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The map label for this gene is ethA [H]

Identifier: 87199836

GI number: 87199836

Start: 1918216

End: 1919733

Strand: Direct

Name: ethA [H]

Synonym: Saro_1819

Alternate gene names: 87199836

Gene position: 1918216-1919733 (Clockwise)

Preceding gene: 87199835

Following gene: 87199841

Centisome position: 53.86

GC content: 63.18

Gene sequence:

>1518_bases
ATGGCTGAGCAAGCGCAGGCTGGCGGCGATTTCGACGTATTGATCGTCGGCGCCGGCATTTCGGGCATCGGGTCCGCATG
GCATCTTCAGGACCAGTGCCCCGACAAGACCTATGCGATCATCGAGAGCAAGGACACTTTCGGCGGGACCTGGGAAACCC
ACAAGTATCCCGGCGTGCGATCGGATTCCGACCTTTACACCTTCGGCTACCGTTTCAAGCCGTGGGTCGGTGCGCCGATC
GCGAGCGCGCAGGCGATCCTCGACTACATGGGCGAGGTGATCGACGAAGCCGGGATCGACCGCCACATCCGCTATGGCCA
CACGATCACGAGCGCCAGATGGTCGAGCGAGACCAACCGCTGGACGCTGGAGGCGCGGCGCAAGGATGGCACGACCGCCA
CGTTCACCGCGAACTTCCTGTGGATGTGCCAGGGGTACTACGACCACCAGGTCCCCTACATTCCGAAGGAATGGAAGGGC
GTATCGGACTTCAAGGGCCTGTTCGTCCACGCCCAGCTCTGGGACCCGGCGACCGACTGGGAAGGCAAGCGCATCCTCGT
GATCGGATCGGGCGCGACCGCCGCCACGGTGGTCCCCGCCTTTGCCGACAAGGCGCAGGTCACGATGCTCCAGCGTTCGC
CGACCTATTTCTACTGCCATCCCAACCAGAACGAGCTGGCCGACCGCCTGCGCCAGATCGGCATCGACGAGCCGACCATC
CATCGCGTCGTGCGCGCGCAGATCATGCATGACCAGGCCGTGATGGACAAACGCTGCGTCGATGAACCCGACGTCGTGTT
CGAGGAGCTGAAGATGGCCGTCCGCGCCTATGCGGGCGAGGATTTCGAGTTCGAGCCGCACTTCACGCCGAAGTACCGGC
CCTGGCAGCAGCGACTGGCATTCTGTCCCGACGGCGACCTGTTCCGCGCTGCCGCCGAGGGCAAGGTGCGCGTCGTGACG
GACACCATCGACCGGTTCACCGAAAAGGGTGTGCTGACCGCTTCGGGCGAACTGCTCGAAGCGGACATCATCGTCGCCTG
CACCGGCTTCCATCTCAAGGTGCTGGGCGACATTCCGTTCGAGGTCGATGGCAAGGCGGTGAACTGGGGCGATACCGTTA
CCTATCGCGGCATGATGTTCACCGGCGTGCCCAACATGGTCTGGGTATTCGGCTATTTCCGGGCAAGCTGGACCCTGCGC
GTCGACATGATGGGAGACTTCGTCTGCCGCCTGCTCAGGCACATGGACGAGCGAGGAGTGAAGAAGGTCGAAGTGGCCTT
CCGCGACGAGGATTCCGGCATGAAGATCCTGCCGTGGATCGAGGCCGACAACTTCAATCCCGGCTATCTCATGCGCGATC
TGGACAAGCTGCCCAAGCGCGGCGACAAGAGCGAATGGCGCCACAACCAGAACTACTGGCTGGAGCGCGAGGCCTTTCCT
GCGATCGATCTCGATGGTCAGGAGTTCATCTACAACGGCGTCCGCGCCGAGCCGCGCGTAGTTGAGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
CTGCCACGACCATCAGGTTGCAAGTTGACACCGATCAATGTCACTTTTCCCATCGAGCCGAAAACGGCCACATGATGGCG
CAAGACCACGGAGAGACAGG

Downstream 100 bases:

>100_bases
AAGTATCCTTTAACTGATTGAAAGCTTTCATATCGAACCTTGATCCCGGACTGCGGACATGCCGCTCCGGGGTCATTTGT
TCTCATTTTGTTTCCCCAGG

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MAEQAQAGGDFDVLIVGAGISGIGSAWHLQDQCPDKTYAIIESKDTFGGTWETHKYPGVRSDSDLYTFGYRFKPWVGAPI
ASAQAILDYMGEVIDEAGIDRHIRYGHTITSARWSSETNRWTLEARRKDGTTATFTANFLWMCQGYYDHQVPYIPKEWKG
VSDFKGLFVHAQLWDPATDWEGKRILVIGSGATAATVVPAFADKAQVTMLQRSPTYFYCHPNQNELADRLRQIGIDEPTI
HRVVRAQIMHDQAVMDKRCVDEPDVVFEELKMAVRAYAGEDFEFEPHFTPKYRPWQQRLAFCPDGDLFRAAAEGKVRVVT
DTIDRFTEKGVLTASGELLEADIIVACTGFHLKVLGDIPFEVDGKAVNWGDTVTYRGMMFTGVPNMVWVFGYFRASWTLR
VDMMGDFVCRLLRHMDERGVKKVEVAFRDEDSGMKILPWIEADNFNPGYLMRDLDKLPKRGDKSEWRHNQNYWLEREAFP
AIDLDGQEFIYNGVRAEPRVVEAAE

Sequences:

>Translated_505_residues
MAEQAQAGGDFDVLIVGAGISGIGSAWHLQDQCPDKTYAIIESKDTFGGTWETHKYPGVRSDSDLYTFGYRFKPWVGAPI
ASAQAILDYMGEVIDEAGIDRHIRYGHTITSARWSSETNRWTLEARRKDGTTATFTANFLWMCQGYYDHQVPYIPKEWKG
VSDFKGLFVHAQLWDPATDWEGKRILVIGSGATAATVVPAFADKAQVTMLQRSPTYFYCHPNQNELADRLRQIGIDEPTI
HRVVRAQIMHDQAVMDKRCVDEPDVVFEELKMAVRAYAGEDFEFEPHFTPKYRPWQQRLAFCPDGDLFRAAAEGKVRVVT
DTIDRFTEKGVLTASGELLEADIIVACTGFHLKVLGDIPFEVDGKAVNWGDTVTYRGMMFTGVPNMVWVFGYFRASWTLR
VDMMGDFVCRLLRHMDERGVKKVEVAFRDEDSGMKILPWIEADNFNPGYLMRDLDKLPKRGDKSEWRHNQNYWLEREAFP
AIDLDGQEFIYNGVRAEPRVVEAAE
>Mature_504_residues
AEQAQAGGDFDVLIVGAGISGIGSAWHLQDQCPDKTYAIIESKDTFGGTWETHKYPGVRSDSDLYTFGYRFKPWVGAPIA
SAQAILDYMGEVIDEAGIDRHIRYGHTITSARWSSETNRWTLEARRKDGTTATFTANFLWMCQGYYDHQVPYIPKEWKGV
SDFKGLFVHAQLWDPATDWEGKRILVIGSGATAATVVPAFADKAQVTMLQRSPTYFYCHPNQNELADRLRQIGIDEPTIH
RVVRAQIMHDQAVMDKRCVDEPDVVFEELKMAVRAYAGEDFEFEPHFTPKYRPWQQRLAFCPDGDLFRAAAEGKVRVVTD
TIDRFTEKGVLTASGELLEADIIVACTGFHLKVLGDIPFEVDGKAVNWGDTVTYRGMMFTGVPNMVWVFGYFRASWTLRV
DMMGDFVCRLLRHMDERGVKKVEVAFRDEDSGMKILPWIEADNFNPGYLMRDLDKLPKRGDKSEWRHNQNYWLEREAFPA
IDLDGQEFIYNGVRAEPRVVEAAE

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57483; Mature: 57351

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQAQAGGDFDVLIVGAGISGIGSAWHLQDQCPDKTYAIIESKDTFGGTWETHKYPGVR
CCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
SDSDLYTFGYRFKPWVGAPIASAQAILDYMGEVIDEAGIDRHIRYGHTITSARWSSETNR
CCCCEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCE
WTLEARRKDGTTATFTANFLWMCQGYYDHQVPYIPKEWKGVSDFKGLFVHAQLWDPATDW
EEEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCC
EGKRILVIGSGATAATVVPAFADKAQVTMLQRSPTYFYCHPNQNELADRLRQIGIDEPTI
CCCEEEEEECCCCHHHEEHHHCCCCEEEEEECCCEEEEECCCHHHHHHHHHHCCCCCHHH
HRVVRAQIMHDQAVMDKRCVDEPDVVFEELKMAVRAYAGEDFEFEPHFTPKYRPWQQRLA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCC
FCPDGDLFRAAAEGKVRVVTDTIDRFTEKGVLTASGELLEADIIVACTGFHLKVLGDIPF
CCCCCCCEECCCCCEEEEEEHHHHHHHHCCEEEECCCEEEEEEEEEECCCEEEEEECCCE
EVDGKAVNWGDTVTYRGMMFTGVPNMVWVFGYFRASWTLRVDMMGDFVCRLLRHMDERGV
EECCCEECCCCCEEECCEEEECCCCCEEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHCCC
KKVEVAFRDEDSGMKILPWIEADNFNPGYLMRDLDKLPKRGDKSEWRHNQNYWLEREAFP
EEEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCEEECCCCC
AIDLDGQEFIYNGVRAEPRVVEAAE
EECCCCHHHHHCCCCCCCCEEECCC
>Mature Secondary Structure 
AEQAQAGGDFDVLIVGAGISGIGSAWHLQDQCPDKTYAIIESKDTFGGTWETHKYPGVR
CCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
SDSDLYTFGYRFKPWVGAPIASAQAILDYMGEVIDEAGIDRHIRYGHTITSARWSSETNR
CCCCEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCE
WTLEARRKDGTTATFTANFLWMCQGYYDHQVPYIPKEWKGVSDFKGLFVHAQLWDPATDW
EEEEEECCCCCEEEEEEEEEEEEECCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCCCCC
EGKRILVIGSGATAATVVPAFADKAQVTMLQRSPTYFYCHPNQNELADRLRQIGIDEPTI
CCCEEEEEECCCCHHHEEHHHCCCCEEEEEECCCEEEEECCCHHHHHHHHHHCCCCCHHH
HRVVRAQIMHDQAVMDKRCVDEPDVVFEELKMAVRAYAGEDFEFEPHFTPKYRPWQQRLA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCC
FCPDGDLFRAAAEGKVRVVTDTIDRFTEKGVLTASGELLEADIIVACTGFHLKVLGDIPF
CCCCCCCEECCCCCEEEEEEHHHHHHHHCCEEEECCCEEEEEEEEEECCCEEEEEECCCE
EVDGKAVNWGDTVTYRGMMFTGVPNMVWVFGYFRASWTLRVDMMGDFVCRLLRHMDERGV
EECCCEECCCCCEEECCEEEECCCCCEEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHCCC
KKVEVAFRDEDSGMKILPWIEADNFNPGYLMRDLDKLPKRGDKSEWRHNQNYWLEREAFP
EEEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCEEECCCCC
AIDLDGQEFIYNGVRAEPRVVEAAE
EECCCCHHHHHCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]