAEFVEESFEERQRQALQSLRGPVSL
CCCCCEECCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
YLHIPYCQEICWYCGCNTGAANKTQRLGAYLEALHHEIELVARNLHSSVRISRIAFGGGS
EEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
PNAIKPTDFVRLVDRLTVNFRLASPVLSIELDPRSLEPGWFLAIRGIGVIKASLGVQTLD
CCCCCHHHHHHHHHHHEEEEEEECCEEEEEECCCCCCCCEEEEEECCCEEEHHCCCCCCC
PRVQAAIGRVQPREHIERAVDGLRKAGVDSINFDLMYGLPFQDDAILADTLDQSVAMGAD
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
RIALFGYAHVPHMIPRQKRIDVSQLPDQRARFRMAAQGHAQLVDAGYRAIGFDHFALPGD
CEEEEEEHHCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCHHHHHCCHHHCCCCCCCCCCC
DLALAAERGALRRNFQGFTDDPAPVLIGLGASSISEFPDLFVQNEKNAGRYRMLVGASQL
CHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCHHHEECCCCCCCEEEEEEHHHH
TGRKGVVRTAEDRRRGAIITDLLCQGGARIDADLLAMNRDRLVPFIERGLARLDGNVLAL
CCCCCCEECHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCEEEE
LAGSEPYARSIAAVFDAYRAGPHQFSSAV
EECCCHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
SPDLMIRPETVADWTYYPELLERPVPRYTSYPTAAEFVEESFEERQRQALQSLRGPVSL
CCCCEECCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
YLHIPYCQEICWYCGCNTGAANKTQRLGAYLEALHHEIELVARNLHSSVRISRIAFGGGS
EEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
PNAIKPTDFVRLVDRLTVNFRLASPVLSIELDPRSLEPGWFLAIRGIGVIKASLGVQTLD
CCCCCHHHHHHHHHHHEEEEEEECCEEEEEECCCCCCCCEEEEEECCCEEEHHCCCCCCC
PRVQAAIGRVQPREHIERAVDGLRKAGVDSINFDLMYGLPFQDDAILADTLDQSVAMGAD
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
RIALFGYAHVPHMIPRQKRIDVSQLPDQRARFRMAAQGHAQLVDAGYRAIGFDHFALPGD
CEEEEEEHHCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCHHHHHCCHHHCCCCCCCCCCC
DLALAAERGALRRNFQGFTDDPAPVLIGLGASSISEFPDLFVQNEKNAGRYRMLVGASQL
CHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCHHHEECCCCCCCEEEEEEHHHH
TGRKGVVRTAEDRRRGAIITDLLCQGGARIDADLLAMNRDRLVPFIERGLARLDGNVLAL
CCCCCCEECHHHHHCCCHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCEEEE
LAGSEPYARSIAAVFDAYRAGPHQFSSAV
EECCCHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]