Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 87200143

GI number: 87200143

Start: 2264590

End: 2266401

Strand: Reverse

Name: mutL

Synonym: Saro_2127

Alternate gene names: 87200143

Gene position: 2266401-2264590 (Counterclockwise)

Preceding gene: 87200149

Following gene: 87200142

Centisome position: 63.63

GC content: 68.43

Gene sequence:

>1812_bases
ATGCGAGTCATCCGTCGTCTTCCCGAAACGCTCATCAACCGCATCGCTGCCGGCGAGGTGGTTGAGCGCCCGGCGAGCGC
GCTCAAGGAACTCGTCGAAAACGCCATCGACGCGGGATCGAGCCACGTCCACGTGCGCCTCTCCGAAGGGGGGCTCGCCA
TGATCGAGGTGTCGGACGATGGCTGCGGCATGCGCCCCGACGAGATCGCGCTGGCGCTCGAACGCCATGCAACCTCCAAG
CTTCCGGACGAGGCCATCGAACTGGTCGAGACGCTCGGCTTCCGGGGAGAGGCGCTGCCCTCGATTGCATCGGTCGCGCG
CGTCACCATCGAAAGCCGCCCCCATGGCACCGCCGAAGGGTGGAAGCGGGTGGTCGACAATGGCGCGCTGGTGGCCGAAG
GCCCCGCCGCGCTTCCGCCCGGGACGCGGGTGAGGGTCGAACATCTGTTCGAGAAGATCCCGGCGCGCCGCAAGTTCCTG
CGCAGCCCGCGCTCGGAATGGGCCGCTGCATCGGATGTCGTCCGCCGCCTCGCCATGGCCCGCCCCGACGTCGGCTTCAC
GCTCGAACACGACGGTCGCCGCGCGCTCCACGTCCAGGCCGGGGAAACGCTCGAGGCCCGCGTGGCGCAACTCGTCGCGC
GCGAACTGGCGGGCAATTCGGTCGAGGTCGACCTCGTCCGGGGCGATTTCCACCTCACCGGCATCGCCGGCTTGCCGACC
TTCAACCGCGGCGTGGCCGATCACCAGTACCTGTTCGTCAATGGCCGTCCGGTGAAAGACCGCCTGCTTATCGGCGCGGT
GCGCGGCGCCTATGCCGACATGCTCGCGCGCGACCGTCATGCCGTGCTGGCGCTGTTCCTGCAGGTTCCGGCCAGCGAGG
TCGACGTCAACGTCCATCCCGCCAAGTCCGAAGTCCGCTTCCGCGACCCGGCGCTGGTGCGCGGCATGGTCGTCTCGGGG
TTGCGCCATGCGCTTTCCACCGGCGACCAGCGATCCGCCCAGGCTCCCTCGGCAAGCGCGATGGCTGCCTGGCAGGCCGA
ACCCATCGCGCCGCCACCACCTTCGTCTCCGTCAAGCGACTGGCAGGGCAGCATCTTTTCGCAACAGTGGAAACCTGAAC
CGCGCGTCAGCGAAGCCGGGCAGGCGTGGCGGGGCTACGAGCAGGCGATCATGGCGCCCCCGTCCGCAAGGGCCGAGCCT
GCGGCCCAGCCGGTGGTCGATGCCGCGCAACATCCGCTCGGCGTGGCGCGCGGGCAGATCTCGAACACCTATATCGTCGC
CGAGGCGGAGGACGGTCTCGTCATCGTCGATCAGCACGCTGCCCACGAACGCCTCGTGCTCGAGAGGCTGCGCGCCGCCG
GGGCGGGGCAGGGCGTGGCGCCTTCGCAGGCGTTGCTCATCCCTGAGGTGGTCGAGCTTGATGAAACGGCGTGCGACCGT
CTGGAAGAAGCTTCGGAAAAGCTTGCCGAATTCGGTCTGGCGCTGGAGCGTTTCGGTCCCAATGCGGTTCTCGTGCGCGC
CATTCCGGCGGCTCTCGCCAAGGGCGATCCGGCAAGGCTGGTGGCAGATGTCGCGGACGATCTTGCCCACCACGGCGATG
CGCTGCTGCTCGGCGAAAAGCTCGACCTCGTCCTCGCCACGATGGCCTGCCACGGCTCGGTCCGCGCAGGGCGCACGCTC
TCGGTGGCGGAAATGAACGCACTGTTGCGCGAAATGGAAGTGACGCCCCGCTCGGGCCAGTGCAACCACGGCCGCCCGAC
CTGGGTGAAACTCGCGCACGGAGACATAGAAAAGCTGTTCGGGAGGAAGTGA

