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The map label for this gene is trpE [H]

Identifier: 87200037

GI number: 87200037

Start: 2154555

End: 2156090

Strand: Direct

Name: trpE [H]

Synonym: Saro_2021

Alternate gene names: 87200037

Gene position: 2154555-2156090 (Clockwise)

Preceding gene: 87200036

Following gene: 87200038

Centisome position: 60.49

GC content: 68.82

Gene sequence:

>1536_bases
ATGACCACGATCGACGCATCCGCCGTCTCGCTGCCGGAAAACCACCGCGCCGCGCTTTCCCAGCTTTCCGCCGGAAAGCC
GGCGCTGGTCTGGCGCAAGCTGATCGTCGATACCGAGACTCCCGTCGGCGCCGCGCTCAAGCTGATGGAAAGCGGTCGCG
GCGATTTCCTGCTCGAATCCGTGCAGGGCGGCGAAGTACGCGGGCGCTACAGCCTGCTCGGGCTCGATCCCGATCTCGTC
TTCCGCGCCACCGGCTCGTCGGCAGAGATCAACCGCATCTGGCGGCACGACAAGGCAGCCTTCGCACCGCTACCCGGCGA
TGCCCTCGCCGAACTGCGCGCGCTCGTCGCCTCCTGCCGCATCGACGTCCCGGCCGAGCTGCCCTCGGCGCTCGCCTGCC
TCGTCGGCTACTTCGGCTACGAGACCATCGGCCTGGTCGAGAAGCTGCCCCGCGCACCGCAGAGCGAGCTTGTCCTGCCC
GACATGCTGTTCACCCGCCCGACCGTGGTGCTGGTGTTCGACCGCCTGTCCGACGAACTCTTCGCCATCGCCCCGGTCTG
GGCCGAAGGCGGCGATCCGGCGCGCCTGCTCGAAGCCGCGGCGGAGCGCATCGACAATGCCCTGCGCCGGCTGTCCGATC
CGGTCCCCGCCGATGCGCGCCTTGCCGAAGCGGTCGACGTCACGCCGCAGCCAGTCATGGCCGCACCCGACTATGCGCGT
ATGGTGACTGCCGCCAAGGACTACATCGAGGCGGGCGACATCTTCCAGGTCGTCCTCGCCCAGCGCTTCACCGCGCCCTT
CCCGCTGCCGCCCATCGCGCTCTACCGTTCGCTGCGCCGCATCAATCCCTCGCCGTTCCTCTACTTCCTCGACATGCCGG
GCTTTGCGCTCACCGGCTCCTCGCCGGAAATCCTGGTCCGCATCCGCGACGGCGAAGTCACGATCCGCCCGATTGCCGGC
ACCCGCCCGCGCGGGCGCACCGCCGAGGAAGACCGGGCCAACGAAGAGAGCCTGCTGGCCGATCCCAAGGAACGCGCCGA
ACACCTCATGCTGCTCGACCTCGGCCGCAACGACGTCGGCCGCGTGGCCAGGGCCGGCACCGTGAAAGTCACCGAAAGCT
ACACGGTCGAACGCTACAGCCACGTGATGCACATCGTCTCGAACGTGGTCGGCCAGCTCGACACGAACCGCGCCGACAGC
GTCGACGCCCTCTTCGCCGGGTTCCCCGCCGGCACAGTCTCGGGCGCACCCAAAGTCCGCGCCTGCGAGATCATCGCCGA
ACTCGAACCCGAGACGCGCGGCGCCTACGCTGGCGGTGTCGGCTATTTCGCGCCCGACGGCTCTGTCGATAGCTGCATCG
TCCTCAGGACCGGCATCCTCAAGGACGGCGTCCTCCATGTCCAGGCTGGCGCCGGCATCGTCGCCGACAGCGACCCCGCC
TACGAACAGCGCGAATGCGAAGCCAAGAGCGGCGCCCTCTTCGCCGCCGCGCGCGAAGCCGTCCGTGTCGCCACAGAACC
GAAGTTTGGCCAATGA

Upstream 100 bases:

>100_bases
GCGATCGGCAAGGACCTTGGCATCGAACGCAACGAATCCGCGATCAAGGCCGTCCGCAACCAGCTGACCGGCGCGAACAA
CCAGTAAGTCCACAAAGACG

Downstream 100 bases:

>100_bases
TCCTCGTCATCGACAACTACGACAGCTTCACCTGGAACCTCGTCCACTACCTGATGGAGATGGGCGCCGAGGTCGAAGTC
GTGCGCAACGATGCGCTGAC

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTTIDASAVSLPENHRAALSQLSAGKPALVWRKLIVDTETPVGAALKLMESGRGDFLLESVQGGEVRGRYSLLGLDPDLV
FRATGSSAEINRIWRHDKAAFAPLPGDALAELRALVASCRIDVPAELPSALACLVGYFGYETIGLVEKLPRAPQSELVLP
DMLFTRPTVVLVFDRLSDELFAIAPVWAEGGDPARLLEAAAERIDNALRRLSDPVPADARLAEAVDVTPQPVMAAPDYAR
MVTAAKDYIEAGDIFQVVLAQRFTAPFPLPPIALYRSLRRINPSPFLYFLDMPGFALTGSSPEILVRIRDGEVTIRPIAG
TRPRGRTAEEDRANEESLLADPKERAEHLMLLDLGRNDVGRVARAGTVKVTESYTVERYSHVMHIVSNVVGQLDTNRADS
VDALFAGFPAGTVSGAPKVRACEIIAELEPETRGAYAGGVGYFAPDGSVDSCIVLRTGILKDGVLHVQAGAGIVADSDPA
YEQRECEAKSGALFAAAREAVRVATEPKFGQ

Sequences:

>Translated_511_residues
MTTIDASAVSLPENHRAALSQLSAGKPALVWRKLIVDTETPVGAALKLMESGRGDFLLESVQGGEVRGRYSLLGLDPDLV
FRATGSSAEINRIWRHDKAAFAPLPGDALAELRALVASCRIDVPAELPSALACLVGYFGYETIGLVEKLPRAPQSELVLP
DMLFTRPTVVLVFDRLSDELFAIAPVWAEGGDPARLLEAAAERIDNALRRLSDPVPADARLAEAVDVTPQPVMAAPDYAR
MVTAAKDYIEAGDIFQVVLAQRFTAPFPLPPIALYRSLRRINPSPFLYFLDMPGFALTGSSPEILVRIRDGEVTIRPIAG
TRPRGRTAEEDRANEESLLADPKERAEHLMLLDLGRNDVGRVARAGTVKVTESYTVERYSHVMHIVSNVVGQLDTNRADS
VDALFAGFPAGTVSGAPKVRACEIIAELEPETRGAYAGGVGYFAPDGSVDSCIVLRTGILKDGVLHVQAGAGIVADSDPA
YEQRECEAKSGALFAAAREAVRVATEPKFGQ
>Mature_510_residues
TTIDASAVSLPENHRAALSQLSAGKPALVWRKLIVDTETPVGAALKLMESGRGDFLLESVQGGEVRGRYSLLGLDPDLVF
RATGSSAEINRIWRHDKAAFAPLPGDALAELRALVASCRIDVPAELPSALACLVGYFGYETIGLVEKLPRAPQSELVLPD
MLFTRPTVVLVFDRLSDELFAIAPVWAEGGDPARLLEAAAERIDNALRRLSDPVPADARLAEAVDVTPQPVMAAPDYARM
VTAAKDYIEAGDIFQVVLAQRFTAPFPLPPIALYRSLRRINPSPFLYFLDMPGFALTGSSPEILVRIRDGEVTIRPIAGT
RPRGRTAEEDRANEESLLADPKERAEHLMLLDLGRNDVGRVARAGTVKVTESYTVERYSHVMHIVSNVVGQLDTNRADSV
DALFAGFPAGTVSGAPKVRACEIIAELEPETRGAYAGGVGYFAPDGSVDSCIVLRTGILKDGVLHVQAGAGIVADSDPAY
EQRECEAKSGALFAAAREAVRVATEPKFGQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=395, Percent_Identity=36.7088607594937, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI1788114, Length=352, Percent_Identity=36.0795454545455, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI87082077, Length=296, Percent_Identity=29.7297297297297, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786809, Length=216, Percent_Identity=32.4074074074074, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=473, Percent_Identity=36.1522198731501, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324361, Length=387, Percent_Identity=27.1317829457364, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54903; Mature: 54772

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIDASAVSLPENHRAALSQLSAGKPALVWRKLIVDTETPVGAALKLMESGRGDFLLES
CCCCCCCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEC
VQGGEVRGRYSLLGLDPDLVFRATGSSAEINRIWRHDKAAFAPLPGDALAELRALVASCR
CCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
IDVPAELPSALACLVGYFGYETIGLVEKLPRAPQSELVLPDMLFTRPTVVLVFDRLSDEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEHHCCCE
FAIAPVWAEGGDPARLLEAAAERIDNALRRLSDPVPADARLAEAVDVTPQPVMAAPDYAR
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHH
MVTAAKDYIEAGDIFQVVLAQRFTAPFPLPPIALYRSLRRINPSPFLYFLDMPGFALTGS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECC
SPEILVRIRDGEVTIRPIAGTRPRGRTAEEDRANEESLLADPKERAEHLMLLDLGRNDVG
CCEEEEEEECCCEEEEECCCCCCCCCCCHHHCCCCHHHCCCHHHHHCEEEEEECCCCCHH
RVARAGTVKVTESYTVERYSHVMHIVSNVVGQLDTNRADSVDALFAGFPAGTVSGAPKVR
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHH
ACEIIAELEPETRGAYAGGVGYFAPDGSVDSCIVLRTGILKDGVLHVQAGAGIVADSDPA
HHHHHHHCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEECCCCEEECCCCC
YEQRECEAKSGALFAAAREAVRVATEPKFGQ
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTIDASAVSLPENHRAALSQLSAGKPALVWRKLIVDTETPVGAALKLMESGRGDFLLES
CCCCCCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEC
VQGGEVRGRYSLLGLDPDLVFRATGSSAEINRIWRHDKAAFAPLPGDALAELRALVASCR
CCCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
IDVPAELPSALACLVGYFGYETIGLVEKLPRAPQSELVLPDMLFTRPTVVLVFDRLSDEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEHHCCCE
FAIAPVWAEGGDPARLLEAAAERIDNALRRLSDPVPADARLAEAVDVTPQPVMAAPDYAR
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCHHHH
MVTAAKDYIEAGDIFQVVLAQRFTAPFPLPPIALYRSLRRINPSPFLYFLDMPGFALTGS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECC
SPEILVRIRDGEVTIRPIAGTRPRGRTAEEDRANEESLLADPKERAEHLMLLDLGRNDVG
CCEEEEEEECCCEEEEECCCCCCCCCCCHHHCCCCHHHCCCHHHHHCEEEEEECCCCCHH
RVARAGTVKVTESYTVERYSHVMHIVSNVVGQLDTNRADSVDALFAGFPAGTVSGAPKVR
HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHH
ACEIIAELEPETRGAYAGGVGYFAPDGSVDSCIVLRTGILKDGVLHVQAGAGIVADSDPA
HHHHHHHCCCCCCCCCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEECCCCEEECCCCC
YEQRECEAKSGALFAAAREAVRVATEPKFGQ
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA