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The map label for this gene is hisI [H]

Identifier: 87200123

GI number: 87200123

Start: 2243640

End: 2243975

Strand: Reverse

Name: hisI [H]

Synonym: Saro_2107

Alternate gene names: 87200123

Gene position: 2243975-2243640 (Counterclockwise)

Preceding gene: 87200124

Following gene: 87200122

Centisome position: 63.0

GC content: 64.29

Gene sequence:

>336_bases
ATGCCGAAGTTCGATGCCAATGGCCTCGTCACCGCCGTCGCGGTCGACCATGCCACCGGTGCGCTGCTGATGCTTGCCCA
CATGGATGCGCAAGCCATCGCCAAAACGCGCGAGACCGGCTTTGCCCATTTCCATTCCCGCTCGCGCGGGCGCCTGTGGA
TGAAGGGGGAAAGCTCCGGCCACGTGCTGAGGATCGTCGAGATCCGCGTCGATTGCGACCAGGATGCGCTCGAACTGCGC
GTCGAGGCGGCAGGCCCTGCGTGCCATACTCTTGCGCCGACGTGCTTCTACCGCCGTCTTGACCATCGCGGCCAACTCGA
ACGCATCGTCGATTGA

Upstream 100 bases:

>100_bases
TTATCCTGCAACAATTCCGCAATCCCCATGCGGGATCGAAAGGTTGCGTTCCTTGGACAGAGTTACTGAAACCGCCCGCC
GCGAGCAGGGCACCGAATTC

Downstream 100 bases:

>100_bases
CGCTTACGTAAGGGGCAGGTAGCAAGATCGGCATGTCACAGTACGATGCCGCCACGACTCACGACCACACCGGGCACCTC
GATCAGCCTGACGCGCTGAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 111; Mature: 110

Protein sequence:

>111_residues
MPKFDANGLVTAVAVDHATGALLMLAHMDAQAIAKTRETGFAHFHSRSRGRLWMKGESSGHVLRIVEIRVDCDQDALELR
VEAAGPACHTLAPTCFYRRLDHRGQLERIVD

Sequences:

>Translated_111_residues
MPKFDANGLVTAVAVDHATGALLMLAHMDAQAIAKTRETGFAHFHSRSRGRLWMKGESSGHVLRIVEIRVDCDQDALELR
VEAAGPACHTLAPTCFYRRLDHRGQLERIVD
>Mature_110_residues
PKFDANGLVTAVAVDHATGALLMLAHMDAQAIAKTRETGFAHFHSRSRGRLWMKGESSGHVLRIVEIRVDCDQDALELRV
EAAGPACHTLAPTCFYRRLDHRGQLERIVD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=40.6593406593407, Blast_Score=85, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=37.3626373626374, Blast_Score=64, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 12306; Mature: 12175

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFDANGLVTAVAVDHATGALLMLAHMDAQAIAKTRETGFAHFHSRSRGRLWMKGESSG
CCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCEECCCCCCEEEEECCCCC
HVLRIVEIRVDCDQDALELRVEAAGPACHTLAPTCFYRRLDHRGQLERIVD
CEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
PKFDANGLVTAVAVDHATGALLMLAHMDAQAIAKTRETGFAHFHSRSRGRLWMKGESSG
CCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCEECCCCCCEEEEECCCCC
HVLRIVEIRVDCDQDALELRVEAAGPACHTLAPTCFYRRLDHRGQLERIVD
CEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA