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The map label for this gene is accC [H]

Identifier: 87200095

GI number: 87200095

Start: 2217156

End: 2218502

Strand: Direct

Name: accC [H]

Synonym: Saro_2079

Alternate gene names: 87200095

Gene position: 2217156-2218502 (Clockwise)

Preceding gene: 87200094

Following gene: 87200098

Centisome position: 62.25

GC content: 64.51

Gene sequence:

>1347_bases
ATGGCCATCAAGCGCCTGCTGATCGCCAATCGCGGCGAGATCGCGCTGCGCATCCATCGCGCGGCTCACGAAATGGGCAT
CGAGACGGTCGCGGTGCACTCCACCGCCGATGCCGATGCGATGCACGTGCGCCTTGCCGACCATGCGGTCTGCATCGGCC
CGCCCGCCGCGAAGGACAGCTATCTCAACGTCGCCGCGATCATCTCGGCTGCCGAGATCACCCATGCCGACGCGATCCAT
CCGGGCTACGGCTTCCTTTCGGAAAACGCCAAGTTCGCGGAAATCGTCGAAGCGCACGGTATCACCTGGGTCGGTCCCAA
GCCAGAACACATCCGCACGATGGGCGACAAGGTCGAGGCCAAGCGCACCGCGGGCGCGCTCGGCCTGCCGCTGGTCCCCG
GTTCCGACGGCGCGGTGTCCGAAATCGACGAGGCCAAGAAGATCGCCGATGCCATCGGCTATCCGGTGATCATCAAGGCA
GCCTCGGGCGGCGGCGGTCGCGGCATGAAGGTTTGCAACAGCGCCGACCAGCTCGAAACGCTGATGCAGCAAGCCGGCAG
CGAGGCGAAGGCCGCGTTCGGCGATGCCACCGTCTATATCGAGAAGTATCTCGGCAACCCGCGCCACATCGAATTCCAGA
TCTTCGGTGACGGCAACGGCAACGCGATCCACCTGGGCGAGCGCGACTGCTCGCTCCAGCGCCGCCACCAGAAGGTGCTC
GAGGAAGCGCCCTCGCCCGTCATCTCGGCCGACGAACGTGCGCGCATGGGCGGCATCGTCGCCAAGGCCATGGCCGACAT
GGGGTATCGCGGCGCGGGCACGATCGAGTTCCTGTGGGAGAACGGCGAGTTCTACTTCATCGAGATGAACACCCGCCTTC
AGGTGGAACATCCGGTGACCGAGGCGATCACCGGCGTCGACCTGGTGCGCGAACAGATCCGCATTGCCGATGGCAAGCCG
CTTTCGGTCACGCAGGACGAGATCGAGTTCAAGGGACACGCGATCGAGTGCCGCATCAATGCGGAAGACCCGTTCACATT
TGCCCCCTCGCCGGGACTGGTGAAGAGCTATCACGCAGCGGGCGGCATGCACGTGCGCGTCGATTCAGGTCTCTACGCCG
GGTACAAGATCCCGCCGTACTATGACTCGATGATTGCCAAGCTGATCGTCTACGGCCGGACCCGCGAAGGCTGCATCATG
CGGCTGAAGCGCGCGCTCGAGGAAATGGTGATCGAAGGCCCCAAGACCTCGATCCCGCTCCACCAGCGCCTGCTGAGCCA
GCCCGACTTCCTCAGCGGCGACTACACGATCAAGTGGCTCGAGGAATGGCTGGCCAAGGACGCCTGA

Upstream 100 bases:

>100_bases
CGCGCCGGCTGCCGGCGTCGTGAAGGCCATCCTCGTCGAGAACGCGCAGCCGGTCGAATTCGACCAGCCGCTGGTCGTGA
TCGCGTAAGGCGCTAGCGAA

Downstream 100 bases:

>100_bases
GGCCCACGCCACGGGCCCGCGCCACGGCAAAGAATCAAGCCCCTGCCTCGGCGGGGGCTTTTTTCGTTCAGCCTCTGGGC
TTCCATACGATGACGCGCCA

Product: biotin carboxylase / acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAIKRLLIANRGEIALRIHRAAHEMGIETVAVHSTADADAMHVRLADHAVCIGPPAAKDSYLNVAAIISAAEITHADAIH
PGYGFLSENAKFAEIVEAHGITWVGPKPEHIRTMGDKVEAKRTAGALGLPLVPGSDGAVSEIDEAKKIADAIGYPVIIKA
ASGGGGRGMKVCNSADQLETLMQQAGSEAKAAFGDATVYIEKYLGNPRHIEFQIFGDGNGNAIHLGERDCSLQRRHQKVL
EEAPSPVISADERARMGGIVAKAMADMGYRGAGTIEFLWENGEFYFIEMNTRLQVEHPVTEAITGVDLVREQIRIADGKP
LSVTQDEIEFKGHAIECRINAEDPFTFAPSPGLVKSYHAAGGMHVRVDSGLYAGYKIPPYYDSMIAKLIVYGRTREGCIM
RLKRALEEMVIEGPKTSIPLHQRLLSQPDFLSGDYTIKWLEEWLAKDA

Sequences:

>Translated_448_residues
MAIKRLLIANRGEIALRIHRAAHEMGIETVAVHSTADADAMHVRLADHAVCIGPPAAKDSYLNVAAIISAAEITHADAIH
PGYGFLSENAKFAEIVEAHGITWVGPKPEHIRTMGDKVEAKRTAGALGLPLVPGSDGAVSEIDEAKKIADAIGYPVIIKA
ASGGGGRGMKVCNSADQLETLMQQAGSEAKAAFGDATVYIEKYLGNPRHIEFQIFGDGNGNAIHLGERDCSLQRRHQKVL
EEAPSPVISADERARMGGIVAKAMADMGYRGAGTIEFLWENGEFYFIEMNTRLQVEHPVTEAITGVDLVREQIRIADGKP
LSVTQDEIEFKGHAIECRINAEDPFTFAPSPGLVKSYHAAGGMHVRVDSGLYAGYKIPPYYDSMIAKLIVYGRTREGCIM
RLKRALEEMVIEGPKTSIPLHQRLLSQPDFLSGDYTIKWLEEWLAKDA
>Mature_447_residues
AIKRLLIANRGEIALRIHRAAHEMGIETVAVHSTADADAMHVRLADHAVCIGPPAAKDSYLNVAAIISAAEITHADAIHP
GYGFLSENAKFAEIVEAHGITWVGPKPEHIRTMGDKVEAKRTAGALGLPLVPGSDGAVSEIDEAKKIADAIGYPVIIKAA
SGGGGRGMKVCNSADQLETLMQQAGSEAKAAFGDATVYIEKYLGNPRHIEFQIFGDGNGNAIHLGERDCSLQRRHQKVLE
EAPSPVISADERARMGGIVAKAMADMGYRGAGTIEFLWENGEFYFIEMNTRLQVEHPVTEAITGVDLVREQIRIADGKPL
SVTQDEIEFKGHAIECRINAEDPFTFAPSPGLVKSYHAAGGMHVRVDSGLYAGYKIPPYYDSMIAKLIVYGRTREGCIMR
LKRALEEMVIEGPKTSIPLHQRLLSQPDFLSGDYTIKWLEEWLAKDA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=47.6404494382022, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=47.6404494382022, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=47.6404494382022, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI116805327, Length=435, Percent_Identity=45.9770114942529, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=45.1901565995526, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=45.1901565995526, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=45.1901565995526, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI38679977, Length=507, Percent_Identity=31.3609467455621, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679967, Length=507, Percent_Identity=31.3609467455621, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679960, Length=507, Percent_Identity=31.3609467455621, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679974, Length=507, Percent_Identity=31.3609467455621, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI38679971, Length=507, Percent_Identity=31.3609467455621, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=31.496062992126, Blast_Score=232, Evalue=5e-61,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=60.2708803611738, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=45.8426966292135, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71987519, Length=436, Percent_Identity=47.0183486238532, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=43.652561247216, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=30.8943089430894, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=26.3261296660118, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=26.3261296660118, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.7589285714286, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.2053571428571, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6319685, Length=430, Percent_Identity=43.0232558139535, Blast_Score=344, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=31.0492505353319, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=29.8245614035088, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.5478841870824, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651757, Length=446, Percent_Identity=43.9461883408072, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=43.3823529411765, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24586458, Length=501, Percent_Identity=30.7385229540918, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI161076409, Length=501, Percent_Identity=30.7385229540918, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=30.7385229540918, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=30.7385229540918, Blast_Score=221, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48701; Mature: 48570

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKRLLIANRGEIALRIHRAAHEMGIETVAVHSTADADAMHVRLADHAVCIGPPAAKDS
CCCCEEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCC
YLNVAAIISAAEITHADAIHPGYGFLSENAKFAEIVEAHGITWVGPKPEHIRTMGDKVEA
CEEHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHH
KRTAGALGLPLVPGSDGAVSEIDEAKKIADAIGYPVIIKAASGGGGRGMKVCNSADQLET
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHH
LMQQAGSEAKAAFGDATVYIEKYLGNPRHIEFQIFGDGNGNAIHLGERDCSLQRRHQKVL
HHHHCCCHHHHHCCCCEEEEEHHCCCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPSPVISADERARMGGIVAKAMADMGYRGAGTIEFLWENGEFYFIEMNTRLQVEHPVT
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EAITGVDLVREQIRIADGKPLSVTQDEIEFKGHAIECRINAEDPFTFAPSPGLVKSYHAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHEECCEEEEEEECCCCCEEECCCCCHHHHHHCC
GGMHVRVDSGLYAGYKIPPYYDSMIAKLIVYGRTREGCIMRLKRALEEMVIEGPKTSIPL
CCEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
HQRLLSQPDFLSGDYTIKWLEEWLAKDA
HHHHCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AIKRLLIANRGEIALRIHRAAHEMGIETVAVHSTADADAMHVRLADHAVCIGPPAAKDS
CCCEEEECCCCCEEEEEEHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCC
YLNVAAIISAAEITHADAIHPGYGFLSENAKFAEIVEAHGITWVGPKPEHIRTMGDKVEA
CEEHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHH
KRTAGALGLPLVPGSDGAVSEIDEAKKIADAIGYPVIIKAASGGGGRGMKVCNSADQLET
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHH
LMQQAGSEAKAAFGDATVYIEKYLGNPRHIEFQIFGDGNGNAIHLGERDCSLQRRHQKVL
HHHHCCCHHHHHCCCCEEEEEHHCCCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPSPVISADERARMGGIVAKAMADMGYRGAGTIEFLWENGEFYFIEMNTRLQVEHPVT
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EAITGVDLVREQIRIADGKPLSVTQDEIEFKGHAIECRINAEDPFTFAPSPGLVKSYHAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHEECCEEEEEEECCCCCEEECCCCCHHHHHHCC
GGMHVRVDSGLYAGYKIPPYYDSMIAKLIVYGRTREGCIMRLKRALEEMVIEGPKTSIPL
CCEEEEECCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCH
HQRLLSQPDFLSGDYTIKWLEEWLAKDA
HHHHCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]