Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 87200147

GI number: 87200147

Start: 2269174

End: 2271243

Strand: Direct

Name: mrdA [H]

Synonym: Saro_2131

Alternate gene names: 87200147

Gene position: 2269174-2271243 (Clockwise)

Preceding gene: 87200146

Following gene: 87200148

Centisome position: 63.71

GC content: 66.81

Gene sequence:

>2070_bases
ATGAAGGCTCGGCTGCCGGTCACGTCGGCGATCCTCACCAATCGTTTCGAGCGGCGCGCCTTCGTGCTGGGCGCGATGCA
GGGCGGCGTGGGCCTGCTGCTGGCGACCCGGCTCGGTTATCTCGCGGTCGCTCAGAACGAGAAGTACCAGGCCGCGTCCG
AAAGCAACCGCGTCAACCTCACGCTCATCCCGCCCCGCCGCGGCTGGGTGATCGACCGCTTCGGCAAGGCGCTGGCCGCC
AATCGCGCGGACTTCCGCGTCGACCTCATCCCCGACCGCATCGAAGATCCGGACAAGACTATGCAGACCCTCGCCGGGCT
GCTCGACCTCCCGCCGGACCGCGTGCGCGACATCCGCGACAAGCTTGACAAGGCGCGCGGGTTCCAGCCGGTGGAAGTCG
CCTCGAGCCTGGACTGGGACAAGTTCGCCGCAGTCAGCGTACGCCTGCCCGAACTGCCCGGCGTGATCCCTCAGCGCGGC
TACTCGCGGTTCTATCCCACGGGCGCGGCGGTCGGCCACCTCGTCGGCTACGTCGGCGCGGCCTCTGCCGAGGACTACGA
GAAGGAGCGCAACCCGCTACTGATCACGCCCGGCTTCAAGATCGGCAAGGACGGTCTGGAAAAGCACTTCGAGACGCGCC
TGCGCGGCGTTCCGGGCGCGCGGCGTGTGGAAGCGACGGCATCGGGCCGCATCGTGCGCGACCTGGGCACGCGCGAGGAC
GTGCCGGGCAAGCCGATCCAGCTCACCATCAACGCCGGCTTGCAGGACTACGCCGCGCGGCGCATCGGGCTGGAATCCGG
CTCGGTCGTGGTGATGGACTGCGAGACGGGCGACATTCTCGCCATGGCTTCGATGCCGAGTTTCGATCCCAACAGCTTTT
CCGACGGCATTGGCCGCGTCGAATGGAAGATGCTGTCCGAGGACGACCACGTTCCCTTGCGCAACAAGATCCTGCGCGGG
CTCTATCCGCCGGGCTCGACGGTAAAGCCGATGGTCGCGCTTTCGTTCCTCGAGGCGGGGCTCGATCCCAATGCGACGGT
GCAGTGCAACGGTGGCCTGCGTGTGGGCAACCGCGTGTTCCACTGCTGGCAACGACGCGGGCACGGGACGGTGGACATGG
CCAAGGGCATCTACCAGTCGTGCGACGTCTACTTCTATCACTTCGCGCAACAGATCGGCATGGACAAGATCGCGGCGATG
GCGCGGCGGCTCGGGCTGGGGCAGGAGTTTCCGATGCCCTACCCCGGCCAGTCTTATGGCACGGTGCCCGATCCCGCGTG
GAAGATGCGGAAATACAAGAAGGAATGGGCGCTTTACGATACCGTCAACGCGACCATCGGCCAGGGCTACATGCTGGTCA
ATCCATTGCAGCAGGCGGTCATGGCGTCGCGCATCGCATCGGGACGCGAGGTCATGCCTCGGCTGCTGCTCGACAGGAAC
GCGCCGCCGGTCAAGCCGATGGGCTTTTCGCAGCAACACCTCGACTATATCCATGCGGCGATGAGCGAAGTGGTCAACGG
GCGCGGCACCGCCGGCCGGGCGCGCATTCCGGTCGATAACGTGCTGCTTGCAGGCAAGACCGGGACGGCGCAGGTCGTCG
GGCTCAACATCGCCAACGGCAAGAGCGGCGCATGGAAGTACCGCGACCACGGCCACTTCATCTGCTTCGCCCCGTTCGAC
AAACCGAAGTTCGCATGCGCCGTCGTCATCGAACACGGCGGCGGCTCCAGCGCGGCCTATCCCATCGCGCGCGACGTGAT
GACCTACATCTTCGCGCCGGACAAGGCGATGGCGGTGCTGGAAGAGTTCGAGAAACAGTGGGGCGGCAACGTGCAGCAGC
GCATGTCCGCGCGCTACGATGTCTATGCGGCGAAGTACGGCGGCACGGCAGCAAAGCCCGCACCCGATGACGAGGACCTG
ACCGAGCGGGTCGAGGAAGGCCGCAAGCCGGACCAGGACCCTGCATCCGTCCAGACCGACGCCGCAGCGCCCGCTCCGGA
ACCGGAAGCGCCGCCGCAGGTGCAGGTGCCCACTCCGGCGCCGTCGCCCACTCCAGCGGGAGGGCAATGA

Upstream 100 bases:

>100_bases
GTGCCGCAACTGCTGTTGTCGCTCGTGCTCTATCCGGTGGTGACGGGCCTGGTCGCCATGCTCGACCGCGTGCGCCTGCT
GCCGCTGAAGAGGCTGTAGG

Downstream 100 bases:

>100_bases
TGCCGCGCGCCTATGTCCCCGCCGCGATCGCGCGCCAGCCGTGGAGCGTGCTGCTGCCGCTGACGGCGCTGGTCAGCTTC
GGCGCGGCGGTGCTGGATTC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MKARLPVTSAILTNRFERRAFVLGAMQGGVGLLLATRLGYLAVAQNEKYQAASESNRVNLTLIPPRRGWVIDRFGKALAA
NRADFRVDLIPDRIEDPDKTMQTLAGLLDLPPDRVRDIRDKLDKARGFQPVEVASSLDWDKFAAVSVRLPELPGVIPQRG
YSRFYPTGAAVGHLVGYVGAASAEDYEKERNPLLITPGFKIGKDGLEKHFETRLRGVPGARRVEATASGRIVRDLGTRED
VPGKPIQLTINAGLQDYAARRIGLESGSVVVMDCETGDILAMASMPSFDPNSFSDGIGRVEWKMLSEDDHVPLRNKILRG
LYPPGSTVKPMVALSFLEAGLDPNATVQCNGGLRVGNRVFHCWQRRGHGTVDMAKGIYQSCDVYFYHFAQQIGMDKIAAM
ARRLGLGQEFPMPYPGQSYGTVPDPAWKMRKYKKEWALYDTVNATIGQGYMLVNPLQQAVMASRIASGREVMPRLLLDRN
APPVKPMGFSQQHLDYIHAAMSEVVNGRGTAGRARIPVDNVLLAGKTGTAQVVGLNIANGKSGAWKYRDHGHFICFAPFD
KPKFACAVVIEHGGGSSAAYPIARDVMTYIFAPDKAMAVLEEFEKQWGGNVQQRMSARYDVYAAKYGGTAAKPAPDDEDL
TERVEEGRKPDQDPASVQTDAAAPAPEPEAPPQVQVPTPAPSPTPAGGQ

Sequences:

>Translated_689_residues
MKARLPVTSAILTNRFERRAFVLGAMQGGVGLLLATRLGYLAVAQNEKYQAASESNRVNLTLIPPRRGWVIDRFGKALAA
NRADFRVDLIPDRIEDPDKTMQTLAGLLDLPPDRVRDIRDKLDKARGFQPVEVASSLDWDKFAAVSVRLPELPGVIPQRG
YSRFYPTGAAVGHLVGYVGAASAEDYEKERNPLLITPGFKIGKDGLEKHFETRLRGVPGARRVEATASGRIVRDLGTRED
VPGKPIQLTINAGLQDYAARRIGLESGSVVVMDCETGDILAMASMPSFDPNSFSDGIGRVEWKMLSEDDHVPLRNKILRG
LYPPGSTVKPMVALSFLEAGLDPNATVQCNGGLRVGNRVFHCWQRRGHGTVDMAKGIYQSCDVYFYHFAQQIGMDKIAAM
ARRLGLGQEFPMPYPGQSYGTVPDPAWKMRKYKKEWALYDTVNATIGQGYMLVNPLQQAVMASRIASGREVMPRLLLDRN
APPVKPMGFSQQHLDYIHAAMSEVVNGRGTAGRARIPVDNVLLAGKTGTAQVVGLNIANGKSGAWKYRDHGHFICFAPFD
KPKFACAVVIEHGGGSSAAYPIARDVMTYIFAPDKAMAVLEEFEKQWGGNVQQRMSARYDVYAAKYGGTAAKPAPDDEDL
TERVEEGRKPDQDPASVQTDAAAPAPEPEAPPQVQVPTPAPSPTPAGGQ
>Mature_689_residues
MKARLPVTSAILTNRFERRAFVLGAMQGGVGLLLATRLGYLAVAQNEKYQAASESNRVNLTLIPPRRGWVIDRFGKALAA
NRADFRVDLIPDRIEDPDKTMQTLAGLLDLPPDRVRDIRDKLDKARGFQPVEVASSLDWDKFAAVSVRLPELPGVIPQRG
YSRFYPTGAAVGHLVGYVGAASAEDYEKERNPLLITPGFKIGKDGLEKHFETRLRGVPGARRVEATASGRIVRDLGTRED
VPGKPIQLTINAGLQDYAARRIGLESGSVVVMDCETGDILAMASMPSFDPNSFSDGIGRVEWKMLSEDDHVPLRNKILRG
LYPPGSTVKPMVALSFLEAGLDPNATVQCNGGLRVGNRVFHCWQRRGHGTVDMAKGIYQSCDVYFYHFAQQIGMDKIAAM
ARRLGLGQEFPMPYPGQSYGTVPDPAWKMRKYKKEWALYDTVNATIGQGYMLVNPLQQAVMASRIASGREVMPRLLLDRN
APPVKPMGFSQQHLDYIHAAMSEVVNGRGTAGRARIPVDNVLLAGKTGTAQVVGLNIANGKSGAWKYRDHGHFICFAPFD
KPKFACAVVIEHGGGSSAAYPIARDVMTYIFAPDKAMAVLEEFEKQWGGNVQQRMSARYDVYAAKYGGTAAKPAPDDEDL
TERVEEGRKPDQDPASVQTDAAAPAPEPEAPPQVQVPTPAPSPTPAGGQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=609, Percent_Identity=31.3628899835796, Blast_Score=293, Evalue=3e-80,
Organism=Escherichia coli, GI1786272, Length=589, Percent_Identity=25.6366723259762, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 75181; Mature: 75181

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARLPVTSAILTNRFERRAFVLGAMQGGVGLLLATRLGYLAVAQNEKYQAASESNRVNL
CCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCEEE
TLIPPRRGWVIDRFGKALAANRADFRVDLIPDRIEDPDKTMQTLAGLLDLPPDRVRDIRD
EEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
KLDKARGFQPVEVASSLDWDKFAAVSVRLPELPGVIPQRGYSRFYPTGAAVGHLVGYVGA
HHHHHCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
ASAEDYEKERNPLLITPGFKIGKDGLEKHFETRLRGVPGARRVEATASGRIVRDLGTRED
CCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHCCCCCC
VPGKPIQLTINAGLQDYAARRIGLESGSVVVMDCETGDILAMASMPSFDPNSFSDGIGRV
CCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCE
EWKMLSEDDHVPLRNKILRGLYPPGSTVKPMVALSFLEAGLDPNATVQCNGGLRVGNRVF
EEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHH
HCWQRRGHGTVDMAKGIYQSCDVYFYHFAQQIGMDKIAAMARRLGLGQEFPMPYPGQSYG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
TVPDPAWKMRKYKKEWALYDTVNATIGQGYMLVNPLQQAVMASRIASGREVMPRLLLDRN
CCCCHHHHHHHHHHHHHHHHCCCHHHCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHCCC
APPVKPMGFSQQHLDYIHAAMSEVVNGRGTAGRARIPVDNVLLAGKTGTAQVVGLNIANG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEECCCCCEEEEEEEEECC
KSGAWKYRDHGHFICFAPFDKPKFACAVVIEHGGGSSAAYPIARDVMTYIFAPDKAMAVL
CCCCEEECCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHH
EEFEKQWGGNVQQRMSARYDVYAAKYGGTAAKPAPDDEDLTERVEEGRKPDQDPASVQTD
HHHHHHHCCCHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
AAAPAPEPEAPPQVQVPTPAPSPTPAGGQ
CCCCCCCCCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKARLPVTSAILTNRFERRAFVLGAMQGGVGLLLATRLGYLAVAQNEKYQAASESNRVNL
CCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCEEE
TLIPPRRGWVIDRFGKALAANRADFRVDLIPDRIEDPDKTMQTLAGLLDLPPDRVRDIRD
EEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
KLDKARGFQPVEVASSLDWDKFAAVSVRLPELPGVIPQRGYSRFYPTGAAVGHLVGYVGA
HHHHHCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
ASAEDYEKERNPLLITPGFKIGKDGLEKHFETRLRGVPGARRVEATASGRIVRDLGTRED
CCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHCCCCCC
VPGKPIQLTINAGLQDYAARRIGLESGSVVVMDCETGDILAMASMPSFDPNSFSDGIGRV
CCCCCEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCE
EWKMLSEDDHVPLRNKILRGLYPPGSTVKPMVALSFLEAGLDPNATVQCNGGLRVGNRVF
EEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHH
HCWQRRGHGTVDMAKGIYQSCDVYFYHFAQQIGMDKIAAMARRLGLGQEFPMPYPGQSYG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
TVPDPAWKMRKYKKEWALYDTVNATIGQGYMLVNPLQQAVMASRIASGREVMPRLLLDRN
CCCCHHHHHHHHHHHHHHHHCCCHHHCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHCCC
APPVKPMGFSQQHLDYIHAAMSEVVNGRGTAGRARIPVDNVLLAGKTGTAQVVGLNIANG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEECCCCCEEEEEEEEECC
KSGAWKYRDHGHFICFAPFDKPKFACAVVIEHGGGSSAAYPIARDVMTYIFAPDKAMAVL
CCCCEEECCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHH
EEFEKQWGGNVQQRMSARYDVYAAKYGGTAAKPAPDDEDLTERVEEGRKPDQDPASVQTD
HHHHHHHCCCHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
AAAPAPEPEAPPQVQVPTPAPSPTPAGGQ
CCCCCCCCCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]