Upstream 100 bases:

>100_bases
GGCGAAGTCCGCAAAGCCCATGGGTTTGTGCGGCTTTGGACGGATAACTTCACCGCTTGTCTCGAAATAAAGCGGGTTCG
GCGCTAGTCGTGTTCGGACC

Downstream 100 bases:

>100_bases
CGATGCAAGGAATGGCGCGCACCGCTTTGATTTCACTCGCTCTTCTAGGCACCTCTGGTTGCGGCGAGAAGGCGCCGAGC
GATGCCGAGGCCATCGCCGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MRVIRRLPETLINRIAAGEVVERPASALKELVENAIDAGSSHVHVRLSEGGLAMIEVSDDGCGMRPDEIALALERHATSK
LPDEAIELVETLGFRGEALPSIASVARVTIESRPHGTAEGWKRVVDNGALVAEGPAALPPGTRVRVEHLFEKIPARRKFL
RSPRSEWAAASDVVRRLAMARPDVGFTLEHDGRRALHVQAGETLEARVAQLVARELAGNSVEVDLVRGDFHLTGIAGLPT
FNRGVADHQYLFVNGRPVKDRLLIGAVRGAYADMLARDRHAVLALFLQVPASEVDVNVHPAKSEVRFRDPALVRGMVVSG
LRHALSTGDQRSAQAPSASAMAAWQAEPIAPPPPSSPSSDWQGSIFSQQWKPEPRVSEAGQAWRGYEQAIMAPPSARAEP
AAQPVVDAAQHPLGVARGQISNTYIVAEAEDGLVIVDQHAAHERLVLERLRAAGAGQGVAPSQALLIPEVVELDETACDR
LEEASEKLAEFGLALERFGPNAVLVRAIPAALAKGDPARLVADVADDLAHHGDALLLGEKLDLVLATMACHGSVRAGRTL
SVAEMNALLREMEVTPRSGQCNHGRPTWVKLAHGDIEKLFGRK

Sequences:

>Translated_603_residues
MRVIRRLPETLINRIAAGEVVERPASALKELVENAIDAGSSHVHVRLSEGGLAMIEVSDDGCGMRPDEIALALERHATSK
LPDEAIELVETLGFRGEALPSIASVARVTIESRPHGTAEGWKRVVDNGALVAEGPAALPPGTRVRVEHLFEKIPARRKFL
RSPRSEWAAASDVVRRLAMARPDVGFTLEHDGRRALHVQAGETLEARVAQLVARELAGNSVEVDLVRGDFHLTGIAGLPT
FNRGVADHQYLFVNGRPVKDRLLIGAVRGAYADMLARDRHAVLALFLQVPASEVDVNVHPAKSEVRFRDPALVRGMVVSG
LRHALSTGDQRSAQAPSASAMAAWQAEPIAPPPPSSPSSDWQGSIFSQQWKPEPRVSEAGQAWRGYEQAIMAPPSARAEP
AAQPVVDAAQHPLGVARGQISNTYIVAEAEDGLVIVDQHAAHERLVLERLRAAGAGQGVAPSQALLIPEVVELDETACDR
LEEASEKLAEFGLALERFGPNAVLVRAIPAALAKGDPARLVADVADDLAHHGDALLLGEKLDLVLATMACHGSVRAGRTL
SVAEMNALLREMEVTPRSGQCNHGRPTWVKLAHGDIEKLFGRK
>Mature_603_residues
MRVIRRLPETLINRIAAGEVVERPASALKELVENAIDAGSSHVHVRLSEGGLAMIEVSDDGCGMRPDEIALALERHATSK
LPDEAIELVETLGFRGEALPSIASVARVTIESRPHGTAEGWKRVVDNGALVAEGPAALPPGTRVRVEHLFEKIPARRKFL
RSPRSEWAAASDVVRRLAMARPDVGFTLEHDGRRALHVQAGETLEARVAQLVARELAGNSVEVDLVRGDFHLTGIAGLPT
FNRGVADHQYLFVNGRPVKDRLLIGAVRGAYADMLARDRHAVLALFLQVPASEVDVNVHPAKSEVRFRDPALVRGMVVSG
LRHALSTGDQRSAQAPSASAMAAWQAEPIAPPPPSSPSSDWQGSIFSQQWKPEPRVSEAGQAWRGYEQAIMAPPSARAEP
AAQPVVDAAQHPLGVARGQISNTYIVAEAEDGLVIVDQHAAHERLVLERLRAAGAGQGVAPSQALLIPEVVELDETACDR
LEEASEKLAEFGLALERFGPNAVLVRAIPAALAKGDPARLVADVADDLAHHGDALLLGEKLDLVLATMACHGSVRAGRTL
SVAEMNALLREMEVTPRSGQCNHGRPTWVKLAHGDIEKLFGRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=315, Percent_Identity=37.4603174603175, Blast_Score=193, Evalue=5e-49,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=29.512893982808, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=29.512893982808, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=27.190332326284, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI4505911, Length=331, Percent_Identity=27.190332326284, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI189458896, Length=314, Percent_Identity=26.1146496815287, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI310128480, Length=304, Percent_Identity=28.9473684210526, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI91992160, Length=342, Percent_Identity=25.4385964912281, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI91992162, Length=342, Percent_Identity=25.4385964912281, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI263191589, Length=220, Percent_Identity=31.8181818181818, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790612, Length=560, Percent_Identity=35.3571428571429, Blast_Score=260, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71991825, Length=324, Percent_Identity=36.1111111111111, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=338, Percent_Identity=28.698224852071, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=363, Percent_Identity=30.8539944903581, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=337, Percent_Identity=26.1127596439169, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=720, Percent_Identity=20.5555555555556, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=36.7741935483871, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17136970, Length=351, Percent_Identity=27.3504273504274, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 64732; Mature: 64732

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVIRRLPETLINRIAAGEVVERPASALKELVENAIDAGSSHVHVRLSEGGLAMIEVSDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCC
GCGMRPDEIALALERHATSKLPDEAIELVETLGFRGEALPSIASVARVTIESRPHGTAEG
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHH
WKRVVDNGALVAEGPAALPPGTRVRVEHLFEKIPARRKFLRSPRSEWAAASDVVRRLAMA
HHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHC
RPDVGFTLEHDGRRALHVQAGETLEARVAQLVARELAGNSVEVDLVRGDFHLTGIAGLPT
CCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEEECCCC
FNRGVADHQYLFVNGRPVKDRLLIGAVRGAYADMLARDRHAVLALFLQVPASEVDVNVHP
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECC
AKSEVRFRDPALVRGMVVSGLRHALSTGDQRSAQAPSASAMAAWQAEPIAPPPPSSPSSD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
WQGSIFSQQWKPEPRVSEAGQAWRGYEQAIMAPPSARAEPAAQPVVDAAQHPLGVARGQI
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHCCCC
SNTYIVAEAEDGLVIVDQHAAHERLVLERLRAAGAGQGVAPSQALLIPEVVELDETACDR
CCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHCHHHHHH
LEEASEKLAEFGLALERFGPNAVLVRAIPAALAKGDPARLVADVADDLAHHGDALLLGEK
HHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCH
LDLVLATMACHGSVRAGRTLSVAEMNALLREMEVTPRSGQCNHGRPTWVKLAHGDIEKLF
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHC
GRK
CCC
>Mature Secondary Structure
MRVIRRLPETLINRIAAGEVVERPASALKELVENAIDAGSSHVHVRLSEGGLAMIEVSDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCC
GCGMRPDEIALALERHATSKLPDEAIELVETLGFRGEALPSIASVARVTIESRPHGTAEG
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHH
WKRVVDNGALVAEGPAALPPGTRVRVEHLFEKIPARRKFLRSPRSEWAAASDVVRRLAMA
HHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHC
RPDVGFTLEHDGRRALHVQAGETLEARVAQLVARELAGNSVEVDLVRGDFHLTGIAGLPT
CCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEEECCCC
FNRGVADHQYLFVNGRPVKDRLLIGAVRGAYADMLARDRHAVLALFLQVPASEVDVNVHP
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECC
AKSEVRFRDPALVRGMVVSGLRHALSTGDQRSAQAPSASAMAAWQAEPIAPPPPSSPSSD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
WQGSIFSQQWKPEPRVSEAGQAWRGYEQAIMAPPSARAEPAAQPVVDAAQHPLGVARGQI
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHCCCC
SNTYIVAEAEDGLVIVDQHAAHERLVLERLRAAGAGQGVAPSQALLIPEVVELDETACDR
CCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHCHHHHHH
LEEASEKLAEFGLALERFGPNAVLVRAIPAALAKGDPARLVADVADDLAHHGDALLLGEK
HHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCH
LDLVLATMACHGSVRAGRTLSVAEMNALLREMEVTPRSGQCNHGRPTWVKLAHGDIEKLF
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHC
GRK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA